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Protein

Interleukin-3

Gene

IL3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164399-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP08700.
SIGNORiP08700.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3
Short name:
IL-3
Alternative name(s):
Hematopoietic growth factor
Mast cell growth factor
Short name:
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor
Gene namesi
Name:IL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:6011. IL3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3562.
OpenTargetsiENSG00000164399.
PharmGKBiPA29830.

Chemistry databases

DrugBankiDB01025. Amlexanox.

Polymorphism and mutation databases

BioMutaiIL3.
DMDMi124330.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000001551620 – 152Interleukin-3Add BLAST133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi35 ↔ 103
Glycosylationi89N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08700.
PeptideAtlasiP08700.
PRIDEiP08700.
TopDownProteomicsiP08700.

Expressioni

Tissue specificityi

Activated T-cells, mast cells, natural killer cells.

Gene expression databases

BgeeiENSG00000164399.
CleanExiHS_IL3.
GenevisibleiP08700. HS.

Organism-specific databases

HPAiCAB013718.

Interactioni

Subunit structurei

Monomer.

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • interleukin-3 receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi109777. 3 interactors.
DIPiDIP-6N.
IntActiP08700. 1 interactor.
STRINGi9606.ENSP00000296870.

Structurei

Secondary structure

1152
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi35 – 45Combined sources11
Helixi61 – 68Combined sources8
Helixi73 – 86Combined sources14
Helixi91 – 100Combined sources10
Helixi101 – 103Combined sources3
Helixi123 – 141Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
ProteinModelPortaliP08700.
SMRiP08700.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08700.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JJGT. Eukaryota.
ENOG411147A. LUCA.
GeneTreeiENSGT00730000111772.
HOGENOMiHOG000037939.
HOVERGENiHBG004103.
InParanoidiP08700.
KOiK04736.
OMAiNCSNMID.
OrthoDBiEOG091G0W94.
PhylomeDBiP08700.
TreeFamiTF338567.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view]
PANTHERiPTHR10079. PTHR10079. 1 hit.
PfamiPF02059. IL3. 1 hit.
[Graphical view]
PIRSFiPIRSF001939. IL-3. 1 hit.
PRINTSiPR00430. INTERLEUKIN3.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08700-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP
60 70 80 90 100
LPLLDFNNLN GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL
110 120 130 140 150
LPCLPLATAA PTRHPIHIKD GDWNEFRRKL TFYLKTLENA QAQQTTLSLA

IF
Length:152
Mass (Da):17,233
Last modified:October 1, 1989 - v2
Checksum:iBB46F23FAC1259A4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0340143R → C.Corresponds to variant rs35415145dbSNPEnsembl.1
Natural variantiVAR_01307115R → H.1 PublicationCorresponds to variant rs2069787dbSNPEnsembl.1
Natural variantiVAR_01307227P → S.3 PublicationsCorresponds to variant rs40401dbSNPEnsembl.1
Natural variantiVAR_03401560N → S.Corresponds to variant rs35482671dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14743 mRNA. Translation: AAA59146.1.
M20137 mRNA. Translation: AAA59147.1.
M17115 mRNA. Translation: AAA35725.1.
AF365976 Genomic DNA. Translation: AAK38378.1.
AC004511 Genomic DNA. Translation: AAC08706.1.
BC066272 mRNA. Translation: AAH66272.1.
BC066273 mRNA. Translation: AAH66273.1.
BC066276 mRNA. Translation: AAH66276.1.
BC069472 mRNA. Translation: AAH69472.1.
CCDSiCCDS4149.1.
PIRiA24427.
RefSeqiNP_000579.2. NM_000588.3.
UniGeneiHs.694.

Genome annotation databases

EnsembliENST00000296870; ENSP00000296870; ENSG00000164399.
GeneIDi3562.
KEGGihsa:3562.
UCSCiuc003kwe.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14743 mRNA. Translation: AAA59146.1.
M20137 mRNA. Translation: AAA59147.1.
M17115 mRNA. Translation: AAA35725.1.
AF365976 Genomic DNA. Translation: AAK38378.1.
AC004511 Genomic DNA. Translation: AAC08706.1.
BC066272 mRNA. Translation: AAH66272.1.
BC066273 mRNA. Translation: AAH66273.1.
BC066276 mRNA. Translation: AAH66276.1.
BC069472 mRNA. Translation: AAH69472.1.
CCDSiCCDS4149.1.
PIRiA24427.
RefSeqiNP_000579.2. NM_000588.3.
UniGeneiHs.694.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
ProteinModelPortaliP08700.
SMRiP08700.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109777. 3 interactors.
DIPiDIP-6N.
IntActiP08700. 1 interactor.
STRINGi9606.ENSP00000296870.

Chemistry databases

DrugBankiDB01025. Amlexanox.

Polymorphism and mutation databases

BioMutaiIL3.
DMDMi124330.

Proteomic databases

PaxDbiP08700.
PeptideAtlasiP08700.
PRIDEiP08700.
TopDownProteomicsiP08700.

Protocols and materials databases

DNASUi3562.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000296870; ENSP00000296870; ENSG00000164399.
GeneIDi3562.
KEGGihsa:3562.
UCSCiuc003kwe.2. human.

Organism-specific databases

CTDi3562.
DisGeNETi3562.
GeneCardsiIL3.
HGNCiHGNC:6011. IL3.
HPAiCAB013718.
MIMi147740. gene.
neXtProtiNX_P08700.
OpenTargetsiENSG00000164399.
PharmGKBiPA29830.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410JJGT. Eukaryota.
ENOG411147A. LUCA.
GeneTreeiENSGT00730000111772.
HOGENOMiHOG000037939.
HOVERGENiHBG004103.
InParanoidiP08700.
KOiK04736.
OMAiNCSNMID.
OrthoDBiEOG091G0W94.
PhylomeDBiP08700.
TreeFamiTF338567.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000164399-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-512988. Interleukin-3, 5 and GM-CSF signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP08700.
SIGNORiP08700.

Miscellaneous databases

EvolutionaryTraceiP08700.
GeneWikiiInterleukin_3.
GenomeRNAii3562.
PROiP08700.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000164399.
CleanExiHS_IL3.
GenevisibleiP08700. HS.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view]
PANTHERiPTHR10079. PTHR10079. 1 hit.
PfamiPF02059. IL3. 1 hit.
[Graphical view]
PIRSFiPIRSF001939. IL-3. 1 hit.
PRINTSiPR00430. INTERLEUKIN3.
SUPFAMiSSF47266. SSF47266. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIL3_HUMAN
AccessioniPrimary (citable) accession number: P08700
Secondary accession number(s): Q6GS87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 1, 1989
Last modified: November 2, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.