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Protein

Keratin, type I cytoskeletal 13

Gene

Krt13

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 13
Alternative name(s):
47 kDa cytokeratin
Cytokeratin-13
Short name:
CK-13
Keratin-13
Short name:
K13
Gene namesi
Name:Krt13
Synonyms:Krt1-13
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:101925. Krt13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636481 – 437Keratin, type I cytoskeletal 13Add BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11PhosphoserineBy similarity1
Modified residuei27Omega-N-methylarginineBy similarity1
Modified residuei35Omega-N-methylarginineBy similarity1
Modified residuei50PhosphoserineBy similarity1

Post-translational modificationi

O-glycosylated; glycans consist of single N-acetylglucosamine residues.By similarity

Keywords - PTMi

Glycoprotein, Methylation, Phosphoprotein

Proteomic databases

PaxDbiP08730.
PeptideAtlasiP08730.
PRIDEiP08730.

PTM databases

iPTMnetiP08730.
PhosphoSitePlusiP08730.

Expressioni

Tissue specificityi

Expressed in the suprabasal layers of internal stratified squamous epithelia that line the oral cavity and the upper digestive tract, including tongue and esophagus.1 Publication

Gene expression databases

BgeeiENSMUSG00000044041.
CleanExiMM_KRT13.
GenevisibleiP08730. MM.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-4 is generally associated with keratin-13 (By similarity).By similarity

Protein-protein interaction databases

BioGridi201018. 1 interactor.
IntActiP08730. 4 interactors.
MINTiMINT-1859004.
STRINGi10090.ENSMUSP00000007275.

Structurei

3D structure databases

ProteinModelPortaliP08730.
SMRiP08730.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 95HeadAdd BLAST95
Regioni96 – 404RodAdd BLAST309
Regioni96 – 131Coil 1AAdd BLAST36
Regioni132 – 150Linker 1Add BLAST19
Regioni151 – 242Coil 1BAdd BLAST92
Regioni243 – 265Linker 12Add BLAST23
Regioni266 – 404Coil 2Add BLAST139
Regioni405 – 437TailAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi13 – 94Gly-richAdd BLAST82

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP08730.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiP08730.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08730-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSCRFQSSSM SYGGGFGAGS CQLGGGRNIS SCSSRFVTGG SAGGYGGGMS
60 70 80 90 100
CGFGGGAGGG FGGGFGGGFG GSYGGGFGGG FGDFGGVDGG LLSGNEKITM
110 120 130 140 150
QNLNDRLASY LDKVRALEAA NADLEVKIRD WHLKQSPASP ERDYSAYYKT
160 170 180 190 200
IEELRIKILE ATTDNNRIIL EIDNARLAAD DFRLKYENEL TLRQSVEADI
210 220 230 240 250
NGLRRVLDEL TLAKTDLEMQ IESLNEELAY LKKNHEEEMK EFSNQVVGQV
260 270 280 290 300
NVEMDATPGI DLTRVLAEMR EQYEALAEKN RRDAEEWFQT KSAELNKEVS
310 320 330 340 350
SNAEMIQTSK TEITELRRTL QGLEIELQSQ LSMKAGLEST LAETECRYAL
360 370 380 390 400
QLQQIQGLIS SIEAQLSELR SEMECQNQEY KMLLDIKTRL EQEIATYRSL
410 420 430
LEGQDAKMTG FNSGGNNTTT SNGSPSSNSG RPDFRKY
Length:437
Mass (Da):47,754
Last modified:October 1, 1996 - v2
Checksum:i924128DBAC317E2F
GO
Isoform 2 (identifier: P08730-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     300-425: Missing.

Note: No experimental confirmation available.
Show »
Length:311
Mass (Da):33,718
Checksum:iBA1E649830FDA92C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016378300 – 425Missing in isoform 2. 1 PublicationAdd BLAST126

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13921 Genomic DNA. Translation: AAC52150.1.
AK132640 mRNA. Translation: BAE21276.1.
BC060286 mRNA. Translation: AAH60286.1.
X53320 Genomic DNA. Translation: CAA37407.1.
X03492 mRNA. Translation: CAA27208.1.
CCDSiCCDS25409.1. [P08730-1]
PIRiA55682.
RefSeqiNP_001300878.1. NM_001313949.1.
NP_034792.1. NM_010662.2. [P08730-1]
UniGeneiMm.4646.

Genome annotation databases

EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041. [P08730-1]
GeneIDi16663.
KEGGimmu:16663.
UCSCiuc007lkj.1. mouse. [P08730-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13921 Genomic DNA. Translation: AAC52150.1.
AK132640 mRNA. Translation: BAE21276.1.
BC060286 mRNA. Translation: AAH60286.1.
X53320 Genomic DNA. Translation: CAA37407.1.
X03492 mRNA. Translation: CAA27208.1.
CCDSiCCDS25409.1. [P08730-1]
PIRiA55682.
RefSeqiNP_001300878.1. NM_001313949.1.
NP_034792.1. NM_010662.2. [P08730-1]
UniGeneiMm.4646.

3D structure databases

ProteinModelPortaliP08730.
SMRiP08730.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201018. 1 interactor.
IntActiP08730. 4 interactors.
MINTiMINT-1859004.
STRINGi10090.ENSMUSP00000007275.

PTM databases

iPTMnetiP08730.
PhosphoSitePlusiP08730.

Proteomic databases

PaxDbiP08730.
PeptideAtlasiP08730.
PRIDEiP08730.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007275; ENSMUSP00000007275; ENSMUSG00000044041. [P08730-1]
GeneIDi16663.
KEGGimmu:16663.
UCSCiuc007lkj.1. mouse. [P08730-1]

Organism-specific databases

CTDi3860.
MGIiMGI:101925. Krt13.

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiP08730.
KOiK07604.
OMAiEEWFHSK.
OrthoDBiEOG091G087I.
PhylomeDBiP08730.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiP08730.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044041.
CleanExiMM_KRT13.
GenevisibleiP08730. MM.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C13_MOUSE
AccessioniPrimary (citable) accession number: P08730
Secondary accession number(s): Q3V176, Q6PAI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: October 1, 1996
Last modified: November 30, 2016
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.