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Protein

Granzyme F

Gene

Gzmf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cytolysis

Protein family/group databases

MEROPSiS01.401.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme F (EC:3.4.21.-)
Alternative name(s):
C134
CTL serine protease 3
Cytotoxic cell protease 4
Short name:
CCP4
Cytotoxic serine protease 3
MCSP3
Gene namesi
Name:Gzmf
Synonyms:Ccp4, Ctla-7, Ctla7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109254. Gzmf.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000002740919 – 202 Publications2
ChainiPRO_000002741021 – 248Granzyme FAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Glycosylationi154N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi175 ↔ 189PROSITE-ProRule annotation
Glycosylationi223N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP08883.
PeptideAtlasiP08883.
PRIDEiP08883.

PTM databases

iPTMnetiP08883.
PhosphoSitePlusiP08883.

Expressioni

Gene expression databases

BgeeiENSMUSG00000015441.
CleanExiMM_GZMF.
ExpressionAtlasiP08883. baseline and differential.
GenevisibleiP08883. MM.

Interactioni

Protein-protein interaction databases

BioGridi200139. 1 interactor.
IntActiP08883. 1 interactor.
MINTiMINT-4096717.
STRINGi10090.ENSMUSP00000022757.

Structurei

3D structure databases

ProteinModelPortaliP08883.
SMRiP08883.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08883.
OMAiWGRTSIN.
OrthoDBiEOG091G0G5F.
PhylomeDBiP08883.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08883-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPILILLTL LLPLRAGAEE IIGGHEVKPH SRPYMARVRF VKDNGKRHSC
60 70 80 90 100
GGFLVQDYFV LTAAHCTGSS MRVILGAHNI RAKEETQQII PVAKAIPHPA
110 120 130 140 150
YDDKDNTSDI MLLKLESKAK RTKAVRPLKL PRPNARVKPG HVCSVAGWGR
160 170 180 190 200
TSINATQRSS CLREAQLIIQ KDKECKKYFY KYFKTMQICA GDPKKIQSTY
210 220 230 240
SGDSGGPLVC NNKAYGVLTY GLNRTIGPGV FTKVVHYLPW ISRNMKLL
Length:248
Mass (Da):27,642
Last modified:November 1, 1988 - v1
Checksum:i02B4BB67F100DC38
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36902 mRNA. Translation: AAA37488.1.
X56989 Genomic DNA. Translation: CAA40307.1.
M96930 Genomic DNA. Translation: AAA37741.1.
J03257 mRNA. Translation: AAA37738.1.
X12823 mRNA. Translation: CAA31310.1.
X14094 mRNA. Translation: CAA32256.1.
CCDSiCCDS36936.1.
PIRiS24940. S01007.
RefSeqiNP_034504.1. NM_010374.3.
UniGeneiMm.457976.

Genome annotation databases

EnsembliENSMUST00000022757; ENSMUSP00000022757; ENSMUSG00000015441.
GeneIDi14943.
KEGGimmu:14943.
UCSCiuc007ubs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M36902 mRNA. Translation: AAA37488.1.
X56989 Genomic DNA. Translation: CAA40307.1.
M96930 Genomic DNA. Translation: AAA37741.1.
J03257 mRNA. Translation: AAA37738.1.
X12823 mRNA. Translation: CAA31310.1.
X14094 mRNA. Translation: CAA32256.1.
CCDSiCCDS36936.1.
PIRiS24940. S01007.
RefSeqiNP_034504.1. NM_010374.3.
UniGeneiMm.457976.

3D structure databases

ProteinModelPortaliP08883.
SMRiP08883.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200139. 1 interactor.
IntActiP08883. 1 interactor.
MINTiMINT-4096717.
STRINGi10090.ENSMUSP00000022757.

Protein family/group databases

MEROPSiS01.401.

PTM databases

iPTMnetiP08883.
PhosphoSitePlusiP08883.

Proteomic databases

PaxDbiP08883.
PeptideAtlasiP08883.
PRIDEiP08883.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022757; ENSMUSP00000022757; ENSMUSG00000015441.
GeneIDi14943.
KEGGimmu:14943.
UCSCiuc007ubs.1. mouse.

Organism-specific databases

CTDi14943.
MGIiMGI:109254. Gzmf.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08883.
OMAiWGRTSIN.
OrthoDBiEOG091G0G5F.
PhylomeDBiP08883.
TreeFamiTF333630.

Miscellaneous databases

ChiTaRSiGzmf. mouse.
PROiP08883.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000015441.
CleanExiMM_GZMF.
ExpressionAtlasiP08883. baseline and differential.
GenevisibleiP08883. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRAF_MOUSE
AccessioniPrimary (citable) accession number: P08883
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.