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P08668

- GP_HANTV

UniProt

P08668 - GP_HANTV

Protein

Envelope glycoprotein

Gene

GP

Organism
Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Jan 1988)
      Previous versions | rss
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    Functioni

    Glycoprotein G1 and glycoprotein G2 interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. G1 contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei645 – 6462Cleavage; by host signal peptidase

    GO - Biological processi

    1. endocytosis involved in viral entry into host cell Source: UniProtKB-KW
    2. fusion of virus membrane with host endosome membrane Source: UniProtKB-KW
    3. signal transduction Source: InterPro
    4. suppression by virus of host innate immune response Source: UniProtKB-KW
    5. suppression by virus of host TRAF activity Source: UniProtKB-KW
    6. virion attachment to host cell Source: UniProtKB-KW

    Keywords - Biological processi

    Fusion of virus membrane with host endosomal membrane, Fusion of virus membrane with host membrane, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host RLR pathway by virus, Inhibition of host TRAFs by virus, Viral attachment to host cell, Viral immunoevasion, Viral penetration into host cytoplasm, Virus endocytosis by host, Virus entry into host cell

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Envelope glycoprotein
    Short name:
    GP
    Alternative name(s):
    M polyprotein
    Cleaved into the following 2 chains:
    Gene namesi
    Name:GP
    OrganismiHantaan virus (strain 76-118) (Korean hemorrhagic fever virus)
    Taxonomic identifieri11602 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesBunyaviridaeHantavirus
    Virus hostiApodemus agrarius (Eurasian field mouse) [TaxID: 39030]
    Homo sapiens (Human) [TaxID: 9606]
    ProteomesiUP000008627: Genome

    Subcellular locationi

    Chain Glycoprotein G1 : Virion membrane Curated. Host Golgi apparatus membrane Curated; Single-pass type I membrane protein Curated. Host endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
    Note: Interaction between G1 and G2 is essential for proper targeting of G1 to the Golgi complex, where virion budding occurs.By similarity

    GO - Cellular componenti

    1. host cell endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. host cell Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW
    4. viral envelope Source: UniProtKB-KW
    5. virion membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Host endoplasmic reticulum, Host Golgi apparatus, Host membrane, Membrane, Viral envelope protein, Virion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Add
    BLAST
    Chaini19 – 11351117Envelope glycoproteinPRO_0000036815Add
    BLAST
    Chaini19 – ?648630Glycoprotein G1PRO_0000036816Add
    BLAST
    Chaini649 – ?1126478Glycoprotein G2PRO_0000036817Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi134 – 1341N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi235 – 2351N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi347 – 3471N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi399 – 3991N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi928 – 9281N-linked (GlcNAc...); by hostSequence Analysis

    Post-translational modificationi

    Specific enzymatic cleavages in vivo yield mature proteins including glycoprotein G1 and glycoprotein G2.1 Publication

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Subunit structurei

    G1 and G2 interacts with each other.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP08668.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 485467LumenalSequence AnalysisAdd
    BLAST
    Topological domaini507 – 648142CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini649 – 1105457LumenalSequence AnalysisAdd
    BLAST
    Topological domaini1127 – 11359CytoplasmicSequence Analysis

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei1106 – 112621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini611 – 63424ITAMPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 ITAM domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Family and domain databases

    InterProiIPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view]
    PfamiPF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view]
    PIRSFiPIRSF003945. M_poly_HantaV. 1 hit.
    ProDomiPD001813. Hanta_G2. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS51056. ITAM_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08668-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGIWKWLVMA SLVWPVLTLR NVYDMKIECP HTVSFGENSV IGYVELPPVP     50
    LADTAQMVPE SSCNMDNHQS LNTITKYTQV SWRGKADQSQ SSQNSFETVS 100
    TEVDLKGTCV LKHKMVEESY RSRKSVTCYD LSCNSTYCKP TLYMIVPIHA 150
    CNMMKSCLIA LGPYRVQVVY ERSYCMTGVL IEGKCFVPDQ SVVSIIKHGI 200
    FDIASVHIVC FFVAVKGNTY KIFEQVKKSF ESTCNDTENK VQGYYICIVG 250
    GNSAPIYVPT LDDFRSMEAF TGIFRSPHGE DHDLAGEEIA SYSIVGPANA 300
    KVPHSASSDT LSLIAYSGIP SYSSLSILTS STEAKHVFSP GLFPKLNHTN 350
    CDKSAIPLIW TGMIDLPGYY EAVHPCTVFC VLSGPGASCE AFSEGGIFNI 400
    TSPMCLVSKQ NRFRLTEQQV NFVCQRVDMD IVVYCNGQRK VILTKTLVIG 450
    QCIYTITSLF SLLPGVAHSI AVELCVPGFH GWATAALLVT FCFGWVLIPA 500
    ITFIILTVLK FIANIFHTSN QENRLKSVLR KIKEEFEKTK GSMVCDVCKY 550
    ECETYKELKA HGVSCPQSQC PYCFTHCEPT EAAFQAHYKV CQVTHRFRDD 600
    LKKTVTPQNF TPGCYRTLNL FRYKSRCYIF TMWIFLLVLE SILWAASASE 650
    TPLTPVWNDN AHGVGSVPMH TDLELDFSLT SSSKYTYRRK LTNPLEEAQS 700
    IDLHIEIEEQ TIGVDVHALG HWFDGRLNLK TSFHCYGACT KYEYPWHTAK 750
    CHYERDYQYE TSWGCNPSDC PGVGTGCTAC GLYLDQLKPV GSAYKIITIR 800
    YSRRVCVQFG EENLCKIIDM NDCFVSRHVK VCIIGTVSKF SQGDTLLFFG 850
    PLEGGGLIFK HWCTSTCQFG DPGDIMSPRD KGFLCPEFPG SFRKKCNFAT 900
    TPICEYDGNM VSGYKKVMAT IDSFQSFNTS TMHFTDERIE WKDPDGMLRD 950
    HINILVTKDI DFDNLGENPC KIGLQTSSIE GAWGSGVGFT LTCLVSLTEC 1000
    PTFLTSIKAC DKAICYGAES VTLTRGQNTV KVSGKGGHSG STFRCCHGED 1050
    CSQIGLHAAA PHLDKVNGIS EIENSKVYDD GAPQCGIKCW FVKSGEWISG 1100
    IFSGNWIVLI VLCVFLLFSL VLLSILCPVR KHKKS 1135
    Length:1,135
    Mass (Da):126,421
    Last modified:January 1, 1988 - v1
    Checksum:i8E40B8EA68EA62FA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 371E → G in CAA68456. (PubMed:3114716)Curated
    Sequence conflicti64 – 641N → S in CAA68456. (PubMed:3114716)Curated
    Sequence conflicti173 – 1731S → T in CAA68456. (PubMed:3114716)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14627 Genomic RNA. Translation: AAA43836.1.
    Y00386 mRNA. Translation: CAA68456.1.
    PIRiA26348. GNVUHV.
    A29382. GNVUH7.
    RefSeqiNP_941978.1. NC_005219.1.

    Genome annotation databases

    GeneIDi2943079.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M14627 Genomic RNA. Translation: AAA43836.1 .
    Y00386 mRNA. Translation: CAA68456.1 .
    PIRi A26348. GNVUHV.
    A29382. GNVUH7.
    RefSeqi NP_941978.1. NC_005219.1.

    3D structure databases

    ProteinModelPortali P08668.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2943079.

    Family and domain databases

    InterProi IPR016402. Envelope_gylcoprot_Hantavirus.
    IPR002534. Hanta_G1.
    IPR002532. Hanta_G2.
    IPR012316. ITAM_motif_hantavir-typ.
    [Graphical view ]
    Pfami PF01567. Hanta_G1. 1 hit.
    PF01561. Hanta_G2. 1 hit.
    PF10538. ITAM_Cys-rich. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF003945. M_poly_HantaV. 1 hit.
    ProDomi PD001813. Hanta_G2. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS51056. ITAM_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hantaan virus M RNA: coding strategy, nucleotide sequence, and gene order."
      Schmaljohn C.S., Schmaljohn A.L., Dalrymple J.M.
      Virology 157:31-39(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Nucleotide sequence of the M segment of the genomic RNA of Hantaan virus 76-118."
      Yoo D., Kang C.Y.
      Nucleic Acids Res. 15:6299-6299(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "The Hantaan virus glycoprotein precursor is cleaved at the conserved pentapeptide WAASA."
      Loeber C., Anheier B., Lindow S., Klenk H.-D., Feldmann H.
      Virology 289:224-229(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CLEAVAGE BY SIGNAL PEPTIDASE.
    4. "Hantaan virus enters cells by clathrin-dependent receptor-mediated endocytosis."
      Jin M., Park J., Lee S., Park B., Shin J., Song K.J., Ahn T.I., Hwang S.Y., Ahn B.Y., Ahn K.
      Virology 294:60-69(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiGP_HANTV
    AccessioniPrimary (citable) accession number: P08668
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 1, 1988
    Last sequence update: January 1, 1988
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    It was not possible to precisely define the C-terminus of G1 and G2 mature glycoproteins.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3