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Protein

Arsenate reductase

Gene

arsC

Organism
Escherichia coli
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance.

Catalytic activityi

Arsenate + glutaredoxin = arsenite + glutaredoxin disulfide + H2O.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processArsenical resistance

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenate reductase (EC:1.20.4.1)
Alternative name(s):
Arsenical pump modifier
Gene namesi
Name:arsC
Encoded oniPlasmid R7730 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Pathology & Biotechi

Chemistry databases

DrugBankiDB03352 S-Arsonocysteine
DB03289 Thiarsa Dihydroxy Cysteine
DB01808 Thiarsahydroxy-Cysteine
DB04456 Trihydroxyarsenite(Iii)

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001625371 – 141Arsenate reductaseAdd BLAST141

Structurei

Secondary structure

1141
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 7Combined sources3
Helixi13 – 24Combined sources12
Beta strandi30 – 32Combined sources3
Turni34 – 36Combined sources3
Helixi41 – 51Combined sources11
Helixi55 – 58Combined sources4
Beta strandi61 – 63Combined sources3
Helixi64 – 68Combined sources5
Turni69 – 72Combined sources4
Helixi78 – 87Combined sources10
Helixi89 – 91Combined sources3
Beta strandi96 – 99Combined sources4
Beta strandi102 – 105Combined sources4
Helixi109 – 114Combined sources6
Beta strandi131 – 133Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1I9DX-ray1.65A1-141[»]
1J9BX-ray1.26A1-141[»]
1JZWX-ray1.76A1-140[»]
1S3CX-ray1.25A1-141[»]
1S3DX-ray1.54A3-140[»]
1SD8X-ray1.59A1-141[»]
1SD9X-ray1.65A1-141[»]
1SJZX-ray1.80A1-140[»]
1SK0X-ray1.80A1-140[»]
1SK1X-ray1.55A1-140[»]
1SK2X-ray1.54A1-140[»]
ProteinModelPortaliP08692
SMRiP08692
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08692

Family & Domainsi

Sequence similaritiesi

Belongs to the ArsC family.Curated

Family and domain databases

CDDicd03034 ArsC_ArsC, 1 hit
InterProiView protein in InterPro
IPR006659 Arsenate_reductase
IPR006660 Arsenate_reductase-like
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF03960 ArsC, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
TIGRFAMsiTIGR00014 arsC, 1 hit
PROSITEiView protein in PROSITE
PS51353 ARSC, 1 hit

Sequencei

Sequence statusi: Complete.

P08692-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNITIYHNP ACGTSRNTLE MIRNSGTEPT IILYLENPPS RDELVKLIAD
60 70 80 90 100
MGISVRALLR KNVEPYEQLG LAEDKFTDDQ LIDFMLQHPI LINRPIVVTP
110 120 130 140
LGTRLCRPSE VVLDILQDAQ KGAFTKEDGE KVVDEAGKRL K
Length:141
Mass (Da):15,830
Last modified:January 1, 1988 - v1
Checksum:i240F4105487E2FBF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02591 Genomic DNA Translation: AAA21096.1
PIRiC25937
RefSeqiWP_011117598.1, NZ_PIJR01000022.1

Similar proteinsi

Entry informationi

Entry nameiARSC1_ECOLX
AccessioniPrimary (citable) accession number: P08692
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 23, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Plasmid

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