Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P08908

- 5HT1A_HUMAN

UniProt

P08908 - 5HT1A_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

5-hydroxytryptamine receptor 1A

Gene

HTR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications

GO - Molecular functioni

  1. serotonin receptor activity Source: UniProtKB

GO - Biological processi

  1. adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
  2. behavioral fear response Source: UniProtKB
  3. cell proliferation Source: InterPro
  4. exploration behavior Source: UniProtKB
  5. G-protein coupled receptor signaling pathway Source: UniProtKB
  6. positive regulation of cell proliferation Source: ProtInc
  7. regulation of behavior Source: InterPro
  8. regulation of dopamine metabolic process Source: UniProtKB
  9. regulation of hormone secretion Source: InterPro
  10. regulation of serotonin secretion Source: UniProtKB
  11. serotonin metabolic process Source: UniProtKB
  12. serotonin receptor signaling pathway Source: UniProtKB
  13. vasoconstriction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Behavior

Enzyme and pathway databases

ReactomeiREACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 1A
Short name:
5-HT-1A
Short name:
5-HT1A
Alternative name(s):
G-21
Serotonin receptor 1A
Gene namesi
Name:HTR1A
Synonyms:ADRB2RL1, ADRBRL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:5286. HTR1A.

Subcellular locationi

Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.

Organism-specific databases

MIMi614674. phenotype.
PharmGKBiPA192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4224225-hydroxytryptamine receptor 1APRO_0000068903Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Cross-linki334 – 334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP08908.
PRIDEiP08908.

PTM databases

PhosphoSiteiP08908.

Expressioni

Tissue specificityi

Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications

Gene expression databases

BgeeiP08908.
CleanExiHS_HTR1A.
ExpressionAtlasiP08908. baseline.
GenevestigatoriP08908.

Organism-specific databases

HPAiHPA018073.

Interactioni

Subunit structurei

Heterodimer; heterodimerizes with GPER1.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
FGFR1P1136211EBI-6570214,EBI-1028277

Protein-protein interaction databases

BioGridi109582. 6 interactions.
IntActiP08908. 4 interactions.
STRINGi9606.ENSP00000316244.

Structurei

3D structure databases

ProteinModelPortaliP08908.
SMRiP08908. Positions 31-418.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3636ExtracellularBy similarityAdd
BLAST
Topological domaini63 – 7311CytoplasmicBy similarityAdd
BLAST
Topological domaini99 – 11012ExtracellularBy similarityAdd
BLAST
Topological domaini133 – 15220CytoplasmicBy similarityAdd
BLAST
Topological domaini179 – 19113ExtracellularBy similarityAdd
BLAST
Topological domaini218 – 345128CytoplasmicBy similarityAdd
BLAST
Topological domaini368 – 37811ExtracellularBy similarityAdd
BLAST
Topological domaini404 – 42219CytoplasmicBy similarityAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei37 – 6226Helical; Name=1By similarityAdd
BLAST
Transmembranei74 – 9825Helical; Name=2By similarityAdd
BLAST
Transmembranei111 – 13222Helical; Name=3By similarityAdd
BLAST
Transmembranei153 – 17826Helical; Name=4By similarityAdd
BLAST
Transmembranei192 – 21726Helical; Name=5By similarityAdd
BLAST
Transmembranei346 – 36722Helical; Name=6By similarityAdd
BLAST
Transmembranei379 – 40325Helical; Name=7By similarityAdd
BLAST

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni112 – 12110Agonist bindingBy similarity
Regioni358 – 3625Agonist bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi133 – 1353DRY motif; important for ligand-induced conformation changesBy similarity
Motifi396 – 4005NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG249628.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.
InParanoidiP08908.
KOiK04153.
OMAiTGAPCAN.
PhylomeDBiP08908.
TreeFamiTF316350.

Family and domain databases

Gene3Di1.20.1070.10. 2 hits.
InterProiIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24247:SF20. PTHR24247:SF20. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08908-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA
60 70 80 90 100
VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN
110 120 130 140 150
KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP
160 170 180 190 200
RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST
210 220 230 240 250
FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP
260 270 280 290 300
KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN
310 320 330 340 350
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII
360 370 380 390 400
MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY
410 420
AYFNKDFQNA FKKIIKCKFC RQ
Length:422
Mass (Da):46,107
Last modified:April 1, 1993 - v3
Checksum:i762664FCF62CFD8F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti152 – 1543RAA → PR in AAA36440. (PubMed:3041227)Curated
Sequence conflicti152 – 1543RAA → PR in CAA31908. (PubMed:3041227)Curated
Sequence conflicti172 – 1721M → I in AAA36440. (PubMed:3041227)Curated
Sequence conflicti172 – 1721M → I in CAA31908. (PubMed:3041227)Curated
Sequence conflicti200 – 2023TFG → RPR no nucleotide entry (PubMed:8393041)Curated
Sequence conflicti228 – 2281K → R no nucleotide entry (PubMed:8393041)Curated
Sequence conflicti244 – 2441A → AA no nucleotide entry (PubMed:8393041)Curated
Sequence conflicti355 – 3551I → T no nucleotide entry (PubMed:8393041)Curated
Sequence conflicti363 – 3653IVA → MRP no nucleotide entry (PubMed:8393041)Curated
Sequence conflicti418 – 4181K → N in AAA36440. (PubMed:3041227)Curated
Sequence conflicti418 – 4181K → N in CAA31908. (PubMed:3041227)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti16 – 161P → L.1 Publication
Corresponds to variant rs1800041 [ dbSNP | Ensembl ].
VAR_003446
Natural varianti22 – 221G → S.1 Publication
Corresponds to variant rs1799920 [ dbSNP | Ensembl ].
VAR_011826
Natural varianti28 – 281I → V.1 Publication
Corresponds to variant rs1799921 [ dbSNP | Ensembl ].
VAR_011827
Natural varianti184 – 1841P → L.
Corresponds to variant rs1800043 [ dbSNP | Ensembl ].
VAR_011828
Natural varianti220 – 2201R → L.
Corresponds to variant rs1800044 [ dbSNP | Ensembl ].
VAR_011829
Natural varianti273 – 2731G → D.1 Publication
Corresponds to variant rs1800042 [ dbSNP | Ensembl ].
VAR_011830

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28269 Genomic DNA. Translation: AAA36440.1.
X13556 Genomic DNA. Translation: CAA31908.1.
X57829 Genomic DNA. Translation: CAA40962.1.
M83181 Genomic DNA. Translation: AAA66493.1.
AB041403 Genomic DNA. Translation: BAA94488.1.
AF498978 mRNA. Translation: AAM21125.1.
BC069159 mRNA. Translation: AAH69159.1.
Z11168 Genomic DNA. Translation: CAA77560.1.
CCDSiCCDS34168.1.
PIRiI38209.
RefSeqiNP_000515.2. NM_000524.3.
UniGeneiHs.247940.

Genome annotation databases

EnsembliENST00000323865; ENSP00000316244; ENSG00000178394.
GeneIDi3350.
KEGGihsa:3350.
UCSCiuc011cqt.3. human.

Polymorphism databases

DMDMi231454.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M28269 Genomic DNA. Translation: AAA36440.1 .
X13556 Genomic DNA. Translation: CAA31908.1 .
X57829 Genomic DNA. Translation: CAA40962.1 .
M83181 Genomic DNA. Translation: AAA66493.1 .
AB041403 Genomic DNA. Translation: BAA94488.1 .
AF498978 mRNA. Translation: AAM21125.1 .
BC069159 mRNA. Translation: AAH69159.1 .
Z11168 Genomic DNA. Translation: CAA77560.1 .
CCDSi CCDS34168.1.
PIRi I38209.
RefSeqi NP_000515.2. NM_000524.3.
UniGenei Hs.247940.

3D structure databases

ProteinModelPortali P08908.
SMRi P08908. Positions 31-418.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109582. 6 interactions.
IntActi P08908. 4 interactions.
STRINGi 9606.ENSP00000316244.

Chemistry

BindingDBi P08908.
ChEMBLi CHEMBL2111460.
DrugBanki DB01614. Acepromazine.
DB00866. Alprenolol.
DB01616. Alverine.
DB00321. Amitriptyline.
DB00543. Amoxapine.
DB00714. Apomorphine.
DB01238. Aripiprazole.
DB06216. Asenapine.
DB08807. Bopindolol.
DB01200. Bromocriptine.
DB00490. Buspirone.
DB00248. Cabergoline.
DB00477. Chlorpromazine.
DB08810. Cinitapride.
DB00363. Clozapine.
DB01151. Desipramine.
DB00988. Dopamine.
DB01142. Doxepin.
DB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00696. Ergotamine.
DB04946. Iloperidone.
DB00458. Imipramine.
DB01221. Ketamine.
DB00589. Lisuride.
DB00408. Loxapine.
DB08815. Lurasidone.
DB00247. Methysergide.
DB06148. Mianserin.
DB01618. Molindone.
DB00952. Naratriptan.
DB01149. Nefazodone.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00904. Ondansetron.
DB01267. Paliperidone.
DB01359. Penbutolol.
DB01186. Pergolide.
DB00960. Pindolol.
DB01621. Pipotiazine.
DB00413. Pramipexole.
DB00571. Propranolol.
DB01224. Quetiapine.
DB00734. Risperidone.
DB00268. Ropinirole.
DB05271. Rotigotine.
DB00669. Sumatriptan.
DB01622. Thioproperazine.
DB00656. Trazodone.
DB00726. Trimipramine.
DB06684. Vilazodone.
DB01392. Yohimbine.
DB00246. Ziprasidone.
DB00315. Zolmitriptan.
GuidetoPHARMACOLOGYi 1.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P08908.

Polymorphism databases

DMDMi 231454.

Proteomic databases

PaxDbi P08908.
PRIDEi P08908.

Protocols and materials databases

DNASUi 3350.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000323865 ; ENSP00000316244 ; ENSG00000178394 .
GeneIDi 3350.
KEGGi hsa:3350.
UCSCi uc011cqt.3. human.

Organism-specific databases

CTDi 3350.
GeneCardsi GC05M063292.
HGNCi HGNC:5286. HTR1A.
HPAi HPA018073.
MIMi 109760. gene.
614674. phenotype.
neXtProti NX_P08908.
PharmGKBi PA192.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG249628.
HOGENOMi HOG000239242.
HOVERGENi HBG106962.
InParanoidi P08908.
KOi K04153.
OMAi TGAPCAN.
PhylomeDBi P08908.
TreeFami TF316350.

Enzyme and pathway databases

Reactomei REACT_17064. Serotonin receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 3350.
NextBioi 13248.
PROi P08908.
SOURCEi Search...

Gene expression databases

Bgeei P08908.
CleanExi HS_HTR1A.
ExpressionAtlasi P08908. baseline.
Genevestigatori P08908.

Family and domain databases

Gene3Di 1.20.1070.10. 2 hits.
InterProi IPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
PANTHERi PTHR24247:SF20. PTHR24247:SF20. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."
    Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., Francke U., Lefkowitz R.J., Caron M.G.
    Nature 329:75-79(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  2. "Nucleotide and deduced amino acid sequence of the human serotonin 5-HT1a receptor gene."
    Saltzman A.G., Morse B., Felder S.
    Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.
    Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Human-specific amino acid changes found in 103 protein-coding genes."
    Kitano T., Liu Y.-H., Ueda S., Saitou N.
    Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Puhl H.L. III, Ikeda S.R., Aronstam R.S.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  7. "A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."
    Parks C.L., Chang L.S., Shenk T.
    Nucleic Acids Res. 19:7155-7160(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
  8. "Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."
    Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A.
    J. Immunol. 151:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-365, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  9. "The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."
    Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., Lefkowitz R.J.
    Nature 335:358-360(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  10. "Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors."
    Harrington M.A., Shaw K., Zhong P., Ciaranello R.D.
    J. Pharmacol. Exp. Ther. 268:1098-1106(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  11. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
    Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
    J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334.
    Tissue: Lung adenocarcinoma.
  12. Cited for: REVIEW.
  13. "5-HT1A receptor-regulated signal transduction pathways in brain."
    Polter A.M., Li X.
    Cell. Signal. 22:1406-1412(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  14. "Serotonin receptors - from molecular biology to clinical applications."
    Pytliak M., Vargova V., Mechirova V., Felsoci M.
    Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  15. "Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene."
    Jiang Y.C., Wu H.M., Cheng K.H., Sunny Sun H.
    Hum. Mutat. 33:209-217(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PFMC.
  16. "Role of glycosphingolipids in the function of human serotonin(1)A receptors."
    Singh P., Paila Y.D., Chattopadhyay A.
    J. Neurochem. 123:716-724(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  17. "Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."
    Akama K.T., Thompson L.I., Milner T.A., McEwen B.S.
    J. Biol. Chem. 288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
  18. "Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."
    Nakhai B., Nielsen D.A., Linnoila M., Goldman D.
    Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS SER-22 AND VAL-28.
  19. "Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."
    Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.
    Am. J. Med. Genet. 81:434-439(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS LEU-16 AND ASP-273.

Entry informationi

Entry namei5HT1A_HUMAN
AccessioniPrimary (citable) accession number: P08908
Secondary accession number(s): Q6LAE7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1993
Last modified: October 29, 2014
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3