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P08681 (COX1_CHLRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c oxidase subunit 1

EC=1.9.3.1
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene names
Name:COX1
Synonyms:COI, COXI
Encoded onMitochondrion
OrganismChlamydomonas reinhardtii (Chlamydomonas smithii)
Taxonomic identifier3055 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeChlorophytaChlorophyceaeChlamydomonadalesChlamydomonadaceaeChlamydomonas

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505Cytochrome c oxidase subunit 1
PRO_0000183307

Regions

Transmembrane14 – 3421Helical; Potential
Transmembrane55 – 7521Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane143 – 16321Helical; Potential
Transmembrane180 – 20021Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane261 – 28121Helical; Potential
Transmembrane302 – 32221Helical; Potential
Transmembrane332 – 35221Helical; Potential
Transmembrane374 – 39421Helical; Potential
Transmembrane408 – 42821Helical; Potential
Transmembrane446 – 46621Helical; Potential

Sites

Metal binding601Iron (heme A axial ligand) Probable
Metal binding2351Copper B Probable
Metal binding2391Copper B Probable
Metal binding2841Copper B Probable
Metal binding2851Copper B Probable
Metal binding3701Iron (heme A3 axial ligand) Probable
Metal binding3721Iron (heme A axial ligand) Probable

Amino acid modifications

Cross-link235 ↔ 2391'-histidyl-3'-tyrosine (His-Tyr) By similarity

Experimental info

Sequence conflict3881Y → C in CAA47114. Ref.2
Sequence conflict4281A → V in CAA47114. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P08681 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 042C316203E88B9E

FASTA50555,160
        10         20         30         40         50         60 
MRWLYSTSHK DIGLLYLVFA FFGGLLGTSL SMLIRYELAL PGRGLLDGNG QLYNVIITGH 

        70         80         90        100        110        120 
GIIMLLFMVM PALFGGFGNW LLPIMIGAPD MAFPRLNNIS FWLNPPALAL LLLSTLVEQG 

       130        140        150        160        170        180 
PGTGWTAYPP LSVQHSGTSV DLAILSLHLN GLSSILGAVN MLVTVAGLRA PGMKLLHMPL 

       190        200        210        220        230        240 
FVWAIALTAV LVILAVPVLA AALVMLLTDR NINTAYFCES GDLILYQHLF WFFGHPEVYI 

       250        260        270        280        290        300 
LILPAFGIVS QVVSFFSQKP VFGLTGMICA MGAISLLGFI VWAHHMFTVG LDLDTVAYFT 

       310        320        330        340        350        360 
SATMIIAVPT GMKIFSWMAT IYSGRVWFTT PMWFAVGFIC LFTLGGVTGV VLANAGVDML 

       370        380        390        400        410        420 
VHDTYYVVAH FHYVLSMGAV FGIFAGVYFW GNLITGLGYH EGRAMVHFWL LFIGVNLTFF 

       430        440        450        460        470        480 
PQHFLGLAGM PRRMFDYADC FAGWNAVSSF GASISFISVI VFATTFQEAV RTVPRTATTL 

       490        500 
EWVLLATPAH HALSQVPVLR TASSH 

« Hide

References

[1]"Nucleotide sequence of a protein coding region in Chlamydomonas reinhardtii mitochondrial DNA."
Boer P.H., Gray M.W.
Nucleic Acids Res. 14:7506-7507(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: CW15-2.
[2]"Short dispersed repeats localized in spacer regions of Chlamydomonas reinhardtii mitochondrial DNA."
Boer P.H., Gray M.W.
Curr. Genet. 19:309-312(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cw15.
[3]"Mitochondrial DNA of Chlamydomonas reinhardtii: sequence and arrangement of URF5 and the gene for cytochrome oxidase subunit I."
Vahrenholz C., Pratje E., Michaelis G., Dujon B.
Mol. Gen. Genet. 201:213-224(1985)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: cw15.
[4]"Genes for respiratory chain proteins and ribosomal RNAs are present on a 16-kilobase-pair DNA species from Chlamydomonas reinhardtii mitochondria."
Boer P.H., Bonen L., Lee R.W., Gray M.W.
Proc. Natl. Acad. Sci. U.S.A. 82:3340-3344(1985) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 79-234.
[5]"The URF 5 gene of Chlamydomonas reinhardtii mitochondria: DNA sequence and mode of transcription."
Boer P.H., Gray M.W.
EMBO J. 5:21-28(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-30.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U03843 Genomic DNA. Translation: AAB93443.1.
X54860 Genomic DNA. Translation: CAA38642.1.
X66484 Genomic DNA. Translation: CAA47114.1.
X03464 Genomic DNA. Translation: CAA27180.1.
PIRA24707.
RefSeqNP_042567.1. NC_001638.1.

3D structure databases

ProteinModelPortalP08681.
SMRP08681. Positions 1-500.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID801495.
KEGGcre:ChrepMp04.

Phylogenomic databases

KOK02256.

Enzyme and pathway databases

BioCycCHLAMY:CHREPMP04-MONOMER.
UniPathwayUPA00705.

Family and domain databases

Gene3D1.20.210.10. 1 hit.
InterProIPR000883. Cyt_c_Oxase_su1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERPTHR10422. PTHR10422. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
SUPFAMSSF81442. SSF81442. 1 hit.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOX1_CHLRE
AccessionPrimary (citable) accession number: P08681
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: April 16, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways