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P08892

- PGKD_TRYBB

UniProt

P08892 - PGKD_TRYBB

Protein

Phosphoglycerate kinase A

Gene
N/A
Organism
Trypanosoma brucei brucei
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei48 – 481SubstrateBy similarity
    Binding sitei224 – 2241SubstrateBy similarity
    Binding sitei261 – 2611SubstrateBy similarity
    Binding sitei312 – 3121ATPBy similarity
    Binding sitei434 – 4341ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi464 – 4674ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase A (EC:2.7.2.3)
    Alternative name(s):
    PGK A allele 4
    OrganismiTrypanosoma brucei brucei
    Taxonomic identifieri5702 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Phosphoglycerate kinase APRO_0000145863Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Structurei

    3D structure databases

    ProteinModelPortaliP08892.
    SMRiP08892. Positions 14-507.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni33 – 353Substrate bindingBy similarity
    Regioni71 – 744Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Curated

    Family and domain databases

    Gene3Di3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 2 hits.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08892-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTAPNAKNN ISLKKSVGDV FRLTAKRVLM RVDFNVPMQN GHITNDYRIR    50
    AAIPTIRRVI DQGGICILLS HLGRPRGVSM VAGVRDIRRR YHEAQFHDNK 100
    GKTAFFSVLP GEEKVKILAK SSAREEATHI SPEVKSGKTM LFARLPEDEK 150
    KSLLMQYLNE NKDSALPQMS VSAGYEEQYS LRPVAVRLAE LLGQHVYFAH 200
    DCLDARVEVS RLKRGNVMLL ENVRFYSEEN GENAEEREAM AKILASYGDV 250
    YISDAFGAAH RDSATMTGIP KILGHGAAGY LMEKEISYFA KVLGNPPRPL 300
    VAIVGGAKVS EKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GYSIGKSKCE 350
    ESKLEFARSL LKKAEDRKVQ IILPIDHVCH TEFKAVDSPL ITEDQNIPEG 400
    HMALDIGPKT IEKYVQTIGK CKSAIWNGPM GVFEMVPYSK GTFAIAKAMG 450
    RGTQKRGLMS IIGGGESAGA AELCGKLSIS HVSTGGGASL ELLEGKTLPG 500
    VAVLDDKE 508
    Length:508
    Mass (Da):55,668
    Last modified:November 1, 1988 - v1
    Checksum:iD6C96922FDEC498A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05890 Genomic DNA. Translation: CAA29319.1.
    PIRiS02233. TVUT4B.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X05890 Genomic DNA. Translation: CAA29319.1 .
    PIRi S02233. TVUT4B.

    3D structure databases

    ProteinModelPortali P08892.
    SMRi P08892. Positions 14-507.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 2 hits.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR027250. Pgk_euglenozoa.
    IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PIRSF500126. Pgk_euglenozoa. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 2 hits.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evidence for gene conversion between the phosphoglycerate kinase genes of Trypanosoma brucei."
      le Blancq S.M., Swinkels B.W., Gibson W.C., Borst P.
      J. Mol. Biol. 200:439-447(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiPGKD_TRYBB
    AccessioniPrimary (citable) accession number: P08892
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Miscellaneous

    In T.brucei, three genes code for phosphoglycerate kinase isozymes, which are transported to different cell compartments.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3