Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Tachykinin-3

Gene

TAC3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Is a critical central regulator of gonadal function (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionNeuropeptide

Enzyme and pathway databases

ReactomeiR-BTA-380095. Tachykinin receptors bind tachykinins.
R-BTA-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Tachykinin-3
Cleaved into the following chain:
Neurokinin-B
Short name:
NKB
Alternative name(s):
Neuromedin-K
Gene namesi
Name:TAC3
Synonyms:NKNB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 5

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000003356221 – 83Add BLAST63
PeptideiPRO_000003356386 – 95Neurokinin-B10
PropeptideiPRO_000003356499 – 126Add BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei95Methionine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues

Proteomic databases

PaxDbiP08858.

Expressioni

Gene expression databases

BgeeiENSBTAG00000021807.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029067.

Structurei

3D structure databases

SMRiP08858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the tachykinin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J2QH. Eukaryota.
ENOG4111D7S. LUCA.
GeneTreeiENSGT00390000000335.
HOGENOMiHOG000154597.
HOVERGENiHBG016587.
InParanoidiP08858.
KOiK05240.
OMAiAVCEESQ.
OrthoDBiEOG091G0X8Y.
TreeFamiTF337038.

Family and domain databases

InterProiView protein in InterPro
IPR003635. Neurokinin-B/TAC3.
IPR013055. Tachy_Neuro_lke_CS.
PANTHERiPTHR15536. PTHR15536. 1 hit.
PfamiView protein in Pfam
PF03823. Neurokinin_B. 1 hit.
PIRSFiPIRSF001843. Neurokinin. 1 hit.
PRINTSiPR01828. NEUROKININB.
PROSITEiView protein in PROSITE
PS00267. TACHYKININ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSTLLFAVI LALSSARSLG AVCEESQEQV VPGGGHSKKD SNLYQLPPSL
60 70 80 90 100
LRRLYDSRVV SLDGLLKMLS KASVGPKESP LPQKRDMHDF FVGLMGKRNL
110 120
QPDTPVDINQ ENIPSFGTFK YPPSVE
Length:126
Mass (Da):13,871
Last modified:November 1, 1988 - v1
Checksum:i446EF433498EC059
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14351
, M14347, M14348, M14349, M14350 Genomic DNA. Translation: AAA30723.1.
PIRiA25905.
RefSeqiNP_851360.1. NM_181017.2.
XP_010803423.1. XM_010805121.2.

Genome annotation databases

EnsembliENSBTAT00000029067; ENSBTAP00000029067; ENSBTAG00000021807.
GeneIDi281513.
KEGGibta:281513.

Similar proteinsi

Entry informationi

Entry nameiTKNK_BOVIN
AccessioniPrimary (citable) accession number: P08858
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: June 7, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families