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P08651

- NFIC_HUMAN

UniProt

P08651 - NFIC_HUMAN

Protein

Nuclear factor 1 C-type

Gene

NFIC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 156 (01 Oct 2014)
      Sequence version 2 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi1 – 195195CTF/NF-IPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter proximal region DNA binding Source: Ensembl
    2. double-stranded DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW
    2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    3. odontogenesis of dentin-containing tooth Source: Ensembl
    4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    5. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    DNA replication, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_63. RNA Polymerase III Transcription Termination.
    SignaLinkiP08651.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear factor 1 C-type
    Short name:
    NF1-C
    Short name:
    Nuclear factor 1/C
    Alternative name(s):
    CCAAT-box-binding transcription factor
    Short name:
    CTF
    Nuclear factor I/C
    Short name:
    NF-I/C
    Short name:
    NFI-C
    TGGCA-binding protein
    Gene namesi
    Name:NFIC
    Synonyms:NFI
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:7786. NFIC.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31592.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Nuclear factor 1 C-typePRO_0000100199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei194 – 1941Phosphoserine1 Publication
    Modified residuei294 – 2941Phosphoserine1 Publication
    Modified residuei323 – 3231Phosphoserine2 Publications
    Modified residuei333 – 3331Phosphoserine4 Publications
    Modified residuei337 – 3371Phosphoserine1 Publication
    Modified residuei339 – 3391Phosphoserine2 Publications
    Modified residuei343 – 3431Phosphoserine2 Publications
    Modified residuei487 – 4871Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP08651.
    PaxDbiP08651.
    PRIDEiP08651.

    PTM databases

    PhosphoSiteiP08651.

    Expressioni

    Gene expression databases

    ArrayExpressiP08651.
    BgeeiP08651.
    CleanExiHS_NFIC.
    GenevestigatoriP08651.

    Organism-specific databases

    HPAiCAB004300.
    CAB004674.
    HPA052625.

    Interactioni

    Subunit structurei

    Binds DNA as a homodimer.

    Protein-protein interaction databases

    BioGridi110854. 15 interactions.
    IntActiP08651. 7 interactions.
    MINTiMINT-1439785.

    Structurei

    3D structure databases

    ProteinModelPortaliP08651.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CTF/NF-I family.PROSITE-ProRule annotation
    Contains 1 CTF/NF-I DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG252172.
    HOVERGENiHBG006561.
    KOiK09170.
    OMAiMEGGISP.
    OrthoDBiEOG7WDN2K.
    PhylomeDBiP08651.

    Family and domain databases

    InterProiIPR000647. CTF/NFI.
    IPR020604. CTF/NFI_DNA-bd-dom.
    IPR019739. CTF/NFI_DNA-bd_CS.
    IPR019548. CTF/NFI_DNA-bd_N.
    IPR003619. MAD_homology1_Dwarfin-type.
    [Graphical view]
    PANTHERiPTHR11492. PTHR11492. 1 hit.
    PfamiPF00859. CTF_NFI. 1 hit.
    PF03165. MH1. 1 hit.
    PF10524. NfI_DNAbd_pre-N. 1 hit.
    [Graphical view]
    SMARTiSM00523. DWA. 1 hit.
    [Graphical view]
    PROSITEiPS00349. CTF_NFI_1. 1 hit.
    PS51080. CTF_NFI_2. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 4 (identifier: P08651-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS    50
    KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 100
    APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 150
    LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 200
    SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 250
    ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 300
    TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 350
    QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 400
    NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP 450
    RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY 500
    QAQSWYLG 508
    Length:508
    Mass (Da):55,675
    Last modified:June 1, 2001 - v2
    Checksum:i3D0F97DA0F3AF992
    GO
    Isoform 1 (identifier: P08651-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MYSSPLCLTQ → M

    Show »
    Length:499
    Mass (Da):54,682
    Checksum:iB6A59BD10B4B6D1B
    GO
    Isoform 2 (identifier: P08651-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MYSSPLCLTQ → M
         424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
         440-508: Missing.

    Show »
    Length:430
    Mass (Da):47,901
    Checksum:i99820E6484D655B3
    GO
    Isoform 3 (identifier: P08651-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-10: MYSSPLCLTQ → M
         188-211: Missing.
         424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
         440-508: Missing.

    Show »
    Length:406
    Mass (Da):45,413
    Checksum:iEA00A93762A9FAC1
    GO
    Isoform 5 (identifier: P08651-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         424-503: Missing.

    Show »
    Length:428
    Mass (Da):47,629
    Checksum:i239F7A15BBEA2539
    GO
    Isoform 6 (identifier: P08651-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

    Note: No experimental confirmation available.

    Show »
    Length:439
    Mass (Da):48,894
    Checksum:i5A9A6B88FAF84891
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti130 – 1301L → P in BAH12681. (PubMed:14702039)Curated
    Sequence conflicti212 – 2121D → V in CAA63440. (PubMed:8710515)Curated
    Sequence conflicti329 – 3291E → K in BAH12681. (PubMed:14702039)Curated
    Sequence conflicti353 – 3531H → Y in BAH12681. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti417 – 4171A → S.
    Corresponds to variant rs10412720 [ dbSNP | Ensembl ].
    VAR_057656

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1010MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 PublicationsVSP_003552
    Alternative sequencei188 – 21124Missing in isoform 3. 1 PublicationVSP_003553Add
    BLAST
    Alternative sequencei424 – 50885LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationVSP_047539Add
    BLAST
    Alternative sequencei424 – 50380Missing in isoform 5. 2 PublicationsVSP_003554Add
    BLAST
    Alternative sequencei424 – 43916LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsVSP_003555Add
    BLAST
    Alternative sequencei440 – 50869Missing in isoform 2 and isoform 3. 2 PublicationsVSP_003556Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12492 mRNA. Translation: CAA31012.1.
    X92857 mRNA. Translation: CAA63440.1.
    AK289885 mRNA. Translation: BAF82574.1.
    AK297867 mRNA. Translation: BAH12681.1.
    AK304816 mRNA. Translation: BAH14259.1.
    AC005514 Genomic DNA. Translation: AAC32593.1.
    AC005514 Genomic DNA. Translation: AAC32594.1.
    AC005551 Genomic DNA. Translation: AAC33190.1.
    AC005551 Genomic DNA. Translation: AAC33191.1.
    AC005551 Genomic DNA. Translation: AAC33192.1.
    AC005778 Genomic DNA. Translation: AAC62842.1.
    CH471139 Genomic DNA. Translation: EAW69325.1.
    CH471139 Genomic DNA. Translation: EAW69326.1.
    BC012120 mRNA. Translation: AAH12120.1.
    CCDSiCCDS12107.1. [P08651-5]
    CCDS45914.1. [P08651-2]
    CCDS58640.1. [P08651-3]
    CCDS59330.1. [P08651-1]
    CCDS59331.1. [P08651-6]
    PIRiB33416.
    S01038.
    RefSeqiNP_001231931.1. NM_001245002.1. [P08651-1]
    NP_001231933.1. NM_001245004.1. [P08651-6]
    NP_001231934.1. NM_001245005.1. [P08651-3]
    NP_005588.2. NM_005597.3. [P08651-5]
    NP_995315.1. NM_205843.2. [P08651-2]
    UniGeneiHs.170131.

    Genome annotation databases

    EnsembliENST00000341919; ENSP00000342194; ENSG00000141905. [P08651-5]
    ENST00000395111; ENSP00000378543; ENSG00000141905. [P08651-3]
    ENST00000443272; ENSP00000396843; ENSG00000141905. [P08651-1]
    ENST00000586919; ENSP00000465177; ENSG00000141905. [P08651-4]
    ENST00000589123; ENSP00000465655; ENSG00000141905. [P08651-2]
    ENST00000590282; ENSP00000466647; ENSG00000141905. [P08651-6]
    GeneIDi4782.
    KEGGihsa:4782.
    UCSCiuc002lxo.3. human. [P08651-2]
    uc002lxp.3. human. [P08651-5]
    uc010xhh.2. human. [P08651-3]
    uc010xhi.2. human. [P08651-1]

    Polymorphism databases

    DMDMi14195672.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X12492 mRNA. Translation: CAA31012.1 .
    X92857 mRNA. Translation: CAA63440.1 .
    AK289885 mRNA. Translation: BAF82574.1 .
    AK297867 mRNA. Translation: BAH12681.1 .
    AK304816 mRNA. Translation: BAH14259.1 .
    AC005514 Genomic DNA. Translation: AAC32593.1 .
    AC005514 Genomic DNA. Translation: AAC32594.1 .
    AC005551 Genomic DNA. Translation: AAC33190.1 .
    AC005551 Genomic DNA. Translation: AAC33191.1 .
    AC005551 Genomic DNA. Translation: AAC33192.1 .
    AC005778 Genomic DNA. Translation: AAC62842.1 .
    CH471139 Genomic DNA. Translation: EAW69325.1 .
    CH471139 Genomic DNA. Translation: EAW69326.1 .
    BC012120 mRNA. Translation: AAH12120.1 .
    CCDSi CCDS12107.1. [P08651-5 ]
    CCDS45914.1. [P08651-2 ]
    CCDS58640.1. [P08651-3 ]
    CCDS59330.1. [P08651-1 ]
    CCDS59331.1. [P08651-6 ]
    PIRi B33416.
    S01038.
    RefSeqi NP_001231931.1. NM_001245002.1. [P08651-1 ]
    NP_001231933.1. NM_001245004.1. [P08651-6 ]
    NP_001231934.1. NM_001245005.1. [P08651-3 ]
    NP_005588.2. NM_005597.3. [P08651-5 ]
    NP_995315.1. NM_205843.2. [P08651-2 ]
    UniGenei Hs.170131.

    3D structure databases

    ProteinModelPortali P08651.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110854. 15 interactions.
    IntActi P08651. 7 interactions.
    MINTi MINT-1439785.

    PTM databases

    PhosphoSitei P08651.

    Polymorphism databases

    DMDMi 14195672.

    Proteomic databases

    MaxQBi P08651.
    PaxDbi P08651.
    PRIDEi P08651.

    Protocols and materials databases

    DNASUi 4782.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341919 ; ENSP00000342194 ; ENSG00000141905 . [P08651-5 ]
    ENST00000395111 ; ENSP00000378543 ; ENSG00000141905 . [P08651-3 ]
    ENST00000443272 ; ENSP00000396843 ; ENSG00000141905 . [P08651-1 ]
    ENST00000586919 ; ENSP00000465177 ; ENSG00000141905 . [P08651-4 ]
    ENST00000589123 ; ENSP00000465655 ; ENSG00000141905 . [P08651-2 ]
    ENST00000590282 ; ENSP00000466647 ; ENSG00000141905 . [P08651-6 ]
    GeneIDi 4782.
    KEGGi hsa:4782.
    UCSCi uc002lxo.3. human. [P08651-2 ]
    uc002lxp.3. human. [P08651-5 ]
    uc010xhh.2. human. [P08651-3 ]
    uc010xhi.2. human. [P08651-1 ]

    Organism-specific databases

    CTDi 4782.
    GeneCardsi GC19P003310.
    HGNCi HGNC:7786. NFIC.
    HPAi CAB004300.
    CAB004674.
    HPA052625.
    MIMi 600729. gene.
    neXtProti NX_P08651.
    PharmGKBi PA31592.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG252172.
    HOVERGENi HBG006561.
    KOi K09170.
    OMAi MEGGISP.
    OrthoDBi EOG7WDN2K.
    PhylomeDBi P08651.

    Enzyme and pathway databases

    Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_63. RNA Polymerase III Transcription Termination.
    SignaLinki P08651.

    Miscellaneous databases

    ChiTaRSi NFIC. human.
    GeneWikii NFIC_(gene).
    GenomeRNAii 4782.
    NextBioi 18440.
    PROi P08651.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08651.
    Bgeei P08651.
    CleanExi HS_NFIC.
    Genevestigatori P08651.

    Family and domain databases

    InterProi IPR000647. CTF/NFI.
    IPR020604. CTF/NFI_DNA-bd-dom.
    IPR019739. CTF/NFI_DNA-bd_CS.
    IPR019548. CTF/NFI_DNA-bd_N.
    IPR003619. MAD_homology1_Dwarfin-type.
    [Graphical view ]
    PANTHERi PTHR11492. PTHR11492. 1 hit.
    Pfami PF00859. CTF_NFI. 1 hit.
    PF03165. MH1. 1 hit.
    PF10524. NfI_DNAbd_pre-N. 1 hit.
    [Graphical view ]
    SMARTi SM00523. DWA. 1 hit.
    [Graphical view ]
    PROSITEi PS00349. CTF_NFI_1. 1 hit.
    PS51080. CTF_NFI_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs."
      Santoro C., Mermod N., Andrews P.C., Tjian R.
      Nature 334:218-224(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE.
    2. "CTF5 -- a new transcriptional activator of the NFI/CTF family."
      Wenzelides S., Altmann S., Wendler W., Winnacker E.L.
      Nucleic Acids Res. 24:2416-2421(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6).
      Tissue: Caudate nucleus, Heart and Uterus.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Uterus.
    7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294; SER-323; SER-333 AND SER-339, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-323; SER-333; SER-337; SER-339; SER-343 AND SER-487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiNFIC_HUMAN
    AccessioniPrimary (citable) accession number: P08651
    Secondary accession number(s): A8K1H0
    , B7Z4U5, B7Z9C3, K7EMU1, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3