ID ARSA1_ECOLX Reviewed; 583 AA. AC P08690; DT 01-JAN-1988, integrated into UniProtKB/Swiss-Prot. DT 01-JAN-1988, sequence version 1. DT 13-SEP-2023, entry version 122. DE RecName: Full=Arsenical pump-driving ATPase; DE EC=7.3.2.7; DE AltName: Full=Arsenical resistance ATPase; DE AltName: Full=Arsenite-translocating ATPase; DE AltName: Full=Arsenite-transporting ATPase; GN Name=arsA; OS Escherichia coli. OG Plasmid R773. OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; OC Enterobacteriaceae; Escherichia. OX NCBI_TaxID=562; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX PubMed=3021763; DOI=10.1016/s0021-9258(18)66824-3; RA Chen C.-M., Misra T.K., Silver S., Rosen B.P.; RT "Nucleotide sequence of the structural genes for an anion pump. The RT plasmid-encoded arsenical resistance operon."; RL J. Biol. Chem. 261:15030-15038(1986). RN [2] RP REVIEW. RX PubMed=1704144; DOI=10.1016/0923-2508(90)90008-e; RA Rosen B.P.; RT "The plasmid-encoded arsenical resistance pump: an anion-translocating RT ATPase."; RL Res. Microbiol. 141:336-341(1990). CC -!- FUNCTION: Anion-transporting ATPase. Catalyzes the extrusion of the CC oxyanions arsenite, antimonite and arsenate. Maintenance of a low CC intracellular concentration of oxyanion produces resistance to the CC toxic agents. CC -!- CATALYTIC ACTIVITY: CC Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) + CC phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7; CC -!- SIMILARITY: Belongs to the arsA ATPase family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02591; AAA21094.1; -; Genomic_DNA. DR PIR; A25937; A25937. DR PDB; 1F48; X-ray; 2.30 A; A=1-583. DR PDB; 1IHU; X-ray; 2.15 A; A=1-583. DR PDB; 1II0; X-ray; 2.40 A; A/B=1-583. DR PDB; 1II9; X-ray; 2.60 A; A/B=1-583. DR PDBsum; 1F48; -. DR PDBsum; 1IHU; -. DR PDBsum; 1II0; -. DR PDBsum; 1II9; -. DR AlphaFoldDB; P08690; -. DR SMR; P08690; -. DR DIP; DIP-16995N; -. DR DrugBank; DB02453; Antimonous acid. DR DrugBank; DB04456; Arsenous acid. DR DrugBank; DB04395; Phosphoaminophosphonic Acid-Adenylate Ester. DR TCDB; 3.A.4.1.1; the arsenite-antimonite (arsab) efflux family. DR BioCyc; MetaCyc:MONOMER-21684; -. DR BRENDA; 7.3.2.7; 2026. DR EvolutionaryTrace; P08690; -. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro. DR GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-EC. DR CDD; cd02035; ArsA; 2. DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2. DR InterPro; IPR003593; AAA+_ATPase. DR InterPro; IPR025723; Anion-transp_ATPase-like_dom. DR InterPro; IPR027541; Ars_ATPase. DR InterPro; IPR016300; ATPase_ArsA/GET3. DR InterPro; IPR027417; P-loop_NTPase. DR NCBIfam; TIGR04291; arsen_driv_ArsA; 1. DR NCBIfam; TIGR00345; GET3_arsA_TRC40; 1. DR PANTHER; PTHR10803; ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE; 1. DR PANTHER; PTHR10803:SF3; ATPASE GET3; 1. DR Pfam; PF02374; ArsA_ATPase; 3. DR PIRSF; PIRSF001327; Arsenical_pump-driving_ATPase; 1. DR SMART; SM00382; AAA; 2. DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2. PE 1: Evidence at protein level; KW 3D-structure; Arsenical resistance; ATP-binding; Nucleotide-binding; KW Plasmid; Translocase. FT CHAIN 1..583 FT /note="Arsenical pump-driving ATPase" FT /id="PRO_0000152251" FT BINDING 15..22 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT BINDING 334..341 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000255" FT HELIX 2..4 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 9..14 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 21..34 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 39..43 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 50..53 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 71..75 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 78..90 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 91..93 FT /evidence="ECO:0007829|PDB:1IHU" FT TURN 94..96 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 99..108 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 112..128 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 132..135 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 137..143 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 147..154 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 156..159 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 167..169 FT /evidence="ECO:0007829|PDB:1II0" FT HELIX 170..172 FT /evidence="ECO:0007829|PDB:1II0" FT HELIX 174..178 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 183..194 FT /evidence="ECO:0007829|PDB:1IHU" FT TURN 196..198 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 199..207 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 209..225 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 230..237 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 240..243 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 247..261 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 265..268 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 272..276 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 285..290 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 315..323 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 328..333 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 340..353 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 358..363 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 380..384 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 387..403 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 408..417 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 421..432 FT /evidence="ECO:0007829|PDB:1IHU" FT TURN 433..435 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 436..440 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 442..447 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 452..460 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 482..486 FT /evidence="ECO:0007829|PDB:1IHU" FT TURN 488..490 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 491..497 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 501..516 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 523..530 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 538..555 FT /evidence="ECO:0007829|PDB:1IHU" FT TURN 556..558 FT /evidence="ECO:0007829|PDB:1IHU" FT STRAND 560..566 FT /evidence="ECO:0007829|PDB:1IHU" FT HELIX 575..582 FT /evidence="ECO:0007829|PDB:1IHU" SQ SEQUENCE 583 AA; 63188 MW; 658C5AF65E5E75F5 CRC64; MQFLQNIPPY LFFTGKGGVG KTSISCATAI RLAEQGKRVL LVSTDPASNV GQVFSQTIGI TIQAIASVPG LSALEIDPQA AAQQYRARIV DPIKGVLPDD VVSSINEQLS GACTTEIAAF DEFTGLLTDA SLLTRFDHII FDTAPTGHTI RLLQLPGAWS SFIDSNPEGA SCLGPMAGLE KQREQYAYAV EALSDPKRTR LVLVARLQKS TLQEVARTHL ELAAIGLKNQ YLVINGVLPK TEAANDTLAA AIWEREQEAL ANLPADLAGL PTDTLFLQPV NMVGVSALSR LLSTQPVASP SSDEYLQQRP DIPSLSALVD DIARNEHGLI MLMGKGGVGK TTMAAAIAVR LADMGFDVHL TTSDPAAHLS MTLNGSLNNL QVSRIDPHEE TERYRQHVLE TKGKELDEAG KRLLEEDLRS PCTEEIAVFQ AFSRVIREAG KRFVVMDTAP TGHTLLLLDA TGAYHREIAK KMGEKGHFTT PMMLLQDPER TKVLLVTLPE TTPVLEAANL QADLERAGIH PWGWIINNSL SIADTRSPLL RMRAQQELPQ IESVKRQHAS RVALVPVLAS EPTGIDKLKQ LAG //