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P08730

- K1C13_MOUSE

UniProt

P08730 - K1C13_MOUSE

Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 123 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. structural molecule activity Source: InterPro

    GO - Biological processi

    1. cellular response to retinoic acid Source: Ensembl
    2. response to radiation Source: Ensembl
    3. tongue morphogenesis Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 13
    Alternative name(s):
    47 kDa cytokeratin
    Cytokeratin-13
    Short name:
    CK-13
    Keratin-13
    Short name:
    K13
    Gene namesi
    Name:Krt13
    Synonyms:Krt1-13
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:101925. Krt13.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: Ensembl
    2. keratin filament Source: Ensembl

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 437437Keratin, type I cytoskeletal 13PRO_0000063648Add
    BLAST

    Post-translational modificationi

    O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiP08730.
    PaxDbiP08730.
    PRIDEiP08730.

    PTM databases

    PhosphoSiteiP08730.

    Expressioni

    Tissue specificityi

    Expressed in the suprabasal layers of internal stratified squamous epithelia that line the oral cavity and the upper digestive tract, including tongue and esophagus.1 Publication

    Gene expression databases

    BgeeiP08730.
    CleanExiMM_KRT13.
    GenevestigatoriP08730.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi201018. 1 interaction.
    IntActiP08730. 4 interactions.
    MINTiMINT-1859004.

    Structurei

    3D structure databases

    ProteinModelPortaliP08730.
    SMRiP08730. Positions 107-132, 147-245, 261-403.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9595HeadAdd
    BLAST
    Regioni96 – 404309RodAdd
    BLAST
    Regioni96 – 13136Coil 1AAdd
    BLAST
    Regioni132 – 15019Linker 1Add
    BLAST
    Regioni151 – 24292Coil 1BAdd
    BLAST
    Regioni243 – 26523Linker 12Add
    BLAST
    Regioni266 – 404139Coil 2Add
    BLAST
    Regioni405 – 43733TailAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi13 – 9482Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG148784.
    GeneTreeiENSGT00610000085921.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiP08730.
    KOiK07604.
    OMAiTCSTRFV.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiP08730.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P08730-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS SCSSRFVTGG SAGGYGGGMS    50
    CGFGGGAGGG FGGGFGGGFG GSYGGGFGGG FGDFGGVDGG LLSGNEKITM 100
    QNLNDRLASY LDKVRALEAA NADLEVKIRD WHLKQSPASP ERDYSAYYKT 150
    IEELRIKILE ATTDNNRIIL EIDNARLAAD DFRLKYENEL TLRQSVEADI 200
    NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQVVGQV 250
    NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEEWFQT KSAELNKEVS 300
    SNAEMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL 350
    QLQQIQGLIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL 400
    LEGQDAKMTG FNSGGNNTTT SNGSPSSNSG RPDFRKY 437
    Length:437
    Mass (Da):47,754
    Last modified:October 1, 1996 - v2
    Checksum:i924128DBAC317E2F
    GO
    Isoform 2 (identifier: P08730-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         300-425: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:311
    Mass (Da):33,718
    Checksum:iBA1E649830FDA92C
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei300 – 425126Missing in isoform 2. 1 PublicationVSP_016378Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13921 Genomic DNA. Translation: AAC52150.1.
    AK132640 mRNA. Translation: BAE21276.1.
    BC060286 mRNA. Translation: AAH60286.1.
    X53320 Genomic DNA. Translation: CAA37407.1.
    X03492 mRNA. Translation: CAA27208.1.
    CCDSiCCDS25409.1. [P08730-1]
    PIRiA55682.
    RefSeqiNP_034792.1. NM_010662.1. [P08730-1]
    UniGeneiMm.4646.

    Genome annotation databases

    EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041. [P08730-1]
    GeneIDi16663.
    KEGGimmu:16663.
    UCSCiuc007lkj.1. mouse. [P08730-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U13921 Genomic DNA. Translation: AAC52150.1 .
    AK132640 mRNA. Translation: BAE21276.1 .
    BC060286 mRNA. Translation: AAH60286.1 .
    X53320 Genomic DNA. Translation: CAA37407.1 .
    X03492 mRNA. Translation: CAA27208.1 .
    CCDSi CCDS25409.1. [P08730-1 ]
    PIRi A55682.
    RefSeqi NP_034792.1. NM_010662.1. [P08730-1 ]
    UniGenei Mm.4646.

    3D structure databases

    ProteinModelPortali P08730.
    SMRi P08730. Positions 107-132, 147-245, 261-403.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 201018. 1 interaction.
    IntActi P08730. 4 interactions.
    MINTi MINT-1859004.

    PTM databases

    PhosphoSitei P08730.

    Proteomic databases

    MaxQBi P08730.
    PaxDbi P08730.
    PRIDEi P08730.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000007275 ; ENSMUSP00000007275 ; ENSMUSG00000044041 . [P08730-1 ]
    GeneIDi 16663.
    KEGGi mmu:16663.
    UCSCi uc007lkj.1. mouse. [P08730-1 ]

    Organism-specific databases

    CTDi 3860.
    MGIi MGI:101925. Krt13.

    Phylogenomic databases

    eggNOGi NOG148784.
    GeneTreei ENSGT00610000085921.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi P08730.
    KOi K07604.
    OMAi TCSTRFV.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi P08730.
    TreeFami TF332742.

    Miscellaneous databases

    NextBioi 290367.
    PROi P08730.
    SOURCEi Search...

    Gene expression databases

    Bgeei P08730.
    CleanExi MM_KRT13.
    Genevestigatori P08730.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Arrangement of a cluster of three mouse type I keratin genes expressed sequentially during esophageal-type epithelial cell differentiation."
      Filion M., Sarafian V., Lussier M., Belanger C., Lapointe L., Royal A.
      Genomics 24:303-310(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/Sv.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Head.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "Tissue-specific expression of murine keratin K13 in internal stratified squamous epithelia and its aberrant expression during two-stage mouse skin carcinogenesis is associated with the methylation state of a distinct CpG site in the remote 5'-flanking region of the gene."
      Winter H., Rentrop M., Nischt R., Schweizer J.
      Differentiation 43:105-114(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-157, TISSUE SPECIFICITY.
      Tissue: Liver.
    5. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 107-113; 177-183; 194-204 AND 390-398, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    6. "Nonepidermal members of the keratin multigene family: cDNA sequences and in situ localization of the mRNAs."
      Knapp B., Rentrop M., Schweizer J., Winter H.
      Nucleic Acids Res. 14:751-763(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 126-437 (ISOFORM 1).

    Entry informationi

    Entry nameiK1C13_MOUSE
    AccessioniPrimary (citable) accession number: P08730
    Secondary accession number(s): Q3V176, Q6PAI1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 123 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3