ID   BPHB_PSEPS              Reviewed;         275 AA.
AC   P08694;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1991, sequence version 2.
DT   16-JUN-2009, entry version 62.
DE   RecName: Full=Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase;
DE            EC=1.3.1.56;
DE   AltName: Full=Biphenyl-2,3-dihydro-2,3-diol dehydrogenase;
DE   AltName: Full=Biphenyl-cis-diol dehydrogenase;
DE   AltName: Full=2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase;
DE   AltName: Full=2,3-dihydroxy-4-phenylhexa-4,6-diene dehydrogenase;
GN   Name=bphB;
OS   Pseudomonas pseudoalcaligenes.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=330;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=KF707;
RX   MEDLINE=87083404; PubMed=3793719;
RA   Furukawa K., Arimura N., Miyazaki T.;
RT   "Nucleotide sequence of the 2,3-dihydroxybiphenyl dioxygenase gene of
RT   Pseudomonas pseudoalcaligenes.";
RL   J. Bacteriol. 169:427-429(1987).
CC   -!- CATALYTIC ACTIVITY: Cis-3-phenylcyclohexa-3,5-diene-1,2-diol +
CC       NAD(+) = biphenyl-2,3-diol + NADH.
CC   -!- PATHWAY: Xenobiotic degradation; biphenyl degradation; 2-hydroxy-
CC       2,4-pentadienoic acid and benzoic acid from biphenyl: step 2/4.
CC   -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases
CC       (SDR) family.
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DR   EMBL; M15333; AAA25752.1; ALT_INIT; Genomic_DNA.
DR   HSSP; P47227; 1BDB.
DR   SMR; P08694; 1-274.
DR   BRENDA; 1.3.1.56; 3804.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0018509; F:cis-2,3-dihydrobiphenyl-2,3-diol dehydrogen...; IEA:EC.
DR   GO; GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR017711; BphB_TodD.
DR   InterPro; IPR002198; DH_sc/Rdtase_SDR.
DR   InterPro; IPR002347; Glc/ribitol_DH.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   PANTHER; PTHR19410; ADH_short_C2; 1.
DR   Pfam; PF00106; adh_short; 1.
DR   PRINTS; PR00081; GDHRDH.
DR   PRINTS; PR00080; SDRFAMILY.
DR   TIGRFAMs; TIGR03325; BphB_TodD; 1.
DR   PROSITE; PS00061; ADH_SHORT; 1.
PE   3: Inferred from homology;
KW   Aromatic hydrocarbons catabolism; NAD; Oxidoreductase.
FT   CHAIN         1    275       Cis-2,3-dihydrobiphenyl-2,3-diol
FT                                dehydrogenase.
FT                                /FTId=PRO_0000054533.
FT   NP_BIND       9     33       NAD (By similarity).
FT   ACT_SITE    153    153       Proton acceptor (By similarity).
FT   BINDING     140    140       Substrate (By similarity).
SQ   SEQUENCE   275 AA;  28726 MW;  F32A4A870B47E566 CRC64;
     MKLKGEAVLI TGGASGLGRA LVDRFVAEAK VAVLDKSAER LAELETDLGD NVLGIVGDVR
     SLEDQKQAAS RCVARFGKID TLIPNAGIWD YSTALVDLPE ESLDAAFDEV FHINVKGYIH
     AVKALPALVA SRGNVIFTIS NAGFYPNGGG PLYTAAKQAI VGLVRELAFE LAPYVRVNGV
     GPGGMNSDMR GPSSLGMGSK AISTVPLADM LKSVLPIGRM PEVEEYTGAY VFFATRGDAA
     PASGALVNYD GGLGVRGFFS GAGGNDLLEQ LNIHP
//