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P08754

- GNAI3_HUMAN

UniProt

P08754 - GNAI3_HUMAN

Protein

Guanine nucleotide-binding protein G(k) subunit alpha

Gene

GNAI3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 170 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G(k) is the stimulatory G protein of receptor-regulated K+ channels. The active GTP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi47 – 471MagnesiumBy similarity
    Metal bindingi181 – 1811MagnesiumBy similarity
    Binding sitei326 – 3261GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi40 – 478GTPBy similarity
    Nucleotide bindingi175 – 1817GTPBy similarity
    Nucleotide bindingi200 – 2045GTPBy similarity
    Nucleotide bindingi269 – 2724GTPBy similarity

    GO - Molecular functioni

    1. G-protein beta/gamma-subunit complex binding Source: RefGenome
    2. G-protein coupled serotonin receptor binding Source: RefGenome
    3. GTPase activity Source: RefGenome
    4. GTP binding Source: UniProtKB-KW
    5. metal ion binding Source: UniProtKB-KW
    6. signal transducer activity Source: RefGenome

    GO - Biological processi

    1. adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway Source: Reactome
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
    3. blood coagulation Source: Reactome
    4. cell cycle Source: UniProtKB-KW
    5. cell division Source: UniProtKB
    6. negative regulation of adenylate cyclase activity Source: ProtInc
    7. platelet activation Source: Reactome
    8. synaptic transmission Source: Reactome
    9. transport Source: ProtInc
    10. vesicle fusion Source: Ensembl

    Keywords - Molecular functioni

    Transducer

    Keywords - Biological processi

    Cell cycle, Cell division

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15426. PLC beta mediated events.
    REACT_15457. G-protein activation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    SignaLinkiP08754.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein G(k) subunit alpha
    Alternative name(s):
    G(i) alpha-3
    Gene namesi
    Name:GNAI3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:4387. GNAI3.

    Subcellular locationi

    Cytoplasm 1 Publication. Cell membrane 1 Publication. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome 1 Publication
    Note: Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody.

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. Golgi apparatus Source: Ensembl
    5. heterotrimeric G-protein complex Source: RefGenome
    6. lysosomal membrane Source: UniProtKB
    7. membrane Source: UniProtKB
    8. membrane raft Source: Ensembl
    9. midbody Source: UniProtKB
    10. plasma membrane Source: UniProtKB
    11. zymogen granule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Cytoskeleton, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Auriculocondylar syndrome 1 (ARCND1) [MIM:602483]: An autosomal dominant craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401G → R in ARCND1. 1 Publication
    VAR_068558

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi602483. phenotype.
    Orphaneti137888. Auriculocondylar syndrome.
    PharmGKBiPA173.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 354353Guanine nucleotide-binding protein G(k) subunit alphaPRO_0000203692Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi2 – 21N-myristoyl glycineBy similarity
    Lipidationi3 – 31S-palmitoyl cysteineBy similarity
    Modified residuei178 – 1781ADP-ribosylarginine; by cholera toxinBy similarity
    Modified residuei351 – 3511ADP-ribosylcysteine; by pertussis toxinBy similarity

    Keywords - PTMi

    ADP-ribosylation, Lipoprotein, Myristate, Palmitate

    Proteomic databases

    MaxQBiP08754.
    PaxDbiP08754.
    PeptideAtlasiP08754.
    PRIDEiP08754.

    PTM databases

    PhosphoSiteiP08754.

    Expressioni

    Gene expression databases

    ArrayExpressiP08754.
    BgeeiP08754.
    CleanExiHS_GNAI3.
    GenevestigatoriP08754.

    Organism-specific databases

    HPAiCAB022099.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts (via active GTP- or inactive GDP-bound form) with RGS14 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109035. 59 interactions.
    IntActiP08754. 21 interactions.
    MINTiMINT-1146232.
    STRINGi9606.ENSP00000358867.

    Structurei

    Secondary structure

    1
    354
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi34 – 396
    Helixi46 – 5712
    Helixi63 – 686
    Helixi70 – 9122
    Helixi100 – 11011
    Turni111 – 1166
    Helixi121 – 13111
    Helixi134 – 1418
    Helixi142 – 1454
    Helixi152 – 1576
    Helixi159 – 1624
    Helixi171 – 1755
    Beta strandi183 – 1919
    Beta strandi194 – 2018
    Helixi205 – 21410
    Beta strandi219 – 2268
    Helixi227 – 2315
    Beta strandi237 – 2415
    Helixi242 – 25413
    Helixi257 – 2593
    Beta strandi262 – 2698
    Helixi271 – 2788
    Helixi283 – 2853
    Helixi296 – 30813
    Turni314 – 3163
    Beta strandi319 – 3235
    Helixi329 – 34618

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2IHBX-ray2.71A32-354[»]
    2ODEX-ray1.90A/C4-350[»]
    2V4ZX-ray2.80A4-350[»]
    4G5OX-ray2.90A/B/C/D25-354[»]
    4G5RX-ray3.48A/B/C/D25-354[»]
    4G5SX-ray3.62A/B/C/D25-354[»]
    ProteinModelPortaliP08754.
    SMRiP08754. Positions 5-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08754.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(i/o/t/z) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG322962.
    HOGENOMiHOG000038730.
    HOVERGENiHBG063184.
    InParanoidiP08754.
    KOiK04630.
    OMAiGEAARAX.
    OrthoDBiEOG72C50B.
    PhylomeDBiP08754.
    TreeFamiTF300673.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR001408. Gprotein_alpha_I.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00441. GPROTEINAI.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08754-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGCTLSAEDK AAVERSKMID RNLREDGEKA AKEVKLLLLG AGESGKSTIV    50
    KQMKIIHEDG YSEDECKQYK VVVYSNTIQS IIAIIRAMGR LKIDFGEAAR 100
    ADDARQLFVL AGSAEEGVMT PELAGVIKRL WRDGGVQACF SRSREYQLND 150
    SASYYLNDLD RISQSNYIPT QQDVLRTRVK TTGIVETHFT FKDLYFKMFD 200
    VGGQRSERKK WIHCFEGVTA IIFCVALSDY DLVLAEDEEM NRMHESMKLF 250
    DSICNNKWFT ETSIILFLNK KDLFEEKIKR SPLTICYPEY TGSNTYEEAA 300
    AYIQCQFEDL NRRKDTKEIY THFTCATDTK NVQFVFDAVT DVIIKNNLKE 350
    CGLY 354
    Length:354
    Mass (Da):40,532
    Last modified:January 23, 2007 - v3
    Checksum:iEAB6B4DD3646BC01
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211R → C no nucleotide entry (PubMed:2440724)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti40 – 401G → R in ARCND1. 1 Publication
    VAR_068558

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27543 mRNA. Translation: AAA52579.1.
    J03005 mRNA. Translation: AAA52557.1.
    M20604
    , M20597, M20598, M20599, M20600, M20601, M20602, M20603 Genomic DNA. Translation: AAA35895.1.
    J03198 mRNA. Translation: AAA35896.1.
    J03238 mRNA. Translation: AAA35939.1.
    AF493907 mRNA. Translation: AAM12621.1.
    BT019973 mRNA. Translation: AAV38776.1.
    BT019974 mRNA. Translation: AAV38777.1.
    AK312252 mRNA. Translation: BAG35184.1.
    CH471122 Genomic DNA. Translation: EAW56393.1.
    BC025285 mRNA. Translation: AAH25285.1.
    CCDSiCCDS802.1.
    PIRiS02348. RGHUI3.
    RefSeqiNP_006487.1. NM_006496.3.
    UniGeneiHs.73799.
    Hs.741171.

    Genome annotation databases

    EnsembliENST00000369851; ENSP00000358867; ENSG00000065135.
    GeneIDi2773.
    KEGGihsa:2773.
    UCSCiuc001dxz.3. human.

    Polymorphism databases

    DMDMi120996.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M27543 mRNA. Translation: AAA52579.1 .
    J03005 mRNA. Translation: AAA52557.1 .
    M20604
    , M20597 , M20598 , M20599 , M20600 , M20601 , M20602 , M20603 Genomic DNA. Translation: AAA35895.1 .
    J03198 mRNA. Translation: AAA35896.1 .
    J03238 mRNA. Translation: AAA35939.1 .
    AF493907 mRNA. Translation: AAM12621.1 .
    BT019973 mRNA. Translation: AAV38776.1 .
    BT019974 mRNA. Translation: AAV38777.1 .
    AK312252 mRNA. Translation: BAG35184.1 .
    CH471122 Genomic DNA. Translation: EAW56393.1 .
    BC025285 mRNA. Translation: AAH25285.1 .
    CCDSi CCDS802.1.
    PIRi S02348. RGHUI3.
    RefSeqi NP_006487.1. NM_006496.3.
    UniGenei Hs.73799.
    Hs.741171.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2IHB X-ray 2.71 A 32-354 [» ]
    2ODE X-ray 1.90 A/C 4-350 [» ]
    2V4Z X-ray 2.80 A 4-350 [» ]
    4G5O X-ray 2.90 A/B/C/D 25-354 [» ]
    4G5R X-ray 3.48 A/B/C/D 25-354 [» ]
    4G5S X-ray 3.62 A/B/C/D 25-354 [» ]
    ProteinModelPortali P08754.
    SMRi P08754. Positions 5-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109035. 59 interactions.
    IntActi P08754. 21 interactions.
    MINTi MINT-1146232.
    STRINGi 9606.ENSP00000358867.

    Chemistry

    BindingDBi P08754.
    ChEMBLi CHEMBL4221.

    PTM databases

    PhosphoSitei P08754.

    Polymorphism databases

    DMDMi 120996.

    Proteomic databases

    MaxQBi P08754.
    PaxDbi P08754.
    PeptideAtlasi P08754.
    PRIDEi P08754.

    Protocols and materials databases

    DNASUi 2773.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369851 ; ENSP00000358867 ; ENSG00000065135 .
    GeneIDi 2773.
    KEGGi hsa:2773.
    UCSCi uc001dxz.3. human.

    Organism-specific databases

    CTDi 2773.
    GeneCardsi GC01P110091.
    HGNCi HGNC:4387. GNAI3.
    HPAi CAB022099.
    MIMi 139370. gene.
    602483. phenotype.
    neXtProti NX_P08754.
    Orphaneti 137888. Auriculocondylar syndrome.
    PharmGKBi PA173.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG322962.
    HOGENOMi HOG000038730.
    HOVERGENi HBG063184.
    InParanoidi P08754.
    KOi K04630.
    OMAi GEAARAX.
    OrthoDBi EOG72C50B.
    PhylomeDBi P08754.
    TreeFami TF300673.

    Enzyme and pathway databases

    Reactomei REACT_15333. Adenylate cyclase inhibitory pathway.
    REACT_15426. PLC beta mediated events.
    REACT_15457. G-protein activation.
    REACT_19231. G alpha (i) signalling events.
    REACT_19327. G alpha (s) signalling events.
    REACT_19333. G alpha (z) signalling events.
    REACT_20653. ADP signalling through P2Y purinoceptor 12.
    SignaLinki P08754.

    Miscellaneous databases

    ChiTaRSi GNAI3. human.
    EvolutionaryTracei P08754.
    GeneWikii GNAI3.
    GenomeRNAii 2773.
    NextBioi 10906.
    PROi P08754.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08754.
    Bgeei P08754.
    CleanExi HS_GNAI3.
    Genevestigatori P08754.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR001408. Gprotein_alpha_I.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00441. GPROTEINAI.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families."
      Didsbury J.R., Snyderman R.
      FEBS Lett. 219:259-263(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "A small multigene family encodes Gi signal-transduction proteins."
      Beals C.R., Wilson C.B., Perlmutter R.M.
      Proc. Natl. Acad. Sci. U.S.A. 84:7886-7890(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs."
      Itoh H., Toyama R., Kozasa T., Tsukamoto T., Matsuoka M., Kaziro Y.
      J. Biol. Chem. 263:6656-6664(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels."
      Codina J., Olate J., Abramowitz J., Mattera R., Cook R.G., Birnbaumer L.
      J. Biol. Chem. 263:6746-6750(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    5. "Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines."
      Kim S., Ang S.L., Bloch D.B., Bloch K.D., Kawahara Y., Tolman C., Lee R., Seidman J.G., Neer E.J.
      Proc. Natl. Acad. Sci. U.S.A. 85:4153-4157(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Puhl H.L. III, Ikeda S.R., Aronstam R.S.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    9. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    10. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    11. "The human genome encodes at least three non-allelic G proteins with alpha i-type subunits."
      Suki W.N., Abramowitz J., Mattera R., Codina J., Birnbaumer L.
      FEBS Lett. 220:187-192(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-354.
    12. "Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division."
      Cho H., Kehrl J.H.
      J. Cell Biol. 178:245-255(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: VARIANT ARCND1 ARG-40.

    Entry informationi

    Entry nameiGNAI3_HUMAN
    AccessioniPrimary (citable) accession number: P08754
    Secondary accession number(s): P17539, Q5TZX1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1988
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 170 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3