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Protein

Insulin-like growth factor-binding protein 1

Gene

IGFBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.1 Publication

GO - Molecular functioni

  • insulin-like growth factor binding Source: ProtInc
  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • receptor binding Source: ParkinsonsUK-UCL

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Growth factor binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146678-MONOMER.
ReactomeiR-HSA-380994. ATF4 activates genes.
R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
SignaLinkiP08833.
SIGNORiP08833.

Protein family/group databases

MEROPSiI31.951.

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Alternative name(s):
Placental protein 12
Short name:
PP12
Gene namesi
Name:IGFBP1
Synonyms:IBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:5469. IGFBP1.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: Reactome
  • extracellular space Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3484.
OpenTargetsiENSG00000146678.
PharmGKBiPA29703.

Chemistry databases

ChEMBLiCHEMBL4178.

Polymorphism and mutation databases

BioMutaiIGFBP1.
DMDMi124055.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 253 PublicationsAdd BLAST25
ChainiPRO_000001436526 – 259Insulin-like growth factor-binding protein 1Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei45Phosphoserine; by FAM20C1 Publication1
Disulfide bondi71 ↔ 84
Disulfide bondi78 ↔ 104
Modified residuei120Phosphoserine1 Publication1
Modified residuei123Phosphoserine1 Publication1
Modified residuei126Phosphoserine2 Publications1
Modified residuei144PhosphoserineCombined sources2 Publications1
Modified residuei156Phosphoserine; by FAM20C1 Publication1
Modified residuei157Phosphothreonine; by FAM20C1 Publication1
Modified residuei158Phosphotyrosine1 Publication1
Disulfide bondi176 ↔ 206
Modified residuei193Phosphothreonine; by FAM20C1 Publication1
Modified residuei194Phosphoserine; by FAM20C3 Publications1
Modified residuei199Phosphoserine; by FAM20C1 Publication1
Disulfide bondi217 ↔ 228
Disulfide bondi230 ↔ 251
Modified residuei242Phosphoserine; by FAM20C1 Publication1

Post-translational modificationi

Phosphorylated; probably by casein kinase II. Phosphorylation alters the affinity of the protein for IGFs. In amniotic fluid, the unmodified protein is the most abundant form, while mono-, bi-, tri- and tetraphosphorylated forms are present in decreasing amounts. The phosphorylation state may influence the propensity to proteolysis.3 Publications

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP08833.
PaxDbiP08833.
PeptideAtlasiP08833.
PRIDEiP08833.

PTM databases

iPTMnetiP08833.
PhosphoSitePlusiP08833.

Miscellaneous databases

PMAP-CutDBP08833.

Expressioni

Gene expression databases

BgeeiENSG00000146678.
CleanExiHS_IGFBP1.
ExpressionAtlasiP08833. baseline and differential.
GenevisibleiP08833. HS.

Organism-specific databases

HPAiCAB004445.
HPA046972.
HPA050640.

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.1 Publication

GO - Molecular functioni

  • insulin-like growth factor binding Source: ProtInc
  • insulin-like growth factor I binding Source: UniProtKB
  • insulin-like growth factor II binding Source: UniProtKB
  • receptor binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi109705. 20 interactors.
DIPiDIP-59846N.
STRINGi9606.ENSP00000275525.

Chemistry databases

BindingDBiP08833.

Structurei

Secondary structure

1259
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi175 – 193Combined sources19
Beta strandi199 – 201Combined sources3
Beta strandi210 – 212Combined sources3
Beta strandi214 – 217Combined sources4
Beta strandi222 – 224Combined sources3
Beta strandi228 – 231Combined sources4
Turni233 – 235Combined sources3
Beta strandi245 – 247Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZT3X-ray1.80A172-251[»]
1ZT5X-ray1.82A172-251[»]
2DSQX-ray2.80G/H166-259[»]
ProteinModelPortaliP08833.
SMRiP08833.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08833.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 107IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini173 – 251Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi246 – 248Cell attachment site3

Sequence similaritiesi

Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 1 thyroglobulin type-1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP08833.
OMAiGQGACVQ.
OrthoDBiEOG091G0EIN.
PhylomeDBiP08833.
TreeFamiTF331211.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08833-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVPVARVW LVLLLLTVQV GVTAGAPWQC APCSAEKLAL CPPVSASCSE
60 70 80 90 100
VTRSAGCGCC PMCALPLGAA CGVATARCAR GLSCRALPGE QQPLHALTRG
110 120 130 140 150
QGACVQESDA SAPHAAEAGS PESPESTEIT EEELLDNFHL MAPSEEDHSI
160 170 180 190 200
LWDAISTYDG SKALHVTNIK KWKEPCRIEL YRVVESLAKA QETSGEEISK
210 220 230 240 250
FYLPNCNKNG FYHSRQCETS MDGEAGLCWC VYPWNGKRIP GSPEIRGDPN

CQIYFNVQN
Length:259
Mass (Da):27,904
Last modified:November 1, 1988 - v1
Checksum:i8AA75AF7DC966012
GO

Sequence cautioni

The sequence AAA52540 differs from that shown. Reason: Frameshift at positions 55 and 71.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti213H → Q in AAA52540 (PubMed:2454104).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049564114H → D.Corresponds to variant rs41258845dbSNPEnsembl.1
Natural variantiVAR_011905183V → I.1 PublicationCorresponds to variant rs1065782dbSNPEnsembl.1
Natural variantiVAR_003821253I → M.2 PublicationsCorresponds to variant rs4619dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00856 mRNA. Translation: CAA68770.1.
M20841 mRNA. Translation: AAA52540.1. Frameshift.
X12385 mRNA. Translation: CAA30942.1.
X13405 mRNA. Translation: CAA31771.1.
M31145 mRNA. Translation: AAA52542.1.
M59316 Genomic DNA. Translation: AAA52783.1.
M23595
, M23592, M23593, M23594 Genomic DNA. Translation: AAA52785.1.
M74587 Genomic DNA. Translation: AAA52784.1.
BT019685 mRNA. Translation: AAV38491.1.
AY434089 Genomic DNA. Translation: AAQ96599.1.
CH236958 Genomic DNA. Translation: EAL23800.1.
CH471128 Genomic DNA. Translation: EAW61030.1.
CH471128 Genomic DNA. Translation: EAW61031.1.
BC035263 mRNA. Translation: AAH35263.2.
X15002 mRNA. Translation: CAA33110.1.
CCDSiCCDS5504.1.
PIRiA31867. IOHU1.
RefSeqiNP_000587.1. NM_000596.2.
UniGeneiHs.642938.

Genome annotation databases

EnsembliENST00000275525; ENSP00000275525; ENSG00000146678.
GeneIDi3484.
KEGGihsa:3484.
UCSCiuc003tnp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y00856 mRNA. Translation: CAA68770.1.
M20841 mRNA. Translation: AAA52540.1. Frameshift.
X12385 mRNA. Translation: CAA30942.1.
X13405 mRNA. Translation: CAA31771.1.
M31145 mRNA. Translation: AAA52542.1.
M59316 Genomic DNA. Translation: AAA52783.1.
M23595
, M23592, M23593, M23594 Genomic DNA. Translation: AAA52785.1.
M74587 Genomic DNA. Translation: AAA52784.1.
BT019685 mRNA. Translation: AAV38491.1.
AY434089 Genomic DNA. Translation: AAQ96599.1.
CH236958 Genomic DNA. Translation: EAL23800.1.
CH471128 Genomic DNA. Translation: EAW61030.1.
CH471128 Genomic DNA. Translation: EAW61031.1.
BC035263 mRNA. Translation: AAH35263.2.
X15002 mRNA. Translation: CAA33110.1.
CCDSiCCDS5504.1.
PIRiA31867. IOHU1.
RefSeqiNP_000587.1. NM_000596.2.
UniGeneiHs.642938.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZT3X-ray1.80A172-251[»]
1ZT5X-ray1.82A172-251[»]
2DSQX-ray2.80G/H166-259[»]
ProteinModelPortaliP08833.
SMRiP08833.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109705. 20 interactors.
DIPiDIP-59846N.
STRINGi9606.ENSP00000275525.

Chemistry databases

BindingDBiP08833.
ChEMBLiCHEMBL4178.

Protein family/group databases

MEROPSiI31.951.

PTM databases

iPTMnetiP08833.
PhosphoSitePlusiP08833.

Polymorphism and mutation databases

BioMutaiIGFBP1.
DMDMi124055.

Proteomic databases

MaxQBiP08833.
PaxDbiP08833.
PeptideAtlasiP08833.
PRIDEiP08833.

Protocols and materials databases

DNASUi3484.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000275525; ENSP00000275525; ENSG00000146678.
GeneIDi3484.
KEGGihsa:3484.
UCSCiuc003tnp.4. human.

Organism-specific databases

CTDi3484.
DisGeNETi3484.
GeneCardsiIGFBP1.
HGNCiHGNC:5469. IGFBP1.
HPAiCAB004445.
HPA046972.
HPA050640.
MIMi146730. gene.
neXtProtiNX_P08833.
OpenTargetsiENSG00000146678.
PharmGKBiPA29703.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IITJ. Eukaryota.
ENOG4111H9A. LUCA.
GeneTreeiENSGT00550000074457.
HOGENOMiHOG000253012.
HOVERGENiHBG002631.
InParanoidiP08833.
OMAiGQGACVQ.
OrthoDBiEOG091G0EIN.
PhylomeDBiP08833.
TreeFamiTF331211.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000146678-MONOMER.
ReactomeiR-HSA-380994. ATF4 activates genes.
R-HSA-381426. Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs).
SignaLinkiP08833.
SIGNORiP08833.

Miscellaneous databases

EvolutionaryTraceiP08833.
GeneWikiiIGFBP1.
GenomeRNAii3484.
PMAP-CutDBP08833.
PROiP08833.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146678.
CleanExiHS_IGFBP1.
ExpressionAtlasiP08833. baseline and differential.
GenevisibleiP08833. HS.

Family and domain databases

Gene3Di4.10.800.10. 1 hit.
InterProiIPR009030. Growth_fac_rcpt_.
IPR000867. IGFBP-like.
IPR022322. IGFBP1.
IPR009168. IGFBP1-6.
IPR022321. IGFBP_1-6_chordata.
IPR017891. Insulin_GF-bd_Cys-rich_CS.
IPR000716. Thyroglobulin_1.
[Graphical view]
PANTHERiPTHR11551. PTHR11551. 1 hit.
PfamiPF00219. IGFBP. 1 hit.
PF00086. Thyroglobulin_1. 1 hit.
[Graphical view]
PRINTSiPR01976. IGFBPFAMILY.
PR01977. IGFBPFAMILY1.
SMARTiSM00121. IB. 1 hit.
SM00211. TY. 1 hit.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57610. SSF57610. 1 hit.
PROSITEiPS00222. IGFBP_N_1. 1 hit.
PS51323. IGFBP_N_2. 1 hit.
PS00484. THYROGLOBULIN_1_1. 1 hit.
PS51162. THYROGLOBULIN_1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIBP1_HUMAN
AccessioniPrimary (citable) accession number: P08833
Secondary accession number(s): A4D2F4, D3DVL9, Q8IYP5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: November 2, 2016
This is version 189 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.