Reviewed, UniProtKB/Swiss-Prot P08790 (ACOX5_CANTR)

Names and origin

Protein names

Recommended name:
    Acyl-coenzyme A oxidase 5
      Short name=Acyl-CoA oxidase 5
    EC=1.3.3.6
Alternative name(s):
    PXP-5

Gene names

Name:

POX5

Organism

Candida tropicalis (Yeast)

Taxonomic identifier

5482 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	662 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2.
Cofactor	FAD.
Pathway	Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Subunit structure	Homooctamer.
Subcellular location	Peroxisome.
Sequence similarities	Belongs to the acyl-CoA oxidase family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism
Cellular component	Peroxisome
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	fatty acid beta-oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	peroxisome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro acyl-CoA oxidase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed
	Chain	2 – 662	661	Acyl-coenzyme A oxidase 5		PRO_0000204697

Sequences

	Sequence		Length	Mass (Da)
	P08790-1 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: 6746A72B6AD1986C	FASTA	662	74,238
	10 20 30 40 50 60 MPTELQKERE LTKFNPKELN YFLEGSQERS EIISNMVEQM QKDPILKVDA SYYNLTKDQQ 70 80 90 100 110 120 REVTAKKIAR LSRYFEHEYP DQQAQRLSIL GVFDPQVFTR IGVNLGLFVS CVRGNGTNSQ 130 140 150 160 170 180 FFYWTINKGI DKLRGIYGCF GMTELAHGSN VQGIETTATF DEDTDEFVIN TPHIGATKWW 190 200 210 220 230 240 IGGAAHSATH CSVYARLKVK GKDYGVKTFV VPLRDSNHDL EPGVTVGDIG AKMGRDGIDN 250 260 270 280 290 300 GWIQFSNVRI PRFFMLQKYC KVSRSGEVTM PPSEQLSYSA LIGGRVTMMM DSYRMTSRFI 310 320 330 340 350 360 TIALRYAIHR RQFKKKDTDT IETKLIDYPL HQKRLFPFLA AAYLFSQGAL YLEQTMNATN 370 380 390 400 410 420 DKLDEAVSAG EKEAIDAAIV ESKKLFVASG CLKSTCTWLT AEAIDEARQA CGGHGYSSYN 430 440 450 460 470 480 GFGKAYSDWV VQCTWEGDNN ILAMNVAKPM VRDLLKEPEQ KGLVLSSVAD LDDPAKLVKA 490 500 510 520 530 540 FDHALSGLAR DIGAVAEDKG FDITGPSLVL VSKLNAHRFL IDGFFKRITP EWSEVLRPLG 550 560 570 580 590 600 FLYADWILTN FGATFLQYGI ITPDVSRKIS SEHFPALCAK VRPNVVGLTD GFNLTDMMTN 610 620 630 640 650 660 AAIGRYDGNV YEHYFETVKA LNPPENTKAP YSKALEDMLN RPDLEVRERG EKSEEAAEIL SS

References

[1]	"Two acyl-coenzyme A oxidases in peroxisomes of the yeast Candida tropicalis: primary structures deduced from genomic DNA sequence." Okazaki K., Takechi T., Kambara N., Fukui S., Kubota I., Kamiryo T. Proc. Natl. Acad. Sci. U.S.A. 83:1232-1236(1986) [PubMed: 3456583] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	Okazaki K., Takechi T., Kambara N., Fukui S., Kubota I., Kamiryo T. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 265.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M12161 Genomic DNA. Translation: AAA34363.2.
PIR	OXCKX5. B25123.
3D structure databases
HSSP	HSSP built from PDB template 1IS2 based on UniProtKB P07872.
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.3.3.6. 1242.
Family and domain databases
InterPro	IPR006091. Acyl-CoA_Oxase/DH_M. IPR012258. Acyl-CoA_oxidase. IPR002655. Acyl-CoA_oxidase_C. IPR013786. AcylCoA_DH/ox_N. IPR013764. AcylCoA_oxidase/DH_1/2_C. [Graphical view]
Gene3D	G3DSA:2.40.110.10. Acyl_CoA_DH/ox_M. 1 hit. G3DSA:1.10.540.10. AcylCoA_DH/ox_N. 1 hit. G3DSA:1.20.140.10. AcylCoA_DH_1/2_C. 2 hits.
PANTHER	PTHR10909:SF11. Acyl-CoA_oxidase. 1 hit.
Pfam	PF01756. ACOX. 1 hit. PF02770. Acyl-CoA_dh_M. 1 hit. [Graphical view]
PIRSF	PIRSF000168. Acyl-CoA_oxidase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ACOX5_CANTR

Accession

Primary (citable) accession number: P08790

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	January 23, 2007
Last modified:	June 16, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)