P08748 (COX2_PARPR) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:

COII

Encoded on

Mitochondrion

Organism

Paramecium primaurelia

Taxonomic identifier

5886 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Ciliophora › Intramacronucleata › Oligohymenophorea › Peniculida › Parameciidae › Paramecium

Protein attributes

Sequence length	181 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 181	181	Cytochrome c oxidase subunit 2		PRO_0000183652
Sites
	Metal binding	126	1	Copper A Probable
	Metal binding	130	1	Copper A Probable
	Metal binding	134	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P08748 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 910481DF1A455A76	FASTA	181	21,233
	10 20 30 40 50 60 MPLRVKLDKN DLSKNTASVK FTDKPYLVAN KIIKSLEFNA TSLYRCIKKN KLRSENFSVQ 70 80 90 100 110 120 LSRRLLRTKK TLVLPSHVNI TLISNSYDVI LSWFIPALGI KIDCVXGRAT HHTFYCDSVG 130 140 150 160 170 180 FYYGQCAEIC GRYHHHMPIK LCILPFEHFL IWWQHFGLPK LLFTESKNRF ETDYGLKKFC W

References

[1]	"Identification of Paramecium mitochondrial proteins using antibodies raised against fused mitochondrial gene products." Mahalingam R., Seilhamer J.J., Pritchard A.E., Cummings D.J. Gene 49:129-138(1986) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	M15219 Genomic DNA. Translation: AAA32007.2. Sequence problems.
PIR	B26530.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	2.60.40.420. 1 hit.
InterPro	IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. [Graphical view]
Pfam	PF00116. COX2. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit.
PROSITE	PS00078. COX2. False negative. PS50857. COX2_CUA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_PARPR

Accession

Primary (citable) accession number: P08748

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)