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P08749

- COX2_PARTE

UniProt

P08749 - COX2_PARTE

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Paramecium tetraurelia
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Cu cationNote: Binds a copper A center.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi115 – 1151Copper ACurated
Metal bindingi150 – 1501Copper ACurated
Metal bindingi154 – 1541Copper ACurated
Metal bindingi158 – 1581Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiParamecium tetraurelia
Taxonomic identifieri5888 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 205205Cytochrome c oxidase subunit 2PRO_0000183653Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP08749.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08749-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKKMNTDLF YLTLKQKRYK RKKNIPLRIR LDKNDLSANT ASIKFTDKPY
60 70 80 90 100
LVANKIIKSL EFNATSLYRC IKKNKLRSEN FSVQLSRRLL RTKKTLVLPS
110 120 130 140 150
HVNITLISNS YDVIHSWFIP ALGIKIDCVP GRATHHTFYC DSVGFYYGQC
160 170 180 190 200
AEICGRYHHH MPIKLCILPF EHFLIWWQHF GLPKLLFTES KNRFETDYGL

KKFCW
Length:205
Mass (Da):24,312
Last modified:April 1, 1990 - v2
Checksum:iB1552A15A2117115
GO

Sequence cautioni

The sequence AAA32008.2 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAA34055.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15917 Genomic DNA. Translation: CAA34055.1. Different initiation.
M15220 Genomic DNA. Translation: AAA32008.2. Different initiation.
PIRiS07746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15917 Genomic DNA. Translation: CAA34055.1 . Different initiation.
M15220 Genomic DNA. Translation: AAA32008.2 . Different initiation.
PIRi S07746.

3D structure databases

ProteinModelPortali P08749.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR001505. Copper_CuA.
IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS00078. COX2. 1 hit.
PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Stock 51.
  2. "Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products."
    Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J.
    Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_PARTE
AccessioniPrimary (citable) accession number: P08749
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3