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Protein

Elongation factor 1-alpha 1

Gene

eEF1alpha1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-3371511 HSF1 activation
R-DME-6798695 Neutrophil degranulation
R-DME-8876725 Protein methylation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha 1Imported
Short name:
EF-1-alpha-1Imported
Alternative name(s):
50 kDa female-specific protein
Gene namesi
Name:eEF1alpha1Imported
Synonyms:Ef1alpha48DImported, EF1BImported, F11 Publication
ORF Names:CG8280Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0284245 eEF1alpha1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000909061 – 463Elongation factor 1-alpha 1Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3015-glutamyl glycerylphosphorylethanolamine1 Publication1
Modified residuei3745-glutamyl glycerylphosphorylethanolamineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08736
PRIDEiP08736

Expressioni

Gene expression databases

BgeeiFBgn0000556
ExpressionAtlasiP08736 differential
GenevisibleiP08736 DM

Interactioni

Protein-protein interaction databases

BioGridi62056, 59 interactors
IntActiP08736, 5 interactors
MINTiP08736
STRINGi7227.FBpp0304260

Structurei

3D structure databases

ProteinModelPortaliP08736
SMRiP08736
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 242tr-type GAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni194 – 196G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0052 Eukaryota
COG5256 LUCA
GeneTreeiENSGT00910000144046
InParanoidiP08736
KOiK03231
OMAiWYKGWTK
OrthoDBiEOG091G05LW
PhylomeDBiP08736

Family and domain databases

HAMAPiMF_00118_A EF_Tu_A, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR031157 G_TR_CS
IPR027417 P-loop_NTPase
IPR000795 TF_GTP-bd_dom
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
IPR004539 Transl_elong_EF1A_euk/arc
IPR004160 Transl_elong_EFTu/EF1A_C
PfamiView protein in Pfam
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PF03143 GTP_EFTU_D3, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00483 EF-1_alpha, 1 hit
PROSITEiView protein in PROSITE
PS00301 G_TR_1, 1 hit
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P08736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKIHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAQEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDIALWKF ETAKYYVTII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGT GEFEAGISKN GQTREHALLA FTLGVKQLIV
160 170 180 190 200
GVNKMDSSEP PYSEARYEEI KKEVSSYIKK IGYNPAAVAF VPISGWHGDN
210 220 230 240 250
MLEPSTNMPW FKGWKVERKE GNADGKTLID ALDAILPPAR PTDKALRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG VLKPGTVVVF APANITTEVK SVEMHHEALQ
310 320 330 340 350
EAVPGDNVGF NVKNVSVKEL RRGYVAGDSK ANPPKGAADF TAQVIVLNHP
360 370 380 390 400
GQIANGYTPV LDCHTAHIAC KFAEIKEKVD RRSGKTTEEN PKFIKSGDAA
410 420 430 440 450
IVNLVPSKPL CVEAFQEFPP LGRFAVRDMR QTVAVGVIKA VNFKDASGGK
460
VTKAAEKATK GKK
Length:463
Mass (Da):50,307
Last modified:June 21, 2005 - v2
Checksum:i33ECDCDB4DAE8BBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 116LIV → QID in AAA28526 (PubMed:16593598).Curated3
Sequence conflicti114 – 116LIV → QID in CAA29993 (PubMed:3131735).Curated3
Sequence conflicti131G → D in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti131G → D in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti181I → V in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti181I → V in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti215 – 217KVE → EVG in AAA28526 (PubMed:16593598).Curated3
Sequence conflicti215 – 217KVE → EVG in CAA29993 (PubMed:3131735).Curated3
Sequence conflicti229I → V in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti229I → V in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti376K → L in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti376K → L in CAA29993 (PubMed:3131735).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11744 Genomic DNA Translation: AAA28526.1
X06869 Genomic DNA Translation: CAA29993.1
AE013599 Genomic DNA Translation: AAF58608.1
AE013599 Genomic DNA Translation: AHN56119.1
AE013599 Genomic DNA Translation: AHN56120.1
BT011039 mRNA Translation: AAR30199.1
BT099573 mRNA Translation: ACU43535.1
PIRiS00676
RefSeqiNP_001286321.1, NM_001299392.1
NP_001286322.1, NM_001299393.1
NP_477375.1, NM_058027.5
NP_725085.1, NM_165850.3
UniGeneiDm.29457

Genome annotation databases

EnsemblMetazoaiFBtr0088035; FBpp0087142; FBgn0284245
FBtr0331927; FBpp0304260; FBgn0284245
FBtr0345022; FBpp0311272; FBgn0284245
FBtr0345023; FBpp0311273; FBgn0284245
GeneIDi36271
KEGGidme:Dmel_CG8280

Similar proteinsi

Entry informationi

Entry nameiEF1A1_DROME
AccessioniPrimary (citable) accession number: P08736
Secondary accession number(s): C6TP87, Q0E9B9, Q9V631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 21, 2005
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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