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P08668

- GP_HANTV

UniProt

P08668 - GP_HANTV

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Protein
Envelope glycoprotein
Gene
GP
Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei645 – 6462Cleavage; by host signal peptidase

GO - Biological processi

  1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
  2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
  3. signal transduction Source: InterPro
  4. suppression by virus of host TRAF activity Source: UniProtKB-KW
  5. suppression by virus of host innate immune response Source: UniProtKB-KW
  6. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein
Short name:
GP
Alternative name(s):
M polyprotein
Cleaved into the following 2 chains:
Gene namesi
Name:GP
OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Taxonomic identifieri11602 [NCBI]
Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]
ProteomesiUP000008627: Genome

Subcellular locationi

Chain Glycoprotein G1 : Virion membrane Reviewed prediction. Host Golgi apparatus membrane; Single-pass type I membrane protein Reviewed prediction. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Reviewed prediction
Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 485467Lumenal Reviewed prediction
Add
BLAST
Transmembranei486 – 50621Helical; Reviewed prediction
Add
BLAST
Topological domaini507 – 648142Cytoplasmic Reviewed prediction
Add
BLAST
Topological domaini649 – 1105457Lumenal Reviewed prediction
Add
BLAST
Transmembranei1106 – 112621Helical; Reviewed prediction
Add
BLAST
Topological domaini1127 – 11359Cytoplasmic Reviewed prediction

GO - Cellular componenti

  1. host cell Golgi membrane Source: UniProtKB-SubCell
  2. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818
Add
BLAST
Chaini19 – 11351117Envelope glycoprotein
PRO_0000036815Add
BLAST
Chaini19 – ?648630Glycoprotein G1
PRO_0000036816Add
BLAST
Chaini649 – ?1126478Glycoprotein G2
PRO_0000036817Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi134 – 1341N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi235 – 2351N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi347 – 3471N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi399 – 3991N-linked (GlcNAc...); by host Reviewed prediction
Glycosylationi928 – 9281N-linked (GlcNAc...); by host Reviewed prediction

Post-translational modificationi

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Keywords - PTMi

Glycoprotein

Interactioni

Subunit structurei

G1 and G2 interacts with each other By similarity.

Structurei

3D structure databases

ProteinModelPortaliP08668.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini611 – 63424ITAM
Add
BLAST

Sequence similaritiesi

Contains 1 ITAM domain.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamiPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
ProDomiPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS51056. ITAM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08668-1 [UniParc]FASTAAdd to Basket

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MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPVP     50
LADTAQMVPE SSCNMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS 100
TEVDLKGTCV LKHKMVEESY RSRKSVTCYD LSCNSTYCKP TLYMIVPIHA 150
CNMMKSCLIA LGPYRVQVVY ERSYCMTGVL IEGKCFVPDQ SVVSIIKHGI 200
FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG 250
GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEEIA SYSIVGPANA 300
KVPHSASSDT LSLIAYSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN 350
CDKSAIPLIW TGMIDLPGYY EAVHPCTVFC VLSGPGASCE AFSEGGIFNI 400
TSPMCLVSKQ NRFRLTEQQV NFVCQRVDMD IVVYCNGQRK VILTKTLVIG 450
QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA 500
ITFIILTVLK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY 550
ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD 600
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE 650
TPLTPVWNDN AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS 700
IDLHIEIEEQ TIGVDVHALG HWFDGRLNLK TSFHCYGACT KYEYPWHTAK 750
CHYERDYQYE TSWGCNPSDC PGVGTGCTAC GLYLDQLKPV GSAYKIITIR 800
YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF SQGDTLLFFG 850
PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT 900
TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD 950
HINILVTKDI DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC 1000
PTFLTSIKAC DKAICYGAES VTLTRGQNTV KVSGKGGHSG STFRCCHGED 1050
CSQIGLHAAA PHLDKVNGIS EIENSKVYDD GAPQCGIKCW FVKSGEWISG 1100
IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS 1135
Length:1,135
Mass (Da):126,421
Last modified:January 1, 1988 - v1
Checksum:i8E40B8EA68EA62FA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 371E → G in CAA68456. 1 Publication
Sequence conflicti64 – 641N → S in CAA68456. 1 Publication
Sequence conflicti173 – 1731S → T in CAA68456. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14627 Genomic RNA. Translation: AAA43836.1.
Y00386 mRNA. Translation: CAA68456.1.
PIRiA26348. GNVUHV.
A29382. GNVUH7.
RefSeqiNP_941978.1. NC_005219.1.

Genome annotation databases

GeneIDi2943079.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M14627 Genomic RNA. Translation: AAA43836.1 .
Y00386 mRNA. Translation: CAA68456.1 .
PIRi A26348. GNVUHV.
A29382. GNVUH7.
RefSeqi NP_941978.1. NC_005219.1.

3D structure databases

ProteinModelPortali P08668.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2943079.

Family and domain databases

InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view ]
Pfami PF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view ]
PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
ProDomi PD001813. Hanta_G2. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS51056. ITAM_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order."
    Schmaljohn C.S., Schmaljohn A.L., Dalrymple J.M.
    Virology 157:31-39(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118."
    Yoo D., Kang C.Y.
    Nucleic Acids Res. 15:6299-6299(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  3. "The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA."
    Loeber C., Anheier B., Lindow S., Klenk H.-D., Feldmann H.
    Virology 289:224-229(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CLEAVAGE BY SIGNAL PEPTIDASE.
  4. "Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis."
    Jin M., Park J., Lee S., Park B., Shin J., Song K.J., Ahn T.I., Hwang S.Y., Ahn B.Y., Ahn K.
    Virology 294:60-69(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiGP_HANTV
AccessioniPrimary (citable) accession number: P08668
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Miscellaneous

It was not possible to precisely define the C-terminus of G1 and G2 mature glycoproteins.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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