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P08727

- K1C19_HUMAN

UniProt

P08727 - K1C19_HUMAN

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Protein

Keratin, type I cytoskeletal 19

Gene
KRT19
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei267 – 2671Stutter
Sitei327 – 3271Stutter

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. structural constituent of cytoskeleton Source: ProtInc
  3. structural constituent of muscle Source: UniProtKB

GO - Biological processi

  1. cell differentiation involved in embryonic placenta development Source: Ensembl
  2. response to estrogen Source: UniProtKB
  3. sarcomere organization Source: UniProtKB
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 19
Alternative name(s):
Cytokeratin-19
Short name:
CK-19
Keratin-19
Short name:
K19
Gene namesi
Name:KRT19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6436. KRT19.

Subcellular locationi

GO - Cellular componenti

  1. cell periphery Source: MGI
  2. costamere Source: UniProtKB
  3. dystrophin-associated glycoprotein complex Source: Ensembl
  4. extracellular vesicular exosome Source: UniProt
  5. intermediate filament Source: ProtInc
  6. sarcolemma Source: Ensembl
  7. Z disc Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi10 – 101S → A: No effect on phosphorylation; no functional effect. 1 Publication
Mutagenesisi35 – 351S → A: Abolishes phosphorylation; induces perinuclear collapse or short cytoplasmic filaments. 1 Publication

Organism-specific databases

PharmGKBiPA30225.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Keratin, type I cytoskeletal 19PRO_0000063671Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei35 – 351Phosphoserine1 Publication
Modified residuei391 – 3911Phosphotyrosine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP08727.
PaxDbiP08727.
PeptideAtlasiP08727.
PRIDEiP08727.

2D gel databases

SWISS-2DPAGEP08727.

PTM databases

PhosphoSiteiP08727.

Expressioni

Tissue specificityi

Expressed in a defined zone of basal keratinocytes in the deep outer root sheath of hair follicles. Also observed in sweat gland and mammary gland ductal and secretory cells, bile ducts, gastrointestinal tract, bladder urothelium, oral epithelia, esophagus, ectocervical epithelium (at protein level). Expressed in epidermal basal cells, in nipple epidermis and a defined region of the hair follicle. Also seen in a subset of vascular wall cells in both the veins and artery of human umbilical cord, and in umbilical cord vascular smooth muscle. Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma in structures that contain dystrophin and spectrin.3 Publications

Developmental stagei

Present in hair follicles at all stages of development.1 Publication

Gene expression databases

BgeeiP08727.
GenevestigatoriP08727.

Organism-specific databases

HPAiCAB000031.
HPA002465.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins. Interacts with PNN and the actin-binding domain of DMD. Interacts with HCV core protein.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
DMDP115322EBI-742756,EBI-295827

Protein-protein interaction databases

BioGridi110078. 36 interactions.
DIPiDIP-35655N.
IntActiP08727. 19 interactions.
MINTiMINT-1438883.

Structurei

3D structure databases

ProteinModelPortaliP08727.
SMRiP08727. Positions 130-228, 297-386.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 7979HeadAdd
BLAST
Regioni80 – 387308RodAdd
BLAST
Regioni80 – 11536Coil 1AAdd
BLAST
Regioni116 – 13318Linker 1Add
BLAST
Regioni134 – 22592Coil 1BAdd
BLAST
Regioni226 – 24823Linker 12Add
BLAST
Regioni244 – 390147Necessary for interaction with PNNAdd
BLAST
Regioni249 – 387139Coil 2Add
BLAST
Regioni388 – 40013Rod-like helical tailAdd
BLAST

Domaini

This keratin differs from all other IF proteins in lacking the C-terminal tail domain.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148784.
HOVERGENiHBG013015.
InParanoidiP08727.
KOiK07604.
OMAiGQEDHYN.
OrthoDBiEOG7FV3Q8.
PhylomeDBiP08727.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08727-1 [UniParc]FASTAAdd to Basket

« Hide

MTSYSYRQSS ATSSFGGLGG GSVRFGPGVA FRAPSIHGGS GGRGVSVSSA    50
RFVSSSSSGA YGGGYGGVLT ASDGLLAGNE KLTMQNLNDR LASYLDKVRA 100
LEAANGELEV KIRDWYQKQG PGPSRDYSHY YTTIQDLRDK ILGATIENSR 150
IVLQIDNARL AADDFRTKFE TEQALRMSVE ADINGLRRVL DELTLARTDL 200
EMQIEGLKEE LAYLKKNHEE EISTLRGQVG GQVSVEVDSA PGTDLAKILS 250
DMRSQYEVMA EQNRKDAEAW FTSRTEELNR EVAGHTEQLQ MSRSEVTDLR 300
RTLQGLEIEL QSQLSMKAAL EDTLAETEAR FGAQLAHIQA LISGIEAQLG 350
DVRADSERQN QEYQRLMDIK SRLEQEIATY RSLLEGQEDH YNNLSASKVL 400
Length:400
Mass (Da):44,106
Last modified:November 2, 2010 - v4
Checksum:iC559BBBACCE32DCB
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti60 – 601A → G.7 Publications
Corresponds to variant rs4602 [ dbSNP | Ensembl ].
VAR_014629

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti350 – 3501G → A in CAA68556. 1 Publication
Sequence conflicti350 – 3501G → A in AAF27048. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03607 Genomic DNA. Translation: AAA36044.1.
Y00503 mRNA. Translation: CAA68556.1.
AF202321 Genomic DNA. Translation: AAF27048.1.
AK313261 mRNA. Translation: BAG36071.1.
AC019349 Genomic DNA. No translation available.
BC002539 mRNA. Translation: AAH02539.3.
BC007628 mRNA. Translation: AAH07628.1.
BC010409 mRNA. Translation: AAH10409.3.
BC067744 mRNA. Translation: AAH67744.2.
BC084574 mRNA. Translation: AAH84574.2.
AB045973 Genomic DNA. Translation: BAB40770.1.
AB041267 mRNA. Translation: BAA94607.1.
CCDSiCCDS11399.1.
PIRiA31370. KRHU9.
RefSeqiNP_002267.2. NM_002276.4.
UniGeneiHs.654568.

Genome annotation databases

EnsembliENST00000361566; ENSP00000355124; ENSG00000171345.
GeneIDi3880.
KEGGihsa:3880.
UCSCiuc002hxd.4. human.

Polymorphism databases

DMDMi311033484.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J03607 Genomic DNA. Translation: AAA36044.1 .
Y00503 mRNA. Translation: CAA68556.1 .
AF202321 Genomic DNA. Translation: AAF27048.1 .
AK313261 mRNA. Translation: BAG36071.1 .
AC019349 Genomic DNA. No translation available.
BC002539 mRNA. Translation: AAH02539.3 .
BC007628 mRNA. Translation: AAH07628.1 .
BC010409 mRNA. Translation: AAH10409.3 .
BC067744 mRNA. Translation: AAH67744.2 .
BC084574 mRNA. Translation: AAH84574.2 .
AB045973 Genomic DNA. Translation: BAB40770.1 .
AB041267 mRNA. Translation: BAA94607.1 .
CCDSi CCDS11399.1.
PIRi A31370. KRHU9.
RefSeqi NP_002267.2. NM_002276.4.
UniGenei Hs.654568.

3D structure databases

ProteinModelPortali P08727.
SMRi P08727. Positions 130-228, 297-386.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110078. 36 interactions.
DIPi DIP-35655N.
IntActi P08727. 19 interactions.
MINTi MINT-1438883.

PTM databases

PhosphoSitei P08727.

Polymorphism databases

DMDMi 311033484.

2D gel databases

SWISS-2DPAGE P08727.

Proteomic databases

MaxQBi P08727.
PaxDbi P08727.
PeptideAtlasi P08727.
PRIDEi P08727.

Protocols and materials databases

DNASUi 3880.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000361566 ; ENSP00000355124 ; ENSG00000171345 .
GeneIDi 3880.
KEGGi hsa:3880.
UCSCi uc002hxd.4. human.

Organism-specific databases

CTDi 3880.
GeneCardsi GC17M039679.
HGNCi HGNC:6436. KRT19.
HPAi CAB000031.
HPA002465.
MIMi 148020. gene.
neXtProti NX_P08727.
PharmGKBi PA30225.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG148784.
HOVERGENi HBG013015.
InParanoidi P08727.
KOi K07604.
OMAi GQEDHYN.
OrthoDBi EOG7FV3Q8.
PhylomeDBi P08727.
TreeFami TF332742.

Miscellaneous databases

ChiTaRSi KRT19. human.
GeneWikii Keratin_19.
GenomeRNAii 3880.
NextBioi 15231.
PROi P08727.
SOURCEi Search...

Gene expression databases

Bgeei P08727.
Genevestigatori P08727.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence of cDNA coding for human keratin 19."
    Stasiak P.C., Lane E.B.
    Nucleic Acids Res. 15:10058-10058(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-60.
    Tissue: Placenta.
  2. "Low level expression of cytokeratins 8, 18 and 19 in vascular smooth muscle cells of human umbilical cord and in cultured cells derived therefrom, with an analysis of the chromosomal locus containing the cytokeratin 19 gene."
    Bader B.L., Jahn L., Franke W.W.
    Eur. J. Cell Biol. 47:300-319(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY.
  3. "Sequence of the human 40-kDa keratin reveals an unusual structure with very high sequence identity to the corresponding bovine keratin."
    Eckert R.L.
    Proc. Natl. Acad. Sci. U.S.A. 85:1114-1118(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-60.
  4. "Keratin 19: predicted amino acid sequence and broad tissue distribution suggest it evolved from keratinocyte keratins."
    Stasiak P.C., Purkis P.E., Leigh I.M., Lane E.B.
    J. Invest. Dermatol. 92:707-716(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANT GLY-60.
    Tissue: Placenta.
  5. "Genomic organization and amplification of the human keratin 15 and 19 genes."
    Whittock N.V., Eady R.A.J., McGrath J.A.
    Biochem. Biophys. Res. Commun. 267:462-465(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-60.
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-60.
    Tissue: Placenta.
  7. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-60.
    Tissue: Mammary gland, Pancreas and Placenta.
  9. "Cloning and characterization of the 5'-flanking region of human cytokeratin 19 gene in human cholangiocarcinoma cell line."
    Kagaya M., Kaneko S., Ohno H., Inamura K., Kobayashi K.
    J. Hepatol. 35:504-511(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-9.
    Tissue: Peripheral blood leukocyte.
  10. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-31; 151-158 AND 227-237.
    Tissue: Keratinocyte.
  11. "Diversity of keratin 19 gene expressed in lymph nodes of breast cancer patients -- strategy to clear the discrepancy between histological findings and RT-PCR results in the detection of micrometastasis."
    Sato T., Weerasinghe A., Kuwano Y., Kaneko T., Ikeda T., Nagai T., Makino H., Sano M., Honma K., Nemoto K., Abo T., Shima Y.
    Seibutsu Butsuri Kagaku 44:201-204(2000)
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 145-352.
    Tissue: Lymph node.
  12. "Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization."
    Zhou X., Liao J., Hu L., Feng L., Omary M.B.
    J. Biol. Chem. 274:12861-12866(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-35, MUTAGENESIS OF SER-10 AND SER-35.
  13. "Dissection of protein linkage between keratins and pinin, a protein with dual location at desmosome-intermediate filament complex and in the nucleus."
    Shi J., Sugrue S.P.
    J. Biol. Chem. 275:14910-14915(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PNN.
  14. "Specific interaction of the actin-binding domain of dystrophin with intermediate filaments containing keratin 19."
    Stone M.R., O'Neill A., Catino D., Bloch R.J.
    Mol. Biol. Cell 16:4280-4293(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INTERACTION WITH DMD, TISSUE SPECIFICITY.
  15. "Characterization of in vivo keratin 19 phosphorylation on tyrosine-391."
    Zhou Q., Snider N.T., Liao J., Li D.H., Hong A., Ku N.O., Cartwright C.A., Omary M.B.
    PLoS ONE 5:E13538-E13538(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-391.
  16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  17. Cited for: VARIANT [LARGE SCALE ANALYSIS] GLY-60, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiK1C19_HUMAN
AccessioniPrimary (citable) accession number: P08727
Secondary accession number(s): B2R874
, Q5XG83, Q6NW33, Q7L5M9, Q96A53, Q96FV1, Q9BYF9, Q9P1Y4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 2, 2010
Last modified: September 3, 2014
This is version 155 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi