P08651 (NFIC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear factor 1 C-type
Short name=NF1-C
Short name=Nuclear factor 1/C

Alternative name(s):
CCAAT-box-binding transcription factor
Short name=CTF
Nuclear factor I/C
Short name=NF-I/C
Short name=NFI-C
TGGCA-binding protein

Gene names

Name:	NFIC
Synonyms:	NFI

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	508 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Subunit structure	Binds DNA as a homodimer.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the CTF/NF-I family. Contains 1 CTF/NF-I DNA-binding domain.

Ontologies

Keywords
Biological process	DNA replication Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Ligand	DNA-binding
Molecular function	Activator
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19706729. Source: UniProtKB positive regulation of transcription from RNA polymerase II promoter Inferred from direct assay PubMed 19706729. Source: UniProtKB transcription from RNA polymerase II promoter Traceable author statement Ref.2. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW sequence-specific DNA binding transcription factor activity Inferred from direct assay PubMed 1524678. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 4 (identifier: P08651-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P08651-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Isoform 2 (identifier: P08651-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Isoform 3 (identifier: P08651-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Isoform 5 (identifier: P08651-5)

The sequence of this isoform differs from the canonical sequence as follows:
     424-503: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 508	508	Nuclear factor 1 C-type		PRO_0000100199
Regions
	DNA binding	1 – 195	195	CTF/NF-I
Amino acid modifications
	Modified residue	1	1	N-acetylmethionine Ref.12
	Modified residue	194	1	Phosphoserine Ref.12
	Modified residue	294	1	Phosphoserine Ref.10
	Modified residue	323	1	Phosphoserine Ref.10 Ref.12
	Modified residue	333	1	Phosphoserine Ref.7 Ref.10 Ref.11 Ref.12
	Modified residue	337	1	Phosphoserine Ref.12
	Modified residue	339	1	Phosphoserine Ref.10 Ref.12
	Modified residue	343	1	Phosphoserine Ref.8 Ref.12
	Modified residue	378	1	Phosphothreonine By similarity
	Modified residue	487	1	Phosphoserine Ref.12
Natural variations
	Alternative sequence	1 – 10	10	MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3.		VSP_003552
	Alternative sequence	188 – 211	24	Missing in isoform 3.		VSP_003553
	Alternative sequence	424 – 503	80	Missing in isoform 5.		VSP_003554
	Alternative sequence	424 – 439	16	LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3.		VSP_003555
	Alternative sequence	440 – 508	69	Missing in isoform 2 and isoform 3.		VSP_003556
	Natural variant	417	1	A → S. Corresponds to variant rs10412720 [ dbSNP | Ensembl ].		VAR_057656
Experimental info
	Sequence conflict	212	1	D → V in CAA63440. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 4 [UniParc]. Last modified June 1, 2001. Version 2. Checksum: 3D0F97DA0F3AF992	FASTA	508	55,675
	10 20 30 40 50 60 MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 70 80 90 100 110 120 LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK APGCVLSNPD QKGKMRRIDC 130 140 150 160 170 180 LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAQCGHP VLCVQPHHIG VAVKELDLYL 190 200 210 220 230 240 AYFVRERDAE QSGSPRTGMG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV 250 260 270 280 290 300 TGTGPNFSLG ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 310 320 330 340 350 360 TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH 370 380 390 400 410 420 SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPASQQ 430 440 450 460 470 480 PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP RLALPPATKP ATTSEGGATS PTSPSYSPPD 490 500 TSPANRSFVG LGPRDPAGIY QAQSWYLG
	Isoform 1 [UniParc]. Checksum: B6A59BD10B4B6D1B	FASTA	499	54,682
	10 20 30 40 50 60 MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLGEKPEVK 70 80 90 100 110 120 QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP DQKGKMRRID CLRQADKVWR 130 140 150 160 170 180 LDLVMVILFK GIPLESTDGE RLVKAAQCGH PVLCVQPHHI GVAVKELDLY LAYFVRERDA 190 200 210 220 230 240 EQSGSPRTGM GSDQEDSKPI TLDTTDFQES FVTSGVFSVT ELIQVSRTPV VTGTGPNFSL 250 260 270 280 290 300 GELQGHLAYD LNPASTGLRR TLPSTSSSGS KRHKSGSMEE DVDTSPGGDY YTSPSSPTSS 310 320 330 340 350 360 SRNWTEDMEG GISSPVKKTE MDKSPFNSPS PQDSPRLSSF TQHHRPVIAV HSGIARSPHP 370 380 390 400 410 420 SSALHFPTTS ILPQTASTYF PHTAIRYPPH LNPQDPLKDL VSLACDPASQ QPGPLNGSGQ 430 440 450 460 470 480 LKMPSHCLSA QMLAPPPPGL PRLALPPATK PATTSEGGAT SPTSPSYSPP DTSPANRSFV 490 GLGPRDPAGI YQAQSWYLG
	Isoform 2 [UniParc]. Checksum: 99820E6484D655B3	FASTA	430	47,901
	10 20 30 40 50 60 MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLGEKPEVK 70 80 90 100 110 120 QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP DQKGKMRRID CLRQADKVWR 130 140 150 160 170 180 LDLVMVILFK GIPLESTDGE RLVKAAQCGH PVLCVQPHHI GVAVKELDLY LAYFVRERDA 190 200 210 220 230 240 EQSGSPRTGM GSDQEDSKPI TLDTTDFQES FVTSGVFSVT ELIQVSRTPV VTGTGPNFSL 250 260 270 280 290 300 GELQGHLAYD LNPASTGLRR TLPSTSSSGS KRHKSGSMEE DVDTSPGGDY YTSPSSPTSS 310 320 330 340 350 360 SRNWTEDMEG GISSPVKKTE MDKSPFNSPS PQDSPRLSSF TQHHRPVIAV HSGIARSPHP 370 380 390 400 410 420 SSALHFPTTS ILPQTASTYF PHTAIRYPPH LNPQDPLKDL VSLACDPASQ QPGPPTLRPT 430 RPLQTVPLWD
	Isoform 3 [UniParc]. Checksum: EA00A93762A9FAC1	FASTA	406	45,413
	10 20 30 40 50 60 MDEFHPFIEA LLPHVRAFAY TWFNLQARKR KYFKKHEKRM SKDEERAVKD ELLGEKPEVK 70 80 90 100 110 120 QKWASRLLAK LRKDIRPECR EDFVLSITGK KAPGCVLSNP DQKGKMRRID CLRQADKVWR 130 140 150 160 170 180 LDLVMVILFK GIPLESTDGE RLVKAAQCGH PVLCVQPHHI GVAVKELDLY LAYFVRERDT 190 200 210 220 230 240 TDFQESFVTS GVFSVTELIQ VSRTPVVTGT GPNFSLGELQ GHLAYDLNPA STGLRRTLPS 250 260 270 280 290 300 TSSSGSKRHK SGSMEEDVDT SPGGDYYTSP SSPTSSSRNW TEDMEGGISS PVKKTEMDKS 310 320 330 340 350 360 PFNSPSPQDS PRLSSFTQHH RPVIAVHSGI ARSPHPSSAL HFPTTSILPQ TASTYFPHTA 370 380 390 400 IRYPPHLNPQ DPLKDLVSLA CDPASQQPGP PTLRPTRPLQ TVPLWD
	Isoform 5 [UniParc]. Checksum: 239F7A15BBEA2539	FASTA	428	47,629
	10 20 30 40 50 60 MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS KDEERAVKDE 70 80 90 100 110 120 LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK APGCVLSNPD QKGKMRRIDC 130 140 150 160 170 180 LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAAQCGHP VLCVQPHHIG VAVKELDLYL 190 200 210 220 230 240 AYFVRERDAE QSGSPRTGMG SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV 250 260 270 280 290 300 TGTGPNFSLG ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 310 320 330 340 350 360 TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT QHHRPVIAVH 370 380 390 400 410 420 SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPASQQ PGPSWYLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs." Santoro C., Mermod N., Andrews P.C., Tjian R. Nature 334:218-224(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE.
[2]	"CTF5 -- a new transcriptional activator of the NFI/CTF family." Wenzelides S., Altmann S., Wendler W., Winnacker E.L. Nucleic Acids Res. 24:2416-2421(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Caudate nucleus and Uterus.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5). Tissue: Uterus.
[7]	"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M. Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[8]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[10]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294; SER-323; SER-333 AND SER-339, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[12]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-323; SER-333; SER-337; SER-339; SER-343 AND SER-487, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X12492 mRNA. Translation: CAA31012.1. X92857 mRNA. Translation: CAA63440.1. AK289885 mRNA. Translation: BAF82574.1. AK304816 mRNA. Translation: BAH14259.1. AC005514 Genomic DNA. Translation: AAC32593.1. AC005514 Genomic DNA. Translation: AAC32594.1. AC005551 Genomic DNA. Translation: AAC33190.1. AC005551 Genomic DNA. Translation: AAC33191.1. AC005551 Genomic DNA. Translation: AAC33192.1. AC005778 Genomic DNA. Translation: AAC62842.1. CH471139 Genomic DNA. Translation: EAW69325.1. CH471139 Genomic DNA. Translation: EAW69326.1. BC012120 mRNA. Translation: AAH12120.1.
IPI	IPI00029795. IPI00218037. IPI00218039. IPI00218041. IPI00941207.
PIR	B33416. S01038.
RefSeq	NP_001231931.1. NM_001245002.1. NP_001231933.1. NM_001245004.1. NP_001231934.1. NM_001245005.1. NP_005588.2. NM_005597.3. NP_995315.1. NM_205843.2.
UniGene	Hs.170131.
3D structure databases
ProteinModelPortal	P08651.
ModBase	Search...
Protein-protein interaction databases
IntAct	P08651. 5 interactions.
MINT	MINT-1439785.
PTM databases
PhosphoSite	P08651.
Polymorphism databases
DMDM	14195672.
Proteomic databases
PaxDb	P08651.
PRIDE	P08651.
Protocols and materials databases
DNASU	4782.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341919; ENSP00000342194; ENSG00000141905. ENST00000346156; ENSP00000301935; ENSG00000141905. ENST00000395111; ENSP00000378543; ENSG00000141905. ENST00000443272; ENSP00000396843; ENSG00000141905. ENST00000586919; ENSP00000465177; ENSG00000141905. ENST00000589123; ENSP00000465655; ENSG00000141905.
GeneID	4782.
KEGG	hsa:4782.
UCSC	uc002lxo.3. human. uc002lxp.3. human. uc010xhh.2. human. uc010xhi.2. human.
Organism-specific databases
CTD	4782.
GeneCards	GC19P003310.
HGNC	HGNC:7786. NFIC.
HPA	CAB004300. CAB004674.
MIM	600729. gene.
neXtProt	NX_P08651.
PharmGKB	PA31592.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG252172.
HOVERGEN	HBG006561.
KO	K09170.
PhylomeDB	P08651.
Enzyme and pathway databases
Pathway_Interaction_DB	hnf3apathway. FOXA1 transcription factor network.
SignaLink	P08651.
Gene expression databases
Bgee	P08651.
CleanEx	HS_NFIC.
Genevestigator	P08651.
GermOnline	ENSG00000141905. Homo sapiens.
Family and domain databases
InterPro	IPR000647. CTF/NFI. IPR020604. CTF/NFI_DNA-bd-dom. IPR019739. CTF/NFI_DNA-bd_CS. IPR019548. CTF/NFI_DNA-bd_N. IPR003619. MAD_homology1_Dwarfin-type. [Graphical view]
PANTHER	PTHR11492. PTHR11492. 1 hit.
Pfam	PF00859. CTF_NFI. 1 hit. PF03165. MH1. 1 hit. PF10524. NfI_DNAbd_pre-N. 1 hit. [Graphical view]
SMART	SM00523. DWA. 1 hit. [Graphical view]
PROSITE	PS00349. CTF_NFI_1. 1 hit. PS51080. CTF_NFI_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	NFIC. human.
GenomeRNAi	4782.
NextBio	18440.
SOURCE	Search...

Entry information

Entry name

NFIC_HUMAN

Accession

Primary (citable) accession number: P08651
Secondary accession number(s): A8K1H0 , B7Z9C3, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 143 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.