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Protein

Annexin A5

Gene

ANXA5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • calcium-transporting ATPase activity Source: Ensembl
  • peptide hormone binding Source: Ensembl
  • phospholipase inhibitor activity Source: ProtInc
  • phospholipid binding Source: ProtInc

GO - Biological processi

  • blood coagulation Source: UniProtKB-KW
  • cellular response to gonadotropin-releasing hormone Source: Ensembl
  • cellular response to lead ion Source: Ensembl
  • mitophagy in response to mitochondrial depolarization Source: ParkinsonsUK-UCL
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of blood coagulation Source: Ensembl
  • negative regulation of prolactin secretion Source: Ensembl
  • positive regulation of apoptotic process Source: Ensembl
  • positive regulation of defense response to virus by host Source: ParkinsonsUK-UCL
  • protein homooligomerization Source: Ensembl
  • regulation of sperm motility Source: Ensembl
  • response to calcium ion Source: Ensembl
  • response to thyroid hormone Source: Ensembl
  • signal transduction Source: UniProtKB
  • xenophagy Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Biological processi

Blood coagulation, Hemostasis

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

SignaLinkiP08758.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:ANXA5
Synonyms:ANX5, ENX2, PP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:543. ANXA5.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: Ensembl
  • cytoplasm Source: UniProtKB
  • cytosol Source: Ensembl
  • dendrite Source: Ensembl
  • endoplasmic reticulum Source: Ensembl
  • endothelial microparticle Source: Ensembl
  • external side of plasma membrane Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
  • intercalated disc Source: Ensembl
  • intracellular Source: LIFEdb
  • membrane Source: UniProtKB
  • nucleus Source: Ensembl
  • perikaryon Source: Ensembl
  • sarcolemma Source: Ensembl
  • synaptic vesicle Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Pregnancy loss, recurrent, 3 (RPRGL3)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions.
See also OMIM:614391

Organism-specific databases

MalaCardsiANXA5.
MIMi614391. phenotype.
PharmGKBiPA24833.

Polymorphism and mutation databases

BioMutaiANXA5.
DMDMi113960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources1 Publication
Chaini2 – 320319Annexin A5PRO_0000067487Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Cross-linki29 – 29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Cross-linki29 – 29Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei70 – 701N6-acetyllysineCombined sources
Modified residuei76 – 761N6-acetyllysineCombined sources
Modified residuei79 – 791N6-acetyllysineCombined sources
Modified residuei97 – 971N6-acetyllysineCombined sources
Modified residuei101 – 1011N6-acetyllysineCombined sources
Modified residuei290 – 2901N6-succinyllysineBy similarity

Post-translational modificationi

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.1 Publication

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDiP08758.
PaxDbiP08758.
PeptideAtlasiP08758.
PRIDEiP08758.
TopDownProteomicsiP08758.

2D gel databases

OGPiP08758.
REPRODUCTION-2DPAGEIPI00329801.
P08758.

PTM databases

iPTMnetiP08758.
PhosphoSiteiP08758.
SwissPalmiP08758.

Expressioni

Gene expression databases

BgeeiENSG00000164111.
CleanExiHS_ANXA5.
ExpressionAtlasiP08758. baseline and differential.
GenevisibleiP08758. HS.

Organism-specific databases

HPAiCAB003677.
HPA035330.

Interactioni

Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity). Interacts with hepatitis B virus (HBV).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TINF2Q9BSI42EBI-296601,EBI-717399

Protein-protein interaction databases

BioGridi106805. 41 interactions.
IntActiP08758. 21 interactions.
MINTiMINT-1382250.
STRINGi9606.ENSP00000296511.

Structurei

Secondary structure

1
320
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi17 – 2812Combined sources
Beta strandi29 – 324Combined sources
Helixi35 – 439Combined sources
Helixi47 – 6115Combined sources
Helixi65 – 728Combined sources
Helixi75 – 8511Combined sources
Helixi88 – 10013Combined sources
Beta strandi102 – 1043Combined sources
Helixi107 – 11610Combined sources
Helixi119 – 13315Combined sources
Helixi137 – 1448Combined sources
Helixi147 – 15711Combined sources
Helixi169 – 18214Combined sources
Turni183 – 1853Combined sources
Beta strandi186 – 1883Combined sources
Helixi191 – 20010Combined sources
Helixi203 – 21715Combined sources
Helixi221 – 2288Combined sources
Helixi231 – 24515Combined sources
Helixi247 – 25610Combined sources
Helixi257 – 2593Combined sources
Beta strandi260 – 2634Combined sources
Helixi266 – 27611Combined sources
Turni277 – 2804Combined sources
Helixi281 – 29010Combined sources
Beta strandi292 – 2943Combined sources
Helixi296 – 3038Combined sources
Helixi306 – 31611Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]
ProteinModelPortaliP08758.
SMRiP08758. Positions 3-318.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08758.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 8461Annexin 1Add
BLAST
Repeati96 – 15661Annexin 2Add
BLAST
Repeati180 – 24061Annexin 3Add
BLAST
Repeati255 – 31561Annexin 4Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi314 – 3196[IL]-x-C-x-x-[DE] motif1 Publication

Domaini

The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.1 Publication
A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08758.
KOiK16646.
OMAiIRHEFRK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP08758.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08758-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQVLRGTVT DFPGFDERAD AETLRKAMKG LGTDEESILT LLTSRSNAQR
60 70 80 90 100
QEISAAFKTL FGRDLLDDLK SELTGKFEKL IVALMKPSRL YDAYELKHAL
110 120 130 140 150
KGAGTNEKVL TEIIASRTPE ELRAIKQVYE EEYGSSLEDD VVGDTSGYYQ
160 170 180 190 200
RMLVVLLQAN RDPDAGIDEA QVEQDAQALF QAGELKWGTD EEKFITIFGT
210 220 230 240 250
RSVSHLRKVF DKYMTISGFQ IEETIDRETS GNLEQLLLAV VKSIRSIPAY
260 270 280 290 300
LAETLYYAMK GAGTDDHTLI RVMVSRSEID LFNIRKEFRK NFATSLYSMI
310 320
KGDTSGDYKK ALLLLCGEDD
Length:320
Mass (Da):35,937
Last modified:January 23, 2007 - v2
Checksum:i45E14E3964BA4D1A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti135 – 1351S → L in CAG38759 (Ref. 10) Curated
Sequence conflicti279 – 2791I → T in AAH18671 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18366 mRNA. Translation: AAA35570.1.
D00172 mRNA. Translation: BAA00122.1.
X12454 mRNA. Translation: CAA30985.1.
J03745 mRNA. Translation: AAA52386.1.
M21731 mRNA. Translation: AAA36166.1.
M19384 mRNA. Translation: AAB59545.1.
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA. Translation: AAB40047.1.
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA. Translation: AAB60648.1.
AK312644 mRNA. Translation: BAG35528.1.
CR536522 mRNA. Translation: CAG38759.1.
CR541842 mRNA. Translation: CAG46640.1.
AC096730 Genomic DNA. Translation: AAY40954.1.
CH471056 Genomic DNA. Translation: EAX05257.1.
CH471056 Genomic DNA. Translation: EAX05258.1.
BC001429 mRNA. Translation: AAH01429.1.
BC004993 mRNA. Translation: AAH04993.1.
BC012804 mRNA. Translation: AAH12804.1.
BC012822 mRNA. Translation: AAH12822.1.
BC018671 mRNA. Translation: AAH18671.1.
CCDSiCCDS3720.1.
PIRiD29250. AQHUP.
RefSeqiNP_001145.1. NM_001154.3.
UniGeneiHs.480653.

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111.
GeneIDi308.
KEGGihsa:308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M18366 mRNA. Translation: AAA35570.1.
D00172 mRNA. Translation: BAA00122.1.
X12454 mRNA. Translation: CAA30985.1.
J03745 mRNA. Translation: AAA52386.1.
M21731 mRNA. Translation: AAA36166.1.
M19384 mRNA. Translation: AAB59545.1.
U01691
, U01681, U01682, U01683, U01685, U01686, U01687, U01689, U01690 Genomic DNA. Translation: AAB40047.1.
U05770
, U05760, U05761, U05762, U05764, U05765, U05766, U05767, U05768, U05769 Genomic DNA. Translation: AAB60648.1.
AK312644 mRNA. Translation: BAG35528.1.
CR536522 mRNA. Translation: CAG38759.1.
CR541842 mRNA. Translation: CAG46640.1.
AC096730 Genomic DNA. Translation: AAY40954.1.
CH471056 Genomic DNA. Translation: EAX05257.1.
CH471056 Genomic DNA. Translation: EAX05258.1.
BC001429 mRNA. Translation: AAH01429.1.
BC004993 mRNA. Translation: AAH04993.1.
BC012804 mRNA. Translation: AAH12804.1.
BC012822 mRNA. Translation: AAH12822.1.
BC018671 mRNA. Translation: AAH18671.1.
CCDSiCCDS3720.1.
PIRiD29250. AQHUP.
RefSeqiNP_001145.1. NM_001154.3.
UniGeneiHs.480653.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ANWX-ray2.40A/B2-320[»]
1ANXX-ray1.90A/B/C2-320[»]
1AVHX-ray2.30A/B1-320[»]
1AVRX-ray2.30A1-320[»]
1HAKX-ray3.00A/B1-320[»]
1HVDX-ray2.00A2-320[»]
1HVEX-ray2.30A2-320[»]
1HVFX-ray2.00A2-320[»]
1HVGX-ray3.00A2-320[»]
1SAVX-ray2.50A1-320[»]
2XO2X-ray2.80A1-320[»]
2XO3X-ray2.30A1-320[»]
ProteinModelPortaliP08758.
SMRiP08758. Positions 3-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106805. 41 interactions.
IntActiP08758. 21 interactions.
MINTiMINT-1382250.
STRINGi9606.ENSP00000296511.

PTM databases

iPTMnetiP08758.
PhosphoSiteiP08758.
SwissPalmiP08758.

Polymorphism and mutation databases

BioMutaiANXA5.
DMDMi113960.

2D gel databases

OGPiP08758.
REPRODUCTION-2DPAGEIPI00329801.
P08758.

Proteomic databases

EPDiP08758.
PaxDbiP08758.
PeptideAtlasiP08758.
PRIDEiP08758.
TopDownProteomicsiP08758.

Protocols and materials databases

DNASUi308.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296511; ENSP00000296511; ENSG00000164111.
GeneIDi308.
KEGGihsa:308.

Organism-specific databases

CTDi308.
GeneCardsiANXA5.
HGNCiHGNC:543. ANXA5.
HPAiCAB003677.
HPA035330.
MalaCardsiANXA5.
MIMi131230. gene.
614391. phenotype.
neXtProtiNX_P08758.
PharmGKBiPA24833.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP08758.
KOiK16646.
OMAiIRHEFRK.
OrthoDBiEOG091G0H6H.
PhylomeDBiP08758.
TreeFamiTF105452.

Enzyme and pathway databases

SignaLinkiP08758.

Miscellaneous databases

ChiTaRSiANXA5. human.
EvolutionaryTraceiP08758.
GeneWikiiAnnexin_A5.
GenomeRNAii308.
PROiP08758.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164111.
CleanExiHS_ANXA5.
ExpressionAtlasiP08758. baseline and differential.
GenevisibleiP08758. HS.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR015473. Annexins_V.
IPR002392. AnnexinV.
[Graphical view]
PANTHERiPTHR10502:SF26. PTHR10502:SF26. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00201. ANNEXINV.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA5_HUMAN
AccessioniPrimary (citable) accession number: P08758
Secondary accession number(s): D3DNW7
, Q6FHB3, Q6FI16, Q8WV69, Q9UDH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1988
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 192 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.