Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08748 (COX2_PARPR) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COII
Encoded onMitochondrion
OrganismParamecium primaurelia
Taxonomic identifier5886 [NCBI]
Taxonomic lineageEukaryotaAlveolataCiliophoraIntramacronucleataOligohymenophoreaPeniculidaParameciidaeParamecium

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Cytochrome c oxidase subunit 2
PRO_0000183652

Sites

Metal binding1261Copper A Probable
Metal binding1301Copper A Probable
Metal binding1341Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P08748 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: 910481DF1A455A76

FASTA18121,233
        10         20         30         40         50         60 
MPLRVKLDKN DLSKNTASVK FTDKPYLVAN KIIKSLEFNA TSLYRCIKKN KLRSENFSVQ 

        70         80         90        100        110        120 
LSRRLLRTKK TLVLPSHVNI TLISNSYDVI LSWFIPALGI KIDCVXGRAT HHTFYCDSVG 

       130        140        150        160        170        180 
FYYGQCAEIC GRYHHHMPIK LCILPFEHFL IWWQHFGLPK LLFTESKNRF ETDYGLKKFC 


W 

« Hide

References

[1]"Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products."
Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J.
Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M15219 Genomic DNA. Translation: AAA32007.2. Sequence problems.
PIRB26530.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.60.40.420. 1 hit.
InterProIPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
[Graphical view]
PfamPF00116. COX2. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PARPR
AccessionPrimary (citable) accession number: P08748
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families