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Protein

Granzyme C

Gene

Gzmc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
Biological processCytolysis

Enzyme and pathway databases

ReactomeiR-MMU-75108 Activation, myristolyation of BID and translocation to mitochondria

Protein family/group databases

MEROPSiS01.137

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme C (EC:3.4.21.-)
Alternative name(s):
B10
Cytotoxic cell protease 2
Short name:
CCP2
Gene namesi
Name:Gzmc
Synonyms:Ctla-5, Ctla5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:109256 Gzmc

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000002740319 – 201 Publication2
ChainiPRO_000002740421 – 248Granzyme CAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

EPDiP08882
PaxDbiP08882
PeptideAtlasiP08882
PRIDEiP08882

PTM databases

iPTMnetiP08882
PhosphoSitePlusiP08882

Expressioni

Gene expression databases

BgeeiENSMUSG00000079186
CleanExiMM_GZMC
ExpressionAtlasiP08882 baseline and differential
GenevisibleiP08882 MM

Interactioni

Protein-protein interaction databases

IntActiP08882, 1 interactor
MINTiP08882
STRINGi10090.ENSMUSP00000015585

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 41Combined sources7
Beta strandi43 – 45Combined sources3
Beta strandi47 – 56Combined sources10
Beta strandi59 – 62Combined sources4
Beta strandi69 – 76Combined sources8
Beta strandi88 – 97Combined sources10
Turni103 – 106Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi142 – 149Combined sources8
Beta strandi162 – 168Combined sources7
Helixi171 – 178Combined sources8
Turni179 – 181Combined sources3
Turni184 – 186Combined sources3
Beta strandi187 – 190Combined sources4
Turni200 – 205Combined sources6
Beta strandi207 – 210Combined sources4
Beta strandi213 – 220Combined sources8
Beta strandi223 – 225Combined sources3
Beta strandi226 – 233Combined sources8
Helixi234 – 236Combined sources3
Helixi238 – 245Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FZZX-ray2.50A/B21-247[»]
3G01X-ray2.50A/B21-247[»]
ProteinModelPortaliP08882
SMRiP08882
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08882

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00760000118895
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiP08882
OMAiNAHVKPG
OrthoDBiEOG091G0G5F
PhylomeDBiP08882
TreeFamiTF333630

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVLILLTL LLPLRAGAEE IIGGNEISPH SRPYMAYYEF LKVGGKKMFC
60 70 80 90 100
GGFLVRDKFV LTAAHCKGSS MTVTLGAHNI KAKEETQQII PVAKAIPHPD
110 120 130 140 150
YNPDDRSNDI MLLKLVRNAK RTRAVRPLNL PRRNAHVKPG DECYVAGWGK
160 170 180 190 200
VTPDGEFPKT LHEVKLTVQK DQVCESQFQS SYNRANEICV GDSKIKGASF
210 220 230 240
EEDSGGPLVC KRAAAGIVSY GQTDGSAPQV FTRVLSFVSW IKKTMKHS
Length:248
Mass (Da):27,311
Last modified:November 1, 1988 - v1
Checksum:iAA6247655EC52289
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69S → R in AAA37734 (PubMed:3257230).Curated1
Sequence conflicti181S → F in AAA37384 (PubMed:3518058).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22527 Genomic DNA Translation: AAA85454.1
X12822 mRNA Translation: CAA31309.1
M18459 mRNA Translation: AAA37734.1
M12301 mRNA Translation: AAA37384.1
CCDSiCCDS27146.1
PIRiB28952 PRMSC2
RefSeqiNP_034501.2, NM_010371.3
XP_011243265.1, XM_011244963.2
UniGeneiMm.14465

Genome annotation databases

EnsembliENSMUST00000015585; ENSMUSP00000015585; ENSMUSG00000079186
GeneIDi14940
KEGGimmu:14940
UCSCiuc007ubu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGRAC_MOUSE
AccessioniPrimary (citable) accession number: P08882
Secondary accession number(s): Q61389
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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