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P08684

- CP3A4_HUMAN

UniProt

P08684 - CP3A4_HUMAN

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Protein

Cytochrome P450 3A4

Gene

CYP3A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.1 Publication

Catalytic activityi

Quinine + NADPH + O2 = 3-hydroxyquinine + NADP+ + H2O.1 Publication
Taurochenodeoxycholate + NADPH + O2 = taurohyocholate + NADP+ + H2O.1 Publication
Lithocholate + NADPH + O2 = hyodeoxycholate + NADP+ + H2O.1 Publication
Albendazole + NADPH + O2 = albendazole S-oxide + NADP+ + H2O.1 Publication
1,8-cineole + NADPH + O2 = 2-exo-hydroxy-1,8-cineole + NADP+ + H2O.1 Publication

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi442 – 4421Iron (heme axial ligand)

GO - Molecular functioni

  1. albendazole monooxygenase activity Source: UniProtKB-EC
  2. caffeine oxidase activity Source: BHF-UCL
  3. enzyme binding Source: BHF-UCL
  4. heme binding Source: InterPro
  5. iron ion binding Source: BHF-UCL
  6. monooxygenase activity Source: UniProtKB
  7. oxidoreductase activity Source: BHF-UCL
  8. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: InterPro
  9. oxygen binding Source: ProtInc
  10. quinine 3-monooxygenase activity Source: UniProtKB-EC
  11. steroid binding Source: BHF-UCL
  12. steroid hydroxylase activity Source: BHF-UCL
  13. taurochenodeoxycholate 6alpha-hydroxylase activity Source: UniProtKB-EC
  14. testosterone 6-beta-hydroxylase activity Source: BHF-UCL
  15. vitamin D 24-hydroxylase activity Source: BHF-UCL
  16. vitamin D3 25-hydroxylase activity Source: BHF-UCL

GO - Biological processi

  1. alkaloid catabolic process Source: BHF-UCL
  2. androgen metabolic process Source: BHF-UCL
  3. calcitriol biosynthetic process from calciol Source: GOC
  4. drug catabolic process Source: BHF-UCL
  5. drug metabolic process Source: BHF-UCL
  6. exogenous drug catabolic process Source: BHF-UCL
  7. heterocycle metabolic process Source: BHF-UCL
  8. lipid metabolic process Source: ProtInc
  9. monoterpenoid metabolic process Source: BHF-UCL
  10. oxidation-reduction process Source: BHF-UCL
  11. oxidative demethylation Source: BHF-UCL
  12. small molecule metabolic process Source: Reactome
  13. steroid catabolic process Source: BHF-UCL
  14. steroid metabolic process Source: BHF-UCL
  15. vitamin D metabolic process Source: BHF-UCL
  16. xenobiotic metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding, NADP

Enzyme and pathway databases

BioCyciMetaCyc:HS08544-MONOMER.
ReactomeiREACT_13543. Xenobiotics.
REACT_228214. Aflatoxin activation and detoxification.
SABIO-RKP08684.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 3A4 (EC:1.14.13.-)
Alternative name(s):
1,8-cineole 2-exo-monooxygenase (EC:1.14.13.157)
Albendazole monooxygenase (EC:1.14.13.32)
Albendazole sulfoxidase
CYPIIIA3
CYPIIIA4
Cytochrome P450 3A3
Cytochrome P450 HLp
Cytochrome P450 NF-25
Cytochrome P450-PCN1
Nifedipine oxidase
Quinine 3-monooxygenase (EC:1.14.13.67)
Taurochenodeoxycholate 6-alpha-hydroxylase (EC:1.14.13.97)
Gene namesi
Name:CYP3A4
Synonyms:CYP3A3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:2637. CYP3A4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei2 – 2221HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. endoplasmic reticulum membrane Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. intracellular membrane-bounded organelle Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA130.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 503502Cytochrome P450 3A4PRO_0000051786Add
BLAST

Post-translational modificationi

Polyubiquitinated in the presence of AMFR and UBE2G1 and also STUB1/CHIP and UBE2D1 (in vitro).1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiP08684.
PRIDEiP08684.

PTM databases

PhosphoSiteiP08684.

Expressioni

Tissue specificityi

Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level).6 Publications

Inductioni

By glucocorticoids. Also induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens.

Gene expression databases

BgeeiP08684.
CleanExiHS_CYP3A4.
ExpressionAtlasiP08684. baseline and differential.
GenevestigatoriP08684.

Organism-specific databases

HPAiCAB033671.

Interactioni

Protein-protein interaction databases

BioGridi107948. 9 interactions.
IntActiP08684. 2 interactions.
STRINGi9606.ENSP00000337915.

Structurei

Secondary structure

1
503
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi29 – 313Combined sources
Helixi32 – 365Combined sources
Turni45 – 473Combined sources
Helixi50 – 556Combined sources
Helixi57 – 6812Combined sources
Beta strandi70 – 767Combined sources
Beta strandi79 – 846Combined sources
Helixi87 – 948Combined sources
Turni95 – 1017Combined sources
Helixi112 – 1165Combined sources
Turni118 – 1203Combined sources
Helixi123 – 13311Combined sources
Helixi134 – 1374Combined sources
Helixi139 – 16628Combined sources
Helixi172 – 18918Combined sources
Helixi195 – 1973Combined sources
Helixi202 – 2076Combined sources
Beta strandi209 – 2124Combined sources
Beta strandi215 – 2173Combined sources
Helixi218 – 2258Combined sources
Helixi229 – 2357Combined sources
Helixi243 – 26220Combined sources
Helixi271 – 2799Combined sources
Helixi292 – 32231Combined sources
Helixi325 – 33814Combined sources
Turni340 – 3423Combined sources
Helixi347 – 3526Combined sources
Helixi354 – 36613Combined sources
Beta strandi369 – 3713Combined sources
Beta strandi373 – 3764Combined sources
Beta strandi381 – 3833Combined sources
Beta strandi386 – 3883Combined sources
Beta strandi393 – 3964Combined sources
Helixi398 – 4025Combined sources
Turni405 – 4073Combined sources
Beta strandi408 – 4103Combined sources
Helixi416 – 4194Combined sources
Helixi421 – 4244Combined sources
Turni429 – 4313Combined sources
Helixi438 – 4403Combined sources
Helixi445 – 46016Combined sources
Beta strandi463 – 4664Combined sources
Beta strandi469 – 4713Combined sources
Beta strandi479 – 4824Combined sources
Beta strandi485 – 4873Combined sources
Beta strandi490 – 4956Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TQNX-ray2.05A24-503[»]
1W0EX-ray2.80A25-503[»]
1W0FX-ray2.65A25-503[»]
1W0GX-ray2.74A25-503[»]
2J0DX-ray2.75A/B25-503[»]
2V0MX-ray2.80A/B/C/D25-503[»]
3NXUX-ray2.00A/B25-503[»]
3TJSX-ray2.25A1-503[»]
3UA1X-ray2.15A23-503[»]
4I3QX-ray2.60A23-503[»]
4I4GX-ray2.72A23-503[»]
4I4HX-ray2.90A23-503[»]
4K9TX-ray2.50A23-503[»]
4K9UX-ray2.85A23-503[»]
4K9VX-ray2.60A23-503[»]
4K9WX-ray2.40A/B/C/D23-503[»]
4K9XX-ray2.76A23-503[»]
4NY4X-ray2.95A25-503[»]
ProteinModelPortaliP08684.
SMRiP08684. Positions 28-499.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08684.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000039127.
HOVERGENiHBG108567.
InParanoidiP08684.
KOiK17689.
OMAiDMECHKK.
OrthoDBiEOG744TBS.
PhylomeDBiP08684.
TreeFamiTF105087.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08684-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MALIPDLAME TWLLLAVSLV LLYLYGTHSH GLFKKLGIPG PTPLPFLGNI
60 70 80 90 100
LSYHKGFCMF DMECHKKYGK VWGFYDGQQP VLAITDPDMI KTVLVKECYS
110 120 130 140 150
VFTNRRPFGP VGFMKSAISI AEDEEWKRLR SLLSPTFTSG KLKEMVPIIA
160 170 180 190 200
QYGDVLVRNL RREAETGKPV TLKDVFGAYS MDVITSTSFG VNIDSLNNPQ
210 220 230 240 250
DPFVENTKKL LRFDFLDPFF LSITVFPFLI PILEVLNICV FPREVTNFLR
260 270 280 290 300
KSVKRMKESR LEDTQKHRVD FLQLMIDSQN SKETESHKAL SDLELVAQSI
310 320 330 340 350
IFIFAGYETT SSVLSFIMYE LATHPDVQQK LQEEIDAVLP NKAPPTYDTV
360 370 380 390 400
LQMEYLDMVV NETLRLFPIA MRLERVCKKD VEINGMFIPK GVVVMIPSYA
410 420 430 440 450
LHRDPKYWTE PEKFLPERFS KKNKDNIDPY IYTPFGSGPR NCIGMRFALM
460 470 480 490 500
NMKLALIRVL QNFSFKPCKE TQIPLKLSLG GLLQPEKPVV LKVESRDGTV

SGA
Length:503
Mass (Da):57,343
Last modified:January 23, 2007 - v4
Checksum:i38ED122BF89F74F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti3 – 31L → V in AAA35747. (PubMed:2463251)Curated
Sequence conflicti12 – 121W → R in AAF13598. 1 PublicationCurated
Sequence conflicti72 – 721W → C in AAA35747. (PubMed:2463251)Curated
Sequence conflicti92 – 921T → L in BAA00001. (PubMed:3460094)Curated
Sequence conflicti92 – 921T → L in AAA35742. (PubMed:3460094)Curated
Sequence conflicti106 – 1061R → E in BAA00001. (PubMed:3460094)Curated
Sequence conflicti106 – 1061R → E in AAA35742. (PubMed:3460094)Curated
Sequence conflicti164 – 1641A → R in BAA00001. (PubMed:3460094)Curated
Sequence conflicti164 – 1641A → R in AAA35742. (PubMed:3460094)Curated
Sequence conflicti187 – 1871T → S in BAA00001. (PubMed:3460094)Curated
Sequence conflicti187 – 1871T → S in AAA35742. (PubMed:3460094)Curated
Sequence conflicti193 – 1931I → V in BAA00001. (PubMed:3460094)Curated
Sequence conflicti193 – 1931I → V in AAA35742. (PubMed:3460094)Curated
Sequence conflicti203 – 2031F → L in BAA00001. (PubMed:3460094)Curated
Sequence conflicti203 – 2031F → L in AAA35742. (PubMed:3460094)Curated
Sequence conflicti224 – 2252TV → I in AAA35747. (PubMed:2463251)Curated
Sequence conflicti279 – 2791Q → HK in BAA00001. (PubMed:3460094)Curated
Sequence conflicti279 – 2791Q → HK in AAA35742. (PubMed:3460094)Curated
Sequence conflicti307 – 3071Y → C in AAF13598. 1 PublicationCurated
Sequence conflicti392 – 3921V → W in BAA00001. (PubMed:3460094)Curated
Sequence conflicti392 – 3921V → W in AAA35742. (PubMed:3460094)Curated
Sequence conflicti392 – 3921V → W in AAA35744. (PubMed:3464943)Curated
Sequence conflicti392 – 3921V → W in CAA30944. (PubMed:2563251)Curated
Sequence conflicti392 – 3921V → W in AAA35747. (PubMed:2463251)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti15 – 151L → P in allele CYP3A4*14. 1 Publication
Corresponds to variant rs12721634 [ dbSNP | Ensembl ].
VAR_011597
Natural varianti56 – 561G → D in allele CYP3A4*7. 1 Publication
Corresponds to variant rs56324128 [ dbSNP | Ensembl ].
VAR_011598
Natural varianti96 – 961K → E.
Corresponds to variant rs3091339 [ dbSNP | Ensembl ].
VAR_037547
Natural varianti118 – 1181I → V in allele CYP3A4*4. 1 Publication
Corresponds to variant rs55951658 [ dbSNP | Ensembl ].
VAR_011599
Natural varianti130 – 1301R → Q in allele CYP3A4*8. 1 Publication
VAR_011600
Natural varianti162 – 1621R → Q in allele CYP3A4*15. 2 Publications
Corresponds to variant rs4986907 [ dbSNP | Ensembl ].
VAR_011601
Natural varianti170 – 1701V → I in allele CYP3A4*9. 1 Publication
VAR_011602
Natural varianti174 – 1741D → H in allele CYP3A4*10. 3 Publications
Corresponds to variant rs4986908 [ dbSNP | Ensembl ].
VAR_011603
Natural varianti185 – 1851T → S in allele CYP3A4*16. 2 Publications
Corresponds to variant rs12721627 [ dbSNP | Ensembl ].
VAR_011604
Natural varianti189 – 1891F → S in allele CYP3A4*17; exhibits lower turnover numbers for testosterone and chlorpyrifos. 1 Publication
Corresponds to variant rs4987161 [ dbSNP | Ensembl ].
VAR_014322
Natural varianti218 – 2181P → R in allele CYP3A4*5. 1 Publication
Corresponds to variant rs55901263 [ dbSNP | Ensembl ].
VAR_011605
Natural varianti222 – 2221S → P in allele CYP3A4*2; exhibits a lower intrinsic clearance toward nifedipine. 1 Publication
Corresponds to variant rs55785340 [ dbSNP | Ensembl ].
VAR_008363
Natural varianti252 – 2521S → A.1 Publication
Corresponds to variant rs3208363 [ dbSNP | Ensembl ].
VAR_037548
Natural varianti293 – 2931L → P in allele CYP3A4*18; exhibits higher turnover numbers for testosterone and chlorpyrifos. 2 Publications
Corresponds to variant rs28371759 [ dbSNP | Ensembl ].
VAR_014323
Natural varianti349 – 3491T → N.
Corresponds to variant rs10250778 [ dbSNP | Ensembl ].
VAR_037549
Natural varianti363 – 3631T → M in allele CYP3A4*11; unstable form. 1 Publication
Corresponds to variant rs67784355 [ dbSNP | Ensembl ].
VAR_011606
Natural varianti373 – 3731L → F in allele CYP3A4*12; has an altered testosterone hydroxylase activity. 2 Publications
Corresponds to variant rs12721629 [ dbSNP | Ensembl ].
VAR_011607
Natural varianti416 – 4161P → L in allele CYP3A4*13; lack of expression. 1 Publication
Corresponds to variant rs4986909 [ dbSNP | Ensembl ].
VAR_011608
Natural varianti431 – 4311I → T.2 Publications
Corresponds to variant rs1041988 [ dbSNP | Ensembl ].
VAR_037550
Natural varianti445 – 4451M → T in allele CYP3A4*3. 2 Publications
Corresponds to variant rs4986910 [ dbSNP | Ensembl ].
VAR_008364
Natural varianti467 – 4671P → S in allele CYP3A4*19. 1 Publication
Corresponds to variant rs4986913 [ dbSNP | Ensembl ].
VAR_014324

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00003 mRNA. Translation: BAA00001.1.
M13785 mRNA. Translation: AAA35742.1.
M18907 mRNA. Translation: AAA35745.1.
M14096 mRNA. Translation: AAA35744.1.
X12387 mRNA. Translation: CAA30944.1.
J04449 mRNA. Translation: AAA35747.1.
AF182273 mRNA. Translation: AAF13598.1.
AF280107 Genomic DNA. Translation: AAG32290.1.
AF209389 Genomic DNA. Translation: AAF21034.1.
CCDSiCCDS5674.1.
PIRiA29410.
A29815.
RefSeqiNP_001189784.1. NM_001202855.2.
NP_059488.2. NM_017460.5.
UniGeneiHs.728751.

Genome annotation databases

EnsembliENST00000336411; ENSP00000337915; ENSG00000160868.
GeneIDi1576.
KEGGihsa:1576.
UCSCiuc003urv.2. human.

Polymorphism databases

DMDMi116241312.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Cytochrome P450 Allele Nomenclature Committee

CYP3A4 alleles

Wikipedia

CYP3A4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D00003 mRNA. Translation: BAA00001.1 .
M13785 mRNA. Translation: AAA35742.1 .
M18907 mRNA. Translation: AAA35745.1 .
M14096 mRNA. Translation: AAA35744.1 .
X12387 mRNA. Translation: CAA30944.1 .
J04449 mRNA. Translation: AAA35747.1 .
AF182273 mRNA. Translation: AAF13598.1 .
AF280107 Genomic DNA. Translation: AAG32290.1 .
AF209389 Genomic DNA. Translation: AAF21034.1 .
CCDSi CCDS5674.1.
PIRi A29410.
A29815.
RefSeqi NP_001189784.1. NM_001202855.2.
NP_059488.2. NM_017460.5.
UniGenei Hs.728751.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1TQN X-ray 2.05 A 24-503 [» ]
1W0E X-ray 2.80 A 25-503 [» ]
1W0F X-ray 2.65 A 25-503 [» ]
1W0G X-ray 2.74 A 25-503 [» ]
2J0D X-ray 2.75 A/B 25-503 [» ]
2V0M X-ray 2.80 A/B/C/D 25-503 [» ]
3NXU X-ray 2.00 A/B 25-503 [» ]
3TJS X-ray 2.25 A 1-503 [» ]
3UA1 X-ray 2.15 A 23-503 [» ]
4I3Q X-ray 2.60 A 23-503 [» ]
4I4G X-ray 2.72 A 23-503 [» ]
4I4H X-ray 2.90 A 23-503 [» ]
4K9T X-ray 2.50 A 23-503 [» ]
4K9U X-ray 2.85 A 23-503 [» ]
4K9V X-ray 2.60 A 23-503 [» ]
4K9W X-ray 2.40 A/B/C/D 23-503 [» ]
4K9X X-ray 2.76 A 23-503 [» ]
4NY4 X-ray 2.95 A 25-503 [» ]
ProteinModelPortali P08684.
SMRi P08684. Positions 28-499.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107948. 9 interactions.
IntActi P08684. 2 interactions.
STRINGi 9606.ENSP00000337915.

Chemistry

BindingDBi P08684.
ChEMBLi CHEMBL2364675.
DrugBanki DB05812. Abiraterone.
DB01418. Acenocoumarol.
DB00316. Acetaminophen.
DB00819. Acetazolamide.
DB00546. Adinazolam.
DB05773. ado-trastuzumab emtansine.
DB00518. Albendazole.
DB00240. Alclometasone.
DB00041. Aldesleukin.
DB00802. Alfentanil.
DB00346. Alfuzosin.
DB01246. Alimemazine.
DB01258. Aliskiren.
DB01431. Allylestrenol.
DB00918. Almotriptan.
DB06203. Alogliptin.
DB00969. Alosetron.
DB00404. Alprazolam.
DB06742. Ambroxol.
DB00357. Aminoglutethimide.
DB01424. Aminophenazone.
DB01223. Aminophylline.
DB01118. Amiodarone.
DB00321. Amitriptyline.
DB00381. Amlodipine.
DB00701. Amprenavir.
DB01217. Anastrozole.
DB01435. Antipyrine.
DB06605. Apixaban.
DB00673. Aprepitant.
DB00278. Argatroban.
DB01238. Aripiprazole.
DB01169. Arsenic trioxide.
DB06697. Artemether.
DB06216. Asenapine.
DB00637. Astemizole.
DB01072. Atazanavir.
DB00289. Atomoxetine.
DB01076. Atorvastatin.
DB06237. Avanafil.
DB06626. Axitinib.
DB00719. Azatadine.
DB00972. Azelastine.
DB00207. Azithromycin.
DB08903. Bedaquiline.
DB00865. Benzphetamine.
DB06770. Benzyl alcohol.
DB00443. Betamethasone.
DB00307. Bexarotene.
DB01393. Bezafibrate.
DB01128. Bicalutamide.
DB04794. Bifonazole.
DB00612. Bisoprolol.
DB08873. Boceprevir.
DB00188. Bortezomib.
DB00559. Bosentan.
DB06616. Bosutinib.
DB08870. Brentuximab vedotin.
DB01194. Brinzolamide.
DB01558. Bromazepam.
DB01200. Bromocriptine.
DB00835. Brompheniramine.
DB01222. Budesonide.
DB00297. Bupivacaine.
DB00921. Buprenorphine.
DB01156. Bupropion.
DB00490. Buspirone.
DB01008. Busulfan.
DB06772. Cabazitaxel.
DB00248. Cabergoline.
DB08875. Cabozantinib.
DB00201. Caffeine.
DB00136. Calcitriol.
DB08907. Canagliflozin.
DB00564. Carbamazepine.
DB00748. Carbinoxamine.
DB01136. Carvedilol.
DB00520. Caspofungin.
DB01333. Cefradine.
DB00482. Celecoxib.
DB00567. Cephalexin.
DB00185. Cevimeline.
DB06777. Chenodeoxycholic acid.
DB00446. Chloramphenicol.
DB00475. Chlordiazepoxide.
DB00608. Chloroquine.
DB01114. Chlorphenamine.
DB00856. Chlorphenesin.
DB00477. Chlorpromazine.
DB00356. Chlorzoxazone.
DB00169. Cholecalciferol.
DB01410. Ciclesonide.
DB01166. Cilostazol.
DB00501. Cimetidine.
DB01012. Cinacalcet.
DB00537. Ciprofloxacin.
DB00604. Cisapride.
DB00215. Citalopram.
DB01211. Clarithromycin.
DB00283. Clemastine.
DB04920. Clevidipine.
DB01190. Clindamycin.
DB00349. Clobazam.
DB00845. Clofazimine.
DB00636. Clofibrate.
DB00882. Clomifene.
DB01242. Clomipramine.
DB01068. Clonazepam.
DB00575. Clonidine.
DB00758. Clopidogrel.
DB00628. Clorazepate.
DB01559. Clotiazepam.
DB00257. Clotrimazole.
DB00363. Clozapine.
DB00907. Cocaine.
DB00318. Codeine.
DB01394. Colchicine.
DB00872. Conivaptan.
DB00286. Conjugated Estrogens.
DB01380. Cortisone acetate.
DB08865. Crizotinib.
DB00924. Cyclobenzaprine.
DB00531. Cyclophosphamide.
DB00091. Cyclosporine.
DB00987. Cytarabine.
DB08912. Dabrafenib.
DB01764. Dalfopristin.
DB01406. Danazol.
DB01219. Dantrolene.
DB06292. Dapagliflozin.
DB00250. Dapsone.
DB00496. Darifenacin.
DB01264. Darunavir.
DB01254. Dasatinib.
DB00694. Daunorubicin.
DB01609. Deferasirox.
DB00705. Delavirdine.
DB01151. Desipramine.
DB06700. Desvenlafaxine.
DB01234. Dexamethasone.
DB00514. Dextromethorphan.
DB00647. Dextropropoxyphene.
DB00829. Diazepam.
DB00586. Diclofenac.
DB00485. Dicloxacillin.
DB00255. Diethylstilbestrol.
DB01396. Digitoxin.
DB00390. Digoxin.
DB01551. Dihydrocodeine.
DB00320. Dihydroergotamine.
DB00343. Diltiazem.
DB01093. Dimethyl sulfoxide.
DB00280. Disopyramide.
DB00822. Disulfiram.
DB01248. Docetaxel.
DB00204. Dofetilide.
DB00757. Dolasetron.
DB08930. Dolutegravir.
DB01184. Domperidone.
DB00843. Donepezil.
DB00869. Dorzolamide.
DB01142. Doxepin.
DB00997. Doxorubicin.
DB00254. Doxycycline.
DB00470. Dronabinol.
DB04855. Dronedarone.
DB01126. Dutasteride.
DB01127. Econazole.
DB00625. Efavirenz.
DB00216. Eletriptan.
DB00584. Enalapril.
DB08899. Enzalutamide.
DB00751. Epinastine.
DB00668. Epinephrine.
DB00700. Eplerenone.
DB00153. Ergocalciferol.
DB01049. Ergoloid mesylate.
DB01253. Ergonovine.
DB00696. Ergotamine.
DB00530. Erlotinib.
DB00199. Erythromycin.
DB01175. Escitalopram.
DB00736. Esomeprazole.
DB01215. Estazolam.
DB00783. Estradiol.
DB08866. Estradiol valerate/Dienogest.
DB01196. Estramustine.
DB00655. Estrone.
DB04574. Estropipate.
DB00402. Eszopiclone.
DB00898. Ethanol.
DB00977. Ethinyl Estradiol.
DB00593. Ethosuximide.
DB01466. Ethylmorphine.
DB00294. Etonogestrel.
DB00773. Etoposide.
DB01628. Etoricoxib.
DB06414. Etravirine.
DB01590. Everolimus.
DB00990. Exemestane.
DB00973. Ezetimibe.
DB00426. Famciclovir.
DB00949. Felbamate.
DB01023. Felodipine.
DB01039. Fenofibrate.
DB00813. Fentanyl.
DB06702. Fesoterodine.
DB01216. Finasteride.
DB08868. Fingolimod.
DB00301. Flucloxacillin.
DB00196. Fluconazole.
DB00180. Flunisolide.
DB01544. Flunitrazepam.
DB00324. Fluorometholone.
DB00472. Fluoxetine.
DB00690. Flurazepam.
DB00499. Flutamide.
DB08906. Fluticasone furoate.
DB00588. Fluticasone Propionate.
DB01095. Fluvastatin.
DB00176. Fluvoxamine.
DB01319. Fosamprenavir.
DB01320. Fosphenytoin.
DB00947. Fulvestrant.
DB00674. Galantamine.
DB00317. Gefitinib.
DB01241. Gemfibrozil.
DB01067. Glipizide.
DB01016. Glyburide.
DB00889. Granisetron.
DB00400. Griseofulvin.
DB01170. Guanethidine.
DB01018. Guanfacine.
DB01218. Halofantrine.
DB00502. Haloperidol.
DB01159. Halothane.
DB01355. Hexobarbital.
DB00667. Histamine Phosphate.
DB01275. Hydralazine.
DB00956. Hydrocodone.
DB00769. Hydrocortamate.
DB00741. Hydrocortisone.
DB00327. Hydromorphone.
DB01181. Ifosfamide.
DB04946. Iloperidone.
DB00619. Imatinib.
DB00458. Imipramine.
DB00724. Imiquimod.
DB05039. Indacaterol.
DB00808. Indapamide.
DB00224. Indinavir.
DB00332. Ipratropium bromide.
DB01029. Irbesartan.
DB00762. Irinotecan.
DB00951. Isoniazid.
DB00883. Isosorbide Dinitrate.
DB01020. Isosorbide Mononitrate.
DB00270. Isradipine.
DB01167. Itraconazole.
DB08820. Ivacaftor.
DB00602. Ivermectin.
DB04845. Ixabepilone.
DB01321. Josamycin.
DB01221. Ketamine.
DB01587. Ketazolam.
DB06738. Ketobemidone.
DB01026. Ketoconazole.
DB00448. Lansoprazole.
DB01259. Lapatinib.
DB00528. Lercanidipine.
DB01006. Letrozole.
DB01002. Levobupivacaine.
DB01137. Levofloxacin.
DB01227. Levomethadyl Acetate.
DB08918. Levomilnacipran.
DB00367. Levonorgestrel.
DB00451. Levothyroxine.
DB00281. Lidocaine.
DB08882. Linagliptin.
DB00589. Lisuride.
DB08827. Lomitapide.
DB01206. Lomustine.
DB00836. Loperamide.
DB01601. Lopinavir.
DB00455. Loratadine.
DB04871. Lorcaserin.
DB00678. Losartan.
DB00227. Lovastatin.
DB08933. LULICONAZOLE.
DB06708. Lumefantrine.
DB08815. Lurasidone.
DB08932. MACITENTAN.
DB04835. Maraviroc.
DB00643. Mebendazole.
DB00603. Medroxyprogesterone Acetate.
DB00358. Mefloquine.
DB00814. Meloxicam.
DB01071. Mequitazine.
DB00333. Methadone.
DB00703. Methazolamide.
DB00763. Methimazole.
DB00553. Methoxsalen.
DB01028. Methoxyflurane.
DB00353. Methylergometrine.
DB00959. Methylprednisolone.
DB06710. Methyltestosterone.
DB00916. Metronidazole.
DB01011. Metyrapone.
DB00379. Mexiletine.
DB06148. Mianserin.
DB01110. Miconazole.
DB00683. Midazolam.
DB00834. Mifepristone.
DB08893. Mirabegron.
DB00370. Mirtazapine.
DB01204. Mitoxantrone.
DB00745. Modafinil.
DB00471. Montelukast.
DB00295. Morphine.
DB00688. Mycophenolate mofetil.
DB00607. Nafcillin.
DB01183. Naloxone.
DB00731. Nateglinide.
DB01149. Nefazodone.
DB00220. Nelfinavir.
DB00238. Nevirapine.
DB00622. Nicardipine.
DB00184. Nicotine.
DB01115. Nifedipine.
DB04868. Nilotinib.
DB06712. Nilvadipine.
DB00393. Nimodipine.
DB00401. Nisoldipine.
DB01595. Nitrazepam.
DB01054. Nitrendipine.
DB00435. Nitric Oxide.
DB00717. Norethindrone.
DB01059. Norfloxacin.
DB00540. Nortriptyline.
DB00334. Olanzapine.
DB00768. Olopatadine.
DB00338. Omeprazole.
DB00904. Ondansetron.
DB01083. Orlistat.
DB01173. Orphenadrine.
DB04938. Ospemifene.
DB00842. Oxazepam.
DB00776. Oxcarbazepine.
DB00239. Oxiconazole.
DB01062. Oxybutynin.
DB00497. Oxycodone.
DB01192. Oxymorphone.
DB01229. Paclitaxel.
DB01267. Paliperidone.
DB00377. Palonosetron.
DB00213. Pantoprazole.
DB00617. Paramethadione.
DB01384. Paramethasone.
DB00910. Paricalcitol.
DB06589. Pazopanib.
DB00082. Pegvisomant.
DB00738. Pentamidine.
DB00312. Pentobarbital.
DB08883. Perampanel.
DB01186. Pergolide.
DB01074. Perhexiline.
DB04930. Permethrin.
DB00850. Perphenazine.
DB00454. Pethidine.
DB00780. Phenelzine.
DB01174. Phenobarbital.
DB00925. Phenoxybenzamine.
DB00946. Phenprocoumon.
DB00812. Phenylbutazone.
DB00252. Phenytoin.
DB01085. Pilocarpine.
DB00337. Pimecrolimus.
DB01100. Pimozide.
DB01132. Pioglitazone.
DB01621. Pipotiazine.
DB01179. Podofilox.
DB08910. Pomalidomide.
DB08901. Ponatinib.
DB01263. Posaconazole.
DB01411. Pranlukast.
DB06209. Prasugrel.
DB00175. Pravastatin.
DB01588. Prazepam.
DB01058. Praziquantel.
DB00860. Prednisolone.
DB00635. Prednisone.
DB01087. Primaquine.
DB00794. Primidone.
DB01032. Probenecid.
DB00433. Prochlorperazine.
DB00396. Progesterone.
DB01131. Proguanil.
DB00420. Promazine.
DB01182. Propafenone.
DB00818. Propofol.
DB00571. Propranolol.
DB00339. Pyrazinamide.
DB00545. Pyridostigmine.
DB01589. Quazepam.
DB01224. Quetiapine.
DB01103. Quinacrine.
DB00908. Quinidine.
DB00468. Quinine.
DB01369. Quinupristin.
DB01129. Rabeprazole.
DB00481. Raloxifene.
DB00980. Ramelteon.
DB00863. Ranitidine.
DB00243. Ranolazine.
DB00234. Reboxetine.
DB08896. Regorafenib.
DB00912. Repaglinide.
DB01256. Retapamulin.
DB00615. Rifabutin.
DB01045. Rifampicin.
DB01201. Rifapentine.
DB01220. Rifaximin.
DB08864. Rilpivirine.
DB06155. Rimonabant.
DB00734. Risperidone.
DB00503. Ritonavir.
DB06228. Rivaroxaban.
DB00989. Rivastigmine.
DB01301. Rolitetracycline.
DB00268. Ropinirole.
DB00296. Ropivacaine.
DB01098. Rosuvastatin.
DB05271. Rotigotine.
DB00778. Roxithromycin.
DB06201. Rufinamide.
DB08877. Ruxolitinib.
DB01001. Salbutamol.
DB00938. Salmeterol.
DB01232. Saquinavir.
DB06335. Saxagliptin.
DB01037. Selegiline.
DB06144. Sertindole.
DB01104. Sertraline.
DB01236. Sevoflurane.
DB01105. Sibutramine.
DB00203. Sildenafil.
DB06207. Silodosin.
DB06290. SIMEPREVIR.
DB00641. Simvastatin.
DB00877. Sirolimus.
DB01261. Sitagliptin.
DB06268. Sitaxentan.
DB01591. Solifenacin.
DB00398. Sorafenib.
DB00708. Sufentanil.
DB00359. Sulfadiazine.
DB01015. Sulfamethoxazole.
DB00259. Sulfanilamide.
DB01138. Sulfinpyrazone.
DB01268. Sunitinib.
DB00864. Tacrolimus.
DB00820. Tadalafil.
DB00675. Tamoxifen.
DB00706. Tamsulosin.
DB01349. Tasosartan.
DB05521. Telaprevir.
DB00976. Telithromycin.
DB00231. Temazepam.
DB00853. Temozolomide.
DB06287. Temsirolimus.
DB00444. Teniposide.
DB00857. Terbinafine.
DB00624. Testosterone.
DB00759. Tetracycline.
DB00277. Theophylline.
DB00599. Thiopental.
DB04572. Thiotepa.
DB00906. Tiagabine.
DB08816. Ticagrelor.
DB00208. Ticlopidine.
DB00911. Tinidazole.
DB01007. Tioconazole.
DB01409. Tiotropium.
DB00932. Tipranavir.
DB08895. Tofacitinib.
DB08811. Tofisopam.
DB01036. Tolterodine.
DB06212. Tolvaptan.
DB00273. Topiramate.
DB01030. Topotecan.
DB00539. Toremifene.
DB05109. Trabectedin.
DB00193. Tramadol.
DB08911. Trametinib.
DB00752. Tranylcypromine.
DB00656. Trazodone.
DB00755. Tretinoin.
DB00620. Triamcinolone.
DB00897. Triazolam.
DB00347. Trimethadione.
DB00440. Trimethoprim.
DB00726. Trimipramine.
DB01361. Troleandomycin.
DB06267. Udenafil.
DB00313. Valproic Acid.
DB05294. Vandetanib.
DB00862. Vardenafil.
DB08881. Vemurafenib.
DB00285. Venlafaxine.
DB00661. Verapamil.
DB06684. Vilazodone.
DB00570. Vinblastine.
DB00541. Vincristine.
DB00309. Vindesine.
DB00361. Vinorelbine.
DB08828. Vismodegib.
DB00582. Voriconazole.
DB00682. Warfarin.
DB01392. Yohimbine.
DB00549. Zafirlukast.
DB00943. Zalcitabine.
DB00962. Zaleplon.
DB00495. Zidovudine.
DB00744. Zileuton.
DB00246. Ziprasidone.
DB00425. Zolpidem.
DB00909. Zonisamide.
DB01198. Zopiclone.
GuidetoPHARMACOLOGYi 1337.

PTM databases

PhosphoSitei P08684.

Polymorphism databases

DMDMi 116241312.

Proteomic databases

PaxDbi P08684.
PRIDEi P08684.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000336411 ; ENSP00000337915 ; ENSG00000160868 .
GeneIDi 1576.
KEGGi hsa:1576.
UCSCi uc003urv.2. human.

Organism-specific databases

CTDi 1576.
GeneCardsi GC07M099355.
HGNCi HGNC:2637. CYP3A4.
HPAi CAB033671.
MIMi 124010. gene.
neXtProti NX_P08684.
PharmGKBi PA130.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2124.
HOGENOMi HOG000039127.
HOVERGENi HBG108567.
InParanoidi P08684.
KOi K17689.
OMAi DMECHKK.
OrthoDBi EOG744TBS.
PhylomeDBi P08684.
TreeFami TF105087.

Enzyme and pathway databases

BioCyci MetaCyc:HS08544-MONOMER.
Reactomei REACT_13543. Xenobiotics.
REACT_228214. Aflatoxin activation and detoxification.
SABIO-RK P08684.

Miscellaneous databases

ChiTaRSi CYP3A4. human.
EvolutionaryTracei P08684.
GeneWikii CYP3A4.
GenomeRNAii 1576.
NextBioi 6475.
PROi P08684.
SOURCEi Search...

Gene expression databases

Bgeei P08684.
CleanExi HS_CYP3A4.
ExpressionAtlasi P08684. baseline and differential.
Genevestigatori P08684.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR008072. Cyt_P450_E_CYP3A.
IPR002402. Cyt_P450_E_grp-II.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00464. EP450II.
PR01689. EP450IICYP3A.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete cDNA sequence of a cytochrome P-450 inducible by glucocorticoids in human liver."
    Molowa D.T., Schuetz E.G., Wrighton S.A., Watkins P.B., Kremers P., Mendez-Picon G., Parker G.A., Guzelian P.S.
    Proc. Natl. Acad. Sci. U.S.A. 83:5311-5315(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ALA-252.
    Tissue: Liver.
  2. "Human P450PCN1: sequence, chromosome localization, and direct evidence through cDNA expression that P450PCN1 is nifedipine oxidase."
    Gonzalez F.J., Schmid B.J., Umeno M., McBride O.W., Hardwick J.P., Meyer U.A., Gelboin H.V., Idle J.R.
    DNA 7:79-86(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Isolation and sequence determination of a cDNA clone related to human cytochrome P-450 nifedipine oxidase."
    Beaune P.H., Umbenhauer D.R., Bork R.W., Lloyd R.S., Guengerich F.P.
    Proc. Natl. Acad. Sci. U.S.A. 83:8064-8068(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-431.
  4. "The human cytochrome P450 CYP3 locus: assignment to chromosome 7q22-qter."
    Spurr N.K., Gough A.C., Stevenson K., Wolf C.R.
    Hum. Genet. 81:171-174(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  5. "Characterization of mRNA species related to human liver cytochrome P-450 nifedipine oxidase and the regulation of catalytic activity."
    Bork R.W., Muto T., Beaune P.H., Srivastava P.K., Lloyd R.S., Guengerich F.P.
    J. Biol. Chem. 264:910-919(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-431.
    Tissue: Liver.
  6. "Establishment of transgenic cell line CHL-3A4 and its metabolic activation."
    Chen Q., Wu J., Yu Y.
    Zhonghua Yu Fang Yi Xue Za Zhi 32:281-284(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  7. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  8. "Novel mutations of CYP3A4 in Chinese."
    Hsieh K.-P., Lin Y.-Y., Cheng C.-L., Lai M.-L., Lin M.-S., Siest J.-P., Huang J.-D.
    Drug Metab. Dispos. 29:268-273(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-118 AND ARG-218.
  9. "Sequence of a new human cytochrome P450-3A4 cDNA."
    Zhuge J., Qian Y., Xie H., Yu Y.
    Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  10. "Cytochrome P-450 in human liver microsomes: high-performance liquid chromatographic isolation of three forms and their characterization."
    Komori M., Hashizume T., Ohi H., Miura T., Kitada M., Nagashima K., Kamataki T.
    J. Biochem. 104:912-916(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-25, CLEAVAGE OF INITIATOR METHIONINE.
  11. Cited for: PROTEIN SEQUENCE OF 2-21, CLEAVAGE OF INITIATOR METHIONINE.
    Tissue: Liver.
  12. "Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine."
    Aoyama T., Yamano S., Waxman D.J., Lapenson D.P., Meyer U.A., Fischer V., Tyndale R., Inaba T., Kalow W., Gelboin H.V., Gonzalez F.J.
    J. Biol. Chem. 264:10388-10395(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  13. "Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians."
    Shimada T., Yamazaki H., Mimura M., Inui Y., Guengerich F.P.
    J. Pharmacol. Exp. Ther. 270:414-423(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  14. "CYP3A gene expression in human gut epithelium."
    Kolars J.C., Lown K.S., Schmiedlin-Ren P., Ghosh M., Fang C., Wrighton S.A., Merion R.M., Watkins P.B.
    Pharmacogenetics 4:247-259(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  15. "Evidence for involvement of human CYP3A in the 3-hydroxylation of quinine."
    Zhang H., Coville P.F., Walker R.J., Miners J.O., Birkett D.J., Wanwimolruk S.
    Br. J. Clin. Pharmacol. 43:245-252(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  16. "Mutual inhibition between quinine and etoposide by human liver microsomes. Evidence for cytochrome P4503A4 involvement in their major metabolic pathways."
    Zhao X.J., Kawashiro T., Ishizaki T.
    Drug Metab. Dispos. 26:188-191(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  17. "Oxidation of 1,8-cineole, the monoterpene cyclic ether originated from eucalyptus polybractea, by cytochrome P450 3A enzymes in rat and human liver microsomes."
    Miyazawa M., Shindo M., Shimada T.
    Drug Metab. Dispos. 29:200-205(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CATALYTIC ACTIVITY, FUNCTION AS 1,8-CINEOLE 2-EXO-MONOOXYGENASE.
  18. "Intergenic mRNA molecules resulting from trans-splicing."
    Finta C., Zaphiropoulos P.G.
    J. Biol. Chem. 277:5882-5890(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: TRANS-SPLICING.
  19. "ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier."
    Dauchy S., Dutheil F., Weaver R.J., Chassoux F., Daumas-Duport C., Couraud P.O., Scherrmann J.M., De Waziers I., Decleves X.
    J. Neurochem. 107:1518-1528(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  20. "Drug metabolism in human brain: high levels of cytochrome P4503A43 in brain and metabolism of anti-anxiety drug alprazolam to its active metabolite."
    Agarwal V., Kommaddi R.P., Valli K., Ryder D., Hyde T.M., Kleinman J.E., Strobel H.W., Ravindranath V.
    PLoS ONE 3:E2337-E2337(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  21. "CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases."
    Pabarcus M.K., Hoe N., Sadeghi S., Patterson C., Wiertz E., Correia M.A.
    Arch. Biochem. Biophys. 483:66-74(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION.
  22. "Xenobiotic-metabolizing enzymes and transporters in the normal human brain: regional and cellular mapping as a basis for putative roles in cerebral function."
    Dutheil F., Dauchy S., Diry M., Sazdovitch V., Cloarec O., Mellottee L., Bieche I., Ingelman-Sundberg M., Flinois J.P., de Waziers I., Beaune P., Decleves X., Duyckaerts C., Loriot M.A.
    Drug Metab. Dispos. 37:1528-1538(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  23. "The structure of human microsomal cytochrome P450 3A4 determined by X-ray crystallography to 2.05-A resolution."
    Yano J.K., Wester M.R., Schoch G.A., Griffin K.J., Stout C.D., Johnson E.F.
    J. Biol. Chem. 279:38091-38094(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 24-503.
  24. "Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone."
    Williams P.A., Cosme J., Vinkovic D.M., Ward A., Angove H.C., Day P.J., Vonrhein C., Tickle I.J., Jhoti H.
    Science 305:683-686(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 25-503.
  25. "CYP3A4 allelic variants with amino acid substitutions in exons 7 and 12: evidence for an allelic variant with altered catalytic activity."
    Sata F., Sapone A., Elizondo G., Stocker P., Miller V.P., Zheng W., Raunio H., Crespi C.L., Gonzalez F.J.
    Clin. Pharmacol. Ther. 67:48-56(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-222 AND THR-445.
  26. "Identification of variants of CYP3A4 and characterization of their abilities to metabolize testosterone and chlorpyrifos."
    Dai D., Tang J., Rose R., Hodgson E., Bienstock R.J., Mohrenweiser H.W., Goldstein J.A.
    J. Pharmacol. Exp. Ther. 299:825-831(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS GLN-162; SER-189; PRO-293; THR-445 AND SER-467, CHARACTERIZATION OF THE VARIANTS.
  27. Cited for: VARIANTS ASP-56; GLN-130; ILE-170; HIS-174; MET-363; PHE-373 AND LEU-416.
  28. "Common allelic variants of cytochrome P4503A4 and their prevalence in different populations."
    Lamba J.K., Lin Y.S., Thummel K., Daly A., Watkins P.B., Strom S., Zhang J., Schuetz E.G.
    Pharmacogenetics 12:121-132(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-15; GLN-162; HIS-174; SER-185 AND PHE-373.
  29. "Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population."
    Solus J.F., Arietta B.J., Harris J.R., Sexton D.P., Steward J.Q., McMunn C., Ihrie P., Mehall J.M., Edwards T.L., Dawson E.P.
    Pharmacogenomics 5:895-931(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-174; SER-185 AND PRO-293.

Entry informationi

Entry nameiCP3A4_HUMAN
AccessioniPrimary (citable) accession number: P08684
Secondary accession number(s): P05184, Q16757, Q9UK50
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 171 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Chimeric transcripts, characterized by CYP3A43 exon 1 joined at canonical splice sites to distinct sets of CYP3A4 exons, have been detected. All are possibly produced by trans-splicing. The chimeric transcripts exist in 3 different combinations: CYP3A43 exon 1 joined in frame to CYP3A4 exons 2-13, CYP3A43 exon 1 joined in frame to CYP3A4 exons 4-13 and CYP3A43 exon 1 joined in frame to CYP3A4 exon 7-13. The longest chimeric isoform (CYP3A43 exon 1 joined to CYP3A4 exons 2-13) exhibits 6-beta-hydroxylase activity, while a shorter isoform (CYP3A43 exon 1 joined to CYP3A4 exons 4-13) does not. All chimeric transcripts are expressed at very low levels in the liver (PubMed:11726664).1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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