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Protein

Granzyme C

Gene

Gzmc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Charge relay systemBy similarity1
Active sitei109Charge relay systemBy similarity1
Active sitei204Charge relay systemBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Cytolysis

Enzyme and pathway databases

ReactomeiR-MMU-75108. Activation, myristolyation of BID and translocation to mitochondria.

Protein family/group databases

MEROPSiS01.137.

Names & Taxonomyi

Protein namesi
Recommended name:
Granzyme C (EC:3.4.21.-)
Alternative name(s):
B10
Cytotoxic cell protease 2
Short name:
CCP2
Gene namesi
Name:Gzmc
Synonyms:Ctla-5, Ctla5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:109256. Gzmc.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Add BLAST18
PropeptideiPRO_000002740319 – 201 Publication2
ChainiPRO_000002740421 – 248Granzyme CAdd BLAST228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi50 ↔ 66PROSITE-ProRule annotation
Disulfide bondi143 ↔ 210PROSITE-ProRule annotation
Disulfide bondi174 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Zymogen

Proteomic databases

EPDiP08882.
PaxDbiP08882.
PeptideAtlasiP08882.
PRIDEiP08882.

PTM databases

PhosphoSitePlusiP08882.

Expressioni

Gene expression databases

BgeeiENSMUSG00000079186.
CleanExiMM_GZMC.
ExpressionAtlasiP08882. baseline and differential.
GenevisibleiP08882. MM.

Interactioni

Protein-protein interaction databases

IntActiP08882. 1 interactor.
MINTiMINT-4096670.
STRINGi10090.ENSMUSP00000015585.

Structurei

Secondary structure

1248
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi35 – 41Combined sources7
Beta strandi43 – 45Combined sources3
Beta strandi47 – 56Combined sources10
Beta strandi59 – 62Combined sources4
Beta strandi69 – 76Combined sources8
Beta strandi88 – 97Combined sources10
Turni103 – 106Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi142 – 149Combined sources8
Beta strandi162 – 168Combined sources7
Helixi171 – 178Combined sources8
Turni179 – 181Combined sources3
Turni184 – 186Combined sources3
Beta strandi187 – 190Combined sources4
Turni200 – 205Combined sources6
Beta strandi207 – 210Combined sources4
Beta strandi213 – 220Combined sources8
Beta strandi223 – 225Combined sources3
Beta strandi226 – 233Combined sources8
Helixi234 – 236Combined sources3
Helixi238 – 245Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FZZX-ray2.50A/B21-247[»]
3G01X-ray2.50A/B21-247[»]
ProteinModelPortaliP08882.
SMRiP08882.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08882.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 246Peptidase S1PROSITE-ProRule annotationAdd BLAST226

Sequence similaritiesi

Belongs to the peptidase S1 family. Granzyme subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08882.
OMAiICVGDSK.
OrthoDBiEOG091G0G5F.
PhylomeDBiP08882.
TreeFamiTF333630.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08882-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPVLILLTL LLPLRAGAEE IIGGNEISPH SRPYMAYYEF LKVGGKKMFC
60 70 80 90 100
GGFLVRDKFV LTAAHCKGSS MTVTLGAHNI KAKEETQQII PVAKAIPHPD
110 120 130 140 150
YNPDDRSNDI MLLKLVRNAK RTRAVRPLNL PRRNAHVKPG DECYVAGWGK
160 170 180 190 200
VTPDGEFPKT LHEVKLTVQK DQVCESQFQS SYNRANEICV GDSKIKGASF
210 220 230 240
EEDSGGPLVC KRAAAGIVSY GQTDGSAPQV FTRVLSFVSW IKKTMKHS
Length:248
Mass (Da):27,311
Last modified:November 1, 1988 - v1
Checksum:iAA6247655EC52289
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69S → R in AAA37734 (PubMed:3257230).Curated1
Sequence conflicti181S → F in AAA37384 (PubMed:3518058).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22527 Genomic DNA. Translation: AAA85454.1.
X12822 mRNA. Translation: CAA31309.1.
M18459 mRNA. Translation: AAA37734.1.
M12301 mRNA. Translation: AAA37384.1.
CCDSiCCDS27146.1.
PIRiB28952. PRMSC2.
RefSeqiNP_034501.2. NM_010371.3.
XP_011243265.1. XM_011244963.2.
UniGeneiMm.14465.

Genome annotation databases

EnsembliENSMUST00000015585; ENSMUSP00000015585; ENSMUSG00000079186.
GeneIDi14940.
KEGGimmu:14940.
UCSCiuc007ubu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22527 Genomic DNA. Translation: AAA85454.1.
X12822 mRNA. Translation: CAA31309.1.
M18459 mRNA. Translation: AAA37734.1.
M12301 mRNA. Translation: AAA37384.1.
CCDSiCCDS27146.1.
PIRiB28952. PRMSC2.
RefSeqiNP_034501.2. NM_010371.3.
XP_011243265.1. XM_011244963.2.
UniGeneiMm.14465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FZZX-ray2.50A/B21-247[»]
3G01X-ray2.50A/B21-247[»]
ProteinModelPortaliP08882.
SMRiP08882.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08882. 1 interactor.
MINTiMINT-4096670.
STRINGi10090.ENSMUSP00000015585.

Protein family/group databases

MEROPSiS01.137.

PTM databases

PhosphoSitePlusiP08882.

Proteomic databases

EPDiP08882.
PaxDbiP08882.
PeptideAtlasiP08882.
PRIDEiP08882.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000015585; ENSMUSP00000015585; ENSMUSG00000079186.
GeneIDi14940.
KEGGimmu:14940.
UCSCiuc007ubu.2. mouse.

Organism-specific databases

CTDi14940.
MGIiMGI:109256. Gzmc.

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
GeneTreeiENSGT00760000118895.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP08882.
OMAiICVGDSK.
OrthoDBiEOG091G0G5F.
PhylomeDBiP08882.
TreeFamiTF333630.

Enzyme and pathway databases

ReactomeiR-MMU-75108. Activation, myristolyation of BID and translocation to mitochondria.

Miscellaneous databases

EvolutionaryTraceiP08882.
PROiP08882.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079186.
CleanExiMM_GZMC.
ExpressionAtlasiP08882. baseline and differential.
GenevisibleiP08882. MM.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGRAC_MOUSE
AccessioniPrimary (citable) accession number: P08882
Secondary accession number(s): Q61389
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.