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P08683

- CP2CB_RAT

UniProt

P08683 - CP2CB_RAT

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Protein

Cytochrome P450 2C11

Gene

Cyp2c11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi435 – 4351Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
  4. testosterone 16-alpha-hydroxylase activity Source: RGD

GO - Biological processi

  1. xenobiotic metabolic process Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

SABIO-RKP08683.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2C11 (EC:1.14.14.1)
Alternative name(s):
CYPIIC11
Cytochrome P-450(M-1)
Cytochrome P450-UT-2
Cytochrome P450-UT-A
Cytochrome P450H
Gene namesi
Name:Cyp2c11
Synonyms:Cyp2c, Cyp2c-11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 1

Organism-specific databases

RGDi2469. Cyp2c11.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 2C11PRO_0000051701Add
BLAST

Proteomic databases

PaxDbiP08683.
PRIDEiP08683.

Expressioni

Tissue specificityi

Liver; male-specific.

Inductioni

Constitutively expressed.

Gene expression databases

GenevestigatoriP08683.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliP08683.
SMRiP08683. Positions 30-490.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118775.
HOGENOMiHOG000036992.
HOVERGENiHBG015789.
InParanoidiP08683.
KOiK07413.
OMAiRICAGEA.
OrthoDBiEOG7RBZ85.
PhylomeDBiP08683.
TreeFamiTF352043.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08683-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDPVLVLVLT LSSLLLLSLW RQSFGRGKLP PGPTPLPIIG NTLQIYMKDI
60 70 80 90 100
GQSIKKFSKV YGPIFTLYLG MKPFVVLHGY EAVKEALVDL GEEFSGRGSF
110 120 130 140 150
PVSERVNKGL GVIFSNGMQW KEIRRFSIMT LRTFGMGKRT IEDRIQEEAQ
160 170 180 190 200
CLVEELRKSK GAPFDPTFIL GCAPCNVICS IIFQNRFDYK DPTFLNLMHR
210 220 230 240 250
FNENFRLFSS PWLQVCNTFP AIIDYFPGSH NQVLKNFFYI KNYVLEKVKE
260 270 280 290 300
HQESLDKDNP RDFIDCFLNK MEQEKHNPQS EFTLESLVAT VTDMFGAGTE
310 320 330 340 350
TTSTTLRYGL LLLLKHVDVT AKVQEEIERV IGRNRSPCMK DRSQMPYTDA
360 370 380 390 400
VVHEIQRYID LVPTNLPHLV TRDIKFRNYF IPKGTNVIVS LSSILHDDKE
410 420 430 440 450
FPNPEKFDPG HFLDERGNFK KSDYFMPFSA GKRICAGEAL ARTELFLFFT
460 470 480 490 500
TILQNFNLKS LVDVKDIDTT PAISGFGHLP PFYEACFIPV QRADSLSSHL
Length:500
Mass (Da):57,181
Last modified:January 1, 1988 - v1
Checksum:i8DCE0E356D8A5AC3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti329 – 3291R → H in AAA41007. (PubMed:2894840)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti4 – 41V → A in strain: Wistar Gunn.
Natural varianti116 – 1161N → S in strain: Wistar Gunn.
Natural varianti187 – 1871F → L in strain: Wistar Gunn.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02657 mRNA. Translation: AAA41062.1.
M18363
, M18356, M18357, M18359, M18360, M18361, M18362 Genomic DNA. Translation: AAA41007.1.
U33173 mRNA. Translation: AAB02144.1.
BC088146 mRNA. Translation: AAH88146.1.
X79081 Genomic DNA. Translation: CAA55686.3.
PIRiA26685.
S62785.
RefSeqiNP_062057.2. NM_019184.2.
UniGeneiRn.10870.

Genome annotation databases

EnsembliENSRNOT00000017310; ENSRNOP00000017310; ENSRNOG00000012896.
GeneIDi29277.
KEGGirno:29277.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
J02657 mRNA. Translation: AAA41062.1 .
M18363
, M18356 , M18357 , M18359 , M18360 , M18361 , M18362 Genomic DNA. Translation: AAA41007.1 .
U33173 mRNA. Translation: AAB02144.1 .
BC088146 mRNA. Translation: AAH88146.1 .
X79081 Genomic DNA. Translation: CAA55686.3 .
PIRi A26685.
S62785.
RefSeqi NP_062057.2. NM_019184.2.
UniGenei Rn.10870.

3D structure databases

ProteinModelPortali P08683.
SMRi P08683. Positions 30-490.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi P08683.
ChEMBLi CHEMBL4971.

Proteomic databases

PaxDbi P08683.
PRIDEi P08683.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000017310 ; ENSRNOP00000017310 ; ENSRNOG00000012896 .
GeneIDi 29277.
KEGGi rno:29277.

Organism-specific databases

CTDi 29277.
RGDi 2469. Cyp2c11.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118775.
HOGENOMi HOG000036992.
HOVERGENi HBG015789.
InParanoidi P08683.
KOi K07413.
OMAi RICAGEA.
OrthoDBi EOG7RBZ85.
PhylomeDBi P08683.
TreeFami TF352043.

Enzyme and pathway databases

SABIO-RK P08683.

Miscellaneous databases

NextBioi 608643.

Gene expression databases

Genevestigatori P08683.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers."
    Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T.
    J. Biol. Chem. 262:1706-1711(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver."
    Morishima N., Yoshioka H., Higashi Y., Sogawa K., Fujii-Kuriyama Y.
    Biochemistry 26:8279-8285(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver."
    Stroem A., Mode A., Zaphiropoulos P.G., Nilsson A.G., Morgan E., Gustafsson J.-A.
    Acta Endocrinol. 118:314-320(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.
  4. "cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells."
    Biagini C., Celier C.
    Arch. Biochem. Biophys. 326:298-305(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar Gunn.
    Tissue: Liver.
  5. "Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
    Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
    Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  7. "Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver."
    Stroem A., Eguchi H., Mode A., Legraverend C., Tollet P., Stroemstedt P.-E., Gustafsson J.-A.
    DNA Cell Biol. 13:805-819(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  8. Stroem A.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION TO 12.
  9. "Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes."
    Matsumoto T., Emi Y., Kawabata S., Omura T.
    J. Biochem. 100:1359-1371(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 1-30.

Entry informationi

Entry nameiCP2CB_RAT
AccessioniPrimary (citable) accession number: P08683
Secondary accession number(s): Q63141, Q64554
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3