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P08758

- ANXA5_HUMAN

UniProt

P08758 - ANXA5_HUMAN

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Protein

Annexin A5

Gene

ANXA5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

GO - Molecular functioni

  1. calcium-dependent phospholipid binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. phospholipase inhibitor activity Source: ProtInc
  4. phospholipid binding Source: ProtInc

GO - Biological processi

  1. blood coagulation Source: UniProtKB-KW
  2. negative regulation of apoptotic process Source: UniProtKB
  3. negative regulation of catalytic activity Source: GOC
  4. negative regulation of coagulation Source: InterPro
  5. response to organic substance Source: Ensembl
  6. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

SignaLinkiP08758.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:ANXA5
Synonyms:ANX5, ENX2, PP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:543. ANXA5.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. endothelial microparticle Source: Ensembl
  3. external side of plasma membrane Source: Ensembl
  4. extracellular vesicular exosome Source: UniProtKB
  5. focal adhesion Source: UniProtKB
  6. intracellular Source: LIFEdb
  7. membrane Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Pregnancy loss, recurrent, 3 (RPRGL3) [MIM:614391]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.1 Publication
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Organism-specific databases

MIMi614391. phenotype.
PharmGKBiPA24833.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 320319Annexin A5PRO_0000067487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine2 Publications
Modified residuei70 – 701N6-acetyllysine1 Publication
Modified residuei76 – 761N6-acetyllysine1 Publication
Modified residuei79 – 791N6-acetyllysine1 Publication
Modified residuei97 – 971N6-acetyllysine1 Publication
Modified residuei101 – 1011N6-acetyllysine1 Publication
Modified residuei290 – 2901N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP08758.
PaxDbiP08758.
PeptideAtlasiP08758.
PRIDEiP08758.

2D gel databases

OGPiP08758.
REPRODUCTION-2DPAGEIPI00329801.
P08758.

PTM databases

PhosphoSiteiP08758.

Expressioni

Gene expression databases

BgeeiP08758.
CleanExiHS_ANXA5.
ExpressionAtlasiP08758. baseline and differential.
GenevestigatoriP08758.

Organism-specific databases

HPAiCAB003677.
HPA035330.

Interactioni

Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).By similarity1 Publication

Protein-protein interaction databases

BioGridi106805. 33 interactions.
IntActiP08758. 16 interactions.
MINTiMINT-1382250.
STRINGi9606.ENSP00000296511.

Structurei

Secondary structure

1
320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 2812
Beta strandi29 – 324
Helixi35 – 439
Helixi47 – 6115
Helixi65 – 728
Helixi75 – 8511
Helixi88 – 10013
Beta strandi102 – 1043
Helixi107 – 11610
Helixi119 – 13315
Helixi137 – 1448
Helixi147 – 15711
Helixi169 – 18214
Turni183 – 1853
Beta strandi186 – 1883
Helixi191 – 20010
Helixi203 – 21715
Helixi221 – 2288
Helixi231 – 24515
Helixi247 – 25610
Helixi257 – 2593
Beta strandi260 – 2634
Helixi266 – 27611
Turni277 – 2804
Helixi281 – 29010
Beta strandi292 – 2943
Helixi296 – 3038
Helixi306 – 31611

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]
ProteinModelPortaliP08758.
SMRiP08758. Positions 3-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08758.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8461Annexin 1Add
BLAST
Repeati96 – 15661Annexin 2Add
BLAST
Repeati180 – 24061Annexin 3Add
BLAST
Repeati255 – 31561Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiNOG281174.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08758.
KOiK16646.
OMAiVRNIKQV.
OrthoDBiEOG74XS72.
PhylomeDBiP08758.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08758-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR
60 70 80 90 100
QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL
110 120 130 140 150
KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ
160 170 180 190 200
RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT
210 220 230 240 250
RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY
260 270 280 290 300
LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI
310 320
KGDTSGDYKK ALLLLCGEDD
Length:320
Mass (Da):35,937
Last modified:January 23, 2007 - v2
Checksum:i45E14E3964BA4D1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351S → L in CAG38759. 1 PublicationCurated
Sequence conflicti279 – 2791I → T in AAH18671. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18366 mRNA. Translation: AAA35570.1.
D00172 mRNA. Translation: BAA00122.1.
X12454 mRNA. Translation: CAA30985.1.
J03745 mRNA. Translation: AAA52386.1.
M21731 mRNA. Translation: AAA36166.1.
M19384 mRNA. Translation: AAB59545.1.
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA. Translation: AAB40047.1.
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA. Translation: AAB60648.1.
AK312644 mRNA. Translation: BAG35528.1.
CR536522 mRNA. Translation: CAG38759.1.
CR541842 mRNA. Translation: CAG46640.1.
AC096730 Genomic DNA. Translation: AAY40954.1.
CH471056 Genomic DNA. Translation: EAX05257.1.
CH471056 Genomic DNA. Translation: EAX05258.1.
BC001429 mRNA. Translation: AAH01429.1.
BC004993 mRNA. Translation: AAH04993.1.
BC012804 mRNA. Translation: AAH12804.1.
BC012822 mRNA. Translation: AAH12822.1.
BC018671 mRNA. Translation: AAH18671.1.
CCDSiCCDS3720.1.
PIRiD29250. AQHUP.
RefSeqiNP_001145.1. NM_001154.3.
UniGeneiHs.480653.

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111.
GeneIDi308.
KEGGihsa:308.
UCSCiuc003idu.4. human.

Polymorphism databases

DMDMi113960.

Cross-referencesi

Web resourcesi

R&D Systems' cytokine source book: Annexin V

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M18366 mRNA. Translation: AAA35570.1 .
D00172 mRNA. Translation: BAA00122.1 .
X12454 mRNA. Translation: CAA30985.1 .
J03745 mRNA. Translation: AAA52386.1 .
M21731 mRNA. Translation: AAA36166.1 .
M19384 mRNA. Translation: AAB59545.1 .
U01691
, U01681 , U01682 , U01683 , U01685 , U01686 , U01687 , U01689 , U01690 Genomic DNA. Translation: AAB40047.1 .
U05770
, U05760 , U05761 , U05762 , U05764 , U05765 , U05766 , U05767 , U05768 , U05769 Genomic DNA. Translation: AAB60648.1 .
AK312644 mRNA. Translation: BAG35528.1 .
CR536522 mRNA. Translation: CAG38759.1 .
CR541842 mRNA. Translation: CAG46640.1 .
AC096730 Genomic DNA. Translation: AAY40954.1 .
CH471056 Genomic DNA. Translation: EAX05257.1 .
CH471056 Genomic DNA. Translation: EAX05258.1 .
BC001429 mRNA. Translation: AAH01429.1 .
BC004993 mRNA. Translation: AAH04993.1 .
BC012804 mRNA. Translation: AAH12804.1 .
BC012822 mRNA. Translation: AAH12822.1 .
BC018671 mRNA. Translation: AAH18671.1 .
CCDSi CCDS3720.1.
PIRi D29250. AQHUP.
RefSeqi NP_001145.1. NM_001154.3.
UniGenei Hs.480653.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ANW X-ray 2.40 A/B 2-320 [» ]
1ANX X-ray 1.90 A/B/C 2-320 [» ]
1AVH X-ray 2.30 A/B 1-320 [» ]
1AVR X-ray 2.30 A 1-320 [» ]
1HAK X-ray 3.00 A/B 1-320 [» ]
1HVD X-ray 2.00 A 2-320 [» ]
1HVE X-ray 2.30 A 2-320 [» ]
1HVF X-ray 2.00 A 2-320 [» ]
1HVG X-ray 3.00 A 2-320 [» ]
1SAV X-ray 2.50 A 1-320 [» ]
2XO2 X-ray 2.80 A 1-320 [» ]
2XO3 X-ray 2.30 A 1-320 [» ]
ProteinModelPortali P08758.
SMRi P08758. Positions 3-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106805. 33 interactions.
IntActi P08758. 16 interactions.
MINTi MINT-1382250.
STRINGi 9606.ENSP00000296511.

PTM databases

PhosphoSitei P08758.

Polymorphism databases

DMDMi 113960.

2D gel databases

OGPi P08758.
REPRODUCTION-2DPAGE IPI00329801.
P08758.

Proteomic databases

MaxQBi P08758.
PaxDbi P08758.
PeptideAtlasi P08758.
PRIDEi P08758.

Protocols and materials databases

DNASUi 308.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296511 ; ENSP00000296511 ; ENSG00000164111 .
GeneIDi 308.
KEGGi hsa:308.
UCSCi uc003idu.4. human.

Organism-specific databases

CTDi 308.
GeneCardsi GC04M122589.
HGNCi HGNC:543. ANXA5.
HPAi CAB003677.
HPA035330.
MIMi 131230. gene.
614391. phenotype.
neXtProti NX_P08758.
PharmGKBi PA24833.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG281174.
HOGENOMi HOG000158803.
HOVERGENi HBG061815.
InParanoidi P08758.
KOi K16646.
OMAi VRNIKQV.
OrthoDBi EOG74XS72.
PhylomeDBi P08758.
TreeFami TF105452.

Enzyme and pathway databases

SignaLinki P08758.

Miscellaneous databases

ChiTaRSi ANXA5. human.
EvolutionaryTracei P08758.
GeneWikii Annexin_A5.
GenomeRNAii 308.
NextBioi 1243.
PROi P08758.
SOURCEi Search...

Gene expression databases

Bgeei P08758.
CleanExi HS_ANXA5.
ExpressionAtlasi P08758. baseline and differential.
Genevestigatori P08758.

Family and domain databases

Gene3Di 1.10.220.10. 4 hits.
InterProi IPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view ]
PANTHERi PTHR10502:SF26. PTHR10502:SF26. 1 hit.
Pfami PF00191. Annexin. 4 hits.
[Graphical view ]
PRINTSi PR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTi SM00335. ANX. 4 hits.
[Graphical view ]
PROSITEi PS00223. ANNEXIN. 4 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary structure of human placental anticoagulant protein."
    Funakoshi T., Hendrickson L.E., McMullen B.A., Fujikawa K.
    Biochemistry 26:8087-8092(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Structure and expression of cDNA for an inhibitor of blood coagulation isolated from human placenta: a new lipocortin-like protein."
    Iwasaki A., Suda M., Nakao H., Nagoya T., Saino Y., Arai K., Mizoguchi T., Sato F., Yoshizaki H., Hirata M., Miyata T., Shidara Y., Murata M., Maki M.
    J. Biochem. 102:1261-1273(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 2-320.
  3. "Cloning and expression of cDNA for human vascular anticoagulant, a Ca2+-dependent phospholipid-binding protein."
    Maurer-Fogy I., Reutelingsperger C.P.M., Pieters J., Bodo G., Stratowa C., Hauptmann R.
    Eur. J. Biochem. 174:585-592(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
  4. "Cloning and expression of cDNA for human endonexin II, a Ca2+ and phospholipid binding protein."
    Kaplan R., Jaye M., Burgess W.H., Schlaepfer D.D., Haigler H.T.
    J. Biol. Chem. 263:8037-8043(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I."
    Pepinsky R.B., Tizard R., Mattaliano R.J., Sinclair L.K., Miller G.T., Browning J.L., Chow E.P., Burne C., Huang K.-S., Pratt D., Wachter L., Hession C., Frey A.Z., Wallner B.P.
    J. Biol. Chem. 263:10799-10811(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "Characterization of cDNA encoding human placental anticoagulant protein (PP4): homology with the lipocortin family."
    Grundmann U., Abel K.-J., Bohn H., Loebermann H., Lottspeich F., Kuepper H.
    Proc. Natl. Acad. Sci. U.S.A. 85:3708-3712(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  7. "The gene encoding human annexin V has a TATA-less promoter with a high G+C content."
    Fernandez M.-P., Morgan R.O., Fernandez M.R., Carcedo M.-T.
    Gene 149:253-260(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Lung.
  8. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  10. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., LaBaer J.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  11. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  12. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  13. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle, Ovary and Skin.
  14. "A 32 kDa lipocortin from human mononuclear cells appears to be identical with the placental inhibitor of blood coagulation."
    Rothhut R., Comera C., Cortial S., Haumont P.-Y., Diep Le K.H., Cavadore J.-C., Conard J., Russo-Marie F., Lederer F.
    Biochem. J. 263:929-935(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE.
  15. Quadroni M., Potts A., Barblan J., Bienvenut W.V.
    Submitted (JAN-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 7-18; 30-45; 187-201 AND 277-286, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Melanoma.
  16. "Endonexin II, present on human liver plasma membranes, is a specific binding protein of small hepatitis B virus (HBV) envelope protein."
    Hertogs K., Leenders W.P., Depla E., De Bruin W.C., Meheus L., Raymackers J., Moshage H., Yap S.H.
    Virology 197:549-557(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 21-31; 93-108; 176-188 AND 304-319, INTERACTION WITH HBV.
  17. "Structural and functional characterization of endonexin II, a calcium- and phospholipid-binding protein."
    Schlaepfer D.D., Mehlman T., Burgess W.H., Haigler H.T.
    Proc. Natl. Acad. Sci. U.S.A. 84:6078-6082(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 86-131; 259-297 AND 300-320.
  18. "Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2 inhibitors from human placenta. Evidence against a mechanistically relevant association between enzyme and inhibitor."
    Ahn N.G., Teller D.C., Bienkowski M.J., McMullen B.A., Lipkin E.W., de Haen C.
    J. Biol. Chem. 263:18657-18663(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 85-93.
    Tissue: Placenta.
  19. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 152-161 AND 246-260.
    Tissue: Adipocyte.
  20. "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."
    Kim S.C., Sprung R., Chen Y., Xu Y., Ball H., Pei J., Cheng T., Kho Y., Xiao H., Xiao L., Grishin N.V., White M., Yang X.-J., Zhao Y.
    Mol. Cell 23:607-618(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  21. "A common haplotype of the annexin A5 (ANXA5) gene promoter is associated with recurrent pregnancy loss."
    Bogdanova N., Horst J., Chlystun M., Croucher P.J., Nebel A., Bohring A., Todorova A., Schreiber S., Gerke V., Krawczak M., Markoff A.
    Hum. Mol. Genet. 16:573-578(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN RPRGL3.
  22. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  23. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-70; LYS-76; LYS-79 AND LYS-97, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  24. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  25. "The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes."
    Huber R., Roemisch J., Paques E.-P.
    EMBO J. 9:3867-3874(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
  26. "The calcium binding sites in human annexin V by crystal structure analysis at 2.0-A resolution. Implications for membrane binding and calcium channel activity."
    Huber R., Schneider M., Mayr I., Roemisch J., Paques E.-P.
    FEBS Lett. 275:15-21(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  27. "Crystal and molecular structure of human annexin V after refinement. Implications for structure, membrane binding and ion channel formation of the annexin family of proteins."
    Huber R., Berendes R., Burger A., Schneider M., Karshikov A., Luecke H., Roemisch J., Paques E.-P.
    J. Mol. Biol. 223:683-704(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS).
  28. "Crystal structure of annexin V with its ligand K-201 as a calcium channel activity inhibitor."
    Kaneko N., Ago H., Matsuda R., Inagaki E., Miyano M.
    J. Mol. Biol. 274:16-20(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
  29. "Residue-specific bioincorporation of non-natural, biologically active amino acids into proteins as possible drug carriers: structure and stability of the per-thiaproline mutant of annexin V."
    Budisa N., Minks C., Medrano F.J., Lutz J., Huber R., Moroder L.
    Proc. Natl. Acad. Sci. U.S.A. 95:455-459(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiANXA5_HUMAN
AccessioniPrimary (citable) accession number: P08758
Secondary accession number(s): D3DNW7
, Q6FHB3, Q6FI16, Q8WV69, Q9UDH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 173 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3