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Protein

Arsenical pump-driving ATPase

Gene

arsA

Organism
Escherichia coli
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Anion-transporting ATPase. Catalyzes the extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents.

Catalytic activityi

ATP + H2O + arsenite(In) = ADP + phosphate + arsenite(Out).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22ATPSequence analysis8
Nucleotide bindingi334 – 341ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Arsenical resistance

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.3.16. 2026.

Protein family/group databases

TCDBi3.A.4.1.1. the arsenite-antimonite (arsab) efflux family.

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenical pump-driving ATPase (EC:3.6.3.16)
Alternative name(s):
Arsenical resistance ATPase
Arsenite-translocating ATPase
Arsenite-transporting ATPase
Gene namesi
Name:arsA
Encoded oniPlasmid R7730 Publication
OrganismiEscherichia coli
Taxonomic identifieri562 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001522511 – 583Arsenical pump-driving ATPaseAdd BLAST583

Proteomic databases

PRIDEiP08690.

Interactioni

Protein-protein interaction databases

DIPiDIP-16995N.

Structurei

Secondary structure

1583
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2 – 4Combined sources3
Beta strandi9 – 14Combined sources6
Helixi21 – 34Combined sources14
Beta strandi39 – 43Combined sources5
Helixi50 – 53Combined sources4
Beta strandi71 – 75Combined sources5
Helixi78 – 90Combined sources13
Helixi91 – 93Combined sources3
Turni94 – 96Combined sources3
Helixi99 – 108Combined sources10
Helixi112 – 128Combined sources17
Helixi132 – 135Combined sources4
Beta strandi137 – 143Combined sources7
Helixi147 – 154Combined sources8
Helixi156 – 159Combined sources4
Beta strandi167 – 169Combined sources3
Helixi170 – 172Combined sources3
Helixi174 – 178Combined sources5
Helixi183 – 194Combined sources12
Turni196 – 198Combined sources3
Beta strandi199 – 207Combined sources9
Helixi209 – 225Combined sources17
Beta strandi230 – 237Combined sources8
Helixi240 – 243Combined sources4
Helixi247 – 261Combined sources15
Helixi265 – 268Combined sources4
Beta strandi272 – 276Combined sources5
Helixi285 – 290Combined sources6
Helixi315 – 323Combined sources9
Beta strandi328 – 333Combined sources6
Helixi340 – 353Combined sources14
Beta strandi358 – 363Combined sources6
Beta strandi380 – 384Combined sources5
Helixi387 – 403Combined sources17
Helixi408 – 417Combined sources10
Helixi421 – 432Combined sources12
Turni433 – 435Combined sources3
Helixi436 – 440Combined sources5
Beta strandi442 – 447Combined sources6
Helixi452 – 460Combined sources9
Helixi482 – 486Combined sources5
Turni488 – 490Combined sources3
Beta strandi491 – 497Combined sources7
Helixi501 – 516Combined sources16
Beta strandi523 – 530Combined sources8
Helixi538 – 555Combined sources18
Turni556 – 558Combined sources3
Beta strandi560 – 566Combined sources7
Helixi575 – 582Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F48X-ray2.30A1-583[»]
1IHUX-ray2.15A1-583[»]
1II0X-ray2.40A/B1-583[»]
1II9X-ray2.60A/B1-583[»]
ProteinModelPortaliP08690.
SMRiP08690.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08690.

Family & Domainsi

Sequence similaritiesi

Belongs to the arsA ATPase family.Curated

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025723. Anion-transp_ATPase-like_dom.
IPR027541. Ars_ATPase.
IPR016300. ATPase_ArsA/GET3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10803. PTHR10803. 1 hit.
PfamiPF02374. ArsA_ATPase. 3 hits.
[Graphical view]
PIRSFiPIRSF001327. Arsenical_pump-driving_ATPase. 1 hit.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR04291. arsen_driv_ArsA. 1 hit.
TIGR00345. GET3_arsA_TRC40. 1 hit.

Sequencei

Sequence statusi: Complete.

P08690-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFLQNIPPY LFFTGKGGVG KTSISCATAI RLAEQGKRVL LVSTDPASNV
60 70 80 90 100
GQVFSQTIGI TIQAIASVPG LSALEIDPQA AAQQYRARIV DPIKGVLPDD
110 120 130 140 150
VVSSINEQLS GACTTEIAAF DEFTGLLTDA SLLTRFDHII FDTAPTGHTI
160 170 180 190 200
RLLQLPGAWS SFIDSNPEGA SCLGPMAGLE KQREQYAYAV EALSDPKRTR
210 220 230 240 250
LVLVARLQKS TLQEVARTHL ELAAIGLKNQ YLVINGVLPK TEAANDTLAA
260 270 280 290 300
AIWEREQEAL ANLPADLAGL PTDTLFLQPV NMVGVSALSR LLSTQPVASP
310 320 330 340 350
SSDEYLQQRP DIPSLSALVD DIARNEHGLI MLMGKGGVGK TTMAAAIAVR
360 370 380 390 400
LADMGFDVHL TTSDPAAHLS MTLNGSLNNL QVSRIDPHEE TERYRQHVLE
410 420 430 440 450
TKGKELDEAG KRLLEEDLRS PCTEEIAVFQ AFSRVIREAG KRFVVMDTAP
460 470 480 490 500
TGHTLLLLDA TGAYHREIAK KMGEKGHFTT PMMLLQDPER TKVLLVTLPE
510 520 530 540 550
TTPVLEAANL QADLERAGIH PWGWIINNSL SIADTRSPLL RMRAQQELPQ
560 570 580
IESVKRQHAS RVALVPVLAS EPTGIDKLKQ LAG
Length:583
Mass (Da):63,188
Last modified:January 1, 1988 - v1
Checksum:i658C5AF65E5E75F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02591 Genomic DNA. Translation: AAA21094.1.
PIRiA25937.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02591 Genomic DNA. Translation: AAA21094.1.
PIRiA25937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F48X-ray2.30A1-583[»]
1IHUX-ray2.15A1-583[»]
1II0X-ray2.40A/B1-583[»]
1II9X-ray2.60A/B1-583[»]
ProteinModelPortaliP08690.
SMRiP08690.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-16995N.

Protein family/group databases

TCDBi3.A.4.1.1. the arsenite-antimonite (arsab) efflux family.

Proteomic databases

PRIDEiP08690.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

BRENDAi3.6.3.16. 2026.

Miscellaneous databases

EvolutionaryTraceiP08690.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025723. Anion-transp_ATPase-like_dom.
IPR027541. Ars_ATPase.
IPR016300. ATPase_ArsA/GET3.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10803. PTHR10803. 1 hit.
PfamiPF02374. ArsA_ATPase. 3 hits.
[Graphical view]
PIRSFiPIRSF001327. Arsenical_pump-driving_ATPase. 1 hit.
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
TIGRFAMsiTIGR04291. arsen_driv_ArsA. 1 hit.
TIGR00345. GET3_arsA_TRC40. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiARSA1_ECOLX
AccessioniPrimary (citable) accession number: P08690
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: November 2, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Plasmid

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.