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Protein

Keratin, type I cytoskeletal 19

Gene

KRT19

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei267 – 2671Stutter
Sitei327 – 3271Stutter

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc
  • structural constituent of muscle Source: UniProtKB

GO - Biological processi

  • cell differentiation involved in embryonic placenta development Source: Ensembl
  • Notch signaling pathway Source: Ensembl
  • response to estrogen Source: UniProtKB
  • sarcomere organization Source: UniProtKB
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

SIGNORiP08727.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
Keratin-19
Short name:
K19
Gene namesi
Name:KRT19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6436. KRT19.

Subcellular locationi

GO - Cellular componenti

  • cell periphery Source: MGI
  • costamere Source: UniProtKB
  • dystrophin-associated glycoprotein complex Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • intermediate filament Source: ProtInc
  • plasma membrane Source: CACAO
  • sarcolemma Source: Ensembl
  • terminal web Source: Ensembl
  • Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi10 – 101S → A: No effect on phosphorylation; no functional effect. 1 Publication
Mutagenesisi35 – 351S → A: Abolishes phosphorylation; induces perinuclear collapse or short cytoplasmic filaments. 1 Publication

Organism-specific databases

PharmGKBiPA30225.

Polymorphism and mutation databases

BioMutaiKRT19.
DMDMi311033484.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Keratin, type I cytoskeletal 19PRO_0000063671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei14 – 141PhosphoserineCombined sources
Modified residuei22 – 221PhosphoserineCombined sources
Modified residuei35 – 351Phosphoserine1 Publication
Modified residuei40 – 401PhosphoserineBy similarity
Modified residuei57 – 571PhosphoserineBy similarity
Modified residuei72 – 721PhosphoserineBy similarity
Modified residuei323 – 3231PhosphothreonineCombined sources
Modified residuei391 – 3911Phosphotyrosine1 Publication
Modified residuei395 – 3951PhosphoserineCombined sources
Modified residuei397 – 3971PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP08727.
MaxQBiP08727.
PaxDbiP08727.
PeptideAtlasiP08727.
PRIDEiP08727.

2D gel databases

SWISS-2DPAGEP08727.

PTM databases

iPTMnetiP08727.
PhosphoSiteiP08727.
SwissPalmiP08727.

Expressioni

Tissue specificityi

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.3 Publications

Developmental stagei

Present in hair follicles at all stages of development.1 Publication

Gene expression databases

BgeeiENSG00000171345.
ExpressionAtlasiP08727. baseline and differential.
GenevisibleiP08727. HS.

Organism-specific databases

HPAiCAB000031.
HPA002465.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMOTL2Q9Y2J4-43EBI-742756,EBI-10187270
C1orf109Q9NX043EBI-742756,EBI-8643161
CARD9Q9H2573EBI-742756,EBI-751319
CCDC146Q8IYE0-23EBI-742756,EBI-10247802
CEP57L1Q8IYX8-23EBI-742756,EBI-10181988
DMDP115322EBI-742756,EBI-295827
EIF4E2O605733EBI-742756,EBI-398610
EIF4ENIF1Q9NRA83EBI-742756,EBI-301024
FAM124BQ9H5Z63EBI-742756,EBI-741626
HAUS1Q96CS23EBI-742756,EBI-2514791
IKZF3Q9UKT93EBI-742756,EBI-747204
KIFC3Q9BVG83EBI-742756,EBI-2125614
KRT2P359083EBI-742756,EBI-1247312
POLR1CO151603EBI-742756,EBI-1055079
PPP1R18Q6NYC83EBI-742756,EBI-2557469
TBC1D7Q9P0N93EBI-742756,EBI-3258000
TFPTG5E9B53EBI-742756,EBI-10178002
UBE2IQ7KZS03EBI-742756,EBI-10180829

Protein-protein interaction databases

BioGridi110078. 50 interactions.
DIPiDIP-35655N.
IntActiP08727. 38 interactions.
MINTiMINT-1438883.
STRINGi9606.ENSP00000355124.

Structurei

3D structure databases

ProteinModelPortaliP08727.
SMRiP08727. Positions 130-228, 297-386.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7979HeadAdd
BLAST
Regioni80 – 387308RodAdd
BLAST
Regioni80 – 11536Coil 1AAdd
BLAST
Regioni116 – 13318Linker 1Add
BLAST
Regioni134 – 22592Coil 1BAdd
BLAST
Regioni226 – 24823Linker 12Add
BLAST
Regioni244 – 390147Necessary for interaction with PNNAdd
BLAST
Regioni249 – 387139Coil 2Add
BLAST
Regioni388 – 40013Rod-like helical tailAdd
BLAST

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiP08727.
KOiK07604.
OMAiDAHYNNL.
OrthoDBiEOG091G087I.
PhylomeDBiP08727.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA
60 70 80 90 100
RFVSSSSSGA YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA
110 120 130 140 150
LEAANGELEV KIRDWYQKQG PGPSRDYSHY YTTIQDLRDK ILGATIENSR
160 170 180 190 200
IVLQIDNARL AADDFRTKFE TEQALRMSVE ADINGLRRVL DELTLARTDL
210 220 230 240 250
EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA PGTDLAKILS
260 270 280 290 300
DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR
310 320 330 340 350
RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG
360 370 380 390 400
DVRADSERQN QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL
Length:400
Mass (Da):44,106
Last modified:November 2, 2010 - v4
Checksum:iC559BBBACCE32DCB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501G → A in CAA68556 (PubMed:2447559).Curated
Sequence conflicti350 – 3501G → A in AAF27048 (PubMed:10623642).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601A → G.Combined sources6 Publications
Corresponds to variant rs4602 [ dbSNP | Ensembl ].
VAR_014629

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03607 Genomic DNA. Translation: AAA36044.1.
Y00503 mRNA. Translation: CAA68556.1.
AF202321 Genomic DNA. Translation: AAF27048.1.
AK313261 mRNA. Translation: BAG36071.1.
AC019349 Genomic DNA. No translation available.
BC002539 mRNA. Translation: AAH02539.3.
BC007628 mRNA. Translation: AAH07628.1.
BC010409 mRNA. Translation: AAH10409.3.
BC067744 mRNA. Translation: AAH67744.2.
BC084574 mRNA. Translation: AAH84574.2.
AB045973 Genomic DNA. Translation: BAB40770.1.
AB041267 mRNA. Translation: BAA94607.1.
CCDSiCCDS11399.1.
PIRiA31370. KRHU9.
RefSeqiNP_002267.2. NM_002276.4.
UniGeneiHs.654568.

Genome annotation databases

EnsembliENST00000361566; ENSP00000355124; ENSG00000171345.
GeneIDi3880.
KEGGihsa:3880.
UCSCiuc002hxd.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03607 Genomic DNA. Translation: AAA36044.1.
Y00503 mRNA. Translation: CAA68556.1.
AF202321 Genomic DNA. Translation: AAF27048.1.
AK313261 mRNA. Translation: BAG36071.1.
AC019349 Genomic DNA. No translation available.
BC002539 mRNA. Translation: AAH02539.3.
BC007628 mRNA. Translation: AAH07628.1.
BC010409 mRNA. Translation: AAH10409.3.
BC067744 mRNA. Translation: AAH67744.2.
BC084574 mRNA. Translation: AAH84574.2.
AB045973 Genomic DNA. Translation: BAB40770.1.
AB041267 mRNA. Translation: BAA94607.1.
CCDSiCCDS11399.1.
PIRiA31370. KRHU9.
RefSeqiNP_002267.2. NM_002276.4.
UniGeneiHs.654568.

3D structure databases

ProteinModelPortaliP08727.
SMRiP08727. Positions 130-228, 297-386.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110078. 50 interactions.
DIPiDIP-35655N.
IntActiP08727. 38 interactions.
MINTiMINT-1438883.
STRINGi9606.ENSP00000355124.

PTM databases

iPTMnetiP08727.
PhosphoSiteiP08727.
SwissPalmiP08727.

Polymorphism and mutation databases

BioMutaiKRT19.
DMDMi311033484.

2D gel databases

SWISS-2DPAGEP08727.

Proteomic databases

EPDiP08727.
MaxQBiP08727.
PaxDbiP08727.
PeptideAtlasiP08727.
PRIDEiP08727.

Protocols and materials databases

DNASUi3880.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000361566; ENSP00000355124; ENSG00000171345.
GeneIDi3880.
KEGGihsa:3880.
UCSCiuc002hxd.5. human.

Organism-specific databases

CTDi3880.
GeneCardsiKRT19.
HGNCiHGNC:6436. KRT19.
HPAiCAB000031.
HPA002465.
MIMi148020. gene.
neXtProtiNX_P08727.
PharmGKBiPA30225.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFTF. Eukaryota.
ENOG410Y9IV. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiP08727.
KOiK07604.
OMAiDAHYNNL.
OrthoDBiEOG091G087I.
PhylomeDBiP08727.
TreeFamiTF332742.

Enzyme and pathway databases

SIGNORiP08727.

Miscellaneous databases

ChiTaRSiKRT19. human.
GeneWikiiKeratin_19.
GenomeRNAii3880.
PROiP08727.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000171345.
ExpressionAtlasiP08727. baseline and differential.
GenevisibleiP08727. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C19_HUMAN
AccessioniPrimary (citable) accession number: P08727
Secondary accession number(s): B2R874
, Q5XG83, Q6NW33, Q7L5M9, Q96A53, Q96FV1, Q9BYF9, Q9P1Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 174 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.