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Protein

Keratin, type II cytoskeletal 7

Gene

KRT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei343Stutter1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135480-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type II cytoskeletal 7
Alternative name(s):
Cytokeratin-7
Short name:
CK-7
Keratin-7
Short name:
K7
Sarcolectin
Type-II keratin Kb7
Gene namesi
Name:KRT7
Synonyms:SCL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:6445. KRT7.

Subcellular locationi

  • Cytoplasm 1 Publication

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: UniProtKB
  • keratin filament Source: InterPro
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3855.
OpenTargetsiENSG00000135480.
PharmGKBiPA30233.

Chemistry databases

DrugBankiDB01087. Primaquine.

Polymorphism and mutation databases

BioMutaiKRT7.
DMDMi317373583.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000637252 – 469Keratin, type II cytoskeletal 7Add BLAST468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserine1 Publication1
Modified residuei2PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei20Dimethylated arginine; alternate1 Publication1
Modified residuei20Omega-N-methylarginine; alternate1 Publication1
Modified residuei53PhosphoserineCombined sources1
Modified residuei71PhosphoserineCombined sources1
Modified residuei83PhosphoserineCombined sources1
Modified residuei97PhosphothreonineCombined sources1
Cross-linki130Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei179N6-acetyllysineCombined sources1
Modified residuei252PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei289PhosphothreonineCombined sources1

Post-translational modificationi

Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP08729.
PeptideAtlasiP08729.
PRIDEiP08729.
TopDownProteomicsiP08729.

2D gel databases

SWISS-2DPAGEP08729.

PTM databases

iPTMnetiP08729.
PhosphoSitePlusiP08729.
SwissPalmiP08729.

Expressioni

Tissue specificityi

Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.2 Publications

Inductioni

Up-regulated by retinoic acid.1 Publication

Gene expression databases

BgeeiENSG00000135480.
CleanExiHS_KRT7.
GenevisibleiP08729. HS.

Organism-specific databases

HPAiCAB000028.
HPA007272.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7. Interacts with GPER1.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF3AQ141523EBI-297833,EBI-366617

Protein-protein interaction databases

BioGridi110053. 11 interactors.
IntActiP08729. 7 interactors.
MINTiMINT-256895.
STRINGi9606.ENSP00000329243.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XIFX-ray3.20E/F/G/H8-16[»]
ProteinModelPortaliP08729.
SMRiP08729.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 90HeadAdd BLAST89
Regioni90 – 126Coil 1AAdd BLAST37
Regioni91 – 399RodAdd BLAST309
Regioni92 – 97Interaction with HPV16 E71 Publication6
Regioni127 – 144Linker 1Add BLAST18
Regioni145 – 236Coil 1BAdd BLAST92
Regioni237 – 260Linker 12Add BLAST24
Regioni261 – 399Coil 2Add BLAST139
Regioni400 – 469TailAdd BLAST70

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP08729.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG091G09KR.
PhylomeDBiP08729.
TreeFamiTF317854.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08729-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIHFSSPVF TSRSAAFSGR GAQVRLSSAR PGGLGSSSLY GLGASRPRVA
60 70 80 90 100
VRSAYGGPVG AGIREVTINQ SLLAPLRLDA DPSLQRVRQE ESEQIKTLNN
110 120 130 140 150
KFASFIDKVR FLEQQNKLLE TKWTLLQEQK SAKSSRLPDI FEAQIAGLRG
160 170 180 190 200
QLEALQVDGG RLEAELRSMQ DVVEDFKNKY EDEINHRTAA ENEFVVLKKD
210 220 230 240 250
VDAAYMSKVE LEAKVDALND EINFLRTLNE TELTELQSQI SDTSVVLSMD
260 270 280 290 300
NSRSLDLDGI IAEVKAQYEE MAKCSRAEAE AWYQTKFETL QAQAGKHGDD
310 320 330 340 350
LRNTRNEISE MNRAIQRLQA EIDNIKNQRA KLEAAIAEAE ERGELALKDA
360 370 380 390 400
RAKQEELEAA LQRGKQDMAR QLREYQELMS VKLALDIEIA TYRKLLEGEE
410 420 430 440 450
SRLAGDGVGA VNISVMNSTG GSSSGGGIGL TLGGTMGSNA LSFSSSAGPG
460
LLKAYSIRTA SASRRSARD
Length:469
Mass (Da):51,386
Last modified:January 11, 2011 - v5
Checksum:i070CBE8F66A62497
GO

Sequence cautioni

The sequence CAA26956 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79D → G in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti83 – 84SL → FS in CAB41416 (PubMed:10492017).Curated2
Sequence conflicti97T → A in CAA26956 (PubMed:2415537).Curated1
Sequence conflicti97T → A in CAA31695 (PubMed:2459129).Curated1
Sequence conflicti155L → M in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti164A → Q in CAA26956 (PubMed:2415537).Curated1
Sequence conflicti164A → Q in CAA31695 (PubMed:2459129).Curated1
Sequence conflicti164A → Q in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti165E → G in CAA26956 (PubMed:2415537).Curated1
Sequence conflicti165E → G in CAA31695 (PubMed:2459129).Curated1
Sequence conflicti165E → G in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti168S → T in CAA26956 (PubMed:2415537).Curated1
Sequence conflicti168S → T in CAA31695 (PubMed:2459129).Curated1
Sequence conflicti168S → T in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti342R → C in CAA26956 (PubMed:2415537).Curated1
Sequence conflicti342R → C in CAA31695 (PubMed:2459129).Curated1
Sequence conflicti411V → A in CAB41416 (PubMed:10492017).Curated1
Sequence conflicti467A → T in CAB41416 (PubMed:10492017).Curated1

Mass spectrometryi

Molecular mass is 51203.48 Da from positions 2 - 469. Determined by MALDI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060731186H → R.Combined sources5 PublicationsCorresponds to variant rs6580870dbSNPEnsembl.1
Natural variantiVAR_016321364G → A.5 PublicationsCorresponds to variant rs2608009dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03212 mRNA. Translation: CAA26956.2. Sequence problems.
X13320
, X13346, X13347, X13348, X13349, X13350, X13351, X13352, X13353 Genomic DNA. Translation: CAA31695.1.
AJ238246 mRNA. Translation: CAB41416.1.
AF509887 mRNA. Translation: AAN64031.1.
AF509892, AF509891 Genomic DNA. Translation: AAN64035.1.
AC007338 Genomic DNA. No translation available.
AC007494 Genomic DNA. No translation available.
BC002700 mRNA. Translation: AAH02700.1.
CCDSiCCDS8822.1.
PIRiB24177.
S05602.
RefSeqiNP_005547.3. NM_005556.3.
UniGeneiHs.411501.
Hs.670221.

Genome annotation databases

EnsembliENST00000331817; ENSP00000329243; ENSG00000135480.
GeneIDi3855.
KEGGihsa:3855.
UCSCiuc001saa.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X03212 mRNA. Translation: CAA26956.2. Sequence problems.
X13320
, X13346, X13347, X13348, X13349, X13350, X13351, X13352, X13353 Genomic DNA. Translation: CAA31695.1.
AJ238246 mRNA. Translation: CAB41416.1.
AF509887 mRNA. Translation: AAN64031.1.
AF509892, AF509891 Genomic DNA. Translation: AAN64035.1.
AC007338 Genomic DNA. No translation available.
AC007494 Genomic DNA. No translation available.
BC002700 mRNA. Translation: AAH02700.1.
CCDSiCCDS8822.1.
PIRiB24177.
S05602.
RefSeqiNP_005547.3. NM_005556.3.
UniGeneiHs.411501.
Hs.670221.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4XIFX-ray3.20E/F/G/H8-16[»]
ProteinModelPortaliP08729.
SMRiP08729.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110053. 11 interactors.
IntActiP08729. 7 interactors.
MINTiMINT-256895.
STRINGi9606.ENSP00000329243.

Chemistry databases

DrugBankiDB01087. Primaquine.

PTM databases

iPTMnetiP08729.
PhosphoSitePlusiP08729.
SwissPalmiP08729.

Polymorphism and mutation databases

BioMutaiKRT7.
DMDMi317373583.

2D gel databases

SWISS-2DPAGEP08729.

Proteomic databases

PaxDbiP08729.
PeptideAtlasiP08729.
PRIDEiP08729.
TopDownProteomicsiP08729.

Protocols and materials databases

DNASUi3855.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331817; ENSP00000329243; ENSG00000135480.
GeneIDi3855.
KEGGihsa:3855.
UCSCiuc001saa.2. human.

Organism-specific databases

CTDi3855.
DisGeNETi3855.
GeneCardsiKRT7.
H-InvDBHIX0010643.
HIX0079487.
HGNCiHGNC:6445. KRT7.
HPAiCAB000028.
HPA007272.
MIMi148059. gene.
neXtProtiNX_P08729.
OpenTargetsiENSG00000135480.
PharmGKBiPA30233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG4R. Eukaryota.
ENOG410YY6B. LUCA.
GeneTreeiENSGT00760000118796.
HOGENOMiHOG000230976.
HOVERGENiHBG013015.
InParanoidiP08729.
KOiK07605.
OMAiPGIFEAQ.
OrthoDBiEOG091G09KR.
PhylomeDBiP08729.
TreeFamiTF317854.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135480-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

ChiTaRSiKRT7. human.
GeneWikiiKeratin_7.
GenomeRNAii3855.
PROiP08729.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135480.
CleanExiHS_KRT7.
GenevisibleiP08729. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR032444. Keratin_2_head.
IPR003054. Keratin_II.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
PF16208. Keratin_2_head. 1 hit.
[Graphical view]
PRINTSiPR01276. TYPE2KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK2C7_HUMAN
AccessioniPrimary (citable) accession number: P08729
Secondary accession number(s): Q92676, Q9BUD8, Q9Y3R7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: January 11, 2011
Last modified: November 30, 2016
This is version 184 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.