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Protein

Serum albumin

Gene

ALB

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331CopperBy similarity
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi270 – 2701ZincBy similarity
Metal bindingi272 – 2721ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
  • protein complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei11911. Sus s 1.0101.
757. Sus s 1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 246By similarityPRO_0000001075
Chaini25 – 607583Serum albuminPRO_0000001076Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei89 – 891PhosphoserineBy similarity
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation
Modified residuei228 – 2281N6-succinyllysineBy similarity
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei443 – 4431PhosphothreonineBy similarity
Modified residuei445 – 4451PhosphothreonineBy similarity
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation
Modified residuei512 – 5121PhosphoserineBy similarity
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation
Modified residuei569 – 5691PhosphothreonineBy similarity
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP08835.
PRIDEiP08835.

Expressioni

Tissue specificityi

Plasma.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009549.

Structurei

3D structure databases

ProteinModelPortaliP08835.
SMRiP08835. Positions 29-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 209191Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 402193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 600198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP08835.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08835-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL FLFSSAYSRG VFRRDTYKSE IAHRFKDLGE QYFKGLVLIA
60 70 80 90 100
FSQHLQQCPY EEHVKLVREV TEFAKTCVAD ESAENCDKSI HTLFGDKLCA
110 120 130 140 150
IPSLREHYGD LADCCEKEEP ERNECFLQHK NDNPDIPKLK PDPVALCADF
160 170 180 190 200
QEDEQKFWGK YLYEIARRHP YFYAPELLYY AIIYKDVFSE CCQAADKAAC
210 220 230 240 250
LLPKIEHLRE KVLTSAAKQR LKCASIQKFG ERAFKAWSLA RLSQRFPKAD
260 270 280 290 300
FTEISKIVTD LAKVHKECCH GDLLECADDR ADLAKYICEN QDTISTKLKE
310 320 330 340 350
CCDKPLLEKS HCIAEAKRDE LPADLNPLEH DFVEDKEVCK NYKEAKHVFL
360 370 380 390 400
GTFLYEYSRR HPDYSVSLLL RIAKIYEATL EDCCAKEDPP ACYATVFDKF
410 420 430 440 450
QPLVDEPKNL IKQNCELFEK LGEYGFQNAL IVRYTKKVPQ VSTPTLVEVA
460 470 480 490 500
RKLGLVGSRC CKRPEEERLS CAEDYLSLVL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSALTPDETY KPKEFVEGTF TFHADLCTLP EDEKQIKKQT
560 570 580 590 600
ALVELLKHKP HATEEQLRTV LGNFAAFVQK CCAAPDHEAC FAVEGPKFVI

EIRGILA
Length:607
Mass (Da):69,692
Last modified:February 1, 2005 - v2
Checksum:i7B8DA13543CA99D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti146 – 1516LCADFQ → GYAEFE AA sequence (PubMed:2728927).Curated
Sequence conflicti155 – 1562QK → VN AA sequence (PubMed:2728927).Curated
Sequence conflicti347 – 3471H → D in CAA30970 (PubMed:3174440).Curated
Sequence conflicti347 – 3471H → D in AAA30988 (PubMed:3174440).Curated
Sequence conflicti564 – 5641E → D in AAA30988 (PubMed:3174440).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663543 Genomic DNA. Translation: AAT98610.1.
X12422 mRNA. Translation: CAA30970.1.
M36787 mRNA. Translation: AAA30988.1.
PIRiS01382. ABPGS.
RefSeqiNP_001005208.1. NM_001005208.1.
UniGeneiSsc.56897.

Genome annotation databases

GeneIDi396960.
KEGGissc:396960.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY663543 Genomic DNA. Translation: AAT98610.1.
X12422 mRNA. Translation: CAA30970.1.
M36787 mRNA. Translation: AAA30988.1.
PIRiS01382. ABPGS.
RefSeqiNP_001005208.1. NM_001005208.1.
UniGeneiSsc.56897.

3D structure databases

ProteinModelPortaliP08835.
SMRiP08835. Positions 29-584.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000009549.

Protein family/group databases

Allergomei11911. Sus s 1.0101.
757. Sus s 1.

Proteomic databases

PaxDbiP08835.
PRIDEiP08835.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi396960.
KEGGissc:396960.

Organism-specific databases

CTDi213.

Phylogenomic databases

eggNOGiENOG410IIRZ. Eukaryota.
ENOG410Z40H. LUCA.
HOGENOMiHOG000293137.
HOVERGENiHBG004207.
InParanoidiP08835.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Porcine serum albumin gene."
    Sun S., Deng J., Zhou Y., Lu J., Wu X.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Nucleotide sequence of porcine liver albumin."
    Baldwin G.S., Weinstock J.
    Nucleic Acids Res. 16:9045-9045(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-607.
    Tissue: Liver.
  3. "Serum albumin and its acid hydrolysis peptides dominate preparations of mineral-bound enamel proteins."
    Limeback H., Sakarya H., Chu W., MacKinnon M.
    J. Bone Miner. Res. 4:235-241(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-57 AND 144-157.

Entry informationi

Entry nameiALBU_PIG
AccessioniPrimary (citable) accession number: P08835
Secondary accession number(s): Q29018, Q68NH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: February 1, 2005
Last modified: February 17, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.