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P08681

- COX1_CHLRE

UniProt

P08681 - COX1_CHLRE

Protein

Cytochrome c oxidase subunit 1

Gene

COX1

Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 106 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron (heme A axial ligand)Curated
    Metal bindingi235 – 2351Copper BCurated
    Metal bindingi239 – 2391Copper BCurated
    Metal bindingi284 – 2841Copper BCurated
    Metal bindingi285 – 2851Copper BCurated
    Metal bindingi370 – 3701Iron (heme A3 axial ligand)Curated
    Metal bindingi372 – 3721Iron (heme A axial ligand)Curated

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    BioCyciCHLAMY:CHREPMP04-MONOMER.
    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:COX1
    Synonyms:COI, COXI
    Encoded oniMitochondrion
    OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
    Taxonomic identifieri3055 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505Cytochrome c oxidase subunit 1PRO_0000183307Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP08681.
    SMRiP08681. Positions 1-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei98 – 11821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei180 – 20021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei229 – 24921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei261 – 28121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei302 – 32221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei374 – 39421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei408 – 42821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02256.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P08681-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRWLYSTSHK DIGLLYLVFA FFGGLLGTSL SMLIRYELAL PGRGLLDGNG    50
    QLYNVIITGH GIIMLLFMVM PALFGGFGNW LLPIMIGAPD MAFPRLNNIS 100
    FWLNPPALAL LLLSTLVEQG PGTGWTAYPP LSVQHSGTSV DLAILSLHLN 150
    GLSSILGAVN MLVTVAGLRA PGMKLLHMPL FVWAIALTAV LVILAVPVLA 200
    AALVMLLTDR NINTAYFCES GDLILYQHLF WFFGHPEVYI LILPAFGIVS 250
    QVVSFFSQKP VFGLTGMICA MGAISLLGFI VWAHHMFTVG LDLDTVAYFT 300
    SATMIIAVPT GMKIFSWMAT IYSGRVWFTT PMWFAVGFIC LFTLGGVTGV 350
    VLANAGVDML VHDTYYVVAH FHYVLSMGAV FGIFAGVYFW GNLITGLGYH 400
    EGRAMVHFWL LFIGVNLTFF PQHFLGLAGM PRRMFDYADC FAGWNAVSSF 450
    GASISFISVI VFATTFQEAV RTVPRTATTL EWVLLATPAH HALSQVPVLR 500
    TASSH 505
    Length:505
    Mass (Da):55,160
    Last modified:January 1, 1988 - v1
    Checksum:i042C316203E88B9E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti388 – 3881Y → C in CAA47114. (PubMed:1831072)Curated
    Sequence conflicti428 – 4281A → V in CAA47114. (PubMed:1831072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03843 Genomic DNA. Translation: AAB93443.1.
    X54860 Genomic DNA. Translation: CAA38642.1.
    X66484 Genomic DNA. Translation: CAA47114.1.
    X03464 Genomic DNA. Translation: CAA27180.1.
    PIRiA24707.
    RefSeqiNP_042567.1. NC_001638.1.

    Genome annotation databases

    GeneIDi801495.
    KEGGicre:ChrepMp04.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03843 Genomic DNA. Translation: AAB93443.1 .
    X54860 Genomic DNA. Translation: CAA38642.1 .
    X66484 Genomic DNA. Translation: CAA47114.1 .
    X03464 Genomic DNA. Translation: CAA27180.1 .
    PIRi A24707.
    RefSeqi NP_042567.1. NC_001638.1.

    3D structure databases

    ProteinModelPortali P08681.
    SMRi P08681. Positions 1-500.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 801495.
    KEGGi cre:ChrepMp04.

    Phylogenomic databases

    KOi K02256.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .
    BioCyci CHLAMY:CHREPMP04-MONOMER.

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide sequence of a protein coding region in Chlamydomonas reinhardtii mitochondrial DNA."
      Boer P.H., Gray M.W.
      Nucleic Acids Res. 14:7506-7507(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: CW15-2.
    2. "Short dispersed repeats localized in spacer regions of Chlamydomonas reinhardtii mitochondrial DNA."
      Boer P.H., Gray M.W.
      Curr. Genet. 19:309-312(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cw15.
    3. "Mitochondrial DNA of Chlamydomonas reinhardtii: sequence and arrangement of URF5 and the gene for cytochrome oxidase subunit I."
      Vahrenholz C., Pratje E., Michaelis G., Dujon B.
      Mol. Gen. Genet. 201:213-224(1985)
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cw15.
    4. "Genes for respiratory chain proteins and ribosomal RNAs are present on a 16-kilobase-pair DNA species from Chlamydomonas reinhardtii mitochondria."
      Boer P.H., Bonen L., Lee R.W., Gray M.W.
      Proc. Natl. Acad. Sci. U.S.A. 82:3340-3344(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-234.
    5. "The URF 5 gene of Chlamydomonas reinhardtii mitochondria: DNA sequence and mode of transcription."
      Boer P.H., Gray M.W.
      EMBO J. 5:21-28(1986) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.

    Entry informationi

    Entry nameiCOX1_CHLRE
    AccessioniPrimary (citable) accession number: P08681
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 106 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3