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P08730

- K1C13_MOUSE

UniProt

P08730 - K1C13_MOUSE

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Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. cellular response to retinoic acid Source: Ensembl
  2. cytoskeleton organization Source: Ensembl
  3. response to radiation Source: Ensembl
  4. tongue morphogenesis Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
47 kDa cytokeratin
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Gene namesi
Name:Krt13
Synonyms:Krt1-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:101925. Krt13.

Subcellular locationi

GO - Cellular componenti

  1. extracellular vesicular exosome Source: Ensembl
  2. keratin filament Source: Ensembl
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Keratin, type I cytoskeletal 13PRO_0000063648Add
BLAST

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP08730.
PaxDbiP08730.
PRIDEiP08730.

PTM databases

PhosphoSiteiP08730.

Expressioni

Tissue specificityi

Expressed in the suprabasal layers of internal stratified squamous epithelia that line the oral cavity and the upper digestive tract, including tongue and esophagus.1 Publication

Gene expression databases

BgeeiP08730.
CleanExiMM_KRT13.
GenevestigatoriP08730.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13 By similarity.By similarity

Protein-protein interaction databases

BioGridi201018. 1 interaction.
IntActiP08730. 4 interactions.
MINTiMINT-1859004.

Structurei

3D structure databases

ProteinModelPortaliP08730.
SMRiP08730. Positions 147-245, 261-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9595HeadAdd
BLAST
Regioni96 – 404309RodAdd
BLAST
Regioni96 – 13136Coil 1AAdd
BLAST
Regioni132 – 15019Linker 1Add
BLAST
Regioni151 – 24292Coil 1BAdd
BLAST
Regioni243 – 26523Linker 12Add
BLAST
Regioni266 – 404139Coil 2Add
BLAST
Regioni405 – 43733TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi13 – 9482Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148784.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP08730.
KOiK07604.
OMAiTCSTRFV.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP08730.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: P08730-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS SCSSRFVTGG SAGGYGGGMS
60 70 80 90 100
CGFGGGAGGG FGGGFGGGFG GSYGGGFGGG FGDFGGVDGG LLSGNEKITM
110 120 130 140 150
QNLNDRLASY LDKVRALEAA NADLEVKIRD WHLKQSPASP ERDYSAYYKT
160 170 180 190 200
IEELRIKILE ATTDNNRIIL EIDNARLAAD DFRLKYENEL TLRQSVEADI
210 220 230 240 250
NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQVVGQV
260 270 280 290 300
NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEEWFQT KSAELNKEVS
310 320 330 340 350
SNAEMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL
360 370 380 390 400
QLQQIQGLIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL
410 420 430
LEGQDAKMTG FNSGGNNTTT SNGSPSSNSG RPDFRKY
Length:437
Mass (Da):47,754
Last modified:October 1, 1996 - v2
Checksum:i924128DBAC317E2F
GO
Isoform 2 (identifier: P08730-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-425: Missing.

Note: No experimental confirmation available.

Show »
Length:311
Mass (Da):33,718
Checksum:iBA1E649830FDA92C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei300 – 425126Missing in isoform 2. 1 PublicationVSP_016378Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13921 Genomic DNA. Translation: AAC52150.1.
AK132640 mRNA. Translation: BAE21276.1.
BC060286 mRNA. Translation: AAH60286.1.
X53320 Genomic DNA. Translation: CAA37407.1.
X03492 mRNA. Translation: CAA27208.1.
CCDSiCCDS25409.1. [P08730-1]
PIRiA55682.
RefSeqiNP_034792.1. NM_010662.1. [P08730-1]
UniGeneiMm.4646.

Genome annotation databases

EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041. [P08730-1]
GeneIDi16663.
KEGGimmu:16663.
UCSCiuc007lkj.1. mouse. [P08730-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U13921 Genomic DNA. Translation: AAC52150.1 .
AK132640 mRNA. Translation: BAE21276.1 .
BC060286 mRNA. Translation: AAH60286.1 .
X53320 Genomic DNA. Translation: CAA37407.1 .
X03492 mRNA. Translation: CAA27208.1 .
CCDSi CCDS25409.1. [P08730-1 ]
PIRi A55682.
RefSeqi NP_034792.1. NM_010662.1. [P08730-1 ]
UniGenei Mm.4646.

3D structure databases

ProteinModelPortali P08730.
SMRi P08730. Positions 147-245, 261-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201018. 1 interaction.
IntActi P08730. 4 interactions.
MINTi MINT-1859004.

PTM databases

PhosphoSitei P08730.

Proteomic databases

MaxQBi P08730.
PaxDbi P08730.
PRIDEi P08730.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000007275 ; ENSMUSP00000007275 ; ENSMUSG00000044041 . [P08730-1 ]
GeneIDi 16663.
KEGGi mmu:16663.
UCSCi uc007lkj.1. mouse. [P08730-1 ]

Organism-specific databases

CTDi 3860.
MGIi MGI:101925. Krt13.

Phylogenomic databases

eggNOGi NOG148784.
GeneTreei ENSGT00760000118808.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi P08730.
KOi K07604.
OMAi TCSTRFV.
OrthoDBi EOG7FV3Q8.
PhylomeDBi P08730.
TreeFami TF332742.

Miscellaneous databases

NextBioi 290367.
PROi P08730.
SOURCEi Search...

Gene expression databases

Bgeei P08730.
CleanExi MM_KRT13.
Genevestigatori P08730.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation."
    Filion M., Sarafian V., Lussier M., Belanger C., Lapointe L., Royal A.
    Genomics 24:303-310(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking region of the gene."
    Winter H., Rentrop M., Nischt R., Schweizer J.
    Differentiation 43:105-114(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157, TISSUE SPECIFICITY.
    Tissue: Liver.
  5. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 107-113; 177-183; 194-204 AND 390-398, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  6. "Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs."
    Knapp B., Rentrop M., Schweizer J., Winter H.
    Nucleic Acids Res. 14:751-763(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-437 (ISOFORM 1).

Entry informationi

Entry nameiK1C13_MOUSE
AccessioniPrimary (citable) accession number: P08730
Secondary accession number(s): Q3V176, Q6PAI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3