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Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Oenothera berteroana (Bertero's evening primrose)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi64 – 641Iron (heme A axial ligand)Curated
Metal bindingi243 – 2431Copper BCurated
Metal bindingi247 – 2471Copper BCurated
Metal bindingi292 – 2921Copper BCurated
Metal bindingi293 – 2931Copper BCurated
Metal bindingi378 – 3781Iron (heme A3 axial ligand)Curated
Metal bindingi380 – 3801Iron (heme A axial ligand)Curated

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COI
Encoded oniMitochondrion
OrganismiOenothera berteroana (Bertero's evening primrose)
Taxonomic identifieri3950 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsMyrtalesOnagraceaeOnagroideaeOnagreaeOenothera

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei18 – 3821HelicalSequence AnalysisAdd
BLAST
Transmembranei59 – 7921HelicalSequence AnalysisAdd
BLAST
Transmembranei103 – 12321HelicalSequence AnalysisAdd
BLAST
Transmembranei149 – 16921HelicalSequence AnalysisAdd
BLAST
Transmembranei186 – 20621HelicalSequence AnalysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence AnalysisAdd
BLAST
Transmembranei269 – 28921HelicalSequence AnalysisAdd
BLAST
Transmembranei312 – 33221HelicalSequence AnalysisAdd
BLAST
Transmembranei339 – 35921HelicalSequence AnalysisAdd
BLAST
Transmembranei375 – 39521HelicalSequence AnalysisAdd
BLAST
Transmembranei414 – 43421HelicalSequence AnalysisAdd
BLAST
Transmembranei454 – 47421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 527527Cytochrome c oxidase subunit 1PRO_0000183369Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki243 ↔ 2471'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliP08743.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08743-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNPVRWLFS TNHKDIGTLY FIFGAIAGVM GTCFSVLIRM ELARPGDQIL
60 70 80 90 100
GGNHQLYNVL ITAHAFLMIF FMVMPAMIGG SGNWSVPILI GAPDMAFPRL
110 120 130 140 150
NNISFWLLPP SLLLLLSSAL VEVGSGTGWT VYPPLSGITS HSGGAVDSAI
160 170 180 190 200
SSLHLSGVSS ILGSINFITT ISNMRGLGMT MHRSPLFVWS VLATAFPILL
210 220 230 240 250
SLPVLAGAIT MLLTDRNFNT TFSDPAGGGD PILYQHLFRF FGHPEVYILI
260 270 280 290 300
LPGSGIISHI VSTFSGKPVF GYLGMVYAMI SIGVLGFLVW AHHMFTVGLD
310 320 330 340 350
VDTRAYFTAA TMIIAVPTGV KIFSWIATMW GGSIQYKTPM LFAVGSIFLF
360 370 380 390 400
TVGGLAGIVP ANSGLDIALH DTYYAGAHFH YVLSMGAVFA LFAGFRYWVG
410 420 430 440 450
KIFGRTYPET LGQIHFWITF FGVNPTFFPM HFLGLSGMPR PIPDYPESYA
460 470 480 490 500
GWNALSSFGS YISVVGIRCF FVVVTITSSS GNNKRCAPSP WAVEKNSTTL
510 520
EWMVQSPPAF HTFGELPATK ETKSYVK
Length:527
Mass (Da):57,242
Last modified:October 31, 1995 - v2
Checksum:i526F5448B5B64ABF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05465 Genomic DNA. Translation: CAA29025.1.
PIRiA26170. ODOB1M.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X05465 Genomic DNA. Translation: CAA29025.1.
PIRiA26170. ODOB1M.

3D structure databases

ProteinModelPortaliP08743.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00705.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The cytochrome oxidase subunit I and subunit III genes in Oenothera mitochondria are transcribed from identical promoter sequences."
    Hiesel R., Schobel W., Schuster W., Brennicke A.
    EMBO J. 6:29-34(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cv. Munzia.

Entry informationi

Entry nameiCOX1_OENBE
AccessioniPrimary (citable) accession number: P08743
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 31, 1988
Last sequence update: October 31, 1995
Last modified: March 3, 2015
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.