P08757 (FAS_CAPHI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fatty acid synthase
EC=2.3.1.85

Gene names

Name:	FASN
Synonyms:	FAS

Organism

Capra hircus (Goat)

Taxonomic identifier

9925 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Capra

Protein attributes

Sequence length	35 AA.
Sequence status	Fragment.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. This fragment is from the acyltransferase domain of the fatty acid synthetase.
Catalytic activity	Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO2 + 2n NADP+.
Subunit structure	Homodimer which is arranged in a head to tail fashion.
Subcellular location	Cytoplasm By similarity. Melanosome By similarity.

Ontologies

Keywords
Biological process	Fatty acid biosynthesis Fatty acid metabolism Lipid biosynthesis Lipid metabolism
Cellular component	Cytoplasm
Ligand	NAD NADP
Molecular function	Hydrolase Transferase
Technical term	Multifunctional enzyme
Gene Ontology (GO)
Biological_process	fatty acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	fatty acid synthase activity Inferred from electronic annotation. Source: EC hydrolase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	‹1 – ›35	›35	Fatty acid synthase		PRO_0000180275
Sites
	Active site	12	1
Experimental info
	Non-terminal residue	1	1
	Non-terminal residue	35	1

Sequences

	Sequence		Length	Mass (Da)
	P08757 [UniParc]. Last modified October 1, 1993. Version 2. Checksum: 401BEF8B4ABE562D	FASTA	35	3,808
	10 20 30 MGLRPDGIIG HSLGEVARAY YNGRISQEEA ILSAY

References

[1]	"Amino acid sequence around the active-site serine residue in the acyltransferase domain of goat mammary fatty acid synthetase." Mikkelsen J., Hoejrup P., Rasmussen M.M., Roepstorff P., Knudsen J. Biochem. J. 227:21-27(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
PIR	S07131.
3D structure databases
ProteinModelPortal	P08757.
SMR	P08757. Positions 1-35.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	3.40.366.10. 1 hit.
InterPro	IPR001227. Ac_transferase_dom. IPR014043. Acyl_transferase. [Graphical view]
Pfam	PF00698. Acyl_transf_1. 1 hit. [Graphical view]
PROSITE	PS00606. B_KETOACYL_SYNTHASE. Partial match. PS00012. PHOSPHOPANTETHEINE. Partial match. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FAS_CAPHI

Accession

Primary (citable) accession number: P08757

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1988
Last sequence update:	October 1, 1993
Last modified:	April 3, 2013
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program