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Protein

Elongation factor 1-alpha 1

Gene

Ef1alpha48D

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 21GTPBy similarity8
Nucleotide bindingi91 – 95GTPBy similarity5
Nucleotide bindingi153 – 156GTPBy similarity4

GO - Molecular functioni

Keywordsi

Molecular functionElongation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-156842. Eukaryotic Translation Elongation.
R-DME-3371511. HSF1 activation.
R-DME-6798695. Neutrophil degranulation.
R-DME-8876725. Protein methylation.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor 1-alpha 1
Short name:
EF-1-alpha-1
Alternative name(s):
50 kDa female-specific protein
Gene namesi
Name:Ef1alpha48D
Synonyms:EF1B, F1
ORF Names:CG8280
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2R

Organism-specific databases

FlyBaseiFBgn0000556. Ef1alpha48D.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000909061 – 463Elongation factor 1-alpha 1Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei3015-glutamyl glycerylphosphorylethanolamine1 Publication1
Modified residuei3745-glutamyl glycerylphosphorylethanolamineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08736.
PRIDEiP08736.

Expressioni

Gene expression databases

BgeeiFBgn0000556.
ExpressionAtlasiP08736. differential.
GenevisibleiP08736. DM.

Interactioni

Protein-protein interaction databases

BioGridi62056. 56 interactors.
IntActiP08736. 5 interactors.
MINTiMINT-284766.
STRINGi7227.FBpp0304260.

Structurei

3D structure databases

ProteinModelPortaliP08736.
SMRiP08736.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 242tr-type GAdd BLAST238

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni14 – 21G1By similarity8
Regioni70 – 74G2By similarity5
Regioni91 – 94G3By similarity4
Regioni153 – 156G4By similarity4
Regioni194 – 196G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0052. Eukaryota.
COG5256. LUCA.
GeneTreeiENSGT00670000097815.
InParanoidiP08736.
KOiK03231.
OMAiWYKGWTK.
OrthoDBiEOG091G05LW.
PhylomeDBiP08736.

Family and domain databases

HAMAPiMF_00118_A. EF_Tu_A. 1 hit.
InterProiView protein in InterPro
IPR004161. EFTu-like_2.
IPR031157. G_TR_CS.
IPR027417. P-loop_NTPase.
IPR000795. TF_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004539. Transl_elong_EF1A_euk/arc.
IPR004160. Transl_elong_EFTu/EF1A_C.
PfamiView protein in Pfam
PF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00483. EF-1_alpha. 1 hit.
PROSITEiView protein in PROSITE
PS00301. G_TR_1. 1 hit.
PS51722. G_TR_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P08736-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKEKIHINI VVIGHVDSGK STTTGHLIYK CGGIDKRTIE KFEKEAQEMG
60 70 80 90 100
KGSFKYAWVL DKLKAERERG ITIDIALWKF ETAKYYVTII DAPGHRDFIK
110 120 130 140 150
NMITGTSQAD CAVLIVAAGT GEFEAGISKN GQTREHALLA FTLGVKQLIV
160 170 180 190 200
GVNKMDSSEP PYSEARYEEI KKEVSSYIKK IGYNPAAVAF VPISGWHGDN
210 220 230 240 250
MLEPSTNMPW FKGWKVERKE GNADGKTLID ALDAILPPAR PTDKALRLPL
260 270 280 290 300
QDVYKIGGIG TVPVGRVETG VLKPGTVVVF APANITTEVK SVEMHHEALQ
310 320 330 340 350
EAVPGDNVGF NVKNVSVKEL RRGYVAGDSK ANPPKGAADF TAQVIVLNHP
360 370 380 390 400
GQIANGYTPV LDCHTAHIAC KFAEIKEKVD RRSGKTTEEN PKFIKSGDAA
410 420 430 440 450
IVNLVPSKPL CVEAFQEFPP LGRFAVRDMR QTVAVGVIKA VNFKDASGGK
460
VTKAAEKATK GKK
Length:463
Mass (Da):50,307
Last modified:June 21, 2005 - v2
Checksum:i33ECDCDB4DAE8BBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti114 – 116LIV → QID in AAA28526 (PubMed:16593598).Curated3
Sequence conflicti114 – 116LIV → QID in CAA29993 (PubMed:3131735).Curated3
Sequence conflicti131G → D in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti131G → D in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti181I → V in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti181I → V in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti215 – 217KVE → EVG in AAA28526 (PubMed:16593598).Curated3
Sequence conflicti215 – 217KVE → EVG in CAA29993 (PubMed:3131735).Curated3
Sequence conflicti229I → V in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti229I → V in CAA29993 (PubMed:3131735).Curated1
Sequence conflicti376K → L in AAA28526 (PubMed:16593598).Curated1
Sequence conflicti376K → L in CAA29993 (PubMed:3131735).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M11744 Genomic DNA. Translation: AAA28526.1.
X06869 Genomic DNA. Translation: CAA29993.1.
AE013599 Genomic DNA. Translation: AAF58608.1.
BT011039 mRNA. Translation: AAR30199.1.
PIRiS00676.
RefSeqiNP_001286321.1. NM_001299392.1.
NP_001286322.1. NM_001299393.1.
NP_477375.1. NM_058027.5.
NP_725085.1. NM_165850.3.
UniGeneiDm.29457.

Genome annotation databases

EnsemblMetazoaiFBtr0088035; FBpp0087142; FBgn0000556.
FBtr0331927; FBpp0304260; FBgn0000556.
FBtr0345022; FBpp0311272; FBgn0000556.
FBtr0345023; FBpp0311273; FBgn0000556.
GeneIDi36271.
KEGGidme:Dmel_CG8280.

Similar proteinsi

Entry informationi

Entry nameiEF1A1_DROME
AccessioniPrimary (citable) accession number: P08736
Secondary accession number(s): Q0E9B9, Q9V631
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 21, 2005
Last modified: August 30, 2017
This is version 161 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families