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P08668 (GP_HANTV) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Envelope glycoprotein

Short name=GP
Alternative name(s):
M polyprotein

Cleaved into the following 2 chains:

  1. Glycoprotein G1
  2. Glycoprotein G2
Gene names
Name:GP
OrganismHantaan virus (strain 76-118) (Korean hemorrhagic fever virus) [Reference proteome]
Taxonomic identifier11602 [NCBI]
Taxonomic lineageVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
Virus hostApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
Homo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length1135 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity. Ref.4

Subunit structure

G1 and G2 interacts with each other By similarity.

Subcellular location

Glycoprotein G1: Virion membrane Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential. Host endoplasmic reticulum membrane; Single-pass type I membrane protein Potential. Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs By similarity.

Glycoprotein G2: Virion membrane Potential. Host Golgi apparatus membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.

Miscellaneous

It was not possible to precisely define the C-terminus of G1 and G2 mature glycoproteins.

Sequence similarities

Belongs to the hantavirus envelope glycoprotein family.

Contains 1 ITAM domain.

Ontologies

Keywords
   Biological processFusion of virus membrane with host endosomal membrane
Fusion of virus membrane with host membrane
Host-virus interaction
Inhibition of host innate immune response by virus
Inhibition of host RLR pathway by virus
Inhibition of host TRAFs by virus
Viral attachment to host cell
Viral immunoevasion
Viral penetration into host cytoplasm
Virus endocytosis by host
Virus entry into host cell
   Cellular componentHost endoplasmic reticulum
Host Golgi apparatus
Host membrane
Membrane
Viral envelope protein
Virion
   DomainSignal
Transmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processendocytosis involved in viral entry into host cell

Inferred from electronic annotation. Source: UniProtKB-KW

fusion of virus membrane with host endosome membrane

Inferred from electronic annotation. Source: UniProtKB-KW

signal transduction

Inferred from electronic annotation. Source: InterPro

suppression by virus of host TRAF activity

Inferred from electronic annotation. Source: UniProtKB-KW

suppression by virus of host innate immune response

Inferred from electronic annotation. Source: UniProtKB-KW

virion attachment to host cell

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componenthost cell Golgi membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

host cell endoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

viral envelope

Inferred from electronic annotation. Source: UniProtKB-KW

virion membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818
Chain19 – 11351117Envelope glycoprotein
PRO_0000036815
Chain19 – ?648630Glycoprotein G1
PRO_0000036816
Chain649 – ?1126478Glycoprotein G2
PRO_0000036817

Regions

Topological domain19 – 485467Lumenal Potential
Transmembrane486 – 50621Helical; Potential
Topological domain507 – 648142Cytoplasmic Potential
Topological domain649 – 1105457Lumenal Potential
Transmembrane1106 – 112621Helical; Potential
Topological domain1127 – 11359Cytoplasmic Potential
Domain611 – 63424ITAM

Sites

Site645 – 6462Cleavage; by host signal peptidase

Amino acid modifications

Glycosylation1341N-linked (GlcNAc...); by host Potential
Glycosylation2351N-linked (GlcNAc...); by host Potential
Glycosylation3471N-linked (GlcNAc...); by host Potential
Glycosylation3991N-linked (GlcNAc...); by host Potential
Glycosylation9281N-linked (GlcNAc...); by host Potential

Experimental info

Sequence conflict371E → G in CAA68456. Ref.2
Sequence conflict641N → S in CAA68456. Ref.2
Sequence conflict1731S → T in CAA68456. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P08668 [UniParc].

Last modified January 1, 1988. Version 1.
Checksum: 8E40B8EA68EA62FA

FASTA1,135126,421
        10         20         30         40         50         60 
MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPVP LADTAQMVPE 

        70         80         90        100        110        120 
SSCNMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS TEVDLKGTCV LKHKMVEESY 

       130        140        150        160        170        180 
RSRKSVTCYD LSCNSTYCKP TLYMIVPIHA CNMMKSCLIA LGPYRVQVVY ERSYCMTGVL 

       190        200        210        220        230        240 
IEGKCFVPDQ SVVSIIKHGI FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK 

       250        260        270        280        290        300 
VQGYYICIVG GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEEIA SYSIVGPANA 

       310        320        330        340        350        360 
KVPHSASSDT LSLIAYSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN CDKSAIPLIW 

       370        380        390        400        410        420 
TGMIDLPGYY EAVHPCTVFC VLSGPGASCE AFSEGGIFNI TSPMCLVSKQ NRFRLTEQQV 

       430        440        450        460        470        480 
NFVCQRVDMD IVVYCNGQRK VILTKTLVIG QCIYTITSLF SLLPGVAHSI AVELCVPGFH 

       490        500        510        520        530        540 
GWATAALLVT FCFGWVLIPA ITFIILTVLK FIANIFHTSN QENRLKSVLR KIKEEFEKTK 

       550        560        570        580        590        600 
GSMVCDVCKY ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD 

       610        620        630        640        650        660 
LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE TPLTPVWNDN 

       670        680        690        700        710        720 
AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS IDLHIEIEEQ TIGVDVHALG 

       730        740        750        760        770        780 
HWFDGRLNLK TSFHCYGACT KYEYPWHTAK CHYERDYQYE TSWGCNPSDC PGVGTGCTAC 

       790        800        810        820        830        840 
GLYLDQLKPV GSAYKIITIR YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF 

       850        860        870        880        890        900 
SQGDTLLFFG PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT 

       910        920        930        940        950        960 
TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD HINILVTKDI 

       970        980        990       1000       1010       1020 
DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC PTFLTSIKAC DKAICYGAES 

      1030       1040       1050       1060       1070       1080 
VTLTRGQNTV KVSGKGGHSG STFRCCHGED CSQIGLHAAA PHLDKVNGIS EIENSKVYDD 

      1090       1100       1110       1120       1130 
GAPQCGIKCW FVKSGEWISG IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS 

« Hide

References

[1]"Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order."
Schmaljohn C.S., Schmaljohn A.L., Dalrymple J.M.
Virology 157:31-39(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[2]"Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118."
Yoo D., Kang C.Y.
Nucleic Acids Res. 15:6299-6299(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
[3]"The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA."
Loeber C., Anheier B., Lindow S., Klenk H.-D., Feldmann H.
Virology 289:224-229(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CLEAVAGE BY SIGNAL PEPTIDASE.
[4]"Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis."
Jin M., Park J., Lee S., Park B., Shin J., Song K.J., Ahn T.I., Hwang S.Y., Ahn B.Y., Ahn K.
Virology 294:60-69(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M14627 Genomic RNA. Translation: AAA43836.1.
Y00386 mRNA. Translation: CAA68456.1.
PIRGNVUHV. A26348.
GNVUH7. A29382.
RefSeqNP_941978.1. NC_005219.1.

3D structure databases

ProteinModelPortalP08668.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2943079.

Family and domain databases

InterProIPR016402. Envelope_gylcoprot_Hantavirus.
IPR002534. Hanta_G1.
IPR002532. Hanta_G2.
IPR012316. ITAM_motif_hantavir-typ.
[Graphical view]
PfamPF01567. Hanta_G1. 1 hit.
PF01561. Hanta_G2. 1 hit.
PF10538. ITAM_Cys-rich. 1 hit.
[Graphical view]
PIRSFPIRSF003945. M_poly_HantaV. 1 hit.
ProDomPD001813. Hanta_G2. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEPS51056. ITAM_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGP_HANTV
AccessionPrimary (citable) accession number: P08668
Entry history
Integrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families