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Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei645 – 6462Cleavage; by host signal peptidase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Taxonomic identifieri11602 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008627 Componenti: Genome

Subcellular locationi

Glycoprotein G1 :

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 485467LumenalSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Topological domaini507 – 648142CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini649 – 1105457LumenalSequence AnalysisAdd
BLAST
Transmembranei1106 – 112621HelicalSequence AnalysisAdd
BLAST
Topological domaini1127 – 11359CytoplasmicSequence Analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Add
BLAST
Chaini19 – 11351117Envelope glycoproteinPRO_0000036815Add
BLAST
Chaini19 – ?648630Glycoprotein G1PRO_0000036816Add
BLAST
Chaini649 – ?1126478Glycoprotein G2PRO_0000036817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi235 – 2351N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi399 – 3991N-linked (GlcNAc...); by hostSequence Analysis
Glycosylationi928 – 9281N-linked (GlcNAc...); by hostSequence Analysis

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.1 Publication

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other.By similarity

Structurei

3D structure databases

ProteinModelPortaliP08668.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 63424ITAMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_glycoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08668-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPVP
60 70 80 90 100
LADTAQMVPE SSCNMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS
110 120 130 140 150
TEVDLKGTCV LKHKMVEESY RSRKSVTCYD LSCNSTYCKP TLYMIVPIHA
160 170 180 190 200
CNMMKSCLIA LGPYRVQVVY ERSYCMTGVL IEGKCFVPDQ SVVSIIKHGI
210 220 230 240 250
FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG
260 270 280 290 300
GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEEIA SYSIVGPANA
310 320 330 340 350
KVPHSASSDT LSLIAYSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN
360 370 380 390 400
CDKSAIPLIW TGMIDLPGYY EAVHPCTVFC VLSGPGASCE AFSEGGIFNI
410 420 430 440 450
TSPMCLVSKQ NRFRLTEQQV NFVCQRVDMD IVVYCNGQRK VILTKTLVIG
460 470 480 490 500
QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA
510 520 530 540 550
ITFIILTVLK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY
560 570 580 590 600
ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD
610 620 630 640 650
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE
660 670 680 690 700
TPLTPVWNDN AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS
710 720 730 740 750
IDLHIEIEEQ TIGVDVHALG HWFDGRLNLK TSFHCYGACT KYEYPWHTAK
760 770 780 790 800
CHYERDYQYE TSWGCNPSDC PGVGTGCTAC GLYLDQLKPV GSAYKIITIR
810 820 830 840 850
YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF SQGDTLLFFG
860 870 880 890 900
PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT
910 920 930 940 950
TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD
960 970 980 990 1000
HINILVTKDI DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC
1010 1020 1030 1040 1050
PTFLTSIKAC DKAICYGAES VTLTRGQNTV KVSGKGGHSG STFRCCHGED
1060 1070 1080 1090 1100
CSQIGLHAAA PHLDKVNGIS EIENSKVYDD GAPQCGIKCW FVKSGEWISG
1110 1120 1130
IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS
Length:1,135
Mass (Da):126,421
Last modified:January 1, 1988 - v1
Checksum:i8E40B8EA68EA62FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371E → G in CAA68456 (PubMed:3114716).Curated
Sequence conflicti64 – 641N → S in CAA68456 (PubMed:3114716).Curated
Sequence conflicti173 – 1731S → T in CAA68456 (PubMed:3114716).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14627 Genomic RNA. Translation: AAA43836.1.
Y00386 mRNA. Translation: CAA68456.1.
PIRiA26348. GNVUHV.
A29382. GNVUH7.
RefSeqiNP_941978.1. NC_005219.1.

Genome annotation databases

GeneIDi2943079.
KEGGivg:2943079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14627 Genomic RNA. Translation: AAA43836.1.
Y00386 mRNA. Translation: CAA68456.1.
PIRiA26348. GNVUHV.
A29382. GNVUH7.
RefSeqiNP_941978.1. NC_005219.1.

3D structure databases

ProteinModelPortaliP08668.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi2943079.
KEGGivg:2943079.

Family and domain databases

InterProiIPR016402. Envelope_glycoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order."
    Schmaljohn C.S., Schmaljohn A.L., Dalrymple J.M.
    Virology 157:31-39(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118."
    Yoo D., Kang C.Y.
    Nucleic Acids Res. 15:6299-6299(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA."
    Loeber C., Anheier B., Lindow S., Klenk H.-D., Feldmann H.
    Virology 289:224-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY SIGNAL PEPTIDASE.
  4. "Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis."
    Jin M., Park J., Lee S., Park B., Shin J., Song K.J., Ahn T.I., Hwang S.Y., Ahn B.Y., Ahn K.
    Virology 294:60-69(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGP_HANTV
AccessioniPrimary (citable) accession number: P08668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

It was not possible to precisely define the C-terminus of G1 and G2 mature glycoproteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.