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P08764

- T3RE_BPP1

UniProt

P08764 - T3RE_BPP1

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Protein
Type III restriction-modification system EcoPI enzyme res
Gene
res
Organism
Enterobacteria phage P1 (Bacteriophage P1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This protein cuts the DNA some 25 base-pairs to the 3'-end of the recognition site. It is only required for restriction but needs the presence of the modification enzyme.

Catalytic activityi

Endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates.

Cofactori

Magnesium.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. DNA binding Source: InterPro
  3. Type III site-specific deoxyribonuclease activity Source: UniProtKB-EC
  4. helicase activity Source: UniProtKB-KW

GO - Biological processi

  1. DNA restriction-modification system Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Helicase, Hydrolase, Nuclease

Keywords - Biological processi

Restriction system

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Protein family/group databases

REBASEi988. EcoPI.

Names & Taxonomyi

Protein namesi
Recommended name:
Type III restriction-modification system EcoPI enzyme res (EC:3.1.21.5)
Gene namesi
Name:res
OrganismiEnterobacteria phage P1 (Bacteriophage P1)
Taxonomic identifieri10678 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridaePunalikevirus
Virus hostiEnterobacteriaceae [TaxID: 543]
ProteomesiUP000008091: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 970970Type III restriction-modification system EcoPI enzyme res
PRO_0000077374Add
BLAST

Interactioni

Subunit structurei

Contains two different subunits: res and mod.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR006935. Helicase/UvrB_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF04851. ResIII. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.

Sequencei

Sequence statusi: Complete.

P08764-1 [UniParc]FASTAAdd to Basket

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MSKGFTFEKN LPHQKAGVDA VMNVFVSATS HQEDNVSIRL LVNPELRLTE    50
QQYYKNIKKV QELNGIEHVK NNYDARSNVI DVSMETGTGK TYTYTKTIFD 100
LNKSFGINKF IIIVPTLSIK AGTVNFLKSD ALKEHFRDDY EREIKTYVVE 150
SQKNAGKSTK SYMPQAIHDF VEASNFNKKY IHVLVINTGM IHSKNLNSTY 200
DVGLLDNHFD SPFSALGAVK PFIIIDEPHK FPTGKKTWEN IEKFNAQYII 250
RYGATFSEGY KNLVYRLTAV DAFNEDLVKG IDAYIEDIVG DGDANLKFIK 300
SDGEEVTFEL NENNKKTLFK LTKGESLSKT HSAIHDLTLD ALGKNTVVLS 350
NGIELKIGCS INPYSYDQTL ADSMMRKAIK EHFKLEKEFL TQRPRIKPLT 400
LFFIDDIEGY RDGNNIAGSL KAKFEEYVLA EANELLKIEK DEFYSNYLEK 450
TVKDISSVHG GYFSKDNSDK DDKIEKEINE ILHDKELLLS LDNPRRFIFS 500
KWTLREGWDN PNVFQICKLR SSGSTTSKLQ EVGRGLRLPV NEYMCRVKDR 550
NFTLKYYVDF TEKDFVDSLV KEVNESSFKE RVPSKFTQEL KEQIRAQYPE 600
LSSRALMNEL FNDEIIDDND NFKDSDAYSR LKSKYPAAFP IGVKPGKIKK 650
ATDGKRRTKM RVGKFSELKE LWELINQKAV IEYKINSENE FLSIFKSFML 700
EETERFTKSG VHTRIDKIYI HNDMAMSKSI VSDDDDFAKL NTMSYREFLD 750
NLSQTIFVKH DTLHKVFCDI KDTINITEYL NIQTIRKIKS GFSKYLLNNS 800
FNKFSLGYNL ISGSIHPTKF TNADGKPLDE VLSSDLGVLQ DNSKAPLDTY 850
LFEEVFYDSE LERRNITDRE IQSVVVFSKI PKNSIKIPVA GGYTYSPDFA 900
YVVKTAEGDY LNFIIETKNV DSKDSLRLEE KKKIEHAQAL FNQISQSVKV 950
EFKTQFANDD IYQLIKSALP 970
Length:970
Mass (Da):111,459
Last modified:November 1, 1988 - v1
Checksum:iB599110154D723AA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06287 Genomic DNA. Translation: CAA29615.1.
AF234172 Genomic DNA. Translation: AAQ13982.1.
PIRiS01352.
RefSeqiYP_006476.1. NC_005856.1.

Genome annotation databases

GeneIDi2777489.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X06287 Genomic DNA. Translation: CAA29615.1 .
AF234172 Genomic DNA. Translation: AAQ13982.1 .
PIRi S01352.
RefSeqi YP_006476.1. NC_005856.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 988. EcoPI.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2777489.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
InterProi IPR006935. Helicase/UvrB_dom.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF04851. ResIII. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 3 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Type III DNA restriction and modification systems EcoP1 and EcoP15. Nucleotide sequence of the EcoP1 operon, the EcoP15 mod gene and some EcoP1 mod mutants."
    Huembelin M., Suri B., Rao D.N., Hornby D.P., Eberle H., Pripfl T., Kenel S., Bickle T.A.
    J. Mol. Biol. 200:23-29(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiT3RE_BPP1
AccessioniPrimary (citable) accession number: P08764
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: November 1, 1988
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Restriction enzymes and methylases
    Classification of restriction enzymes and methylases and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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