P08744 (COX2_PEA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 2
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide II

Gene names

Name:	COX2
Synonyms:	COII

Encoded on

Mitochondrion

Organism

Pisum sativum (Garden pea)

Taxonomic identifier

3888 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › fabids › Fabales › Fabaceae › Papilionoideae › Fabeae › Pisum

Protein attributes

Sequence length	258 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. Subunit 2 transfers the electrons from cytochrome c via its binuclear copper A center to the bimetallic center of the catalytic subunit 1.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Cofactor	Copper A.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 2 family.

Ontologies

Keywords
Biological process	Electron transport Respiratory chain Transport
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Ligand	Copper Metal-binding
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	electron transport chain Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell respiratory chain Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	copper ion binding Inferred from electronic annotation. Source: InterPro cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 258	258	Cytochrome c oxidase subunit 2		PRO_0000183654
Regions
	Topological domain	1 – 39	39	Mitochondrial intermembrane Potential
	Transmembrane	40 – 61	22	Helical; Potential
	Topological domain	62 – 85	24	Mitochondrial matrix Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Topological domain	107 – 258	152	Mitochondrial intermembrane Potential
Sites
	Metal binding	186	1	Copper A Probable
	Metal binding	221	1	Copper A Probable
	Metal binding	225	1	Copper A Probable
	Metal binding	229	1	Copper A Probable

Sequences

	Sequence		Length	Mass (Da)
	P08744 [UniParc]. Last modified November 1, 1995. Version 2. Checksum: FD514E00A9524A59	FASTA	258	29,001
	10 20 30 40 50 60 MKLEWLFLTI APCDAAEPWQ LGFQDAATPM MQGIIDLHHD IFFFLILILV FVSRILVRAL 70 80 90 100 110 120 WHFHYKKNPI PQRIVHGTTI EILRTIFPSI IPMFIAIPSF ALLYSMDGVL VDPAMTIKAI 130 140 150 160 170 180 GHQWYRTYEY SDYNSSDEQS LTFDSYTIPE DDLELGQSGL LEVDNRVVVP AKTHLRIIVT 190 200 210 220 230 240 PADVPHSWAV PSLGVKCDAV PGRLNQISIS VQREGVYYGQ CSEICGTNHA FPIVVEAVPS 250 KDYGSRVSNQ LIPQTGEA

References

[1]	"Pea cytochrome oxidase subunit II gene has no intron and generates two mRNA transcripts with different 5'-termini." Moon E., Kao T.-H., Wu R. Nucleic Acids Res. 13:3195-3212(1985) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X02433 Genomic DNA. Translation: CAA26282.1.
PIR	OBPM2. A23012.
3D structure databases
ProteinModelPortal	P08744.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
Gene3D	1.10.287.90. 1 hit. 2.60.40.420. 1 hit.
InterPro	IPR008972. Cupredoxin. IPR002429. Cyt_c_oxidase_su2_C. IPR011759. Cyt_c_oxidase_su2_TM_dom. [Graphical view]
Pfam	PF00116. COX2. 1 hit. PF02790. COX2_TM. 1 hit. [Graphical view]
SUPFAM	SSF49503. Cupredoxin. 1 hit. SSF81464. Cyt_c_oxidase_II-like_TM. 1 hit.
PROSITE	PS00078. COX2. False negative. PS50857. COX2_CUA. 1 hit. PS50999. COX2_TM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX2_PEA

Accession

Primary (citable) accession number: P08744

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 90 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program