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Protein

Nuclear factor 1 C-type

Gene

NFIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST195

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141905-MONOMER.
ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SignaLinkiP08651.
SIGNORiP08651.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1 C-type
Short name:
NF1-C
Short name:
Nuclear factor 1/C
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CTF
Nuclear factor I/C
Short name:
NF-I/C
Short name:
NFI-C
TGGCA-binding protein
Gene namesi
Name:NFIC
Synonyms:NFI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:7786. NFIC.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4782.
OpenTargetsiENSG00000141905.
PharmGKBiPA31592.

Polymorphism and mutation databases

BioMutaiNFIC.
DMDMi14195672.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001991 – 508Nuclear factor 1 C-typeAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei300PhosphotyrosineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei365Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei365Omega-N-methylarginine; alternateCombined sources1
Modified residuei395Asymmetric dimethylarginineCombined sources1
Modified residuei451Omega-N-methylarginineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP08651.
MaxQBiP08651.
PaxDbiP08651.
PeptideAtlasiP08651.
PRIDEiP08651.

PTM databases

iPTMnetiP08651.
PhosphoSitePlusiP08651.

Expressioni

Gene expression databases

BgeeiENSG00000141905.
CleanExiHS_NFIC.
GenevisibleiP08651. HS.

Organism-specific databases

HPAiCAB004300.
CAB004674.
HPA052625.

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi110854. 21 interactors.
DIPiDIP-44692N.
IntActiP08651. 15 interactors.
MINTiMINT-1439785.
STRINGi9606.ENSP00000465655.

Structurei

3D structure databases

ProteinModelPortaliP08651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation
Contains 1 CTF/NF-I DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3663. Eukaryota.
ENOG410Y16G. LUCA.
GeneTreeiENSGT00390000009905.
HOGENOMiHOG000013028.
HOVERGENiHBG006561.
InParanoidiP08651.
KOiK09170.
OMAiIGSDQED.
OrthoDBiEOG091G0HVY.
PhylomeDBiP08651.

Family and domain databases

InterProiIPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view]
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiPF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
PROSITEiPS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: P08651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK
110 120 130 140 150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG
210 220 230 240 250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG
260 270 280 290 300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
310 320 330 340 350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT
360 370 380 390 400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL
410 420 430 440 450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP
460 470 480 490 500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY

QAQSWYLG
Length:508
Mass (Da):55,675
Last modified:June 1, 2001 - v2
Checksum:i3D0F97DA0F3AF992
GO
Isoform 1 (identifier: P08651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Show »
Length:499
Mass (Da):54,682
Checksum:iB6A59BD10B4B6D1B
GO
Isoform 2 (identifier: P08651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:430
Mass (Da):47,901
Checksum:i99820E6484D655B3
GO
Isoform 3 (identifier: P08651-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:406
Mass (Da):45,413
Checksum:iEA00A93762A9FAC1
GO
Isoform 5 (identifier: P08651-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-503: Missing.

Show »
Length:428
Mass (Da):47,629
Checksum:i239F7A15BBEA2539
GO
Isoform 6 (identifier: P08651-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,894
Checksum:i5A9A6B88FAF84891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → P in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti212D → V in CAA63440 (PubMed:8710515).Curated1
Sequence conflicti329E → K in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti353H → Y in BAH12681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057656417A → S.Corresponds to variant rs10412720dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0035521 – 10MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 Publications10
Alternative sequenceiVSP_003553188 – 211Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_047539424 – 508LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_003554424 – 503Missing in isoform 5. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_003555424 – 439LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_003556440 – 508Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12492 mRNA. Translation: CAA31012.1.
X92857 mRNA. Translation: CAA63440.1.
AK289885 mRNA. Translation: BAF82574.1.
AK297867 mRNA. Translation: BAH12681.1.
AK304816 mRNA. Translation: BAH14259.1.
AC005514 Genomic DNA. Translation: AAC32593.1.
AC005514 Genomic DNA. Translation: AAC32594.1.
AC005551 Genomic DNA. Translation: AAC33190.1.
AC005551 Genomic DNA. Translation: AAC33191.1.
AC005551 Genomic DNA. Translation: AAC33192.1.
AC005778 Genomic DNA. Translation: AAC62842.1.
CH471139 Genomic DNA. Translation: EAW69325.1.
CH471139 Genomic DNA. Translation: EAW69326.1.
BC012120 mRNA. Translation: AAH12120.1.
CCDSiCCDS12107.1. [P08651-5]
CCDS45914.1. [P08651-2]
CCDS58640.1. [P08651-3]
CCDS59330.1. [P08651-1]
CCDS59331.1. [P08651-6]
PIRiB33416.
S01038.
RefSeqiNP_001231931.1. NM_001245002.1. [P08651-1]
NP_001231933.1. NM_001245004.1. [P08651-6]
NP_001231934.1. NM_001245005.1. [P08651-3]
NP_005588.2. NM_005597.3. [P08651-5]
NP_995315.1. NM_205843.2. [P08651-2]
XP_016882324.1. XM_017026835.1. [P08651-6]
UniGeneiHs.170131.

Genome annotation databases

EnsembliENST00000341919; ENSP00000342194; ENSG00000141905. [P08651-5]
ENST00000395111; ENSP00000378543; ENSG00000141905. [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905. [P08651-1]
ENST00000586919; ENSP00000465177; ENSG00000141905. [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905. [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905. [P08651-6]
GeneIDi4782.
KEGGihsa:4782.
UCSCiuc002lxo.3. human. [P08651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12492 mRNA. Translation: CAA31012.1.
X92857 mRNA. Translation: CAA63440.1.
AK289885 mRNA. Translation: BAF82574.1.
AK297867 mRNA. Translation: BAH12681.1.
AK304816 mRNA. Translation: BAH14259.1.
AC005514 Genomic DNA. Translation: AAC32593.1.
AC005514 Genomic DNA. Translation: AAC32594.1.
AC005551 Genomic DNA. Translation: AAC33190.1.
AC005551 Genomic DNA. Translation: AAC33191.1.
AC005551 Genomic DNA. Translation: AAC33192.1.
AC005778 Genomic DNA. Translation: AAC62842.1.
CH471139 Genomic DNA. Translation: EAW69325.1.
CH471139 Genomic DNA. Translation: EAW69326.1.
BC012120 mRNA. Translation: AAH12120.1.
CCDSiCCDS12107.1. [P08651-5]
CCDS45914.1. [P08651-2]
CCDS58640.1. [P08651-3]
CCDS59330.1. [P08651-1]
CCDS59331.1. [P08651-6]
PIRiB33416.
S01038.
RefSeqiNP_001231931.1. NM_001245002.1. [P08651-1]
NP_001231933.1. NM_001245004.1. [P08651-6]
NP_001231934.1. NM_001245005.1. [P08651-3]
NP_005588.2. NM_005597.3. [P08651-5]
NP_995315.1. NM_205843.2. [P08651-2]
XP_016882324.1. XM_017026835.1. [P08651-6]
UniGeneiHs.170131.

3D structure databases

ProteinModelPortaliP08651.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110854. 21 interactors.
DIPiDIP-44692N.
IntActiP08651. 15 interactors.
MINTiMINT-1439785.
STRINGi9606.ENSP00000465655.

PTM databases

iPTMnetiP08651.
PhosphoSitePlusiP08651.

Polymorphism and mutation databases

BioMutaiNFIC.
DMDMi14195672.

Proteomic databases

EPDiP08651.
MaxQBiP08651.
PaxDbiP08651.
PeptideAtlasiP08651.
PRIDEiP08651.

Protocols and materials databases

DNASUi4782.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341919; ENSP00000342194; ENSG00000141905. [P08651-5]
ENST00000395111; ENSP00000378543; ENSG00000141905. [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905. [P08651-1]
ENST00000586919; ENSP00000465177; ENSG00000141905. [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905. [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905. [P08651-6]
GeneIDi4782.
KEGGihsa:4782.
UCSCiuc002lxo.3. human. [P08651-1]

Organism-specific databases

CTDi4782.
DisGeNETi4782.
GeneCardsiNFIC.
HGNCiHGNC:7786. NFIC.
HPAiCAB004300.
CAB004674.
HPA052625.
MIMi600729. gene.
neXtProtiNX_P08651.
OpenTargetsiENSG00000141905.
PharmGKBiPA31592.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3663. Eukaryota.
ENOG410Y16G. LUCA.
GeneTreeiENSGT00390000009905.
HOGENOMiHOG000013028.
HOVERGENiHBG006561.
InParanoidiP08651.
KOiK09170.
OMAiIGSDQED.
OrthoDBiEOG091G0HVY.
PhylomeDBiP08651.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000141905-MONOMER.
ReactomeiR-HSA-73980. RNA Polymerase III Transcription Termination.
R-HSA-749476. RNA Polymerase III Abortive And Retractive Initiation.
SignaLinkiP08651.
SIGNORiP08651.

Miscellaneous databases

ChiTaRSiNFIC. human.
GeneWikiiNFIC_(gene).
GenomeRNAii4782.
PROiP08651.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141905.
CleanExiHS_NFIC.
GenevisibleiP08651. HS.

Family and domain databases

InterProiIPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view]
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiPF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
PROSITEiPS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNFIC_HUMAN
AccessioniPrimary (citable) accession number: P08651
Secondary accession number(s): A8K1H0
, B7Z4U5, B7Z9C3, K7EMU1, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.