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P08681

- COX1_CHLRE

UniProt

P08681 - COX1_CHLRE

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Protein
Cytochrome c oxidase subunit 1
Gene
COX1, COI, COXI
Organism
Chlamydomonas reinhardtii (Chlamydomonas smithii)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand) Inferred
Metal bindingi235 – 2351Copper B Inferred
Metal bindingi239 – 2391Copper B Inferred
Metal bindingi284 – 2841Copper B Inferred
Metal bindingi285 – 2851Copper B Inferred
Metal bindingi370 – 3701Iron (heme A3 axial ligand) Inferred
Metal bindingi372 – 3721Iron (heme A axial ligand) Inferred

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciCHLAMY:CHREPMP04-MONOMER.
UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:COX1
Synonyms:COI, COXI
Encoded oniMitochondrion
OrganismiChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifieri3055 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST
Transmembranei55 – 7521Helical; Reviewed prediction
Add
BLAST
Transmembranei98 – 11821Helical; Reviewed prediction
Add
BLAST
Transmembranei143 – 16321Helical; Reviewed prediction
Add
BLAST
Transmembranei180 – 20021Helical; Reviewed prediction
Add
BLAST
Transmembranei229 – 24921Helical; Reviewed prediction
Add
BLAST
Transmembranei261 – 28121Helical; Reviewed prediction
Add
BLAST
Transmembranei302 – 32221Helical; Reviewed prediction
Add
BLAST
Transmembranei332 – 35221Helical; Reviewed prediction
Add
BLAST
Transmembranei374 – 39421Helical; Reviewed prediction
Add
BLAST
Transmembranei408 – 42821Helical; Reviewed prediction
Add
BLAST
Transmembranei446 – 46621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505Cytochrome c oxidase subunit 1
PRO_0000183307Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr) By similarity

Structurei

3D structure databases

ProteinModelPortaliP08681.
SMRiP08681. Positions 1-500.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P08681-1 [UniParc]FASTAAdd to Basket

« Hide

MRWLYSTSHK DIGLLYLVFA FFGGLLGTSL SMLIRYELAL PGRGLLDGNG    50
QLYNVIITGH GIIMLLFMVM PALFGGFGNW LLPIMIGAPD MAFPRLNNIS 100
FWLNPPALAL LLLSTLVEQG PGTGWTAYPP LSVQHSGTSV DLAILSLHLN 150
GLSSILGAVN MLVTVAGLRA PGMKLLHMPL FVWAIALTAV LVILAVPVLA 200
AALVMLLTDR NINTAYFCES GDLILYQHLF WFFGHPEVYI LILPAFGIVS 250
QVVSFFSQKP VFGLTGMICA MGAISLLGFI VWAHHMFTVG LDLDTVAYFT 300
SATMIIAVPT GMKIFSWMAT IYSGRVWFTT PMWFAVGFIC LFTLGGVTGV 350
VLANAGVDML VHDTYYVVAH FHYVLSMGAV FGIFAGVYFW GNLITGLGYH 400
EGRAMVHFWL LFIGVNLTFF PQHFLGLAGM PRRMFDYADC FAGWNAVSSF 450
GASISFISVI VFATTFQEAV RTVPRTATTL EWVLLATPAH HALSQVPVLR 500
TASSH 505
Length:505
Mass (Da):55,160
Last modified:January 1, 1988 - v1
Checksum:i042C316203E88B9E
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti388 – 3881Y → C in CAA47114. 1 Publication
Sequence conflicti428 – 4281A → V in CAA47114. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03843 Genomic DNA. Translation: AAB93443.1.
X54860 Genomic DNA. Translation: CAA38642.1.
X66484 Genomic DNA. Translation: CAA47114.1.
X03464 Genomic DNA. Translation: CAA27180.1.
PIRiA24707.
RefSeqiNP_042567.1. NC_001638.1.

Genome annotation databases

GeneIDi801495.
KEGGicre:ChrepMp04.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U03843 Genomic DNA. Translation: AAB93443.1 .
X54860 Genomic DNA. Translation: CAA38642.1 .
X66484 Genomic DNA. Translation: CAA47114.1 .
X03464 Genomic DNA. Translation: CAA27180.1 .
PIRi A24707.
RefSeqi NP_042567.1. NC_001638.1.

3D structure databases

ProteinModelPortali P08681.
SMRi P08681. Positions 1-500.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 801495.
KEGGi cre:ChrepMp04.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .
BioCyci CHLAMY:CHREPMP04-MONOMER.

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of a protein coding region in Chlamydomonas reinhardtii mitochondrial DNA."
    Boer P.H., Gray M.W.
    Nucleic Acids Res. 14:7506-7507(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: CW15-2.
  2. "Short dispersed repeats localized in spacer regions of Chlamydomonas reinhardtii mitochondrial DNA."
    Boer P.H., Gray M.W.
    Curr. Genet. 19:309-312(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cw15.
  3. "Mitochondrial DNA of Chlamydomonas reinhardtii: sequence and arrangement of URF5 and the gene for cytochrome oxidase subunit I."
    Vahrenholz C., Pratje E., Michaelis G., Dujon B.
    Mol. Gen. Genet. 201:213-224(1985)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: cw15.
  4. "Genes for respiratory chain proteins and ribosomal RNAs are present on a 16-kilobase-pair DNA species from Chlamydomonas reinhardtii mitochondria."
    Boer P.H., Bonen L., Lee R.W., Gray M.W.
    Proc. Natl. Acad. Sci. U.S.A. 82:3340-3344(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-234.
  5. "The URF 5 gene of Chlamydomonas reinhardtii mitochondria: DNA sequence and mode of transcription."
    Boer P.H., Gray M.W.
    EMBO J. 5:21-28(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.

Entry informationi

Entry nameiCOX1_CHLRE
AccessioniPrimary (citable) accession number: P08681
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: September 3, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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