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Protein

Serum albumin

Gene

ALB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei11911 Sus s 1.0101
757 Sus s 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000107519 – 24By similarity6
ChainiPRO_000000107625 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP08835
PeptideAtlasiP08835
PRIDEiP08835

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009549

Structurei

3D structure databases

ProteinModelPortaliP08835
SMRiP08835
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ Eukaryota
ENOG410Z40H LUCA
HOGENOMiHOG000293137
HOVERGENiHBG004207
InParanoidiP08835
KOiK16141

Family and domain databases

CDDicd00015 ALBUMIN, 3 hits
InterProiView protein in InterPro
IPR000264 ALB/AFP/VDB
IPR020858 Serum_albumin-like
IPR021177 Serum_albumin/AFP/Afamin
IPR020857 Serum_albumin_CS
IPR014760 Serum_albumin_N
PANTHERiPTHR11385 PTHR11385, 1 hit
PfamiView protein in Pfam
PF00273 Serum_albumin, 3 hits
PIRSFiPIRSF002520 Serum_albumin_subgroup, 1 hit
PRINTSiPR00802 SERUMALBUMIN
SMARTiView protein in SMART
SM00103 ALBUMIN, 3 hits
SUPFAMiSSF48552 SSF48552, 3 hits
PROSITEiView protein in PROSITE
PS00212 ALBUMIN_1, 3 hits
PS51438 ALBUMIN_2, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRRDTYKSE IAHRFKDLGE QYFKGLVLIA
60 70 80 90 100
FSQHLQQCPY EEHVKLVREV TEFAKTCVAD ESAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPSLREHYGD LADCCEKEEP ERNECFLQHK NDNPDIPKLK PDPVALCADF
160 170 180 190 200
QEDEQKFWGK YLYEIARRHP YFYAPELLYY AIIYKDVFSE CCQAADKAAC
210 220 230 240 250
LLPKIEHLRE KVLTSAAKQR LKCASIQKFG ERAFKAWSLA RLSQRFPKAD
260 270 280 290 300
FTEISKIVTD LAKVHKECCH GDLLECADDR ADLAKYICEN QDTISTKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEAKRDE LPADLNPLEH DFVEDKEVCK NYKEAKHVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKIYEATL EDCCAKEDPP ACYATVFDKF
410 420 430 440 450
QPLVDEPKNL IKQNCELFEK LGEYGFQNAL IVRYTKKVPQ VSTPTLVEVA
460 470 480 490 500
RKLGLVGSRC CKRPEEERLS CAEDYLSLVL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY KPKEFVEGTF TFHADLCTLP EDEKQIKKQT
560 570 580 590 600
ALVELLKHKP HATEEQLRTV LGNFAAFVQK CCAAPDHEAC FAVEGPKFVI

EIRGILA
Length:607
Mass (Da):69,692
Last modified:February 1, 2005 - v2
Checksum:i7B8DA13543CA99D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146 – 151LCADFQ → GYAEFE AA sequence (PubMed:2728927).Curated6
Sequence conflicti155 – 156QK → VN AA sequence (PubMed:2728927).Curated2
Sequence conflicti347H → D in CAA30970 (PubMed:3174440).Curated1
Sequence conflicti347H → D in AAA30988 (PubMed:3174440).Curated1
Sequence conflicti564E → D in AAA30988 (PubMed:3174440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663543 Genomic DNA Translation: AAT98610.1
X12422 mRNA Translation: CAA30970.1
M36787 mRNA Translation: AAA30988.1
PIRiS01382 ABPGS
RefSeqiNP_001005208.1, NM_001005208.1
UniGeneiSsc.56897

Genome annotation databases

GeneIDi396960
KEGGissc:396960

Entry informationi

Entry nameiALBU_PIG
AccessioniPrimary (citable) accession number: P08835
Secondary accession number(s): Q29018, Q68NH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 2005
Last modified: April 25, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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