Cytochrome P450 2C11 - Rattus norvegicus (Rat)

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P08683 (CP2CB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 126. History...

Clusters with 100%, 90%, 50% identity |

Documents (1) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Cytochrome P450 2C11
EC=1.14.14.1

Alternative name(s):
CYPIIC11
Cytochrome P-450(M-1)
Cytochrome P450-UT-2
Cytochrome P450-UT-A
Cytochrome P450H

Gene names

Name:	Cyp2c11
Synonyms:	Cyp2c, Cyp2c-11

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.
Catalytic activity	RH + reduced flavoprotein + O₂ = ROH + oxidized flavoprotein + H₂O.
Cofactor	Heme group By similarity.
Subcellular location	Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue specificity	Liver; male-specific.
Induction	Constitutively expressed.
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane Microsome
Coding sequence diversity	Polymorphism
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	xenobiotic metabolic process Traceable author statement Ref.4. Source: RGD
Cellular_component	endoplasmic reticulum membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro testosterone 16-alpha-hydroxylase activity Inferred from mutant phenotype Ref.4. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 500

500

Cytochrome P450 2C11

PRO_0000051701

Sites

Metal binding

435

Iron (heme axial ligand) By similarity

Natural variations

Natural variant

V → A in strain: Wistar Gunn.

Natural variant

116

N → S in strain: Wistar Gunn.

Natural variant

187

F → L in strain: Wistar Gunn.

Experimental info

Sequence conflict

329

R → H in AAA41007. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P08683 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 8DCE0E356D8A5AC3
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FASTA

500

57,181

        10         20         30         40         50         60 
MDPVLVLVLT LSSLLLLSLW RQSFGRGKLP PGPTPLPIIG NTLQIYMKDI GQSIKKFSKV 

        70         80         90        100        110        120 
YGPIFTLYLG MKPFVVLHGY EAVKEALVDL GEEFSGRGSF PVSERVNKGL GVIFSNGMQW 

       130        140        150        160        170        180 
KEIRRFSIMT LRTFGMGKRT IEDRIQEEAQ CLVEELRKSK GAPFDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DPTFLNLMHR FNENFRLFSS PWLQVCNTFP AIIDYFPGSH NQVLKNFFYI 

       250        260        270        280        290        300 
KNYVLEKVKE HQESLDKDNP RDFIDCFLNK MEQEKHNPQS EFTLESLVAT VTDMFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHVDVT AKVQEEIERV IGRNRSPCMK DRSQMPYTDA VVHEIQRYID 

       370        380        390        400        410        420 
LVPTNLPHLV TRDIKFRNYF IPKGTNVIVS LSSILHDDKE FPNPEKFDPG HFLDERGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEAL ARTELFLFFT TILQNFNLKS LVDVKDIDTT PAISGFGHLP 

       490        500 
PFYEACFIPV QRADSLSSHL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers." Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T. J. Biol. Chem. 262:1706-1711(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver." Morishima N., Yoshioka H., Higashi Y., Sogawa K., Fujii-Kuriyama Y. Biochemistry 26:8279-8285(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver." Stroem A., Mode A., Zaphiropoulos P.G., Nilsson A.G., Morgan E., Gustafsson J.-A. Acta Endocrinol. 118:314-320(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[4]	"cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells." Biagini C., Celier C. Arch. Biochem. Biophys. 326:298-305(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Wistar Gunn. Tissue: Liver.
[5]	"Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha." Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A. Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[7]	"Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver." Stroem A., Eguchi H., Mode A., Legraverend C., Tollet P., Stroemstedt P.-E., Gustafsson J.-A. DNA Cell Biol. 13:805-819(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56. Strain: Sprague-Dawley. Tissue: Liver.
[8]	Stroem A. Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 12.
[9]	"Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes." Matsumoto T., Emi Y., Kawabata S., Omura T. J. Biochem. 100:1359-1371(1986) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 1-30.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	J02657 mRNA. Translation: AAA41062.1. M18363 M18362 Genomic DNA. Translation: AAA41007.1. U33173 mRNA. Translation: AAB02144.1. BC088146 mRNA. Translation: AAH88146.1. X79081 Genomic DNA. Translation: CAA55686.3.
IPI	IPI00327781.
PIR	A26685. S62785.
RefSeq	NP_062057.2. NM_019184.2.
UniGene	Rn.10870.
3D structure databases
ProteinModelPortal	P08683.
SMR	P08683. Positions 30-490.
ModBase	Search...
Proteomic databases
PaxDb	P08683.
PRIDE	P08683.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000017310; ENSRNOP00000017310; ENSRNOG00000012896.
GeneID	29277.
KEGG	rno:29277.
Organism-specific databases
CTD	29277.
RGD	2469. Cyp2c11.
Phylogenomic databases
eggNOG	COG2124.
GeneTree	ENSGT00680000099783.
HOGENOM	HOG000036992.
HOVERGEN	HBG015789.
InParanoid	P08683.
KO	K07413.
OrthoDB	EOG48WC22.
Enzyme and pathway databases
SABIO-RK	P08683.
Gene expression databases
Genevestigator	P08683.
GermOnline	ENSRNOG00000012896. Rattus norvegicus.
Family and domain databases
Gene3D	1.10.630.10. 1 hit.
InterPro	IPR001128. Cyt_P450. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. IPR008068. Cyt_P450_E_grp-I_CYP2B-like. [Graphical view]
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR01685. EP450ICYP2B. PR00385. P450.
SUPFAM	SSF48264. Cytochrome_P450. 1 hit.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P08683.
ChEMBL	CHEMBL4971.
NextBio	608643.

Entry information

Entry name

CP2CB_RAT

Accession

Primary (citable) accession number: P08683
Secondary accession number(s): Q63141, Q64554

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 1, 1988
Last sequence update:	January 1, 1988
Last modified:	April 3, 2013
This is version 126 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Sites

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents