Reviewed,
UniProtKB/Swiss-Prot P08800 (UGPA1_DICDI)
Last modified
February 9, 2010.
Version 56.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: UTP--glucose-1-phosphate uridylyltransferase 1 EC=2.7.7.9 Alternative name(s): UDP-glucose pyrophosphorylase 1 Short name=UGPase 1 Short name=UDPGP 1 | ||||
| Gene names |
| ||||
| Organism | Dictyostelium discoideum (Slime mold) [Complete proteome] | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 511 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Plays a central role as a glucosyl donor in cellular metabolic pathways. During development the lack of the enzyme activity leads to cell death and lysis. Strains which lack UDPG pyrophosphorylase accomplish early developmental events but are unable to culminate. The enzyme affects the growth rate of the cells but is not essential for growth. Ref.1 |
| Catalytic activity | UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose. |
| Pathway | |
| Developmental stage | Expressed in both prestalk and prespore cells. Expression becomes strong after 12 hours of development and peaks at 16 hours. Ref.5 |
| Induction | By cAMP through transmembrane signal transduction. Ref.4 |
| Sequence similarities | Belongs to the UDPGP type 1 family. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Nucleotidyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | metabolic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 511 | 511 | UTP--glucose-1-phosphate uridylyltransferase 1 | PRO_0000185755 | |||||
Experimental info | |||||||||
| Sequence conflict | 28 | 1 | N → D in CAA68340. Ref.1 | ||||||
| Sequence conflict | 28 | 1 | N → D in AAA84450. Ref.2 | ||||||
| Sequence conflict | 28 | 1 | N → D in AAA33271. Ref.3 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Structure and sequence of a UDP glucose pyrophosphorylase gene of Dictyostelium discoideum." Ragheb J.A., Dottin R.P. Nucleic Acids Res. 15:3891-3906(1987) [PubMed: 3035502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION. Strain: AX3. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [3] | "Transmembrane signal transduction regulates gene expression in Dictyostelium discoideum." Pavlovic J., Haribabu B., Dottin R.P. Dev. Genet. 9:371-382(1988) [PubMed: 2854024] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30. |
| [4] | "Identification of a signal transduction response sequence element necessary for induction of a Dictyostelium discoideum gene by extracellular cyclic AMP." Pavlovic J., Haribabu B., Dottin R.P. Mol. Cell. Biol. 9:4660-4669(1989) [PubMed: 2557538] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30, INDUCTION. |
| [5] | "A second UDP-glucose pyrophosphorylase is required for differentiation and development in Dictyostelium discoideum." Bishop J.D., Moon B.C., Harrow F., Ratner D., Gomer R.H., Dottin R.P., Brazill D.T. J. Biol. Chem. 277:32430-32437(2002) [PubMed: 12060658] [Abstract] Cited for: DEVELOPMENTAL STAGE. Strain: AX4. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y00145 Genomic DNA. Translation: CAA68340.1. AAFI02000149 Genomic DNA. Translation: EAL62450.1. M27639 Genomic DNA. Translation: AAA84450.1. M30467 Genomic DNA. Translation: AAA33271.1. |
| PIR | XNDOU. S07383. |
| RefSeq | XP_635982.1. |
3D structure databases | |
| SMR | P08800. Positions 13-401. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 8627397. |
| KEGG | ddi:DDB_0191527. |
Organism-specific databases | |
| dictyBase | DDB_G0289875. uppA. |
Phylogenomic databases | |
| eggNOG | KOG2638. |
| HOGENOM | HBG316482. |
| PhylomeDB | P08800. |
Enzyme and pathway databases | |
| BRENDA | 2.7.7.9. 424. |
Family and domain databases | |
| InterPro | IPR002618. UDPGP_trans. IPR016267. UDPGP_trans_sub. [Graphical view] |
| PANTHER | PTHR11952. UDPGP_trans. 1 hit. |
| Pfam | PF01704. UDPGP. 1 hit. [Graphical view] |
| PIRSF | PIRSF000806. UDPGP. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | UGPA1_DICDI | ||||||||
| Accession | Primary (citable) accession number: P08800 Secondary accession number(s): Q54GT7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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