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P08749 (COX2_PARTE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismParamecium tetraurelia
Taxonomic identifier5888 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length205 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence caution

The sequence AAA32008.2 differs from that shown. Reason: Erroneous initiation.

The sequence CAA34055.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 205205Cytochrome c oxidase subunit 2
PRO_0000183653

Sites

Metal binding1151Copper A Probable
Metal binding1501Copper A Probable
Metal binding1541Copper A Probable
Metal binding1581Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P08749 [UniParc].

Last modified April 1, 1990. Version 2.
Checksum: B1552A15A2117115

FASTA20524,312
        10         20         30         40         50         60 
MEKKMNTDLF YLTLKQKRYK RKKNIPLRIR LDKNDLSANT ASIKFTDKPY LVANKIIKSL 

        70         80         90        100        110        120 
EFNATSLYRC IKKNKLRSEN FSVQLSRRLL RTKKTLVLPS HVNITLISNS YDVIHSWFIP 

       130        140        150        160        170        180 
ALGIKIDCVP GRATHHTFYC DSVGFYYGQC AEICGRYHHH MPIKLCILPF EHFLIWWQHF 

       190        200 
GLPKLLFTES KNRFETDYGL KKFCW 

« Hide

References

[1]"Nucleotide sequence of the mitochondrial genome of Paramecium."
Pritchard A.E., Seilhamer J.J., Mahalingam R., Sable C.L., Venuti S.E., Cummings D.J.
Nucleic Acids Res. 18:173-180(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Stock 51.
[2]"Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products."
Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J.
Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15917 Genomic DNA. Translation: CAA34055.1. Different initiation.
M15220 Genomic DNA. Translation: AAA32008.2. Different initiation.
PIRS07746.

3D structure databases

ProteinModelPortalP08749.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PARTE
AccessionPrimary (citable) accession number: P08749
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families