P08887 (IL6RA_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-6 receptor subunit alpha
Short name=IL-6 receptor subunit alpha
Short name=IL-6R subunit alpha
Short name=IL-6R-alpha
Short name=IL-6RA

Alternative name(s):
IL-6R 1
Membrane glycoprotein 80
Short name=gp80
CD_antigen=CD126

Gene names

Name:

IL6R

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Part of the receptor for interleukin 6. Binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitate an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Ref.13 Ref.14 Low concentration of a soluble form of IL6 receptor acts as an agonist of IL6 activity. Ref.13 Ref.14
Subunit structure	Hexamer of two molecules each of IL6, IL6R and IL6ST.
Subcellular location	Isoform 1: Basolateral cell membrane; Single-pass type I membrane protein Ref.11 Ref.14. Isoform 2: Secreted Ref.11 Ref.14.
Tissue specificity	Isoform 2 is expressed in peripheral blood mononuclear cells and weakly found in urine and serum.
Domain	The two fibronectin type-III-like domains, contained in the N-terminal part, form together a cytokine-binding domain. The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
Post-translational modification	A short soluble form may also be released from the membrane by proteolysis.
Polymorphism	Genetic variations in IL6R determine soluble IL6R serum levels [MIM:614689]. Genetic variations in IL6R define the IL6 serum level quantitative trait locus [MIM:614752].
Sequence similarities	Belongs to the type I cytokine receptor family. Type 3 subfamily. Contains 1 fibronectin type-III domain. Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Traceable author statement PubMed 12832423. Source: BHF-UCL ciliary neurotrophic factor-mediated signaling pathway Inferred from mutant phenotype PubMed 12643274. Source: BHF-UCL defense response to Gram-negative bacterium Inferred from expression pattern PubMed 16034137. Source: BHF-UCL defense response to Gram-positive bacterium Inferred from expression pattern PubMed 16034137. Source: BHF-UCL endocrine pancreas development Inferred from mutant phenotype PubMed 18719127. Source: BHF-UCL hepatic immune response Traceable author statement PubMed 12832423. Source: BHF-UCL interleukin-6-mediated signaling pathway Inferred from mutant phenotype PubMed 12643274. Source: BHF-UCL monocyte chemotaxis Inferred by curator PubMed 10510402. Source: BHF-UCL negative regulation of apoptotic process Inferred from mutant phenotype PubMed 18719127. Source: BHF-UCL negative regulation of collagen biosynthetic process Inferred from direct assay PubMed 12419823. Source: BHF-UCL negative regulation of interleukin-8 production Inferred from expression pattern PubMed 16034137. Source: BHF-UCL neutrophil mediated immunity Inferred by curator PubMed 16034137. Source: BHF-UCL positive regulation of MAPK cascade Inferred from direct assay PubMed 12419823. Source: BHF-UCL positive regulation of activation of Janus kinase activity Inferred from direct assay PubMed 12419823. Source: BHF-UCL positive regulation of chemokine production Inferred from direct assay PubMed 10510402. Source: BHF-UCL positive regulation of interleukin-6 production Inferred from direct assay PubMed 10510402. Source: BHF-UCL positive regulation of leukocyte chemotaxis Inferred by curator PubMed 16034137. Source: BHF-UCL positive regulation of osteoblast differentiation Traceable author statement PubMed 12372336. Source: BHF-UCL positive regulation of smooth muscle cell proliferation Inferred from direct assay PubMed 10510402. Source: BHF-UCL positive regulation of tyrosine phosphorylation of Stat3 protein Inferred from mutant phenotype PubMed 12643274. Source: BHF-UCL
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 16034137. Source: BHF-UCL basolateral plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell cell surface Inferred from electronic annotation. Source: Compara extracellular region Inferred from direct assay PubMed 12748171. Source: UniProtKB extracellular space Inferred from direct assay PubMed 16034137PubMed 12419823PubMed 15579373. Source: BHF-UCL interleukin-6 receptor complex Inferred from direct assay Ref.16PubMed 2261637. Source: BHF-UCL
Molecular_function	interleukin-6 receptor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P08887-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P08887-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     356-365: VQDSSSVPLP → GSRRRGSCGL
     366-468: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 19

19

Ref.11

Chain

20 – 468

449

Interleukin-6 receptor subunit alpha

PRO_0000010895

Regions

Topological domain

20 – 365

346

Extracellular Potential

Transmembrane

366 – 386

21

Helical; Potential

Topological domain

387 – 468

82

Cytoplasmic Potential

Domain

26 – 112

87

Ig-like C2-type

Domain

216 – 311

96

Fibronectin type-III

Motif

303 – 307

5

WSXWS motif

Sites

Site

245

1

Not glycosylated

Amino acid modifications

Glycosylation

55

1

N-linked (GlcNAc...) Ref.10

Glycosylation

93

1

N-linked (GlcNAc...) Ref.10

Glycosylation

221

1

N-linked (GlcNAc...) Ref.10

Disulfide bond

25 ↔ 193

Ref.10

Disulfide bond

47 ↔ 96

Ref.10

Disulfide bond

121 ↔ 132

Ref.10

Disulfide bond

165 ↔ 176

Ref.10

Natural variations

Alternative sequence

356 – 365

10

VQDSSSVPLP → GSRRRGSCGL in isoform 2.

VSP_001682

Alternative sequence

366 – 468

103

Missing in isoform 2.

VSP_001683

Natural variant

358

1

D → A Significantly associated with circulating levels of IL6 and soluble IL6R. Ref.4 Ref.17
Corresponds to variant rs2228145 [ dbSNP | Ensembl ].

VAR_021995

Natural variant

385

1

V → I.
Corresponds to variant rs28730736 [ dbSNP | Ensembl ].

VAR_049166

Experimental info

Mutagenesis

121

1

C → S: Complete loss of ligand-binding.

Mutagenesis

122

1

F → A: No change of ligand-binding and IL6 signaling.

Mutagenesis

132

1

C → A: Complete loss of ligand-binding.

Mutagenesis

134

1

W → L: Complete loss of ligand-binding.

Mutagenesis

140

1

P → G: No change of ligand-binding and IL6 signaling.

Mutagenesis

153

1

F → L: No change of ligand-binding and IL6 signaling.

Mutagenesis

165

1

C → L: Complete loss of ligand-binding.

Mutagenesis

174

1

F → L: No change of ligand-binding and IL6 signaling.

Mutagenesis

176

1

C → A: Complete loss of ligand-binding.

Mutagenesis

184

1

D → T: 30% decrease of ligand-binding and IL6 signaling.

Mutagenesis

190

1

V → G: 80% decrease of ligand-binding and no IL6 signaling.

Mutagenesis

193

1

C → D: Complete loss of ligand-binding.

Mutagenesis

211

1

C → A: No change of ligand-binding and IL6 signaling.

Mutagenesis

217

1

D → V: Complete loss of ligand-binding.

Mutagenesis

232

1

R → S: 30% decrease of ligand-binding and IL6 signaling.

Mutagenesis

233

1

W → Q: 30% decrease of ligand-binding and increase of IL6 signaling.

Mutagenesis

254

1

E → A: 50% decrease of ligand-binding and IL6 signaling.

Mutagenesis

277

1

C → D: 30% increase of ligand-binding and 100% increase in IL6 signaling.

Mutagenesis

278

1

V → N: 50% Decrease of ligand-binding and 50% increase in IL6 signaling.

Mutagenesis

279

1

I → D: Complete loss of ligand-binding.

Mutagenesis

280

1

H → I: No change of ligand-binding and no IL6 signaling.

Mutagenesis

281

1

D → G: 70% decrease of ligand-binding and no IL6 signaling.

Mutagenesis

285

1

G → D: 80% decrease of ligand-binding and no IL6 signaling.

Mutagenesis

291

1

Q → K: Complete loss of ligand-binding.

Mutagenesis

293

1

R → G: Complete loss of ligand-binding.

Sequence conflict

210

1

G → D in BAD97302. Ref.5

Secondary structure

1

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468

Helix Strand Turn

Details...

Beta strand

34 – 37

4

Beta strand

43 – 46

4

Beta strand

56 – 63

8

Beta strand

65 – 68

4

Beta strand

72 – 83

12

Helix

88 – 90

3

Beta strand

92 – 101

10

Beta strand

105 – 110

6

Beta strand

120 – 125

6

Beta strand

130 – 134

5

Beta strand

145 – 157

13

Beta strand

159 – 168

10

Turn

169 – 172

4

Beta strand

173 – 178

6

Beta strand

187 – 196

10

Beta strand

199 – 202

4

Beta strand

206 – 209

4

Turn

210 – 212

3

Beta strand

220 – 226

7

Beta strand

234 – 239

6

Beta strand

247 – 249

3

Beta strand

251 – 259

9

Beta strand

266 – 269

4

Helix

271 – 273

3

Beta strand

275 – 281

7

Beta strand

288 – 296

9

Turn

297 – 299

3

Beta strand

310 – 312

3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 1, 1988. Version 1. Checksum: 62AA239FA14F1B8B	FASTA	468	51,548
	10 20 30 40 50 60 MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW 70 80 90 100 110 120 VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS 130 140 150 160 170 180 CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV 190 200 210 220 230 240 PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD 250 260 270 280 290 300 PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 310 320 330 340 350 360 GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPVQDSS 370 380 390 400 410 420 SVPLPTFLVA GGSLAFGTLL CIAIVLRFKK TWKLRALKEG KTSMHPPYSL GQLVPERPRP 430 440 450 460 TPVLVPLISP PVSPSSLGSD NTSSHNRPDA RDPRSPYDIS NTDYFFPR
	Isoform 2 (Short) [UniParc]. Checksum: ECC8FC9E142823F2	FASTA	365	40,237
	10 20 30 40 50 60 MLAVGCALLA ALLAAPGAAL APRRCPAQEV ARGVLTSLPG DSVTLTCPGV EPEDNATVHW 70 80 90 100 110 120 VLRKPAAGSH PSRWAGMGRR LLLRSVQLHD SGNYSCYRAG RPAGTVHLLV DVPPEEPQLS 130 140 150 160 170 180 CFRKSPLSNV VCEWGPRSTP SLTTKAVLLV RKFQNSPAED FQEPCQYSQE SQKFSCQLAV 190 200 210 220 230 240 PEGDSSFYIV SMCVASSVGS KFSKTQTFQG CGILQPDPPA NITVTAVARN PRWLSVTWQD 250 260 270 280 290 300 PHSWNSSFYR LRFELRYRAE RSKTFTTWMV KDLQHHCVIH DAWSGLRHVV QLRAQEEFGQ 310 320 330 340 350 360 GEWSEWSPEA MGTPWTESRS PPAENEVSTP MQALTTNKDD DNILFRDSAN ATSLPGSRRR GSCGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor." Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Science 241:825-828(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Molecular structure of interleukin 6 receptor." Yamasaki K., Taga T., Hirata Y., Yawata H., Kawanishi Y., Seed B., Taniguchi T., Hirano T., Kishimoto T. Proc. Jpn. Acad., B, Phys. Biol. Sci. 64:209-211(1988) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells." Schooltink H., Stoyan T., Lenz D., Schmitz H., Hirano T., Kishimoto T., Heinrich P.C., Rose-John S. Biochem. J. 277:659-664(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT ALA-358. Tissue: Trachea.
[5]	Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Kidney.
[6]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Lymph.
[9]	"Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism." Horiuchi S., Koyanagi Y., Zhou Y., Miyamoto H., Tanaka Y., Waki M., Matsumoto A., Yamamoto M., Yamamoto N. Eur. J. Immunol. 24:1945-1948(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 313-365 (ISOFORM 2).
[10]	"Disulfide bond structure and N-glycosylation sites of the extracellular domain of the human interleukin-6 receptor." Cole A.R., Hall N.E., Treutlein H.R., Eddes J.S., Reid G.E., Moritz R.L., Simpson R.J. J. Biol. Chem. 274:7207-7215(1999) [PubMed] [Europe PMC] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, GLYCOSYLATION AT ASN-55; ASN-93 AND ASN-221, LACK OF GLYCOSYLATION AT ASN-245, DISULFIDE BONDS.
[11]	"Soluble cytokine receptors are present in normal human urine." Novick D., Engelmann H., Wallach D., Rubinstein M. J. Exp. Med. 170:1409-1414(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 20-49, SUBCELLULAR LOCATION.
[12]	"Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130." Yawata H., Yasukawa K., Natsuka S., Murakami M., Yamasaki K., Hibi M., Taga T., Kishimoto T. EMBO J. 12:1705-1712(1993) [PubMed] [Europe PMC] [Abstract] Cited for: MUTAGENESIS.
[13]	"The cytoplasmic domain of the interleukin-6 receptor gp80 mediates its basolateral sorting in polarized Madin-Darby canine kidney cells." Martens A.S., Bode J.G., Heinrich P.C., Graeve L. J. Cell Sci. 113:3593-3602(2000) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[14]	"Increased association with detergent-resistant membranes/lipid rafts of apically targeted mutants of the interleukin-6 receptor gp80." Buk D.M., Renner O., Graeve L. Eur. J. Cell Biol. 84:819-831(2005) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[15]	"Structure of the extracellular domains of the human interleukin-6 receptor alpha-chain." Varghese J.N., Moritz R.L., Lou M.-Z., Van Donkelaar A., Ji H., Ivancic N., Branson K.M., Hall N.E., Simpson R.J. Proc. Natl. Acad. Sci. U.S.A. 99:15959-15964(2002) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 20-344.
[16]	"Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex." Boulanger M.J., Chow D.-C., Brevnova E.E., Garcia K.C. Science 300:2101-2104(2003) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.65 ANGSTROMS) OF 115-315.
[17]	"Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels." Health, Aging and Body Composition (Health ABC) Study Reich D., Patterson N., Ramesh V., De Jager P.L., McDonald G.J., Tandon A., Choy E., Hu D., Tamraz B., Pawlikowska L., Wassel-Fyr C., Huntsman S., Waliszewska A., Rossin E., Li R., Garcia M., Reiner A., Ferrell R. , Cummings S., Kwok P.Y., Harris T., Zmuda J.M., Ziv E. Am. J. Hum. Genet. 80:716-726(2007) [PubMed] [Europe PMC] [Abstract] Cited for: POLYMORPHISM, VARIANT ALA-358, ASSOCIATION OF VARIANT ALA-358 WITH IL6 AND SOLUBLE IL6R SERUM LEVELS.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X12830 mRNA. Translation: CAA31312.1.
X58298 mRNA. Translation: CAA41231.1.
AK293013 mRNA. Translation: BAF85702.1.
AK312730 mRNA. Translation: BAG35601.1.
AK223582 mRNA. Translation: BAD97302.1.
AL162591 Genomic DNA. Translation: CAH72853.1.
CH471121 Genomic DNA. Translation: EAW53200.1.
BC089410 mRNA. Translation: AAH89410.1.
S72848 mRNA. Translation: AAC60635.1.

IPI

IPI00031171.
IPI00413309.

PIR

A41242.

RefSeq

NP_000556.1. NM_000565.3.
NP_001193795.1. NM_001206866.1.
NP_852004.1. NM_181359.2.

UniGene

Hs.135087.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1N26	X-ray	2.40	A	20-344	[»]
1N2Q	model	-	C/D	20-344	[»]
1P9M	X-ray	3.65	C	115-315	[»]
2ARW	NMR	-	A	212-336	[»]

ProteinModelPortal

P08887.

ModBase

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Protein-protein interaction databases

DIP

DIP-162N.
DIP-3777N.

IntAct

P08887. 2 interactions.

MINT

MINT-190110.

STRING

9606.ENSP00000357470.

PTM databases

PhosphoSite

P08887.

Polymorphism databases

DMDM

124343.

Proteomic databases

PaxDb

P08887.

PRIDE

P08887.

Protocols and materials databases

DNASU

3570.

StructuralBiologyKnowledgebase

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Genome annotation databases

Ensembl

ENST00000344086; ENSP00000340589; ENSG00000160712.
ENST00000368485; ENSP00000357470; ENSG00000160712.

GeneID

3570.

KEGG

hsa:3570.

UCSC

uc001fez.2. human.
uc001ffa.2. human.

Organism-specific databases

CTD

3570.

GeneCards

GC01P154377.

HGNC

HGNC:6019. IL6R.

MIM

147880. gene.
614689. phenotype.
614752. phenotype.

neXtProt

NX_P08887.

PharmGKB

PA29835.

GenAtlas

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Phylogenomic databases

eggNOG

NOG47227.

HOVERGEN

HBG052118.

InParanoid

P08887.

KO

K05055.

OMA

CQLAVPE.

OrthoDB

EOG4TTGHS.

PhylomeDB

P08887.

Enzyme and pathway databases

Pathway_Interaction_DB

il6_7pathway. IL6-mediated signaling events.

Reactome

REACT_6900. Immune System.

SignaLink

P08887.

Gene expression databases

ArrayExpress

P08887.

Bgee

P08887.

CleanEx

HS_IL6R.

Genevestigator

P08887.

GermOnline

ENSG00000160712. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 3 hits.

InterPro

IPR003961. Fibronectin_type3.
IPR003530. Hematopoietin_rcpt_L_F3_CS.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015321. IL6_recept-bd.
[Graphical view]

Pfam

PF09240. IL6Ra-bind. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 2 hits.

PROSITE

PS50853. FN3. 1 hit.
PS01354. HEMATOPO_REC_L_F3. 1 hit.
PS50835. IG_LIKE. 1 hit.
[Graphical view]

ProtoNet

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Other

EvolutionaryTrace

P08887.

GenomeRNAi

3570.

NextBio

13954.

PMAP-CutDB

P08887.

SOURCE

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Entry information

Entry name

IL6RA_HUMAN

Accession

Primary (citable) accession number: P08887
Secondary accession number(s): A8KAE8 , B2R6V4, Q16202, Q53EQ7, Q5FWG2, Q5VZ23

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	November 1, 1988
Last modified:	May 29, 2013
This is version 160 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.