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P08793

- XDH_CALVI

UniProt

P08793 - XDH_CALVI

Protein

Xanthine dehydrogenase

Gene

XDH

Organism
Calliphora vicina (Blue blowfly) (Calliphora erythrocephala)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1988)
      Previous versions | rss
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    Functioni

    Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.By similarity

    Catalytic activityi

    Xanthine + NAD+ + H2O = urate + NADH.
    Hypoxanthine + NAD+ + H2O = xanthine + NADH.

    Cofactori

    Binds 2 2Fe-2S clusters.By similarity
    FAD.By similarity
    Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi56 – 561Iron-sulfur 1By similarity
    Metal bindingi61 – 611Iron-sulfur 1By similarity
    Metal bindingi64 – 641Iron-sulfur 1By similarity
    Metal bindingi86 – 861Iron-sulfur 1By similarity
    Metal bindingi126 – 1261Iron-sulfur 2By similarity
    Metal bindingi129 – 1291Iron-sulfur 2By similarity
    Metal bindingi161 – 1611Iron-sulfur 2By similarity
    Metal bindingi163 – 1631Iron-sulfur 2By similarity
    Binding sitei353 – 3531FADBy similarity
    Binding sitei376 – 3761FADBy similarity
    Binding sitei424 – 4241FAD; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei442 – 4421FADBy similarity
    Metal bindingi790 – 7901MolybdenumBy similarity
    Metal bindingi821 – 8211Molybdenum; via carbonyl oxygenBy similarity
    Binding sitei825 – 8251SubstrateBy similarity
    Binding sitei903 – 9031SubstrateBy similarity
    Metal bindingi935 – 9351Molybdenum; via amide nitrogenBy similarity
    Binding sitei937 – 9371SubstrateBy similarity
    Metal bindingi1102 – 11021Molybdenum; via amide nitrogenBy similarity
    Active sitei1285 – 12851Proton acceptorBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi273 – 2808FADBy similarity
    Nucleotide bindingi363 – 3675FADBy similarity

    GO - Molecular functioni

    1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
    2. electron carrier activity Source: InterPro
    3. flavin adenine dinucleotide binding Source: UniProtKB
    4. iron ion binding Source: InterPro
    5. molybdopterin cofactor binding Source: UniProtKB
    6. UDP-N-acetylmuramate dehydrogenase activity Source: InterPro
    7. xanthine dehydrogenase activity Source: UniProtKB
    8. xanthine oxidase activity Source: InterPro

    GO - Biological processi

    1. xanthine catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    2Fe-2S, FAD, Flavoprotein, Iron, Iron-sulfur, Metal-binding, Molybdenum, NAD

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Xanthine dehydrogenase (EC:1.17.1.4)
    Short name:
    XD
    Gene namesi
    Name:XDH
    OrganismiCalliphora vicina (Blue blowfly) (Calliphora erythrocephala)
    Taxonomic identifieri7373 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeCalliphorinaeCalliphora

    Subcellular locationi

    Peroxisome By similarity

    GO - Cellular componenti

    1. peroxisome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Peroxisome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13531353Xanthine dehydrogenasePRO_0000166078Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP08793.
    SMRiP08793. Positions 15-178.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini17 – 104882Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
    BLAST
    Domaini245 – 434190FAD-binding PCMH-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the xanthine dehydrogenase family.Curated
    Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
    Contains 1 FAD-binding PCMH-type domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.365.10. 6 hits.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.1170.50. 1 hit.
    InterProiIPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR016208. Ald_Oxase/xanthine_DH.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR022407. OxRdtase_Mopterin_BS.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view]
    PfamiPF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000127. Xanthine_DH. 1 hit.
    SMARTiSM01008. Ald_Xan_dh_C. 1 hit.
    SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF54665. SSF54665. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56003. SSF56003. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsiTIGR02963. xanthine_xdhA. 1 hit.
    PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08793-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQEHNAAVL DLNPTFSTLI FFVNGKKVID TNPDPECTLL TYLREKLRLC     50
    GTKLGCGEGG CGACTVMISR IDTLTNRIKH IAVNACLTPV CAMHGSAVTT 100
    VEGIGSTRTR LHPVQERLAK AHGSQCGFCT PGIVMSMYAL LRNLSQPSMK 150
    DLEIAFQGNL CRCTGYRPIL EGYKTFTKEF GCAMGDKCCK VNGNKCGEGM 200
    ENGGDMVDDK LFEKSEFVPF DPSQEPIFPP ELQLNKDWDS QTLVYKGERA 250
    TWYRPGNLED LLKIKAQFPE AKLVVGNTEI GVEVKFKHFL YPVLVNPTKV 300
    KEMIDVQELE DSIYFGASVS LMDIDRILRS SIEKLPEHQT RFFQCAVNML 350
    HYFAGKQIRN VASLGGNIMT GSPISDMNPV LMAGAVKFKV AKYVEGQIKY 400
    REVCMASGFF TGYRKNVIEP TEILVGLYFP KTLEHQYVVA FKQAKRRDDD 450
    IAIVNAAINV FIDPRSITVD KVYMAFGGMA PTTVLATRTA DIMVKQQWNK 500
    VLMERVVENL CAELPLAPSA PGGMIAYRRS LVVSLFFKAY LTITQQLIKS 550
    GILPQDSLPQ EELSGSDVFH TPALKSAQLF EKVSNKQSEC DPIGRPKIHA 600
    SALKQATGEA IYCDDMPRME NELYLALVLS TKAHAKILSI DASEALAMPG 650
    VHAFFSSKDI TQHENEVGPV FHDEEVFASD MVYCQGQVIG AIAADNPNFS 700
    SKTARKVTIE YEDIKPVIIT IEQAIEHKSY FPDYPRFTEI GDVEKAFSEA 750
    DHVYEGSCRM GGQEHFYLET HASLAVPRDS DEIEIFCSTQ HPSEVQKLVA 800
    HVLSTSAHRV VCRAKRLGGG FGGKESRAIA VALPVALACH RLRRPIRCML 850
    DRDEDMMITG TRHPFLFKYK IAFTSEGRLT GCYIECYNNA GWSMDLSFSV 900
    LERAMFHFEN CYKIPNIKVG GWVCKTNLPS NTAFRGFGGP QGMFAGEHII 950
    RDVARILGKD YLEIMKQNFY KEGDITHYQQ KLDNFPIEKC FYDCLQQSNY 1000
    YQKRKEIEEF NRNHRWRKRG ISLVPTKYGI AFGVSHLNQA GALINIYADG 1050
    SVLLSHGGVE IGQGLHTKMI QCCARALQIP IEFIHISETA TDKVPNTSPT 1100
    AASSGSDLNG MAVLDACEKL NKRLAPIKEA NPNGSWTEWI NKAYFERVSL 1150
    SATGFYRMPD IGYDPVQNPN ALMYNYFTNG VGSSIVEIDC LTGDHQVLST 1200
    DIVMDIGSSL NPAIDIGQIE GAFMQGYGLF TLEEMIYSPQ GVLYSRGPGM 1250
    YKLPGFADIP GEFNVTILTG AANPRAVYSS KAVGEPPLFI GCSVFFAIKE 1300
    AITSARLMNG LSEDFKLESP ATSARIRMAC QDEFTNLIEQ PPAGSYVPWN 1350
    IVP 1353
    Length:1,353
    Mass (Da):150,209
    Last modified:November 1, 1988 - v1
    Checksum:i7120361C57C3E297
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07229 mRNA. Translation: CAA30189.1.
    X07323, X07324, X07325 Genomic DNA. Translation: CAA30281.1.
    M18423 Genomic DNA. Translation: AAA27879.1.
    PIRiJQ0407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X07229 mRNA. Translation: CAA30189.1 .
    X07323 , X07324 , X07325 Genomic DNA. Translation: CAA30281.1 .
    M18423 Genomic DNA. Translation: AAA27879.1 .
    PIRi JQ0407.

    3D structure databases

    ProteinModelPortali P08793.
    SMRi P08793. Positions 15-178.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.150.120. 1 hit.
    3.10.20.30. 1 hit.
    3.30.365.10. 6 hits.
    3.30.43.10. 1 hit.
    3.30.465.10. 1 hit.
    3.90.1170.50. 1 hit.
    InterProi IPR002888. 2Fe-2S-bd.
    IPR001041. 2Fe-2S_ferredoxin-type.
    IPR006058. 2Fe2S_fd_BS.
    IPR000674. Ald_Oxase/Xan_DH_a/b.
    IPR016208. Ald_Oxase/xanthine_DH.
    IPR008274. AldOxase/xan_DH_Mopterin-bd.
    IPR012675. Beta-grasp_dom.
    IPR005107. CO_DH_flav_C.
    IPR016169. CO_DH_flavot_FAD-bd_sub2.
    IPR016166. FAD-bd_2.
    IPR016167. FAD-bd_2_sub1.
    IPR002346. Mopterin_DH_FAD-bd.
    IPR022407. OxRdtase_Mopterin_BS.
    IPR014307. Xanthine_DH_ssu.
    [Graphical view ]
    Pfami PF01315. Ald_Xan_dh_C. 1 hit.
    PF02738. Ald_Xan_dh_C2. 1 hit.
    PF03450. CO_deh_flav_C. 1 hit.
    PF00941. FAD_binding_5. 1 hit.
    PF00111. Fer2. 1 hit.
    PF01799. Fer2_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000127. Xanthine_DH. 1 hit.
    SMARTi SM01008. Ald_Xan_dh_C. 1 hit.
    SM01092. CO_deh_flav_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47741. SSF47741. 1 hit.
    SSF54292. SSF54292. 1 hit.
    SSF54665. SSF54665. 1 hit.
    SSF55447. SSF55447. 1 hit.
    SSF56003. SSF56003. 1 hit.
    SSF56176. SSF56176. 1 hit.
    TIGRFAMsi TIGR02963. xanthine_xdhA. 1 hit.
    PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
    PS51085. 2FE2S_FER_2. 1 hit.
    PS51387. FAD_PCMH. 1 hit.
    PS00559. MOLYBDOPTERIN_EUK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Divergence of the nucleotide sequences encoding xanthine dehydrogenase in Calliphora vicina and Drosophila melanogaster."
      Houde M., Tiveron M.C., Bregegere F.
      Gene 85:391-402(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "Cloning and partial characterization of the xanthine dehydrogenase gene of Calliphora vicina, a distant relative of Drosophila melanogaster."
      Rocher-Chambonnet C., Berreur P., Houde M., Tiveron M.C., Lepesant J.-A., Bregegere F.
      Gene 59:201-212(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 208-367.

    Entry informationi

    Entry nameiXDH_CALVI
    AccessioniPrimary (citable) accession number: P08793
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: November 1, 1988
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3