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P08730 (K1C13_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
47 kDa cytokeratin
Cytokeratin-13
Short name=CK-13
Keratin-13
Short name=K13
Gene names
Name:Krt13
Synonyms:Krt1-13
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length437 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13 By similarity.

Tissue specificity

Expressed in the suprabasal layers of internal stratified squamous epithelia that line the oral cavity and the upper digestive tract, including tongue and esophagus. Ref.4

Post-translational modification

O-glycosylated; glycans consist of single N-acetylglucosamine residues By similarity.

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Sequence similarities

Belongs to the intermediate filament family.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P08730-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P08730-2)

The sequence of this isoform differs from the canonical sequence as follows:
     300-425: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 437437Keratin, type I cytoskeletal 13
PRO_0000063648

Regions

Region1 – 9595Head
Region96 – 404309Rod
Region96 – 13136Coil 1A
Region132 – 15019Linker 1
Region151 – 24292Coil 1B
Region243 – 26523Linker 12
Region266 – 404139Coil 2
Region405 – 43733Tail
Compositional bias13 – 9482Gly-rich

Natural variations

Alternative sequence300 – 425126Missing in isoform 2.
VSP_016378

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 1996. Version 2.
Checksum: 924128DBAC317E2F

FASTA43747,754
        10         20         30         40         50         60 
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS SCSSRFVTGG SAGGYGGGMS CGFGGGAGGG 

        70         80         90        100        110        120 
FGGGFGGGFG GSYGGGFGGG FGDFGGVDGG LLSGNEKITM QNLNDRLASY LDKVRALEAA 

       130        140        150        160        170        180 
NADLEVKIRD WHLKQSPASP ERDYSAYYKT IEELRIKILE ATTDNNRIIL EIDNARLAAD 

       190        200        210        220        230        240 
DFRLKYENEL TLRQSVEADI NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK 

       250        260        270        280        290        300 
EFSNQVVGQV NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEEWFQT KSAELNKEVS 

       310        320        330        340        350        360 
SNAEMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL QLQQIQGLIS 

       370        380        390        400        410        420 
SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL LEGQDAKMTG FNSGGNNTTT 

       430 
SNGSPSSNSG RPDFRKY 

« Hide

Isoform 2 [UniParc].

Checksum: BA1E649830FDA92C
Show »

FASTA31133,718

References

« Hide 'large scale' references
[1]"Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation."
Filion M., Sarafian V., Lussier M., Belanger C., Lapointe L., Royal A.
Genomics 24:303-310(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/Sv.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Head.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking region of the gene."
Winter H., Rentrop M., Nischt R., Schweizer J.
Differentiation 43:105-114(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157, TISSUE SPECIFICITY.
Tissue: Liver.
[5]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 107-113; 177-183; 194-204 AND 390-398, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[6]"Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs."
Knapp B., Rentrop M., Schweizer J., Winter H.
Nucleic Acids Res. 14:751-763(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-437 (ISOFORM 1).
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13921 Genomic DNA. Translation: AAC52150.1.
AK132640 mRNA. Translation: BAE21276.1.
BC060286 mRNA. Translation: AAH60286.1.
X53320 Genomic DNA. Translation: CAA37407.1.
X03492 mRNA. Translation: CAA27208.1.
PIRA55682.
RefSeqNP_034792.1. NM_010662.1.
UniGeneMm.4646.

3D structure databases

ProteinModelPortalP08730.
SMRP08730. Positions 94-245, 261-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid201018. 1 interaction.
IntActP08730. 4 interactions.
MINTMINT-1859004.

PTM databases

PhosphoSiteP08730.

Proteomic databases

PaxDbP08730.
PRIDEP08730.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041. [P08730-1]
GeneID16663.
KEGGmmu:16663.
UCSCuc007lkj.1. mouse. [P08730-1]

Organism-specific databases

CTD3860.
MGIMGI:101925. Krt13.

Phylogenomic databases

eggNOGNOG148784.
GeneTreeENSGT00610000085921.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidP08730.
KOK07604.
OMATCSTRFV.
OrthoDBEOG7FV3Q8.
PhylomeDBP08730.
TreeFamTF332742.

Gene expression databases

BgeeP08730.
CleanExMM_KRT13.
GenevestigatorP08730.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio290367.
PROP08730.
SOURCESearch...

Entry information

Entry nameK1C13_MOUSE
AccessionPrimary (citable) accession number: P08730
Secondary accession number(s): Q3V176, Q6PAI1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: April 16, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot