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Reviewed, UniProtKB/Swiss-Prot P08908 (5HT1A_HUMAN)

Last modified June 16, 2009. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    5-hydroxytryptamine receptor 1A
      Short name=5-HT-1A
      Short name=5-HT1A
Alternative name(s):
    Serotonin receptor 1A
    G-21
Gene names
Name: HTR1A
Synonyms: ADRB2RL1, ADRBRL1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Ref.8

Subcellular location

Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4224225-hydroxytryptamine receptor 1A
PRO_0000068903

Regions

Topological domain1 – 3636Extracellular By similarity
Transmembrane37 – 62261 By similarity
Topological domain63 – 7311Cytoplasmic By similarity
Transmembrane74 – 98252 By similarity
Topological domain99 – 10911Extracellular By similarity
Transmembrane110 – 132233 By similarity
Topological domain133 – 15220Cytoplasmic By similarity
Transmembrane153 – 178264 By similarity
Topological domain179 – 19113Extracellular By similarity
Transmembrane192 – 217265 By similarity
Topological domain218 – 345128Cytoplasmic By similarity
Transmembrane346 – 367226 By similarity
Topological domain368 – 37811Extracellular By similarity
Transmembrane379 – 403257 By similarity
Topological domain404 – 42219Cytoplasmic By similarity

Amino acid modifications

Glycosylation101N-linked (GlcNAc...) Potential
Glycosylation111N-linked (GlcNAc...) Potential
Glycosylation241N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 187 By similarity
Cross-link334Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.9

Natural variations

Natural variant161P → L: dbSNP rs1800041. Ref.11
VAR_003446
Natural variant221G → S: dbSNP rs1799920. Ref.10
VAR_011826
Natural variant281I → V: dbSNP rs1799921. Ref.10
VAR_011827
Natural variant1841P → L: dbSNP rs1800043.
VAR_011828
Natural variant2201R → L: dbSNP rs1800044.
VAR_011829
Natural variant2731G → D: dbSNP rs1800042. Ref.11
VAR_011830

Experimental info

Sequence conflict152 – 1543RAA → PR in AAA36440. Ref.1
Sequence conflict152 – 1543RAA → PR in CAA31908. Ref.1
Sequence conflict1721M → I in AAA36440. Ref.1
Sequence conflict1721M → I in CAA31908. Ref.1
Sequence conflict200 – 2023TFG → RPR Ref.7
Sequence conflict2281K → R Ref.7
Sequence conflict2441A → AA Ref.7
Sequence conflict3551I → T Ref.7
Sequence conflict363 – 3653IVA → MRP Ref.7
Sequence conflict4181K → N in AAA36440. Ref.1
Sequence conflict4181K → N in CAA31908. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P08908-1 [UniParc].

Last modified April 1, 1993. Version 3.
Checksum: 762664FCF62CFD8F

FASTA42246,107
        10         20         30         40         50         60 
MDVLSPGQGN NTTSPPAPFE TGGNTTGISD VTVSYQVITS LLLGTLIFCA VLGNACVVAA 

        70         80         90        100        110        120 
IALERSLQNV ANYLIGSLAV TDLMVSVLVL PMAALYQVLN KWTLGQVTCD LFIALDVLCC 

       130        140        150        160        170        180 
TSSILHLCAI ALDRYWAITD PIDYVNKRTP RRAAALISLT WLIGFLISIP PMLGWRTPED 

       190        200        210        220        230        240 
RSDPDACTIS KDHGYTIYST FGAFYIPLLL MLVLYGRIFR AARFRIRKTV KKVEKTGADT 

       250        260        270        280        290        300 
RHGASPAPQP KKSVNGESGS RNWRLGVESK AGGALCANGA VRQGDDGAAL EVIEVHRVGN 

       310        320        330        340        350        360 
SKEHLPLPSE AGPTPCAPAS FERKNERNAE AKRKMALARE RKTVKTLGII MGTFILCWLP 

       370        380        390        400        410        420 
FFIVALVLPF CESSCHMPTL LGAIINWLGY SNSLLNPVIY AYFNKDFQNA FKKIIKCKFC 


RQ 

« Hide

References

« Hide 'large scale' references
[1]"An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins."
Kobilka B.K., Frielle T., Collins S., Yang-Feng T.L., Kobilka T.S., Francke U., Lefkowitz R.J., Caron M.G.
Nature 329:75-79(1987) [PubMed: 3041227] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Saltzman A.G., Morse B., Felder S.
Submitted (FEB-1991) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Human-specific amino acid changes found in 103 protein-coding genes."
Kitano T., Liu Y.-H., Ueda S., Saitou N.
Mol. Biol. Evol. 21:936-944(2004) [PubMed: 15014171] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Puhl H.L. III, Ikeda S.R., Aronstam R.S.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"A polymerase chain reaction mediated by a single primer: cloning of genomic sequences adjacent to a serotonin receptor protein coding region."
Parks C.L., Chang L.S., Shenk T.
Nucleic Acids Res. 19:7155-7160(1991) [PubMed: 1766875] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 1-9.
[7]"Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine."
Aune T.M., McGrath K.M., Sarr T., Bombara M.P., Kelley K.A.
J. Immunol. 151:1175-1183(1993) [PubMed: 8393041] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 200-365.
[8]"The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor."
Fargin A., Raymond J.R., Lohse M.L., Kobilka B.K., Caron M.G., Lefkowitz R.J.
Nature 335:358-360(1988) [PubMed: 3138543] [Abstract]
Cited for: FUNCTION.
[9]"The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells."
Vasilescu J., Zweitzig D.R., Denis N.J., Smith J.C., Ethier M., Haines D.S., Figeys D.
J. Proteome Res. 6:298-305(2007) [PubMed: 17203973] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-334, MASS SPECTROMETRY.
Tissue: Lung adenocarcinoma.
[10]"Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28."
Nakhai B., Nielsen D.A., Linnoila M., Goldman D.
Biochem. Biophys. Res. Commun. 210:530-536(1995) [PubMed: 7755630] [Abstract]
Cited for: VARIANTS SER-22 AND VAL-28.
[11]"Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia."
Kawanishi Y., Harada S., Tachikawa H., Okubo T., Shiraishi H.
Am. J. Med. Genet. 81:434-439(1998) [PubMed: 9754630] [Abstract]
Cited for: VARIANTS LEU-16 AND ASP-273.
+Additional computationally mapped references.

Cross-references

Sequence databases

M28269 Genomic DNA. Translation: AAA36440.1.
X13556 Genomic DNA. Translation: CAA31908.1.
X57829 Genomic DNA. Translation: CAA40962.1.
M83181 Genomic DNA. Translation: AAA66493.1.
AB041403 Genomic DNA. Translation: BAA94488.1.
BC069159 mRNA. Translation: AAH69159.1.
AF498978 mRNA. Translation: AAM21125.1.
Z11168 Genomic DNA. Translation: CAA77560.1.
IPIIPI00031686.
PIRI38209.
RefSeqNP_000515.2.
UniGeneHs.247940

3D structure databases

HSSPHSSP built from PDB template 1HLL based on UniProtKB P08913.
ModBaseSearch...

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP08908.

Proteomic databases

PRIDEP08908.

Genome annotation databases

EnsemblENSG00000178394. Homo sapiens. [Contig view]
GeneID3350.
KEGGhsa:3350.

Organism-specific databases

GeneCardsGC05M063292.
H-InvDBHIX0032004.
HGNCHGNC:5286. HTR1A.
HPAHPA018073.
MIM109760. gene.
PharmGKBPA192.
GenAtlasSearch...

Phylogenomic databases

HOGENOMP08908.
HOVERGENP08908.
OMAP08908. VEKKGAD.

Gene expression databases

ArrayExpressP08908.
BgeeP08908.
CleanExHS_HTR1A.
GermOnlineENSG00000178394. Homo sapiens.

Family and domain databases

InterProIPR000610. 5HT1A_rcpt.
IPR002231. 5HT_rcpt.
IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
PANTHERPTHR19266:SF64. 5HT1A_rcpt. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00512. 5HT1ARECEPTR.
PR01101. 5HTRECEPTOR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

DrugBankDB00866. Alprenolol.
DB01238. Aripiprazole.
DB00490. Buspirone.
DB00363. Clozapine.
DB00216. Eletriptan.
DB01049. Ergoloid mesylate.
DB00176. Fluvoxamine.
DB00589. Lisuride.
DB00247. Methysergide.
DB00370. Mirtazapine.
DB00960. Pindolol.
DB00571. Propranolol.
DB01224. Quetiapine.
DB01104. Sertraline.
DB01079. Tegaserod.
DB00656. Trazodone.
DB00285. Venlafaxine.
DB00246. Ziprasidone.
NextBio13248.
SOURCESearch...

Entry information

Entry name5HT1A_HUMAN
AccessionPrimary (citable) accession number: P08908
Secondary accession number(s): Q6LAE7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1993
Last modified: June 16, 2009
This is version 99 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Recent format changes

Overview of recent format changes

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents