ID   BPHC_PSEPS              Reviewed;         303 AA.
AC   P08695;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-MAR-2009, entry version 60.
DE   RecName: Full=Biphenyl-2,3-diol 1,2-dioxygenase;
DE            EC=1.13.11.39;
DE   AltName: Full=23OHBP oxygenase;
DE   AltName: Full=2,3-dihydroxybiphenyl dioxygenase;
DE            Short=DHBD;
GN   Name=bphC;
OS   Pseudomonas pseudoalcaligenes.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=330;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KF707;
RX   MEDLINE=87083404; PubMed=3793719;
RA   Furukawa K., Arimura N., Miyazaki T.;
RT   "Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of
RT   Pseudomonas pseudoalcaligenes.";
RL   J. Bacteriol. 169:427-429(1987).
CC   -!- CATALYTIC ACTIVITY: Biphenyl-2,3-diol + O(2) = 2-hydroxy-6-oxo-6-
CC       phenylhexa-2,4-dienoate + H(2)O.
CC   -!- COFACTOR: Fe(2+) ion.
CC   -!- PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-
CC       2,4-pentadienoic acid and benzoic acid from biphenyl: step 3/4.
CC   -!- SUBUNIT: Homooctamer.
CC   -!- SIMILARITY: Belongs to the extradiol ring-cleavage dioxygenase
CC       family.
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DR   EMBL; M15333; AAA25753.1; -; Genomic_DNA.
DR   HSSP; P47228; 1KND.
DR   SMR; P08695; 2-288.
DR   BRENDA; 1.13.11.39; 3804.
DR   GO; GO:0018583; F:biphenyl-2,3-diol 1,2-dioxygenase activity; IEA:EC.
DR   GO; GO:0008198; F:ferrous iron binding; IEA:InterPro.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0042178; P:xenobiotic catabolic process; IEA:InterPro.
DR   InterPro; IPR017626; DiOHbiphenyl_dOase.
DR   InterPro; IPR004360; Glyas_bleo-R_dOase.
DR   InterPro; IPR000486; Xdiol_dOase_1_2.
DR   Pfam; PF00903; Glyoxalase; 2.
DR   ProDom; PD002334; Gly_diox; 2.
DR   TIGRFAMs; TIGR03213; 23dbph12diox; 1.
DR   PROSITE; PS00082; EXTRADIOL_DIOXYGENAS; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; Dioxygenase; Iron; Metal-binding;
KW   Oxidoreductase.
FT   INIT_MET      1      1       Removed.
FT   CHAIN         2    303       Biphenyl-2,3-diol 1,2-dioxygenase.
FT                                /FTId=PRO_0000085034.
FT   METAL       146    146       Iron (By similarity).
FT   METAL       210    210       Iron (By similarity).
FT   METAL       260    260       Iron (By similarity).
SQ   SEQUENCE   303 AA;  33206 MW;  6844D0ABBD81FED5 CRC64;
     MSIRSLGYMG FAVSDVAAWR SFLTQKLGLM EAGTTDNGDL FRIDSRAWRI AVQQGEVDDL
     AFAGYEVADA AGLAQMADKL KQAGIAVTTG DASLARRRGV TGLITFADPF GLPLEIYYGA
     SEVFEKPFLP GAAVSGFLTG EQGLGHFVRC VPDSDKALAF YTDVLGFQLS DVIDMKMGPD
     VTVPVYFLHC NERHHTLAIA AFPLPKRIHH FMLEVASLDD VGFAFDRVDA DGLITSTLGR
     HTNDHMVSFY ASTPSGVEVE YGWSARTVDR SWVVVRHDSP SMWGHKSVRD KALRATKHEQ
     QPE
//