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P08683

- CP2CB_RAT

UniProt

P08683 - CP2CB_RAT

Protein

Cytochrome P450 2C11

Gene

Cyp2c11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro
    4. testosterone 16-alpha-hydroxylase activity Source: RGD

    GO - Biological processi

    1. xenobiotic metabolic process Source: RGD

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP08683.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2C11 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIC11
    Cytochrome P-450(M-1)
    Cytochrome P450-UT-2
    Cytochrome P450-UT-A
    Cytochrome P450H
    Gene namesi
    Name:Cyp2c11
    Synonyms:Cyp2c, Cyp2c-11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 1

    Organism-specific databases

    RGDi2469. Cyp2c11.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 2C11PRO_0000051701Add
    BLAST

    Proteomic databases

    PaxDbiP08683.
    PRIDEiP08683.

    Expressioni

    Tissue specificityi

    Liver; male-specific.

    Inductioni

    Constitutively expressed.

    Gene expression databases

    GenevestigatoriP08683.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliP08683.
    SMRiP08683. Positions 30-490.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00680000099783.
    HOGENOMiHOG000036992.
    HOVERGENiHBG015789.
    InParanoidiP08683.
    KOiK07413.
    OMAiRICAGEA.
    OrthoDBiEOG7RBZ85.
    PhylomeDBiP08683.
    TreeFamiTF352043.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08683-1 [UniParc]FASTAAdd to Basket

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    MDPVLVLVLT LSSLLLLSLW RQSFGRGKLP PGPTPLPIIG NTLQIYMKDI    50
    GQSIKKFSKV YGPIFTLYLG MKPFVVLHGY EAVKEALVDL GEEFSGRGSF 100
    PVSERVNKGL GVIFSNGMQW KEIRRFSIMT LRTFGMGKRT IEDRIQEEAQ 150
    CLVEELRKSK GAPFDPTFIL GCAPCNVICS IIFQNRFDYK DPTFLNLMHR 200
    FNENFRLFSS PWLQVCNTFP AIIDYFPGSH NQVLKNFFYI KNYVLEKVKE 250
    HQESLDKDNP RDFIDCFLNK MEQEKHNPQS EFTLESLVAT VTDMFGAGTE 300
    TTSTTLRYGL LLLLKHVDVT AKVQEEIERV IGRNRSPCMK DRSQMPYTDA 350
    VVHEIQRYID LVPTNLPHLV TRDIKFRNYF IPKGTNVIVS LSSILHDDKE 400
    FPNPEKFDPG HFLDERGNFK KSDYFMPFSA GKRICAGEAL ARTELFLFFT 450
    TILQNFNLKS LVDVKDIDTT PAISGFGHLP PFYEACFIPV QRADSLSSHL 500
    Length:500
    Mass (Da):57,181
    Last modified:January 1, 1988 - v1
    Checksum:i8DCE0E356D8A5AC3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti329 – 3291R → H in AAA41007. (PubMed:2894840)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti4 – 41V → A in strain: Wistar Gunn.
    Natural varianti116 – 1161N → S in strain: Wistar Gunn.
    Natural varianti187 – 1871F → L in strain: Wistar Gunn.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02657 mRNA. Translation: AAA41062.1.
    M18363
    , M18356, M18357, M18359, M18360, M18361, M18362 Genomic DNA. Translation: AAA41007.1.
    U33173 mRNA. Translation: AAB02144.1.
    BC088146 mRNA. Translation: AAH88146.1.
    X79081 Genomic DNA. Translation: CAA55686.3.
    PIRiA26685.
    S62785.
    RefSeqiNP_062057.2. NM_019184.2.
    UniGeneiRn.10870.

    Genome annotation databases

    EnsembliENSRNOT00000017310; ENSRNOP00000017310; ENSRNOG00000012896.
    GeneIDi29277.
    KEGGirno:29277.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    J02657 mRNA. Translation: AAA41062.1 .
    M18363
    , M18356 , M18357 , M18359 , M18360 , M18361 , M18362 Genomic DNA. Translation: AAA41007.1 .
    U33173 mRNA. Translation: AAB02144.1 .
    BC088146 mRNA. Translation: AAH88146.1 .
    X79081 Genomic DNA. Translation: CAA55686.3 .
    PIRi A26685.
    S62785.
    RefSeqi NP_062057.2. NM_019184.2.
    UniGenei Rn.10870.

    3D structure databases

    ProteinModelPortali P08683.
    SMRi P08683. Positions 30-490.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi P08683.
    ChEMBLi CHEMBL4971.

    Proteomic databases

    PaxDbi P08683.
    PRIDEi P08683.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000017310 ; ENSRNOP00000017310 ; ENSRNOG00000012896 .
    GeneIDi 29277.
    KEGGi rno:29277.

    Organism-specific databases

    CTDi 29277.
    RGDi 2469. Cyp2c11.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00680000099783.
    HOGENOMi HOG000036992.
    HOVERGENi HBG015789.
    InParanoidi P08683.
    KOi K07413.
    OMAi RICAGEA.
    OrthoDBi EOG7RBZ85.
    PhylomeDBi P08683.
    TreeFami TF352043.

    Enzyme and pathway databases

    SABIO-RK P08683.

    Miscellaneous databases

    NextBioi 608643.

    Gene expression databases

    Genevestigatori P08683.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR01685. EP450ICYP2B.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers."
      Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T.
      J. Biol. Chem. 262:1706-1711(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver."
      Morishima N., Yoshioka H., Higashi Y., Sogawa K., Fujii-Kuriyama Y.
      Biochemistry 26:8279-8285(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver."
      Stroem A., Mode A., Zaphiropoulos P.G., Nilsson A.G., Morgan E., Gustafsson J.-A.
      Acta Endocrinol. 118:314-320(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    4. "cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells."
      Biagini C., Celier C.
      Arch. Biochem. Biophys. 326:298-305(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar Gunn.
      Tissue: Liver.
    5. "Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
      Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
      Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    7. "Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver."
      Stroem A., Eguchi H., Mode A., Legraverend C., Tollet P., Stroemstedt P.-E., Gustafsson J.-A.
      DNA Cell Biol. 13:805-819(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
      Strain: Sprague-Dawley.
      Tissue: Liver.
    8. Stroem A.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 12.
    9. "Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes."
      Matsumoto T., Emi Y., Kawabata S., Omura T.
      J. Biochem. 100:1359-1371(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 1-30.

    Entry informationi

    Entry nameiCP2CB_RAT
    AccessioniPrimary (citable) accession number: P08683
    Secondary accession number(s): Q63141, Q64554
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3