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Protein

Serum albumin

Gene

ALB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi33CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei11911. Sus s 1.0101.
757. Sus s 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000107519 – 24By similarity6
ChainiPRO_000000107625 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP08835.
PeptideAtlasiP08835.
PRIDEiP08835.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009549.

Structurei

3D structure databases

ProteinModelPortaliP08835.
SMRiP08835.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP08835.
KOiK16141.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRRDTYKSE IAHRFKDLGE QYFKGLVLIA
60 70 80 90 100
FSQHLQQCPY EEHVKLVREV TEFAKTCVAD ESAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPSLREHYGD LADCCEKEEP ERNECFLQHK NDNPDIPKLK PDPVALCADF
160 170 180 190 200
QEDEQKFWGK YLYEIARRHP YFYAPELLYY AIIYKDVFSE CCQAADKAAC
210 220 230 240 250
LLPKIEHLRE KVLTSAAKQR LKCASIQKFG ERAFKAWSLA RLSQRFPKAD
260 270 280 290 300
FTEISKIVTD LAKVHKECCH GDLLECADDR ADLAKYICEN QDTISTKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEAKRDE LPADLNPLEH DFVEDKEVCK NYKEAKHVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKIYEATL EDCCAKEDPP ACYATVFDKF
410 420 430 440 450
QPLVDEPKNL IKQNCELFEK LGEYGFQNAL IVRYTKKVPQ VSTPTLVEVA
460 470 480 490 500
RKLGLVGSRC CKRPEEERLS CAEDYLSLVL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY KPKEFVEGTF TFHADLCTLP EDEKQIKKQT
560 570 580 590 600
ALVELLKHKP HATEEQLRTV LGNFAAFVQK CCAAPDHEAC FAVEGPKFVI

EIRGILA
Length:607
Mass (Da):69,692
Last modified:February 1, 2005 - v2
Checksum:i7B8DA13543CA99D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti146 – 151LCADFQ → GYAEFE AA sequence (PubMed:2728927).Curated6
Sequence conflicti155 – 156QK → VN AA sequence (PubMed:2728927).Curated2
Sequence conflicti347H → D in CAA30970 (PubMed:3174440).Curated1
Sequence conflicti347H → D in AAA30988 (PubMed:3174440).Curated1
Sequence conflicti564E → D in AAA30988 (PubMed:3174440).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663543 Genomic DNA. Translation: AAT98610.1.
X12422 mRNA. Translation: CAA30970.1.
M36787 mRNA. Translation: AAA30988.1.
PIRiS01382. ABPGS.
RefSeqiNP_001005208.1. NM_001005208.1.
UniGeneiSsc.56897.

Genome annotation databases

GeneIDi396960.
KEGGissc:396960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663543 Genomic DNA. Translation: AAT98610.1.
X12422 mRNA. Translation: CAA30970.1.
M36787 mRNA. Translation: AAA30988.1.
PIRiS01382. ABPGS.
RefSeqiNP_001005208.1. NM_001005208.1.
UniGeneiSsc.56897.

3D structure databases

ProteinModelPortaliP08835.
SMRiP08835.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009549.

Protein family/group databases

Allergomei11911. Sus s 1.0101.
757. Sus s 1.

Proteomic databases

PaxDbiP08835.
PeptideAtlasiP08835.
PRIDEiP08835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396960.
KEGGissc:396960.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP08835.
KOiK16141.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_PIG
AccessioniPrimary (citable) accession number: P08835
Secondary accession number(s): Q29018, Q68NH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 2005
Last modified: November 30, 2016
This is version 116 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.