5-hydroxytryptamine receptor 1A - Homo sapiens (Human)

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Reviewed, UniProtKB/Swiss-Prot P08908 (5HT1A_HUMAN)

Last modified June 16, 2009. Version 99. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    5-hydroxytryptamine receptor 1A
      Short name=5-HT-1A
      Short name=5-HT1A
Alternative name(s):
    Serotonin receptor 1A
    G-21

Gene names

Name:	HTR1A
Synonyms:	ADRB2RL1, ADRBRL1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Ref.8
Subcellular location	Cell membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

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Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Isopeptide bond Ubl conjugation
Gene Ontology (GO)
Biological process	G-protein coupled receptor protein signaling pathway Traceable author statement. Source: ProtInc behavior Traceable author statement. Source: ProtInc positive regulation of cell proliferation Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Ref.8 Traceable author statement. Source: ProtInc
Molecular function	serotonin receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 422

422

5-hydroxytryptamine receptor 1A

PRO_0000068903

Regions

Topological domain

1 – 36

Extracellular By similarity

Transmembrane

37 – 62

1 By similarity

Topological domain

63 – 73

Cytoplasmic By similarity

Transmembrane

74 – 98

2 By similarity

Topological domain

99 – 109

Extracellular By similarity

Transmembrane

110 – 132

3 By similarity

Topological domain

133 – 152

Cytoplasmic By similarity

Transmembrane

153 – 178

4 By similarity

Topological domain

179 – 191

Extracellular By similarity

Transmembrane

192 – 217

5 By similarity

Topological domain

218 – 345

128

Cytoplasmic By similarity

Transmembrane

346 – 367

6 By similarity

Topological domain

368 – 378

Extracellular By similarity

Transmembrane

379 – 403

7 By similarity

Topological domain

404 – 422

Cytoplasmic By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

N-linked (GlcNAc...) Potential

Disulfide bond

109 ↔ 187

By similarity

Cross-link

334

Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Natural variations

Natural variant

P → L: dbSNP rs1800041. Ref.11

VAR_003446

Natural variant

G → S: dbSNP rs1799920. Ref.10

VAR_011826

Natural variant

I → V: dbSNP rs1799921. Ref.10

VAR_011827

Natural variant

184

P → L: dbSNP rs1800043.

VAR_011828

Natural variant

220

R → L: dbSNP rs1800044.

VAR_011829

Natural variant

273

G → D: dbSNP rs1800042. Ref.11

VAR_011830

Experimental info

Sequence conflict

152 – 154

RAA → PR in AAA36440. Ref.1

Sequence conflict

152 – 154

RAA → PR in CAA31908. Ref.1

Sequence conflict

172

M → I in AAA36440. Ref.1

Sequence conflict

172

M → I in CAA31908. Ref.1

Sequence conflict

200 – 202

TFG → RPR Ref.7

Sequence conflict

228

K → R Ref.7

Sequence conflict

244

A → AA Ref.7

Sequence conflict

355

I → T Ref.7

Sequence conflict

363 – 365

IVA → MRP Ref.7

Sequence conflict

418

K → N in AAA36440. Ref.1

Sequence conflict

418

K → N in CAA31908. Ref.1

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Sequences

Sequence

Length

Mass (Da)

Tools

P08908-1 [UniParc].

Last modified April 1, 1993. Version 3.
Checksum: 762664FCF62CFD8F
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FASTA

422

46,107

        10         20         30         40         50         60 
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA 

        70         80         90        100        110        120 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 

       130        140        150        160        170        180 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 

       190        200        210        220        230        240 
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT 

       250        260        270        280        290        300 
RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 

       310        320        330        340        350        360 
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP 

       370        380        390        400        410        420 
FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 


RQ

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins." Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., Francke U., Lefkowitz R.J., Caron M.G. Nature 329:75-79(1987) [PubMed: 3041227] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Saltzman A.G., Morse B., Felder S. Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Human-specific amino acid changes found in 103 protein-coding genes." Kitano T., Liu Y.-H., Ueda S., Saitou N. Mol. Biol. Evol. 21:936-944(2004) [PubMed: 15014171] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Puhl H.L. III, Ikeda S.R., Aronstam R.S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region." Parks C.L., Chang L.S., Shenk T. Nucleic Acids Res. 19:7155-7160(1991) [PubMed: 1766875] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 1-9.
[7]	"Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine." Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A. J. Immunol. 151:1175-1183(1993) [PubMed: 8393041] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 200-365.
[8]	"The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor." Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., Lefkowitz R.J. Nature 335:358-360(1988) [PubMed: 3138543] [Abstract] Cited for: FUNCTION.
[9]	"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells." Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D. J. Proteome Res. 6:298-305(2007) [PubMed: 17203973] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334, MASS SPECTROMETRY. Tissue: Lung adenocarcinoma.
[10]	"Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28." Nakhai B., Nielsen D.A., Linnoila M., Goldman D. Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed: 7755630] [Abstract] Cited for: VARIANTS SER-22 AND VAL-28.
[11]	"Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia." Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H. Am. J. Med. Genet. 81:434-439(1998) [PubMed: 9754630] [Abstract] Cited for: VARIANTS LEU-16 AND ASP-273.
+	Additional computationally mapped references.

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Cross-references

Sequence databases
	M28269 Genomic DNA. Translation: AAA36440.1. X13556 Genomic DNA. Translation: CAA31908.1. X57829 Genomic DNA. Translation: CAA40962.1. M83181 Genomic DNA. Translation: AAA66493.1. AB041403 Genomic DNA. Translation: BAA94488.1. BC069159 mRNA. Translation: AAH69159.1. AF498978 mRNA. Translation: AAM21125.1. Z11168 Genomic DNA. Translation: CAA77560.1.
IPI	IPI00031686.
PIR	I38209.
RefSeq	NP_000515.2.
UniGene	Hs.247940
3D structure databases
HSSP	HSSP built from PDB template 1HLL based on UniProtKB P08913.
ModBase	Search...
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	P08908.
Proteomic databases
PRIDE	P08908.
Genome annotation databases
Ensembl	ENSG00000178394. Homo sapiens. [Contig view]
GeneID	3350.
KEGG	hsa:3350.
Organism-specific databases
GeneCards	GC05M063292.
H-InvDB	HIX0032004.
HGNC	HGNC:5286. HTR1A.
HPA	HPA018073.
MIM	109760. gene.
PharmGKB	PA192.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P08908.
HOVERGEN	P08908.
OMA	P08908. VEKKGAD.
Gene expression databases
ArrayExpress	P08908.
Bgee	P08908.
CleanEx	HS_HTR1A.
GermOnline	ENSG00000178394. Homo sapiens.
Family and domain databases
InterPro	IPR000610. 5HT1A_rcpt. IPR002231. 5HT_rcpt. IPR000276. 7TM_GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_supfam. [Graphical view]
PANTHER	PTHR19266:SF64. 5HT1A_rcpt. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00512. 5HT1ARECEPTR. PR01101. 5HTRECEPTOR. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
DrugBank	DB00866. Alprenolol. DB01238. Aripiprazole. DB00490. Buspirone. DB00363. Clozapine. DB00216. Eletriptan. DB01049. Ergoloid mesylate. DB00176. Fluvoxamine. DB00589. Lisuride. DB00247. Methysergide. DB00370. Mirtazapine. DB00960. Pindolol. DB00571. Propranolol. DB01224. Quetiapine. DB01104. Sertraline. DB01079. Tegaserod. DB00656. Trazodone. DB00285. Venlafaxine. DB00246. Ziprasidone.
NextBio	13248.
SOURCE	Search...

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Entry information

Entry name

5HT1A_HUMAN

Accession

Primary (citable) accession number: P08908
Secondary accession number(s): Q6LAE7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	April 1, 1993
Last modified:	June 16, 2009
This is version 99 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

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