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P08683 (CP2CB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 133. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2C11

EC=1.14.14.1
Alternative name(s):
CYPIIC11
Cytochrome P-450(M-1)
Cytochrome P450-UT-2
Cytochrome P450-UT-A
Cytochrome P450H
Gene names
Name:Cyp2c11
Synonyms:Cyp2c, Cyp2c-11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Metabolizes testosterone mainly in positions 2 alpha and 16 alpha.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.

Tissue specificity

Liver; male-specific.

Induction

Constitutively expressed.

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Cytochrome P450 2C11
PRO_0000051701

Sites

Metal binding4351Iron (heme axial ligand) By similarity

Natural variations

Natural variant41V → A in strain: Wistar Gunn.
Natural variant1161N → S in strain: Wistar Gunn.
Natural variant1871F → L in strain: Wistar Gunn.

Experimental info

Sequence conflict3291R → H in AAA41007. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P08683 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 8DCE0E356D8A5AC3

FASTA50057,181
        10         20         30         40         50         60 
MDPVLVLVLT LSSLLLLSLW RQSFGRGKLP PGPTPLPIIG NTLQIYMKDI GQSIKKFSKV 

        70         80         90        100        110        120 
YGPIFTLYLG MKPFVVLHGY EAVKEALVDL GEEFSGRGSF PVSERVNKGL GVIFSNGMQW 

       130        140        150        160        170        180 
KEIRRFSIMT LRTFGMGKRT IEDRIQEEAQ CLVEELRKSK GAPFDPTFIL GCAPCNVICS 

       190        200        210        220        230        240 
IIFQNRFDYK DPTFLNLMHR FNENFRLFSS PWLQVCNTFP AIIDYFPGSH NQVLKNFFYI 

       250        260        270        280        290        300 
KNYVLEKVKE HQESLDKDNP RDFIDCFLNK MEQEKHNPQS EFTLESLVAT VTDMFGAGTE 

       310        320        330        340        350        360 
TTSTTLRYGL LLLLKHVDVT AKVQEEIERV IGRNRSPCMK DRSQMPYTDA VVHEIQRYID 

       370        380        390        400        410        420 
LVPTNLPHLV TRDIKFRNYF IPKGTNVIVS LSSILHDDKE FPNPEKFDPG HFLDERGNFK 

       430        440        450        460        470        480 
KSDYFMPFSA GKRICAGEAL ARTELFLFFT TILQNFNLKS LVDVKDIDTT PAISGFGHLP 

       490        500 
PFYEACFIPV QRADSLSSHL 

« Hide

References

« Hide 'large scale' references
[1]"Structural analysis and specific expression of microsomal cytochrome P-450(M-1) mRNA in male rat livers."
Yoshioka H., Morohashi K., Sogawa K., Miyata T., Kawajiri K., Hirose T., Inayama S., Fujii-Kuriyama Y., Omura T.
J. Biol. Chem. 262:1706-1711(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Gene structure of cytochrome P-450(M-1) specifically expressed in male rat liver."
Morishima N., Yoshioka H., Higashi Y., Sogawa K., Fujii-Kuriyama Y.
Biochemistry 26:8279-8285(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Cloning and pretranslational hormonal regulation of testosterone 16 alpha-hydroxylase (P-45016 alpha) in male rat liver."
Stroem A., Mode A., Zaphiropoulos P.G., Nilsson A.G., Morgan E., Gustafsson J.-A.
Acta Endocrinol. 118:314-320(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.
[4]"cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells."
Biagini C., Celier C.
Arch. Biochem. Biophys. 326:298-305(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Wistar Gunn.
Tissue: Liver.
[5]"Sequence and regulation of two growth-hormone-controlled, sex-specific isozymes of cytochrome P-450 in rat liver, P-450(15)beta and P-450(16)alpha."
Zaphiropoulos P.G., Mode A., Stroem A., Husman B., Andersson G., Gustafsson J.-A.
Acta Med. Scand. Suppl. 723:161-167(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[7]"Characterization of the proximal promoter and two silencer elements in the CYP2C11 gene expressed in rat liver."
Stroem A., Eguchi H., Mode A., Legraverend C., Tollet P., Stroemstedt P.-E., Gustafsson J.-A.
DNA Cell Biol. 13:805-819(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-56.
Strain: Sprague-Dawley.
Tissue: Liver.
[8]Stroem A.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION TO 12.
[9]"Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes."
Matsumoto T., Emi Y., Kawabata S., Omura T.
J. Biochem. 100:1359-1371(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 1-30.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J02657 mRNA. Translation: AAA41062.1.
M18363 expand/collapse EMBL AC list , M18356, M18357, M18359, M18360, M18361, M18362 Genomic DNA. Translation: AAA41007.1.
U33173 mRNA. Translation: AAB02144.1.
BC088146 mRNA. Translation: AAH88146.1.
X79081 Genomic DNA. Translation: CAA55686.3.
PIRA26685.
S62785.
RefSeqNP_062057.2. NM_019184.2.
UniGeneRn.10870.

3D structure databases

ProteinModelPortalP08683.
SMRP08683. Positions 30-490.
ModBaseSearch...
MobiDBSearch...

Chemistry

BindingDBP08683.
ChEMBLCHEMBL4971.

Proteomic databases

PaxDbP08683.
PRIDEP08683.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000017310; ENSRNOP00000017310; ENSRNOG00000012896.
GeneID29277.
KEGGrno:29277.

Organism-specific databases

CTD29277.
RGD2469. Cyp2c11.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00680000099783.
HOGENOMHOG000036992.
HOVERGENHBG015789.
InParanoidP08683.
KOK07413.
OMARICAGEA.
OrthoDBEOG7RBZ85.
PhylomeDBP08683.
TreeFamTF352043.

Enzyme and pathway databases

SABIO-RKP08683.

Gene expression databases

GenevestigatorP08683.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
IPR008068. Cyt_P450_E_grp-I_CYP2B-like.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR01685. EP450ICYP2B.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio608643.

Entry information

Entry nameCP2CB_RAT
AccessionPrimary (citable) accession number: P08683
Secondary accession number(s): Q63141, Q64554
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families