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Protein

Tachykinin-3

Gene

TAC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-380095 Tachykinin receptors bind tachykinins
R-BTA-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:TAC3
Synonyms:NKNB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Organism-specific databases

VGNCiVGNC:35556 TAC3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003356221 – 83Add BLAST63
PeptideiPRO_000003356386 – 95Neurokinin-B10
PropeptideiPRO_000003356499 – 126Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP08858

Expressioni

Gene expression databases

BgeeiENSBTAG00000021807

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029067

Structurei

3D structure databases

SMRiP08858
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH Eukaryota
ENOG4111D7S LUCA
GeneTreeiENSGT00390000000335
HOGENOMiHOG000154597
HOVERGENiHBG016587
InParanoidiP08858
KOiK05240
OMAiAVCEESQ
OrthoDBiEOG091G0X8Y
TreeFamiTF337038

Family and domain databases

InterProiView protein in InterPro
IPR003635 Neurokinin-B/TAC3
IPR013055 Tachy_Neuro_lke_CS
PANTHERiPTHR15536 PTHR15536, 1 hit
PfamiView protein in Pfam
PF03823 Neurokinin_B, 1 hit
PIRSFiPIRSF001843 Neurokinin, 1 hit
PRINTSiPR01828 NEUROKININB
PROSITEiView protein in PROSITE
PS00267 TACHYKININ, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTLLFAVI LALSSARSLG AVCEESQEQV VPGGGHSKKD SNLYQLPPSL
60 70 80 90 100
LRRLYDSRVV SLDGLLKMLS KASVGPKESP LPQKRDMHDF FVGLMGKRNL
110 120
QPDTPVDINQ ENIPSFGTFK YPPSVE
Length:126
Mass (Da):13,871
Last modified:November 1, 1988 - v1
Checksum:i446EF433498EC059
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14351
, M14347, M14348, M14349, M14350 Genomic DNA Translation: AAA30723.1
PIRiA25905
RefSeqiNP_851360.1, NM_181017.2
XP_010803423.1, XM_010805121.2

Genome annotation databases

EnsembliENSBTAT00000029067; ENSBTAP00000029067; ENSBTAG00000021807
GeneIDi281513
KEGGibta:281513

Similar proteinsi

Entry informationi

Entry nameiTKNK_BOVIN
AccessioniPrimary (citable) accession number: P08858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: March 28, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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