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P08744 (COX2_PEA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 2

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide II
Gene names
Name:COX2
Synonyms:COII
Encoded onMitochondrion
OrganismPisum sativum (Garden pea)
Taxonomic identifier3888 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeFabeaePisum

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Cofactor

Copper A.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cytochrome c oxidase subunit 2 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258Cytochrome c oxidase subunit 2
PRO_0000183654

Regions

Topological domain1 – 3939Mitochondrial intermembrane Potential
Transmembrane40 – 6122Helical; Potential
Topological domain62 – 8524Mitochondrial matrix Potential
Transmembrane86 – 10621Helical; Potential
Topological domain107 – 258152Mitochondrial intermembrane Potential

Sites

Metal binding1861Copper A Probable
Metal binding2211Copper A Probable
Metal binding2251Copper A Probable
Metal binding2291Copper A Probable

Sequences

Sequence LengthMass (Da)Tools
P08744 [UniParc].

Last modified November 1, 1995. Version 2.
Checksum: FD514E00A9524A59

FASTA25829,001
        10         20         30         40         50         60 
MKLEWLFLTI APCDAAEPWQ LGFQDAATPM MQGIIDLHHD IFFFLILILV FVSRILVRAL 

        70         80         90        100        110        120 
WHFHYKKNPI PQRIVHGTTI EILRTIFPSI IPMFIAIPSF ALLYSMDGVL VDPAMTIKAI 

       130        140        150        160        170        180 
GHQWYRTYEY SDYNSSDEQS LTFDSYTIPE DDLELGQSGL LEVDNRVVVP AKTHLRIIVT 

       190        200        210        220        230        240 
PADVPHSWAV PSLGVKCDAV PGRLNQISIS VQREGVYYGQ CSEICGTNHA FPIVVEAVPS 

       250 
KDYGSRVSNQ LIPQTGEA 

« Hide

References

[1]"Pea cytochrome oxidase subunit II gene has no intron and generates two mRNA transcripts with different 5'-termini."
Moon E., Kao T.-H., Wu R.
Nucleic Acids Res. 13:3195-3212(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X02433 Genomic DNA. Translation: CAA26282.1.
PIROBPM2. A23012.

3D structure databases

ProteinModelPortalP08744.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.287.90. 1 hit.
2.60.40.420. 1 hit.
InterProIPR008972. Cupredoxin.
IPR002429. Cyt_c_oxidase_su2_C.
IPR011759. Cyt_c_oxidase_su2_TM_dom.
[Graphical view]
PfamPF00116. COX2. 1 hit.
PF02790. COX2_TM. 1 hit.
[Graphical view]
SUPFAMSSF49503. SSF49503. 1 hit.
SSF81464. SSF81464. 1 hit.
PROSITEPS50857. COX2_CUA. 1 hit.
PS50999. COX2_TM. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX2_PEA
AccessionPrimary (citable) accession number: P08744
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families