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P08748

- COX2_PARPR

UniProt

P08748 - COX2_PARPR

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Protein

Cytochrome c oxidase subunit 2

Gene

COII

Organism
Paramecium primaurelia
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactori

Copper A.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi126 – 1261Copper ACurated
Metal bindingi130 – 1301Copper ACurated
Metal bindingi134 – 1341Copper ACurated

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. cytochrome-c oxidase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 2 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene namesi
Name:COII
Encoded oniMitochondrion
OrganismiParamecium primaurelia
Taxonomic identifieri5886 [NCBI]
Taxonomic lineageiEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB-KW
  2. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Cytochrome c oxidase subunit 2PRO_0000183652Add
BLAST

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.60.40.420. 1 hit.
InterProiIPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamiPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 1 hit.
PROSITEiPS50857. COX2_CUA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08748-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLRVKLDKN DLSKNTASVK FTDKPYLVAN KIIKSLEFNA TSLYRCIKKN
60 70 80 90 100
KLRSENFSVQ LSRRLLRTKK TLVLPSHVNI TLISNSYDVI LSWFIPALGI
110 120 130 140 150
KIDCVXGRAT HHTFYCDSVG FYYGQCAEIC GRYHHHMPIK LCILPFEHFL
160 170 180
IWWQHFGLPK LLFTESKNRF ETDYGLKKFC W
Length:181
Mass (Da):21,233
Last modified:August 1, 1988 - v1
Checksum:i910481DF1A455A76
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15219 Genomic DNA. Translation: AAA32007.2. Sequence problems.
PIRiB26530.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M15219 Genomic DNA. Translation: AAA32007.2 . Sequence problems.
PIRi B26530.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.60.40.420. 1 hit.
InterProi IPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view ]
Pfami PF00116. COX2. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 1 hit.
PROSITEi PS50857. COX2_CUA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products."
    Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J.
    Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiCOX2_PARPR
AccessioniPrimary (citable) accession number: P08748
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3