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P08908

- 5HT1A_HUMAN

UniProt

P08908 - 5HT1A_HUMAN

Protein

5-hydroxytryptamine receptor 1A

Gene

HTR1A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 3 (01 Apr 1993)
      Previous versions | rss
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    Functioni

    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.4 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. serotonin receptor activity Source: UniProtKB

    GO - Biological processi

    1. adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: UniProtKB
    2. behavioral fear response Source: UniProtKB
    3. cell proliferation Source: InterPro
    4. exploration behavior Source: UniProtKB
    5. G-protein coupled receptor signaling pathway Source: UniProtKB
    6. positive regulation of cell proliferation Source: ProtInc
    7. regulation of behavior Source: InterPro
    8. regulation of dopamine metabolic process Source: UniProtKB
    9. regulation of hormone secretion Source: InterPro
    10. regulation of serotonin secretion Source: UniProtKB
    11. serotonin metabolic process Source: UniProtKB
    12. serotonin receptor signaling pathway Source: UniProtKB
    13. vasoconstriction Source: InterPro

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Behavior

    Enzyme and pathway databases

    ReactomeiREACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-hydroxytryptamine receptor 1A
    Short name:
    5-HT-1A
    Short name:
    5-HT1A
    Alternative name(s):
    G-21
    Serotonin receptor 1A
    Gene namesi
    Name:HTR1A
    Synonyms:ADRB2RL1, ADRBRL1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:5286. HTR1A.

    Subcellular locationi

    Cell membrane 4 Publications; Multi-pass membrane protein 4 Publications

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi614674. phenotype.
    PharmGKBiPA192.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4224225-hydroxytryptamine receptor 1APRO_0000068903Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi10 – 101N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi11 – 111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi24 – 241N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
    Cross-linki334 – 334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Isopeptide bond, Ubl conjugation

    Proteomic databases

    PaxDbiP08908.
    PRIDEiP08908.

    PTM databases

    PhosphoSiteiP08908.

    Expressioni

    Tissue specificityi

    Detected in lymph nodes, thymus and spleen. Detected in activated T-cells, but not in resting T-cells.2 Publications

    Gene expression databases

    ArrayExpressiP08908.
    BgeeiP08908.
    CleanExiHS_HTR1A.
    GenevestigatoriP08908.

    Organism-specific databases

    HPAiHPA018073.

    Interactioni

    Subunit structurei

    Heterodimer; heterodimerizes with GPER1.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FGFR1P1136211EBI-6570214,EBI-1028277

    Protein-protein interaction databases

    BioGridi109582. 6 interactions.
    IntActiP08908. 4 interactions.
    STRINGi9606.ENSP00000316244.

    Structurei

    3D structure databases

    ProteinModelPortaliP08908.
    SMRiP08908. Positions 31-418.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3636ExtracellularBy similarityAdd
    BLAST
    Topological domaini63 – 7311CytoplasmicBy similarityAdd
    BLAST
    Topological domaini99 – 11012ExtracellularBy similarityAdd
    BLAST
    Topological domaini133 – 15220CytoplasmicBy similarityAdd
    BLAST
    Topological domaini179 – 19113ExtracellularBy similarityAdd
    BLAST
    Topological domaini218 – 345128CytoplasmicBy similarityAdd
    BLAST
    Topological domaini368 – 37811ExtracellularBy similarityAdd
    BLAST
    Topological domaini404 – 42219CytoplasmicBy similarityAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei37 – 6226Helical; Name=1By similarityAdd
    BLAST
    Transmembranei74 – 9825Helical; Name=2By similarityAdd
    BLAST
    Transmembranei111 – 13222Helical; Name=3By similarityAdd
    BLAST
    Transmembranei153 – 17826Helical; Name=4By similarityAdd
    BLAST
    Transmembranei192 – 21726Helical; Name=5By similarityAdd
    BLAST
    Transmembranei346 – 36722Helical; Name=6By similarityAdd
    BLAST
    Transmembranei379 – 40325Helical; Name=7By similarityAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni112 – 12110Agonist bindingBy similarity
    Regioni358 – 3625Agonist bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi133 – 1353DRY motif; important for ligand-induced conformation changesBy similarity
    Motifi396 – 4005NPxxY motif; important for ligand-induced conformation changes and signalingBy similarity

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family. 5-hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249628.
    HOGENOMiHOG000239242.
    HOVERGENiHBG106962.
    InParanoidiP08908.
    KOiK04153.
    OMAiTGAPCAN.
    PhylomeDBiP08908.
    TreeFamiTF316350.

    Family and domain databases

    Gene3Di1.20.1070.10. 2 hits.
    InterProiIPR000610. 5HT1A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24247:SF20. PTHR24247:SF20. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00512. 5HT1ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08908-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA    50
    VLGNACVVAA IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN 100
    KWTLGQVTCD LFIALDVLCC TSSILHLCAI ALDRYWAITD PIDYVNKRTP 150
    RRAAALISLT WLIGFLISIP PMLGWRTPED RSDPDACTIS KDHGYTIYST 200
    FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT RHGASPAPQP 250
    KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 300
    SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII 350
    MGTFILCWLP FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY 400
    AYFNKDFQNA FKKIIKCKFC RQ 422
    Length:422
    Mass (Da):46,107
    Last modified:April 1, 1993 - v3
    Checksum:i762664FCF62CFD8F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti152 – 1543RAA → PR in AAA36440. (PubMed:3041227)Curated
    Sequence conflicti152 – 1543RAA → PR in CAA31908. (PubMed:3041227)Curated
    Sequence conflicti172 – 1721M → I in AAA36440. (PubMed:3041227)Curated
    Sequence conflicti172 – 1721M → I in CAA31908. (PubMed:3041227)Curated
    Sequence conflicti200 – 2023TFG → RPR no nucleotide entry (PubMed:8393041)Curated
    Sequence conflicti228 – 2281K → R no nucleotide entry (PubMed:8393041)Curated
    Sequence conflicti244 – 2441A → AA no nucleotide entry (PubMed:8393041)Curated
    Sequence conflicti355 – 3551I → T no nucleotide entry (PubMed:8393041)Curated
    Sequence conflicti363 – 3653IVA → MRP no nucleotide entry (PubMed:8393041)Curated
    Sequence conflicti418 – 4181K → N in AAA36440. (PubMed:3041227)Curated
    Sequence conflicti418 – 4181K → N in CAA31908. (PubMed:3041227)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti16 – 161P → L.1 Publication
    Corresponds to variant rs1800041 [ dbSNP | Ensembl ].
    VAR_003446
    Natural varianti22 – 221G → S.1 Publication
    Corresponds to variant rs1799920 [ dbSNP | Ensembl ].
    VAR_011826
    Natural varianti28 – 281I → V.1 Publication
    Corresponds to variant rs1799921 [ dbSNP | Ensembl ].
    VAR_011827
    Natural varianti184 – 1841P → L.
    Corresponds to variant rs1800043 [ dbSNP | Ensembl ].
    VAR_011828
    Natural varianti220 – 2201R → L.
    Corresponds to variant rs1800044 [ dbSNP | Ensembl ].
    VAR_011829
    Natural varianti273 – 2731G → D.1 Publication
    Corresponds to variant rs1800042 [ dbSNP | Ensembl ].
    VAR_011830

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28269 Genomic DNA. Translation: AAA36440.1.
    X13556 Genomic DNA. Translation: CAA31908.1.
    X57829 Genomic DNA. Translation: CAA40962.1.
    M83181 Genomic DNA. Translation: AAA66493.1.
    AB041403 Genomic DNA. Translation: BAA94488.1.
    AF498978 mRNA. Translation: AAM21125.1.
    BC069159 mRNA. Translation: AAH69159.1.
    Z11168 Genomic DNA. Translation: CAA77560.1.
    CCDSiCCDS34168.1.
    PIRiI38209.
    RefSeqiNP_000515.2. NM_000524.3.
    UniGeneiHs.247940.

    Genome annotation databases

    EnsembliENST00000323865; ENSP00000316244; ENSG00000178394.
    GeneIDi3350.
    KEGGihsa:3350.
    UCSCiuc011cqt.3. human.

    Polymorphism databases

    DMDMi231454.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M28269 Genomic DNA. Translation: AAA36440.1 .
    X13556 Genomic DNA. Translation: CAA31908.1 .
    X57829 Genomic DNA. Translation: CAA40962.1 .
    M83181 Genomic DNA. Translation: AAA66493.1 .
    AB041403 Genomic DNA. Translation: BAA94488.1 .
    AF498978 mRNA. Translation: AAM21125.1 .
    BC069159 mRNA. Translation: AAH69159.1 .
    Z11168 Genomic DNA. Translation: CAA77560.1 .
    CCDSi CCDS34168.1.
    PIRi I38209.
    RefSeqi NP_000515.2. NM_000524.3.
    UniGenei Hs.247940.

    3D structure databases

    ProteinModelPortali P08908.
    SMRi P08908. Positions 31-418.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109582. 6 interactions.
    IntActi P08908. 4 interactions.
    STRINGi 9606.ENSP00000316244.

    Chemistry

    BindingDBi P08908.
    ChEMBLi CHEMBL2096904.
    DrugBanki DB00866. Alprenolol.
    DB01238. Aripiprazole.
    DB00490. Buspirone.
    DB00363. Clozapine.
    DB00216. Eletriptan.
    DB01049. Ergoloid mesylate.
    DB00176. Fluvoxamine.
    DB00589. Lisuride.
    DB00247. Methysergide.
    DB00370. Mirtazapine.
    DB00960. Pindolol.
    DB00571. Propranolol.
    DB01224. Quetiapine.
    DB01104. Sertraline.
    DB01079. Tegaserod.
    DB00656. Trazodone.
    DB00285. Venlafaxine.
    DB00246. Ziprasidone.
    GuidetoPHARMACOLOGYi 1.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P08908.

    Polymorphism databases

    DMDMi 231454.

    Proteomic databases

    PaxDbi P08908.
    PRIDEi P08908.

    Protocols and materials databases

    DNASUi 3350.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000323865 ; ENSP00000316244 ; ENSG00000178394 .
    GeneIDi 3350.
    KEGGi hsa:3350.
    UCSCi uc011cqt.3. human.

    Organism-specific databases

    CTDi 3350.
    GeneCardsi GC05M063292.
    HGNCi HGNC:5286. HTR1A.
    HPAi HPA018073.
    MIMi 109760. gene.
    614674. phenotype.
    neXtProti NX_P08908.
    PharmGKBi PA192.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249628.
    HOGENOMi HOG000239242.
    HOVERGENi HBG106962.
    InParanoidi P08908.
    KOi K04153.
    OMAi TGAPCAN.
    PhylomeDBi P08908.
    TreeFami TF316350.

    Enzyme and pathway databases

    Reactomei REACT_17064. Serotonin receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 3350.
    NextBioi 13248.
    PROi P08908.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08908.
    Bgeei P08908.
    CleanExi HS_HTR1A.
    Genevestigatori P08908.

    Family and domain databases

    Gene3Di 1.20.1070.10. 2 hits.
    InterProi IPR000610. 5HT1A_rcpt.
    IPR002231. 5HT_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24247:SF20. PTHR24247:SF20. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00512. 5HT1ARECEPTR.
    PR01101. 5HTRECEPTOR.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."
      Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., Francke U., Lefkowitz R.J., Caron M.G.
      Nature 329:75-79(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    2. "Nucleotide and deduced amino acid sequence of the human serotonin 5-HT1a receptor gene."
      Saltzman A.G., Morse B., Felder S.
      Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. Levy F.O., Gudermann T., Birnbaumer M., Kaumann A.J., Birnbaumer L.
      Submitted (MAY-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Human-specific amino acid changes found in 103 protein-coding genes."
      Kitano T., Liu Y.-H., Ueda S., Saitou N.
      Mol. Biol. Evol. 21:936-944(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."
      Parks C.L., Chang L.S., Shenk T.
      Nucleic Acids Res. 19:7155-7160(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    8. "Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."
      Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A.
      J. Immunol. 151:1175-1183(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 200-365, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."
      Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., Lefkowitz R.J.
      Nature 335:358-360(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    10. "Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors."
      Harrington M.A., Shaw K., Zhong P., Ciaranello R.D.
      J. Pharmacol. Exp. Ther. 268:1098-1106(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
      Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
      J. Proteome Res. 6:298-305(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334.
      Tissue: Lung adenocarcinoma.
    12. Cited for: REVIEW.
    13. "5-HT1A receptor-regulated signal transduction pathways in brain."
      Polter A.M., Li X.
      Cell. Signal. 22:1406-1412(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    14. "Serotonin receptors - from molecular biology to clinical applications."
      Pytliak M., Vargova V., Mechirova V., Felsoci M.
      Physiol. Res. 60:15-25(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    15. "Menstrual cycle-dependent febrile episode mediated by sequence-specific repression of poly(ADP-ribose) polymerase-1 on the transcription of the human serotonin receptor 1A gene."
      Jiang Y.C., Wu H.M., Cheng K.H., Sunny Sun H.
      Hum. Mutat. 33:209-217(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PFMC.
    16. "Role of glycosphingolipids in the function of human serotonin(1)A receptors."
      Singh P., Paila Y.D., Chattopadhyay A.
      J. Neurochem. 123:716-724(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    17. "Post-synaptic density-95 (PSD-95) binding capacity of G-protein-coupled receptor 30 (GPR30), an estrogen receptor that can be identified in hippocampal dendritic spines."
      Akama K.T., Thompson L.I., Milner T.A., McEwen B.S.
      J. Biol. Chem. 288:6438-6450(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
    18. "Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."
      Nakhai B., Nielsen D.A., Linnoila M., Goldman D.
      Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS SER-22 AND VAL-28.
    19. "Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."
      Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.
      Am. J. Med. Genet. 81:434-439(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LEU-16 AND ASP-273.

    Entry informationi

    Entry namei5HT1A_HUMAN
    AccessioniPrimary (citable) accession number: P08908
    Secondary accession number(s): Q6LAE7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: April 1, 1993
    Last modified: October 1, 2014
    This is version 148 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3