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Protein

Glycoprotein

Gene

G

Organism
Rabies virus (strain Pasteur vaccins / PV) (RABV)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane. There is convincing in vitro evidence that the muscular form of the nicotinic acetylcholine receptor (nAChR), the neuronal cell adhesion molecule (NCAM), and the p75 neurotrophin receptor (p75NTR) bind glycoprotein and thereby facilitate rabies virus entry into cells (By similarity).By similarity

Miscellaneous

Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Glycoprotein
Gene namesi
Name:G
OrganismiRabies virus (strain Pasteur vaccins / PV) (RABV)
Taxonomic identifieri103929 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesRhabdoviridaeLyssavirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Mammalia [TaxID: 40674]
Proteomesi
  • UP000008649 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 459Virion surfaceSequence analysisAdd BLAST440
Transmembranei460 – 480HelicalSequence analysisAdd BLAST21
Topological domaini481 – 524IntravirionSequence analysisAdd BLAST44

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Viral envelope protein, Virion

Pathology & Biotechi

Biotechnological usei

Primary surface antigen capable of inducing and reacting with virus-neutralizing antibodies. Almost all human and veterinary vaccines are based on the functional aspects of the G protein.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000004099520 – 524GlycoproteinAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi56N-linked (GlcNAc...) asparagine; by hostBy similarity1
Glycosylationi266N-linked (GlcNAc...) asparagine; by hostBy similarity1
Glycosylationi338N-linked (GlcNAc...) asparagine; by hostBy similarity1
Lipidationi479S-palmitoyl cysteine; by hostBy similarity1

Post-translational modificationi

Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Interactioni

Subunit structurei

Homotrimer. Interacts with matrix protein (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP08667.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lyssavirus glycoprotein family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

OrthoDBiVOG09000070.

Family and domain databases

InterProiView protein in InterPro
IPR001903. Rhabd_glycop.
PfamiView protein in Pfam
PF00974. Rhabdo_glycop. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08667-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVPQALLFVP LLVFPLCFGK FPIYTIPDKL GPWSPIDIHH LSCPNNLVVE
60 70 80 90 100
DEGCTNLSGF SYMELKVGYI SAIKMNGFTC TGVVTEAETY TNFVGYVTTT
110 120 130 140 150
FKRKHFRPTP DACRAAYNWK MAGDPRYEES LHNPYPDYHW LRTVKTTKES
160 170 180 190 200
LVIISPSVAD LDPYDRSLHS RVFPGGNCSG VAVSSTYCST NHDYTIWMPE
210 220 230 240 250
NPRLGMSCDI FTNSRGKRAS KGSETCGFVD ERGLYKSLKG ACKLKLCGVL
260 270 280 290 300
GLRLMDGTWV AMQTSNETKW CPPGQLVNLH DFRSDEIEHL VVEELVKKRE
310 320 330 340 350
ECLDALESIM TTKSVSFRRL SHLRKLVPGF GKAYTIFNKT LMEADAHYKS
360 370 380 390 400
VRTWNEIIPS KGCLRVGGRC HPHVNGVFFN GIILGPDGNV LIPEMQSSLL
410 420 430 440 450
QQHMELLVSS VIPLMHPLAD PSTVFKNGDE AEDFVEVHLP DVHERISGVD
460 470 480 490 500
LGLPNWGKYV LLSAGALTAL MLIIFLMTCW RRVNRSEPTQ HNLRGTGREV
510 520
SVTPQSGKII SSWESYKSGG ETGL
Length:524
Mass (Da):58,535
Last modified:January 1, 1988 - v1
Checksum:iEACF34361F2AEFE3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13215 Genomic RNA. Translation: AAA47218.1.
PIRiC26275. VGVNRV.
RefSeqiNP_056796.1. NC_001542.1.

Genome annotation databases

GeneIDi1489856.
KEGGivg:1489856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M13215 Genomic RNA. Translation: AAA47218.1.
PIRiC26275. VGVNRV.
RefSeqiNP_056796.1. NC_001542.1.

3D structure databases

ProteinModelPortaliP08667.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi1489856.
KEGGivg:1489856.

Phylogenomic databases

OrthoDBiVOG09000070.

Family and domain databases

InterProiView protein in InterPro
IPR001903. Rhabd_glycop.
PfamiView protein in Pfam
PF00974. Rhabdo_glycop. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGLYCO_RABVP
AccessioniPrimary (citable) accession number: P08667
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 1, 1988
Last sequence update: January 1, 1988
Last modified: May 10, 2017
This is version 69 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.