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UniProtKB - P08842 (STS_HUMAN)

UniProt

P08842 - STS_HUMAN

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Protein

Steryl-sulfatase

Gene

STS

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conversion of sulfated steroid precursors to estrogens during pregnancy.

Catalytic activityi

3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate.

Cofactori

Ca2+1 PublicationNote: Binds 1 Ca2+ ion per subunit.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi35 – 351Calcium1 Publication
Metal bindingi36 – 361Calcium1 Publication
Metal bindingi75 – 751Calcium; via 3-oxoalanine1 Publication
Active sitei136 – 13611 Publication
Metal bindingi342 – 3421Calcium1 Publication
Metal bindingi343 – 3431Calcium1 Publication

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • steryl-sulfatase activity Source: Reactome
  • sulfuric ester hydrolase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism, Pregnancy, Steroid metabolism

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.6.2. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Chemistry

SwissLipidsiSLP:000001236.

Names & Taxonomyi

Protein namesi
Recommended name:
Steryl-sulfatase (EC:3.1.6.2)
Alternative name(s):
Arylsulfatase C
Short name:
ASC
Steroid sulfatase
Steryl-sulfate sulfohydrolase
Gene namesi
Name:STS
Synonyms:ARSC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:11425. STS.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 184163LumenalAdd
BLAST
Transmembranei185 – 20824HelicalAdd
BLAST
Topological domaini209 – 2124Cytoplasmic
Transmembranei213 – 23422HelicalAdd
BLAST
Topological domaini235 – 583349LumenalAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: ProtInc
  • endoplasmic reticulum lumen Source: Reactome
  • endoplasmic reticulum membrane Source: Reactome
  • endosome Source: ProtInc
  • Golgi apparatus Source: ProtInc
  • integral component of membrane Source: UniProtKB-KW
  • intracellular membrane-bounded organelle Source: ProtInc
  • lysosome Source: ProtInc
  • membrane Source: ProtInc
  • nuclear envelope Source: Ensembl
  • plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Ichthyosis, X-linked (IXL)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA keratinization disorder manifesting with mild erythroderma and generalized exfoliation of the skin within a few weeks after birth. Affected boys later develop large, polygonal, dark brown scales, especially on the neck, extremities, trunk, and buttocks.
See also OMIM:308100
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411S → L in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853167 [ dbSNP | Ensembl ].		VAR_007240
Natural varianti372 – 3721W → R in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853165 [ dbSNP | Ensembl ].		VAR_007241
Natural varianti372 – 3721W → S in IXL; loss of activity. 1 Publication
Corresponds to variant rs137853168 [ dbSNP | Ensembl ].		VAR_014020
Natural varianti380 – 3801G → R in IXL. 1 Publication
VAR_014021
Natural varianti444 – 4441H → R in IXL; loss of activity. 1 Publication
Corresponds to variant rs137853169 [ dbSNP | Ensembl ].		VAR_014022
Natural varianti446 – 4461C → Y in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853166 [ dbSNP | Ensembl ].		VAR_007242
Natural varianti560 – 5601Q → P in IXL. 1 Publication
VAR_014023

Keywords - Diseasei

Disease mutation, Ichthyosis

Organism-specific databases

MalaCardsiSTS.
MIMi308100. phenotype.
Orphaneti461. Recessive X-linked ichthyosis.
281090. Syndromic X-linked ichthyosis.
PharmGKBiPA36225.

Chemistry

ChEMBLiCHEMBL3559.
DrugBankiDB06713. Norelgestromin.

Polymorphism and mutation databases

BioMutaiSTS.
DMDMi135006.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 21211 PublicationAdd
BLAST
Chaini22 – 583562Steryl-sulfatasePRO_0000033414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)2 Publications
Modified residuei75 – 7513-oxoalanine (Cys)1 Publication
Disulfide bondi141 ↔ 148
Disulfide bondi170 ↔ 242
Glycosylationi259 – 2591N-linked (GlcNAc...)2 Publications
Disulfide bondi446 ↔ 489
Disulfide bondi481 ↔ 487
Disulfide bondi562 ↔ 570
Disulfide bondi563 ↔ 572

Post-translational modificationi

The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei333 – 3331Not glycosylated
Sitei459 – 4591Not glycosylated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP08842.
MaxQBiP08842.
PaxDbiP08842.
PeptideAtlasiP08842.
PRIDEiP08842.

PTM databases

iPTMnetiP08842.
PhosphoSiteiP08842.
SwissPalmiP08842.

Expressioni

Gene expression databases

BgeeiENSG00000101846.
CleanExiHS_STS.
GenevisibleiP08842. HS.

Organism-specific databases

HPAiHPA002904.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi106905. 21 interactions.
IntActiP08842. 1 interaction.
MINTiMINT-1177440.
STRINGi9606.ENSP00000217961.

Chemistry

BindingDBiP08842.

Structurei

Secondary structure

1
583
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 369Combined sources
Helixi43 – 453Combined sources
Beta strandi48 – 503Combined sources
Helixi53 – 564Combined sources
Turni57 – 615Combined sources
Beta strandi62 – 698Combined sources
Helixi75 – 8410Combined sources
Helixi88 – 914Combined sources
Beta strandi96 – 983Combined sources
Helixi118 – 1247Combined sources
Beta strandi128 – 1347Combined sources
Beta strandi141 – 1433Combined sources
Turni144 – 1463Combined sources
Helixi151 – 1533Combined sources
Beta strandi157 – 1648Combined sources
Helixi168 – 1703Combined sources
Helixi179 – 1857Combined sources
Helixi187 – 20519Combined sources
Helixi213 – 24129Combined sources
Beta strandi244 – 2463Combined sources
Beta strandi249 – 2546Combined sources
Helixi260 – 27314Combined sources
Turni274 – 2774Combined sources
Beta strandi280 – 2856Combined sources
Beta strandi290 – 2923Combined sources
Turni297 – 2993Combined sources
Beta strandi304 – 3063Combined sources
Helixi307 – 32822Combined sources
Helixi332 – 3343Combined sources
Beta strandi335 – 3439Combined sources
Beta strandi352 – 3543Combined sources
Beta strandi370 – 3723Combined sources
Helixi373 – 3764Combined sources
Beta strandi380 – 3834Combined sources
Turni385 – 3873Combined sources
Helixi400 – 4023Combined sources
Helixi403 – 4119Combined sources
Beta strandi417 – 4193Combined sources
Helixi427 – 4304Combined sources
Beta strandi440 – 4467Combined sources
Beta strandi449 – 4557Combined sources
Beta strandi464 – 4685Combined sources
Turni482 – 4843Combined sources
Beta strandi489 – 4913Combined sources
Beta strandi501 – 5033Combined sources
Turni505 – 5073Combined sources
Turni518 – 5214Combined sources
Helixi523 – 53715Combined sources
Helixi550 – 5534Combined sources
Helixi557 – 5593Combined sources
Beta strandi563 – 5686Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P49X-ray2.60A22-583[»]
ProteinModelPortaliP08842.
SMRiP08842. Positions 23-575.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08842.

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfatase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiP08842.
KOiK01131.
OMAiWPRVIQA.
OrthoDBiEOG091G07AL.
PhylomeDBiP08842.
TreeFamiTF314186.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08842-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLRKMKIPF LLLFFLWEAE SHAASRPNII LVMADDLGIG DPGCYGNKTI 
        60         70         80         90        100
RTPNIDRLAS GGVKLTQHLA ASPLCTPSRA AFMTGRYPVR SGMASWSRTG 
       110        120        130        140        150
VFLFTASSGG LPTDEITFAK LLKDQGYSTA LIGKWHLGMS CHSKTDFCHH 
       160        170        180        190        200
PLHHGFNYFY GISLTNLRDC KPGEGSVFTT GFKRLVFLPL QIVGVTLLTL 
       210        220        230        240        250
AALNCLGLLH VPLGVFFSLL FLAALILTLF LGFLHYFRPL NCFMMRNYEI 
       260        270        280        290        300
IQQPMSYDNL TQRLTVEAAQ FIQRNTETPF LLVLSYLHVH TALFSSKDFA 
       310        320        330        340        350
GKSQHGVYGD AVEEMDWSVG QILNLLDELR LANDTLIYFT SDQGAHVEEV 
       360        370        380        390        400
SSKGEIHGGS NGIYKGGKAN NWEGGIRVPG ILRWPRVIQA GQKIDEPTSN 
       410        420        430        440        450
MDIFPTVAKL AGAPLPEDRI IDGRDLMPLL EGKSQRSDHE FLFHYCNAYL 
       460        470        480        490        500
NAVRWHPQNS TSIWKAFFFT PNFNPVGSNG CFATHVCFCF GSYVTHHDPP 
       510        520        530        540        550
LLFDISKDPR ERNPLTPASE PRFYEILKVM QEAADRHTQT LPEVPDQFSW 
       560        570        580 
NNFLWKPWLQ LCCPSTGLSC QCDREKQDKR LSR
Length:583
Mass (Da):65,492
Last modified:April 1, 1990 - v2
Checksum:i74746AFA9D21A0A6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti23 – 231A → E in AAA60596 (PubMed:3032454).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti341 – 3411S → L in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853167 [ dbSNP | Ensembl ].		VAR_007240
Natural varianti372 – 3721W → R in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853165 [ dbSNP | Ensembl ].		VAR_007241
Natural varianti372 – 3721W → S in IXL; loss of activity. 1 Publication
Corresponds to variant rs137853168 [ dbSNP | Ensembl ].		VAR_014020
Natural varianti380 – 3801G → R in IXL. 1 Publication
VAR_014021
Natural varianti444 – 4441H → R in IXL; loss of activity. 1 Publication
Corresponds to variant rs137853169 [ dbSNP | Ensembl ].		VAR_014022
Natural varianti446 – 4461C → Y in IXL; loss of activity. 2 Publications
Corresponds to variant rs137853166 [ dbSNP | Ensembl ].		VAR_007242
Natural varianti560 – 5601Q → P in IXL. 1 Publication
VAR_014023

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA. Translation: AAA60597.1.
M16505 mRNA. Translation: AAA60596.1.
AK314034 mRNA. Translation: BAG36744.1.
BC075030 mRNA. Translation: AAH75030.1.
M23945 Genomic DNA. Translation: AAA60598.1.
M23556 Genomic DNA. Translation: AAA60599.1.
CCDSiCCDS14127.1.
PIRiA32641. KJHUAC.
RefSeqiNP_000342.2. NM_000351.5.
NP_001307679.1. NM_001320750.1.
NP_001307680.1. NM_001320751.1.
NP_001307681.1. NM_001320752.1.
NP_001307682.1. NM_001320753.1.
NP_001307683.1. NM_001320754.1.
UniGeneiHs.522578.
Hs.700558.
Hs.700559.
Hs.740067.

Genome annotation databases

EnsembliENST00000217961; ENSP00000217961; ENSG00000101846.
GeneIDi412.
KEGGihsa:412.
UCSCiuc004cry.5. human.

Cross-referencesi

Web resourcesi

Wikipedia

Steroid sulfatase entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04964 mRNA. Translation: AAA60597.1.
M16505 mRNA. Translation: AAA60596.1.
AK314034 mRNA. Translation: BAG36744.1.
BC075030 mRNA. Translation: AAH75030.1.
M23945 Genomic DNA. Translation: AAA60598.1.
M23556 Genomic DNA. Translation: AAA60599.1.
CCDSiCCDS14127.1.
PIRiA32641. KJHUAC.
RefSeqiNP_000342.2. NM_000351.5.
NP_001307679.1. NM_001320750.1.
NP_001307680.1. NM_001320751.1.
NP_001307681.1. NM_001320752.1.
NP_001307682.1. NM_001320753.1.
NP_001307683.1. NM_001320754.1.
UniGeneiHs.522578.
Hs.700558.
Hs.700559.
Hs.740067.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1P49X-ray2.60A22-583[»]
ProteinModelPortaliP08842.
SMRiP08842. Positions 23-575.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106905. 21 interactions.
IntActiP08842. 1 interaction.
MINTiMINT-1177440.
STRINGi9606.ENSP00000217961.

Chemistry

BindingDBiP08842.
ChEMBLiCHEMBL3559.
DrugBankiDB06713. Norelgestromin.
SwissLipidsiSLP:000001236.

PTM databases

iPTMnetiP08842.
PhosphoSiteiP08842.
SwissPalmiP08842.

Polymorphism and mutation databases

BioMutaiSTS.
DMDMi135006.

Proteomic databases

EPDiP08842.
MaxQBiP08842.
PaxDbiP08842.
PeptideAtlasiP08842.
PRIDEiP08842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000217961; ENSP00000217961; ENSG00000101846.
GeneIDi412.
KEGGihsa:412.
UCSCiuc004cry.5. human.

Organism-specific databases

CTDi412.
GeneCardsiSTS.
HGNCiHGNC:11425. STS.
HPAiHPA002904.
MalaCardsiSTS.
MIMi300747. gene.
308100. phenotype.
neXtProtiNX_P08842.
Orphaneti461. Recessive X-linked ichthyosis.
281090. Syndromic X-linked ichthyosis.
PharmGKBiPA36225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3867. Eukaryota.
COG3119. LUCA.
GeneTreeiENSGT00760000119062.
HOGENOMiHOG000135352.
HOVERGENiHBG004283.
InParanoidiP08842.
KOiK01131.
OMAiWPRVIQA.
OrthoDBiEOG091G07AL.
PhylomeDBiP08842.
TreeFamiTF314186.

Enzyme and pathway databases

BRENDAi3.1.6.2. 2681.
ReactomeiR-HSA-1660662. Glycosphingolipid metabolism.
R-HSA-1663150. The activation of arylsulfatases.

Miscellaneous databases

ChiTaRSiSTS. human.
EvolutionaryTraceiP08842.
GeneWikiiSteroid_sulfatase.
GenomeRNAii412.
PROiP08842.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000101846.
CleanExiHS_STS.
GenevisibleiP08842. HS.

Family and domain databases

Gene3Di3.40.720.10. 2 hits.
InterProiIPR017849. Alkaline_Pase-like_a/b/a.
IPR017850. Alkaline_phosphatase_core.
IPR024607. Sulfatase_CS.
IPR000917. Sulfatase_N.
[Graphical view]
PfamiPF00884. Sulfatase. 1 hit.
[Graphical view]
SUPFAMiSSF53649. SSF53649. 1 hit.
PROSITEiPS00523. SULFATASE_1. 1 hit.
PS00149. SULFATASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSTS_HUMAN
AccessioniPrimary (citable) accession number: P08842
Secondary accession number(s): B2RA47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 173 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.