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P08793 (XDH_CALVI) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Xanthine dehydrogenase

Short name=XD
EC=1.17.1.4
Gene names
Name:XDH
OrganismCalliphora vicina (Blue blowfly) (Calliphora erythrocephala)
Taxonomic identifier7373 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaOestroideaCalliphoridaeCalliphorinaeCalliphora

Protein attributes

Sequence length1353 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid By similarity.

Catalytic activity

Xanthine + NAD+ + H2O = urate + NADH.

Hypoxanthine + NAD+ + H2O = xanthine + NADH.

Cofactor

Binds 2 2Fe-2S clusters By similarity.

FAD By similarity.

Binds 1 molybdenum-molybdopterin (Mo-MPT) cofactor per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Peroxisome By similarity.

Sequence similarities

Belongs to the xanthine dehydrogenase family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 FAD-binding PCMH-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13531353Xanthine dehydrogenase
PRO_0000166078

Regions

Domain17 – 104882Fe-2S ferredoxin-type
Domain245 – 434190FAD-binding PCMH-type
Nucleotide binding273 – 2808FAD By similarity
Nucleotide binding363 – 3675FAD By similarity

Sites

Active site12851Proton acceptor By similarity
Metal binding561Iron-sulfur 1 By similarity
Metal binding611Iron-sulfur 1 By similarity
Metal binding641Iron-sulfur 1 By similarity
Metal binding861Iron-sulfur 1 By similarity
Metal binding1261Iron-sulfur 2 By similarity
Metal binding1291Iron-sulfur 2 By similarity
Metal binding1611Iron-sulfur 2 By similarity
Metal binding1631Iron-sulfur 2 By similarity
Metal binding7901Molybdenum By similarity
Metal binding8211Molybdenum; via carbonyl oxygen By similarity
Metal binding9351Molybdenum; via amide nitrogen By similarity
Metal binding11021Molybdenum; via amide nitrogen By similarity
Binding site3531FAD By similarity
Binding site3761FAD By similarity
Binding site4241FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site4421FAD By similarity
Binding site8251Substrate By similarity
Binding site9031Substrate By similarity
Binding site9371Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
P08793 [UniParc].

Last modified November 1, 1988. Version 1.
Checksum: 7120361C57C3E297

FASTA1,353150,209
        10         20         30         40         50         60 
MTQEHNAAVL DLNPTFSTLI FFVNGKKVID TNPDPECTLL TYLREKLRLC GTKLGCGEGG 

        70         80         90        100        110        120 
CGACTVMISR IDTLTNRIKH IAVNACLTPV CAMHGSAVTT VEGIGSTRTR LHPVQERLAK 

       130        140        150        160        170        180 
AHGSQCGFCT PGIVMSMYAL LRNLSQPSMK DLEIAFQGNL CRCTGYRPIL EGYKTFTKEF 

       190        200        210        220        230        240 
GCAMGDKCCK VNGNKCGEGM ENGGDMVDDK LFEKSEFVPF DPSQEPIFPP ELQLNKDWDS 

       250        260        270        280        290        300 
QTLVYKGERA TWYRPGNLED LLKIKAQFPE AKLVVGNTEI GVEVKFKHFL YPVLVNPTKV 

       310        320        330        340        350        360 
KEMIDVQELE DSIYFGASVS LMDIDRILRS SIEKLPEHQT RFFQCAVNML HYFAGKQIRN 

       370        380        390        400        410        420 
VASLGGNIMT GSPISDMNPV LMAGAVKFKV AKYVEGQIKY REVCMASGFF TGYRKNVIEP 

       430        440        450        460        470        480 
TEILVGLYFP KTLEHQYVVA FKQAKRRDDD IAIVNAAINV FIDPRSITVD KVYMAFGGMA 

       490        500        510        520        530        540 
PTTVLATRTA DIMVKQQWNK VLMERVVENL CAELPLAPSA PGGMIAYRRS LVVSLFFKAY 

       550        560        570        580        590        600 
LTITQQLIKS GILPQDSLPQ EELSGSDVFH TPALKSAQLF EKVSNKQSEC DPIGRPKIHA 

       610        620        630        640        650        660 
SALKQATGEA IYCDDMPRME NELYLALVLS TKAHAKILSI DASEALAMPG VHAFFSSKDI 

       670        680        690        700        710        720 
TQHENEVGPV FHDEEVFASD MVYCQGQVIG AIAADNPNFS SKTARKVTIE YEDIKPVIIT 

       730        740        750        760        770        780 
IEQAIEHKSY FPDYPRFTEI GDVEKAFSEA DHVYEGSCRM GGQEHFYLET HASLAVPRDS 

       790        800        810        820        830        840 
DEIEIFCSTQ HPSEVQKLVA HVLSTSAHRV VCRAKRLGGG FGGKESRAIA VALPVALACH 

       850        860        870        880        890        900 
RLRRPIRCML DRDEDMMITG TRHPFLFKYK IAFTSEGRLT GCYIECYNNA GWSMDLSFSV 

       910        920        930        940        950        960 
LERAMFHFEN CYKIPNIKVG GWVCKTNLPS NTAFRGFGGP QGMFAGEHII RDVARILGKD 

       970        980        990       1000       1010       1020 
YLEIMKQNFY KEGDITHYQQ KLDNFPIEKC FYDCLQQSNY YQKRKEIEEF NRNHRWRKRG 

      1030       1040       1050       1060       1070       1080 
ISLVPTKYGI AFGVSHLNQA GALINIYADG SVLLSHGGVE IGQGLHTKMI QCCARALQIP 

      1090       1100       1110       1120       1130       1140 
IEFIHISETA TDKVPNTSPT AASSGSDLNG MAVLDACEKL NKRLAPIKEA NPNGSWTEWI 

      1150       1160       1170       1180       1190       1200 
NKAYFERVSL SATGFYRMPD IGYDPVQNPN ALMYNYFTNG VGSSIVEIDC LTGDHQVLST 

      1210       1220       1230       1240       1250       1260 
DIVMDIGSSL NPAIDIGQIE GAFMQGYGLF TLEEMIYSPQ GVLYSRGPGM YKLPGFADIP 

      1270       1280       1290       1300       1310       1320 
GEFNVTILTG AANPRAVYSS KAVGEPPLFI GCSVFFAIKE AITSARLMNG LSEDFKLESP 

      1330       1340       1350 
ATSARIRMAC QDEFTNLIEQ PPAGSYVPWN IVP 

« Hide

References

[1]"Divergence of the nucleotide sequences encoding xanthine dehydrogenase in Calliphora vicina and Drosophila melanogaster."
Houde M., Tiveron M.C., Bregegere F.
Gene 85:391-402(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"Cloning and partial characterization of the xanthine dehydrogenase gene of Calliphora vicina, a distant relative of Drosophila melanogaster."
Rocher-Chambonnet C., Berreur P., Houde M., Tiveron M.C., Lepesant J.-A., Bregegere F.
Gene 59:201-212(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 208-367.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X07229 mRNA. Translation: CAA30189.1.
X07323, X07324, X07325 Genomic DNA. Translation: CAA30281.1.
M18423 Genomic DNA. Translation: AAA27879.1.
PIRJQ0407.

3D structure databases

ProteinModelPortalP08793.
SMRP08793. Positions 15-178.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.150.120. 1 hit.
3.10.20.30. 1 hit.
3.30.365.10. 6 hits.
3.30.43.10. 1 hit.
3.30.465.10. 1 hit.
3.90.1170.50. 1 hit.
InterProIPR002888. 2Fe-2S-bd.
IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR000674. Ald_Oxase/Xan_DH_a/b.
IPR016208. Ald_Oxase/xanthine_DH.
IPR008274. AldOxase/xan_DH_Mopterin-bd.
IPR012675. Beta-grasp_dom.
IPR005107. CO_DH_flav_C.
IPR016169. CO_DH_flavot_FAD-bd_sub2.
IPR016166. FAD-bd_2.
IPR016167. FAD-bd_2_sub1.
IPR002346. Mopterin_DH_FAD-bd.
IPR022407. OxRdtase_Mopterin_BS.
IPR014307. Xanthine_DH_ssu.
[Graphical view]
PfamPF01315. Ald_Xan_dh_C. 1 hit.
PF02738. Ald_Xan_dh_C2. 1 hit.
PF03450. CO_deh_flav_C. 1 hit.
PF00941. FAD_binding_5. 1 hit.
PF00111. Fer2. 1 hit.
PF01799. Fer2_2. 1 hit.
[Graphical view]
PIRSFPIRSF000127. Xanthine_DH. 1 hit.
SMARTSM01008. Ald_Xan_dh_C. 1 hit.
SM01092. CO_deh_flav_C. 1 hit.
[Graphical view]
SUPFAMSSF47741. SSF47741. 1 hit.
SSF54292. SSF54292. 1 hit.
SSF54665. SSF54665. 1 hit.
SSF55447. SSF55447. 1 hit.
SSF56003. SSF56003. 1 hit.
SSF56176. SSF56176. 1 hit.
TIGRFAMsTIGR02963. xanthine_xdhA. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS51387. FAD_PCMH. 1 hit.
PS00559. MOLYBDOPTERIN_EUK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameXDH_CALVI
AccessionPrimary (citable) accession number: P08793
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: October 16, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families