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Protein

Arsenate reductase

Gene

arsC

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.

Catalytic activityi

Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Arsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase (EC:1.20.4.1)
Alternative name(s):
Arsenical pump modifier
Gene namesi
Name:arsC
Encoded oniPlasmid R7730 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 141141Arsenate reductasePRO_0000162537Add
BLAST

Structurei

Secondary structure

1
141
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 73Combined sources
Helixi13 – 2412Combined sources
Beta strandi30 – 323Combined sources
Turni34 – 363Combined sources
Helixi41 – 5111Combined sources
Helixi55 – 584Combined sources
Beta strandi61 – 633Combined sources
Helixi64 – 685Combined sources
Turni69 – 724Combined sources
Helixi78 – 8710Combined sources
Helixi89 – 913Combined sources
Beta strandi96 – 994Combined sources
Beta strandi102 – 1054Combined sources
Helixi109 – 1146Combined sources
Beta strandi131 – 1333Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I9DX-ray1.65A1-141[»]
1J9BX-ray1.26A1-141[»]
1JZWX-ray1.76A1-140[»]
1S3CX-ray1.25A1-141[»]
1S3DX-ray1.54A3-140[»]
1SD8X-ray1.59A1-141[»]
1SD9X-ray1.65A1-141[»]
1SJZX-ray1.80A1-140[»]
1SK0X-ray1.80A1-140[»]
1SK1X-ray1.55A1-140[»]
1SK2X-ray1.54A1-140[»]
ProteinModelPortaliP08692.
SMRiP08692. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08692.

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family.Curated

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IILYLENPPS RDELVKLIAD
60 70 80 90 100
MGISVRALLR KNVEPYEQLG LAEDKFTDDQ LIDFMLQHPI LINRPIVVTP
110 120 130 140
LGTRLCRPSE VVLDILQDAQ KGAFTKEDGE KVVDEAGKRL K
Length:141
Mass (Da):15,830
Last modified:January 1, 1988 - v1
Checksum:i240F4105487E2FBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02591 Genomic DNA. Translation: AAA21096.1.
PIRiC25937.
RefSeqiWP_011117598.1. NZ_CP010317.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02591 Genomic DNA. Translation: AAA21096.1.
PIRiC25937.
RefSeqiWP_011117598.1. NZ_CP010317.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1I9DX-ray1.65A1-141[»]
1J9BX-ray1.26A1-141[»]
1JZWX-ray1.76A1-140[»]
1S3CX-ray1.25A1-141[»]
1S3DX-ray1.54A3-140[»]
1SD8X-ray1.59A1-141[»]
1SD9X-ray1.65A1-141[»]
1SJZX-ray1.80A1-140[»]
1SK0X-ray1.80A1-140[»]
1SK1X-ray1.55A1-140[»]
1SK2X-ray1.54A1-140[»]
ProteinModelPortaliP08692.
SMRiP08692. Positions 3-140.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP08692.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR006659. Arsenate_reductase.
IPR006660. Arsenate_reductase-like.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF03960. ArsC. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR00014. arsC. 1 hit.
PROSITEiPS51353. ARSC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide sequence of the structural genes for an anion pump. The plasmid-encoded arsenical resistance operon."
    Chen C.-M., Misra T.K., Silver S., Rosen B.P.
    J. Biol. Chem. 261:15030-15038(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular analysis of an anion pump: purification of the ArsC protein."
    Rosen B.P., Weigel U., Monticello R.A., Edwards B.P.F.
    Arch. Biochem. Biophys. 284:381-385(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 5-13.
  3. "The plasmid-encoded arsenical resistance pump: an anion-translocating ATPase."
    Rosen B.P.
    Res. Microbiol. 141:336-341(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiARSC1_ECOLX
AccessioniPrimary (citable) accession number: P08692
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 14, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.