Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08892 (PGKD_TRYBB) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 74. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase A

EC=2.7.2.3
Alternative name(s):
PGK A allele 4
OrganismTrypanosoma brucei brucei
Taxonomic identifier5702 [NCBI]
Taxonomic lineageEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer.

Miscellaneous

In T.brucei, three genes code for phosphoglycerate kinase isozymes, which are transported to different cell compartments.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Phosphoglycerate kinase A HAMAP-Rule MF_00145
PRO_0000145863

Regions

Nucleotide binding464 – 4674ATP By similarity
Region33 – 353Substrate binding By similarity
Region71 – 744Substrate binding By similarity

Sites

Binding site481Substrate By similarity
Binding site2241Substrate By similarity
Binding site2611Substrate By similarity
Binding site3121ATP By similarity
Binding site4341ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
P08892 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: D6C96922FDEC498A

FASTA50855,668
        10         20         30         40         50         60 
MSTAPNAKNN ISLKKSVGDV FRLTAKRVLM RVDFNVPMQN GHITNDYRIR AAIPTIRRVI 

        70         80         90        100        110        120 
DQGGICILLS HLGRPRGVSM VAGVRDIRRR YHEAQFHDNK GKTAFFSVLP GEEKVKILAK 

       130        140        150        160        170        180 
SSAREEATHI SPEVKSGKTM LFARLPEDEK KSLLMQYLNE NKDSALPQMS VSAGYEEQYS 

       190        200        210        220        230        240 
LRPVAVRLAE LLGQHVYFAH DCLDARVEVS RLKRGNVMLL ENVRFYSEEN GENAEEREAM 

       250        260        270        280        290        300 
AKILASYGDV YISDAFGAAH RDSATMTGIP KILGHGAAGY LMEKEISYFA KVLGNPPRPL 

       310        320        330        340        350        360 
VAIVGGAKVS EKIQLLDNML QRIDYLLIGG AMAYTFLKAQ GYSIGKSKCE ESKLEFARSL 

       370        380        390        400        410        420 
LKKAEDRKVQ IILPIDHVCH TEFKAVDSPL ITEDQNIPEG HMALDIGPKT IEKYVQTIGK 

       430        440        450        460        470        480 
CKSAIWNGPM GVFEMVPYSK GTFAIAKAMG RGTQKRGLMS IIGGGESAGA AELCGKLSIS 

       490        500 
HVSTGGGASL ELLEGKTLPG VAVLDDKE 

« Hide

References

[1]"Evidence for gene conversion between the phosphoglycerate kinase genes of Trypanosoma brucei."
le Blancq S.M., Swinkels B.W., Gibson W.C., Borst P.
J. Mol. Biol. 200:439-447(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X05890 Genomic DNA. Translation: CAA29319.1.
PIRTVUT4B. S02233.

3D structure databases

ProteinModelPortalP08892.
SMRP08892. Positions 14-507.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 2 hits.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR027250. Pgk_euglenozoa.
IPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PIRSF500126. Pgk_euglenozoa. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 2 hits.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGKD_TRYBB
AccessionPrimary (citable) accession number: P08892
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: February 19, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways