P08749 (COX2_PARTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COII

Encoded on

Mitochondrion

Organism

Paramecium tetraurelia

Taxonomic identifier

5888 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	205 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.
Sequence caution	The sequence AAA32008.2 differs from that shown. Reason: Erroneous initiation. The sequence CAA34055.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 205	205	Cytochrome c oxidase subunit 2		PRO_0000183653
Sites
	Metal binding	115	1	Copper A Probable
	Metal binding	150	1	Copper A Probable
	Metal binding	154	1	Copper A Probable
	Metal binding	158	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P08749 [UniParc]. Last modified April 1, 1990. Version 2. Checksum: B1552A15A2117115	FASTA	205	24,312
	10 20 30 40 50 60 MEKKMNTDLF YLTLKQKRYK RKKNIPLRIR LDKNDLSANT ASIKFTDKPY LVANKIIKSL 70 80 90 100 110 120 EFNATSLYRC IKKNKLRSEN FSVQLSRRLL RTKKTLVLPS HVNITLISNS YDVIHSWFIP 130 140 150 160 170 180 ALGIKIDCVP GRATHHTFYC DSVGFYYGQC AEICGRYHHH MPIKLCILPF EHFLIWWQHF 190 200 GLPKLLFTES KNRFETDYGL KKFCW

References

[1]	"Nucleotide sequence of the mitochondrial genome of Paramecium." Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E., Cummings D.J. Nucleic Acids Res. 18:173-180(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Stock 51.
[2]	"Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products." Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J. Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X15917 Genomic DNA. Translation: CAA34055.1. Different initiation. M15220 Genomic DNA. Translation: AAA32008.2. Different initiation.
PIR	S07746.
3D structure databases
ProteinModelPortal	P08749.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.420. 1 hit.
InterPro	IPR001505. Copper_CuA. IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit.
PROSITE	PS00078. COX2. 1 hit. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_PARTE

Accession

Primary (citable) accession number: P08749

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	April 1, 1990
Last modified:	April 3, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)