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P08700

- IL3_HUMAN

UniProt

P08700 - IL3_HUMAN

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Protein
Interleukin-3
Gene
IL3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages.
This CSF induces granulocytes, macrophages, mast cells, stem cells, erythroid cells, eosinophils and megakaryocytes.

GO - Molecular functioni

  1. interleukin-3 receptor binding Source: UniProtKB

GO - Biological processi

  1. cell-cell signaling Source: ProtInc
  2. embryonic hemopoiesis Source: DFLAT
  3. immune response Source: InterPro
  4. nervous system development Source: ProtInc
  5. positive regulation of DNA replication Source: BHF-UCL
  6. positive regulation of cell proliferation Source: UniProtKB
  7. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
  8. positive regulation of tyrosine phosphorylation of Stat5 protein Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Enzyme and pathway databases

ReactomeiREACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
SignaLinkiP08700.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-3
Short name:
IL-3
Alternative name(s):
Hematopoietic growth factor
Mast cell growth factor
Short name:
MCGF
Multipotential colony-stimulating factor
P-cell-stimulating factor
Gene namesi
Name:IL3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:6011. IL3.

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: Reactome
  2. extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29830.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 152133Interleukin-3
PRO_0000015516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi35 ↔ 103
Glycosylationi89 – 891N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP08700.
PRIDEiP08700.

PTM databases

PhosphoSiteiP08700.

Expressioni

Tissue specificityi

Activated T-cells, mast cells, natural killer cells.

Gene expression databases

BgeeiP08700.
CleanExiHS_IL3.
GenevestigatoriP08700.

Interactioni

Subunit structurei

Monomer.

Binary interactionsi

WithEntry#Exp.IntActNotes
CSF2RBP329271EBI-1811718,EBI-1809771

Protein-protein interaction databases

BioGridi109777. 3 interactions.
DIPiDIP-6N.
IntActiP08700. 1 interaction.
STRINGi9606.ENSP00000296870.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi35 – 4511
Helixi61 – 688
Helixi73 – 8614
Helixi91 – 10010
Helixi101 – 1033
Helixi123 – 14119

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1JLINMR-A34-144[»]
ProteinModelPortaliP08700.
SMRiP08700. Positions 34-144.

Miscellaneous databases

EvolutionaryTraceiP08700.

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-3 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG72146.
HOGENOMiHOG000037939.
HOVERGENiHBG004103.
InParanoidiP08700.
KOiK04736.
OMAiQNASAIE.
OrthoDBiEOG7NKKNN.
PhylomeDBiP08700.
TreeFamiTF338567.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view]
PANTHERiPTHR10079. PTHR10079. 1 hit.
PfamiPF02059. IL3. 1 hit.
[Graphical view]
PIRSFiPIRSF001939. IL-3. 1 hit.
PRINTSiPR00430. INTERLEUKIN3.
SUPFAMiSSF47266. SSF47266. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08700-1 [UniParc]FASTAAdd to Basket

« Hide

MSRLPVLLLL QLLVRPGLQA PMTQTTPLKT SWVNCSNMID EIITHLKQPP    50
LPLLDFNNLN GEDQDILMEN NLRRPNLEAF NRAVKSLQNA SAIESILKNL 100
LPCLPLATAA PTRHPIHIKD GDWNEFRRKL TFYLKTLENA QAQQTTLSLA 150
IF 152
Length:152
Mass (Da):17,233
Last modified:October 1, 1989 - v2
Checksum:iBB46F23FAC1259A4
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31R → C.
Corresponds to variant rs35415145 [ dbSNP | Ensembl ].
VAR_034014
Natural varianti15 – 151R → H.1 Publication
Corresponds to variant rs2069787 [ dbSNP | Ensembl ].
VAR_013071
Natural varianti27 – 271P → S.3 Publications
Corresponds to variant rs40401 [ dbSNP | Ensembl ].
VAR_013072
Natural varianti60 – 601N → S.
Corresponds to variant rs35482671 [ dbSNP | Ensembl ].
VAR_034015

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14743 mRNA. Translation: AAA59146.1.
M20137 mRNA. Translation: AAA59147.1.
M17115 mRNA. Translation: AAA35725.1.
AF365976 Genomic DNA. Translation: AAK38378.1.
AC004511 Genomic DNA. Translation: AAC08706.1.
BC066272 mRNA. Translation: AAH66272.1.
BC066273 mRNA. Translation: AAH66273.1.
BC066276 mRNA. Translation: AAH66276.1.
BC069472 mRNA. Translation: AAH69472.1.
CCDSiCCDS4149.1.
PIRiA24427.
RefSeqiNP_000579.2. NM_000588.3.
UniGeneiHs.694.

Genome annotation databases

EnsembliENST00000296870; ENSP00000296870; ENSG00000164399.
GeneIDi3562.
KEGGihsa:3562.
UCSCiuc003kwe.1. human.

Polymorphism databases

DMDMi124330.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14743 mRNA. Translation: AAA59146.1 .
M20137 mRNA. Translation: AAA59147.1 .
M17115 mRNA. Translation: AAA35725.1 .
AF365976 Genomic DNA. Translation: AAK38378.1 .
AC004511 Genomic DNA. Translation: AAC08706.1 .
BC066272 mRNA. Translation: AAH66272.1 .
BC066273 mRNA. Translation: AAH66273.1 .
BC066276 mRNA. Translation: AAH66276.1 .
BC069472 mRNA. Translation: AAH69472.1 .
CCDSi CCDS4149.1.
PIRi A24427.
RefSeqi NP_000579.2. NM_000588.3.
UniGenei Hs.694.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1JLI NMR - A 34-144 [» ]
ProteinModelPortali P08700.
SMRi P08700. Positions 34-144.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109777. 3 interactions.
DIPi DIP-6N.
IntActi P08700. 1 interaction.
STRINGi 9606.ENSP00000296870.

Chemistry

DrugBanki DB01025. Amlexanox.

PTM databases

PhosphoSitei P08700.

Polymorphism databases

DMDMi 124330.

Proteomic databases

PaxDbi P08700.
PRIDEi P08700.

Protocols and materials databases

DNASUi 3562.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000296870 ; ENSP00000296870 ; ENSG00000164399 .
GeneIDi 3562.
KEGGi hsa:3562.
UCSCi uc003kwe.1. human.

Organism-specific databases

CTDi 3562.
GeneCardsi GC05P131396.
HGNCi HGNC:6011. IL3.
MIMi 147740. gene.
neXtProti NX_P08700.
PharmGKBi PA29830.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72146.
HOGENOMi HOG000037939.
HOVERGENi HBG004103.
InParanoidi P08700.
KOi K04736.
OMAi QNASAIE.
OrthoDBi EOG7NKKNN.
PhylomeDBi P08700.
TreeFami TF338567.

Enzyme and pathway databases

Reactomei REACT_23837. Interleukin-3, 5 and GM-CSF signaling.
REACT_23891. Interleukin receptor SHC signaling.
SignaLinki P08700.

Miscellaneous databases

EvolutionaryTracei P08700.
GeneWikii Interleukin_3.
GenomeRNAii 3562.
NextBioi 13912.
PROi P08700.
SOURCEi Search...

Gene expression databases

Bgeei P08700.
CleanExi HS_IL3.
Genevestigatori P08700.

Family and domain databases

Gene3Di 1.20.1250.10. 1 hit.
InterProi IPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR002183. IL-3.
[Graphical view ]
PANTHERi PTHR10079. PTHR10079. 1 hit.
Pfami PF02059. IL3. 1 hit.
[Graphical view ]
PIRSFi PIRSF001939. IL-3. 1 hit.
PRINTSi PR00430. INTERLEUKIN3.
SUPFAMi SSF47266. SSF47266. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a human multilineage-colony-stimulating factor cDNA clone identified by a conserved noncoding sequence in mouse interleukin-3."
    Dorssers L., Burger H., Bot F., Delwel R., Geurts van Kessel A.H.M., Loewenberg B., Wagemaker G.
    Gene 55:115-124(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Isolation and characterization of an expressible cDNA encoding human IL-3. Induction of IL-3 mRNA in human T cell clones."
    Otsuka T., Miyajima A., Brown N., Otsu K., Abrams J., Saeland S., Caux C., de Waal Malefijt R., de Vries J., Meyerson P., Yokota K., Gemmel L., Rennick D., Lee F., Arai N., Arai K., Yokota T.
    J. Immunol. 140:2288-2295(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Human IL-3 (multi-CSF): identification by expression cloning of a novel hematopoietic growth factor related to murine IL-3."
    Yang Y.-C., Ciarletta A.B., Temple P.A., Chung M.P., Kovacic S., Witek-Giannotti J.S., Leary A.C., Kriz R., Donahue R.E., Wong G.G., Clark S.C.
    Cell 47:3-10(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. SeattleSNPs variation discovery resource
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS HIS-15 AND SER-27.
  5. "The DNA sequence and comparative analysis of human chromosome 5."
    Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
    , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
    Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT SER-27.
  7. "Molecular characterization of colony-stimulating factors and their receptors: human interleukin-3."
    Urdal D.L., Price V., Sassenfeld H.M., Cosman D., Gillis S., Park L.S.
    Ann. N. Y. Acad. Sci. 554:167-176(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 20-152, VARIANT SER-27.
  8. "Three-dimensional solution structure and backbone dynamics of a variant of human interleukin-3."
    Feng Y., Klein B.K., McWherter C.A.
    J. Mol. Biol. 259:524-541(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiIL3_HUMAN
AccessioniPrimary (citable) accession number: P08700
Secondary accession number(s): Q6GS87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: October 1, 1989
Last modified: September 3, 2014
This is version 151 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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