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Protein

Cytochrome P450 2C11

Gene

Cyp2c11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.13.159. 5301.
1.14.14.1. 5301.
ReactomeiREACT_315621. Xenobiotics.
SABIO-RKP08683.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C11 (EC:1.14.14.1)
Alternative name(s):
CYPIIC11
Cytochrome P-450(M-1)
Cytochrome P450-UT-2
Cytochrome P450-UT-A
Cytochrome P450H
Gene namesi
Name:Cyp2c11
Synonyms:Cyp2c, Cyp2c-11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unassembled WGS sequence

Organism-specific databases

RGDi2469. Cyp2c11.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2C11PRO_0000051701Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei249 – 2491N6-acetyllysineBy similarity
Modified residuei375 – 3751N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP08683.
PRIDEiP08683.

Expressioni

Tissue specificityi

Liver; male-specific.

Inductioni

Constitutively expressed.

Gene expression databases

GenevisibleiP08683. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017310.

Structurei

3D structure databases

ProteinModelPortaliP08683.
SMRiP08683. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP08683.
KOiK07413.
OMAiRICAGEA.
OrthoDBiEOG7RBZ85.
PhylomeDBiP08683.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08683-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDPVLVLVLT LSSLLLLSLW RQSFGRGKLP PGPTPLPIIG NTLQIYMKDI
60 70 80 90 100
GQSIKKFSKV YGPIFTLYLG MKPFVVLHGY EAVKEALVDL GEEFSGRGSF
110 120 130 140 150
PVSERVNKGL GVIFSNGMQW KEIRRFSIMT LRTFGMGKRT IEDRIQEEAQ
160 170 180 190 200
CLVEELRKSK GAPFDPTFIL GCAPCNVICS IIFQNRFDYK DPTFLNLMHR
210 220 230 240 250
FNENFRLFSS PWLQVCNTFP AIIDYFPGSH NQVLKNFFYI KNYVLEKVKE
260 270 280 290 300
HQESLDKDNP RDFIDCFLNK MEQEKHNPQS EFTLESLVAT VTDMFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHVDVT AKVQEEIERV IGRNRSPCMK DRSQMPYTDA
360 370 380 390 400
VVHEIQRYID LVPTNLPHLV TRDIKFRNYF IPKGTNVIVS LSSILHDDKE
410 420 430 440 450
FPNPEKFDPG HFLDERGNFK KSDYFMPFSA GKRICAGEAL ARTELFLFFT
460 470 480 490 500
TILQNFNLKS LVDVKDIDTT PAISGFGHLP PFYEACFIPV QRADSLSSHL
Length:500
Mass (Da):57,181
Last modified:January 1, 1988 - v1
Checksum:i8DCE0E356D8A5AC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291R → H in AAA41007 (PubMed:2894840).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41V → A in strain: Wistar Gunn.
Natural varianti116 – 1161N → S in strain: Wistar Gunn.
Natural varianti187 – 1871F → L in strain: Wistar Gunn.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02657 mRNA. Translation: AAA41062.1.
M18363
, M18356, M18357, M18359, M18360, M18361, M18362 Genomic DNA. Translation: AAA41007.1.
U33173 mRNA. Translation: AAB02144.1.
BC088146 mRNA. Translation: AAH88146.1.
X79081 Genomic DNA. Translation: CAA55686.3.
PIRiA26685.
S62785.
RefSeqiNP_062057.2. NM_019184.2.
UniGeneiRn.10870.

Genome annotation databases

GeneIDi29277.
KEGGirno:29277.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J02657 mRNA. Translation: AAA41062.1.
M18363
, M18356, M18357, M18359, M18360, M18361, M18362 Genomic DNA. Translation: AAA41007.1.
U33173 mRNA. Translation: AAB02144.1.
BC088146 mRNA. Translation: AAH88146.1.
X79081 Genomic DNA. Translation: CAA55686.3.
PIRiA26685.
S62785.
RefSeqiNP_062057.2. NM_019184.2.
UniGeneiRn.10870.

3D structure databases

ProteinModelPortaliP08683.
SMRiP08683. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000017310.

Chemistry

BindingDBiP08683.
ChEMBLiCHEMBL4971.

Proteomic databases

PaxDbiP08683.
PRIDEiP08683.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi29277.
KEGGirno:29277.

Organism-specific databases

CTDi29277.
RGDi2469. Cyp2c11.

Phylogenomic databases

eggNOGiCOG2124.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP08683.
KOiK07413.
OMAiRICAGEA.
OrthoDBiEOG7RBZ85.
PhylomeDBiP08683.
TreeFamiTF352043.

Enzyme and pathway databases

BRENDAi1.14.13.159. 5301.
1.14.14.1. 5301.
ReactomeiREACT_315621. Xenobiotics.
SABIO-RKP08683.

Miscellaneous databases

NextBioi608643.
PROiP08683.

Gene expression databases

GenevisibleiP08683. RN.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers."
    Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T.
    J. Biol. Chem. 262:1706-1711(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver."
    Morishima N., Yoshioka H., Higashi Y., Sogawa K., Fujii-Kuriyama Y.
    Biochemistry 26:8279-8285(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver."
    Stroem A., Mode A., Zaphiropoulos P.G., Nilsson A.G., Morgan E., Gustafsson J.-A.
    Acta Endocrinol. 118:314-320(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells."
    Biagini C., Celier C.
    Arch. Biochem. Biophys. 326:298-305(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar Gunn.
    Tissue: Liver.
  5. "Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
    Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
    Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver."
    Stroem A., Eguchi H., Mode A., Legraverend C., Tollet P., Stroemstedt P.-E., Gustafsson J.-A.
    DNA Cell Biol. 13:805-819(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  8. Stroem A.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 12.
  9. "Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes."
    Matsumoto T., Emi Y., Kawabata S., Omura T.
    J. Biochem. 100:1359-1371(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-30.

Entry informationi

Entry nameiCP2CB_RAT
AccessioniPrimary (citable) accession number: P08683
Secondary accession number(s): Q63141, Q64554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: July 22, 2015
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.