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Protein

40S ribosomal protein S17

Gene

RPS17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • erythrocyte homeostasis Source: UniProtKB
  • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: Reactome
  • ribosomal small subunit assembly Source: GO_Central
  • ribosomal small subunit biogenesis Source: UniProtKB
  • rRNA processing Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome
  • translation Source: UniProtKB
  • translational initiation Source: UniProtKB
  • viral transcription Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

BioCyciZFISH:G66-33151-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
40S ribosomal protein S17Curated
Gene namesi
Name:RPS17Imported
Synonyms:RPS17LImported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:10397. RPS17.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • cytosolic small ribosomal subunit Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • extracellular matrix Source: BHF-UCL
  • focal adhesion Source: UniProtKB
  • membrane Source: UniProtKB
  • nucleoplasm Source: Reactome
  • ribosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Diamond-Blackfan anemia 4 (DBA4)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
See also OMIM:612527

Keywords - Diseasei

Diamond-Blackfan anemia

Organism-specific databases

DisGeNETi6218.
MalaCardsiRPS17.
MIMi612527. phenotype.
OpenTargetsiENSG00000182774.
ENSG00000278229.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34797.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001415252 – 13540S ribosomal protein S17Add BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19N6-succinyllysineBy similarity1
Cross-linki103Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)Combined sources
Modified residuei113PhosphoserineCombined sources1
Modified residuei130PhosphothreonineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP08708.
PaxDbiP08708.
PeptideAtlasiP08708.
PRIDEiP08708.
TopDownProteomicsiP08708.
P0CW22.

PTM databases

iPTMnetiP08708.
PhosphoSitePlusiP08708.
SwissPalmiP08708.

Expressioni

Gene expression databases

BgeeiENSG00000184779.
CleanExiHS_RPS17.
ExpressionAtlasiP08708. baseline and differential.
GenevisibleiP08708. HS.

Organism-specific databases

HPAiHPA055060.

Interactioni

Protein-protein interaction databases

BioGridi112132. 100 interactors.
IntActiP08708. 32 interactors.
MINTiMINT-5002404.
STRINGi9606.ENSP00000346046.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SR1-135[»]
4V6Xelectron microscopy5.00AR1-135[»]
5A2Qelectron microscopy3.90R1-135[»]
5AJ0electron microscopy3.50BR1-135[»]
5FLXelectron microscopy3.90R1-135[»]
ProteinModelPortaliP08708.
SMRiP08708.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S17e family.Curated

Phylogenomic databases

eggNOGiKOG0187. Eukaryota.
COG1383. LUCA.
GeneTreeiENSGT00390000006548.
HOGENOMiHOG000227166.
HOVERGENiHBG001708.
InParanoidiP08708.
KOiK02962.
OMAiVGMNFRT.
OrthoDBiEOG091G0TNU.
PhylomeDBiP08708.
TreeFamiTF317992.

Family and domain databases

Gene3Di1.10.60.20. 1 hit.
HAMAPiMF_00511. Ribosomal_S17e. 1 hit.
InterProiIPR001210. Ribosomal_S17e.
IPR018273. Ribosomal_S17e_CS.
[Graphical view]
PANTHERiPTHR10732. PTHR10732. 1 hit.
PfamiPF00833. Ribosomal_S17e. 1 hit.
[Graphical view]
SUPFAMiSSF116820. SSF116820. 1 hit.
PROSITEiPS00712. RIBOSOMAL_S17E. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08708-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRVRTKTVK KAARVIIEKY YTRLGNDFHT NKRVCEEIAI IPSKKLRNKI
60 70 80 90 100
AGYVTHLMKR IQRGPVRGIS IKLQEEERER RDNYVPEVSA LDQEIIEVDP
110 120 130
DTKEMLKLLD FGSLSNLQVT QPTVGMNFKT PRGPV
Length:135
Mass (Da):15,550
Last modified:January 23, 2007 - v2
Checksum:i299AD605C5401325
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03447836E → K.Corresponds to variant rs1043734dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13932 mRNA. Translation: AAA60284.1.
M18000 Genomic DNA. Translation: AAA60285.1.
AK026570 mRNA. Translation: BAB15501.1.
AK311951 mRNA. Translation: BAG34891.1.
AC245033 Genomic DNA. No translation available.
CH471188 Genomic DNA. Translation: EAW62454.1.
BC009407 mRNA. Translation: AAH09407.1.
BC019899 mRNA. Translation: AAH19899.1.
BC022370 mRNA. Translation: AAH22370.1.
BC049824 mRNA. Translation: AAH49824.1.
BC070222 mRNA. Translation: AAH70222.1.
BC062715 mRNA. Translation: AAH62715.1.
BC071928 mRNA. Translation: AAH71928.1.
CCDSiCCDS10320.1.
PIRiJT0405. R4HU17.
RefSeqiNP_001012.1. NM_001021.4.
UniGeneiHs.433427.
Hs.512525.

Genome annotation databases

EnsembliENST00000330244; ENSP00000346046; ENSG00000182774.
ENST00000617731; ENSP00000483755; ENSG00000278229.
GeneIDi6218.
KEGGihsa:6218.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Diamond-Blackfan Anemia mutation database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13932 mRNA. Translation: AAA60284.1.
M18000 Genomic DNA. Translation: AAA60285.1.
AK026570 mRNA. Translation: BAB15501.1.
AK311951 mRNA. Translation: BAG34891.1.
AC245033 Genomic DNA. No translation available.
CH471188 Genomic DNA. Translation: EAW62454.1.
BC009407 mRNA. Translation: AAH09407.1.
BC019899 mRNA. Translation: AAH19899.1.
BC022370 mRNA. Translation: AAH22370.1.
BC049824 mRNA. Translation: AAH49824.1.
BC070222 mRNA. Translation: AAH70222.1.
BC062715 mRNA. Translation: AAH62715.1.
BC071928 mRNA. Translation: AAH71928.1.
CCDSiCCDS10320.1.
PIRiJT0405. R4HU17.
RefSeqiNP_001012.1. NM_001021.4.
UniGeneiHs.433427.
Hs.512525.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UG0electron microscopy-SR1-135[»]
4V6Xelectron microscopy5.00AR1-135[»]
5A2Qelectron microscopy3.90R1-135[»]
5AJ0electron microscopy3.50BR1-135[»]
5FLXelectron microscopy3.90R1-135[»]
ProteinModelPortaliP08708.
SMRiP08708.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112132. 100 interactors.
IntActiP08708. 32 interactors.
MINTiMINT-5002404.
STRINGi9606.ENSP00000346046.

PTM databases

iPTMnetiP08708.
PhosphoSitePlusiP08708.
SwissPalmiP08708.

Proteomic databases

EPDiP08708.
PaxDbiP08708.
PeptideAtlasiP08708.
PRIDEiP08708.
TopDownProteomicsiP08708.
P0CW22.

Protocols and materials databases

DNASUi6218.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330244; ENSP00000346046; ENSG00000182774.
ENST00000617731; ENSP00000483755; ENSG00000278229.
GeneIDi6218.
KEGGihsa:6218.

Organism-specific databases

CTDi6218.
DisGeNETi6218.
GeneCardsiRPS17.
GeneReviewsiRPS17.
HGNCiHGNC:10397. RPS17.
HPAiHPA055060.
MalaCardsiRPS17.
MIMi180472. gene.
612527. phenotype.
neXtProtiNX_P08708.
OpenTargetsiENSG00000182774.
ENSG00000278229.
Orphaneti124. Blackfan-Diamond anemia.
PharmGKBiPA34797.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0187. Eukaryota.
COG1383. LUCA.
GeneTreeiENSGT00390000006548.
HOGENOMiHOG000227166.
HOVERGENiHBG001708.
InParanoidiP08708.
KOiK02962.
OMAiVGMNFRT.
OrthoDBiEOG091G0TNU.
PhylomeDBiP08708.
TreeFamiTF317992.

Enzyme and pathway databases

BioCyciZFISH:G66-33151-MONOMER.
ReactomeiR-HSA-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-HSA-156902. Peptide chain elongation.
R-HSA-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-HSA-192823. Viral mRNA Translation.
R-HSA-2408557. Selenocysteine synthesis.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.
R-HSA-72649. Translation initiation complex formation.
R-HSA-72689. Formation of a pool of free 40S subunits.
R-HSA-72695. Formation of the ternary complex, and subsequently, the 43S complex.
R-HSA-72702. Ribosomal scanning and start codon recognition.
R-HSA-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-HSA-72764. Eukaryotic Translation Termination.
R-HSA-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-HSA-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

GeneWikiiRPS17.
GenomeRNAii6218.
PROiP0CW22.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000184779.
CleanExiHS_RPS17.
ExpressionAtlasiP08708. baseline and differential.
GenevisibleiP08708. HS.

Family and domain databases

Gene3Di1.10.60.20. 1 hit.
HAMAPiMF_00511. Ribosomal_S17e. 1 hit.
InterProiIPR001210. Ribosomal_S17e.
IPR018273. Ribosomal_S17e_CS.
[Graphical view]
PANTHERiPTHR10732. PTHR10732. 1 hit.
PfamiPF00833. Ribosomal_S17e. 1 hit.
[Graphical view]
SUPFAMiSSF116820. SSF116820. 1 hit.
PROSITEiPS00712. RIBOSOMAL_S17E. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRS17_HUMAN
AccessioniPrimary (citable) accession number: P08708
Secondary accession number(s): B2R4U4, P0CW22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.