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P08651

- NFIC_HUMAN

UniProt

P08651 - NFIC_HUMAN

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Protein

Nuclear factor 1 C-type

Gene
NFIC, NFI
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi1 – 195195CTF/NF-IAdd
BLAST

GO - Molecular functioni

  1. core promoter proximal region DNA binding Source: Ensembl
  2. double-stranded DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: MGI

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
  2. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  3. odontogenesis of dentin-containing tooth Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

DNA replication, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_63. RNA Polymerase III Transcription Termination.
SignaLinkiP08651.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1 C-type
Short name:
NF1-C
Short name:
Nuclear factor 1/C
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CTF
Nuclear factor I/C
Short name:
NF-I/C
Short name:
NFI-C
TGGCA-binding protein
Gene namesi
Name:NFIC
Synonyms:NFI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:7786. NFIC.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31592.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Nuclear factor 1 C-typePRO_0000100199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei194 – 1941Phosphoserine1 Publication
Modified residuei294 – 2941Phosphoserine1 Publication
Modified residuei323 – 3231Phosphoserine2 Publications
Modified residuei333 – 3331Phosphoserine4 Publications
Modified residuei337 – 3371Phosphoserine1 Publication
Modified residuei339 – 3391Phosphoserine2 Publications
Modified residuei343 – 3431Phosphoserine2 Publications
Modified residuei487 – 4871Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiP08651.
PaxDbiP08651.
PRIDEiP08651.

PTM databases

PhosphoSiteiP08651.

Expressioni

Gene expression databases

ArrayExpressiP08651.
BgeeiP08651.
CleanExiHS_NFIC.
GenevestigatoriP08651.

Organism-specific databases

HPAiCAB004300.
CAB004674.
HPA052625.

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi110854. 15 interactions.
IntActiP08651. 6 interactions.
MINTiMINT-1439785.

Structurei

3D structure databases

ProteinModelPortaliP08651.

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF/NF-I family.

Phylogenomic databases

eggNOGiNOG252172.
HOVERGENiHBG006561.
KOiK09170.
OMAiMEGGISP.
OrthoDBiEOG7WDN2K.
PhylomeDBiP08651.

Family and domain databases

InterProiIPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view]
PANTHERiPTHR11492. PTHR11492. 1 hit.
PfamiPF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view]
SMARTiSM00523. DWA. 1 hit.
[Graphical view]
PROSITEiPS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 4 (identifier: P08651-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS    50
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK 100
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER 150
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG 200
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG 250
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY 300
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT 350
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL 400
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP 450
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY 500
QAQSWYLG 508
Length:508
Mass (Da):55,675
Last modified:June 1, 2001 - v2
Checksum:i3D0F97DA0F3AF992
GO
Isoform 1 (identifier: P08651-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Show »
Length:499
Mass (Da):54,682
Checksum:iB6A59BD10B4B6D1B
GO
Isoform 2 (identifier: P08651-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:430
Mass (Da):47,901
Checksum:i99820E6484D655B3
GO
Isoform 3 (identifier: P08651-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:406
Mass (Da):45,413
Checksum:iEA00A93762A9FAC1
GO
Isoform 5 (identifier: P08651-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-503: Missing.

Show »
Length:428
Mass (Da):47,629
Checksum:i239F7A15BBEA2539
GO
Isoform 6 (identifier: P08651-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

Note: No experimental confirmation available.

Show »
Length:439
Mass (Da):48,894
Checksum:i5A9A6B88FAF84891
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti417 – 4171A → S.
Corresponds to variant rs10412720 [ dbSNP | Ensembl ].
VAR_057656

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1010MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. VSP_003552
Alternative sequencei188 – 21124Missing in isoform 3. VSP_003553Add
BLAST
Alternative sequencei424 – 50885LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. VSP_047539Add
BLAST
Alternative sequencei424 – 50380Missing in isoform 5. VSP_003554Add
BLAST
Alternative sequencei424 – 43916LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. VSP_003555Add
BLAST
Alternative sequencei440 – 50869Missing in isoform 2 and isoform 3. VSP_003556Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti130 – 1301L → P in BAH12681. 1 Publication
Sequence conflicti212 – 2121D → V in CAA63440. 1 Publication
Sequence conflicti329 – 3291E → K in BAH12681. 1 Publication
Sequence conflicti353 – 3531H → Y in BAH12681. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12492 mRNA. Translation: CAA31012.1.
X92857 mRNA. Translation: CAA63440.1.
AK289885 mRNA. Translation: BAF82574.1.
AK297867 mRNA. Translation: BAH12681.1.
AK304816 mRNA. Translation: BAH14259.1.
AC005514 Genomic DNA. Translation: AAC32593.1.
AC005514 Genomic DNA. Translation: AAC32594.1.
AC005551 Genomic DNA. Translation: AAC33190.1.
AC005551 Genomic DNA. Translation: AAC33191.1.
AC005551 Genomic DNA. Translation: AAC33192.1.
AC005778 Genomic DNA. Translation: AAC62842.1.
CH471139 Genomic DNA. Translation: EAW69325.1.
CH471139 Genomic DNA. Translation: EAW69326.1.
BC012120 mRNA. Translation: AAH12120.1.
CCDSiCCDS12107.1. [P08651-5]
CCDS45914.1. [P08651-2]
CCDS58640.1. [P08651-3]
CCDS59330.1. [P08651-1]
CCDS59331.1. [P08651-6]
PIRiB33416.
S01038.
RefSeqiNP_001231931.1. NM_001245002.1. [P08651-1]
NP_001231933.1. NM_001245004.1. [P08651-6]
NP_001231934.1. NM_001245005.1. [P08651-3]
NP_005588.2. NM_005597.3. [P08651-5]
NP_995315.1. NM_205843.2. [P08651-2]
UniGeneiHs.170131.

Genome annotation databases

EnsembliENST00000341919; ENSP00000342194; ENSG00000141905. [P08651-5]
ENST00000346156; ENSP00000301935; ENSG00000141905. [P08651-4]
ENST00000395111; ENSP00000378543; ENSG00000141905. [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905. [P08651-1]
ENST00000586919; ENSP00000465177; ENSG00000141905. [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905. [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905. [P08651-6]
GeneIDi4782.
KEGGihsa:4782.
UCSCiuc002lxo.3. human. [P08651-2]
uc002lxp.3. human. [P08651-5]
uc010xhh.2. human. [P08651-3]
uc010xhi.2. human. [P08651-1]

Polymorphism databases

DMDMi14195672.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X12492 mRNA. Translation: CAA31012.1 .
X92857 mRNA. Translation: CAA63440.1 .
AK289885 mRNA. Translation: BAF82574.1 .
AK297867 mRNA. Translation: BAH12681.1 .
AK304816 mRNA. Translation: BAH14259.1 .
AC005514 Genomic DNA. Translation: AAC32593.1 .
AC005514 Genomic DNA. Translation: AAC32594.1 .
AC005551 Genomic DNA. Translation: AAC33190.1 .
AC005551 Genomic DNA. Translation: AAC33191.1 .
AC005551 Genomic DNA. Translation: AAC33192.1 .
AC005778 Genomic DNA. Translation: AAC62842.1 .
CH471139 Genomic DNA. Translation: EAW69325.1 .
CH471139 Genomic DNA. Translation: EAW69326.1 .
BC012120 mRNA. Translation: AAH12120.1 .
CCDSi CCDS12107.1. [P08651-5 ]
CCDS45914.1. [P08651-2 ]
CCDS58640.1. [P08651-3 ]
CCDS59330.1. [P08651-1 ]
CCDS59331.1. [P08651-6 ]
PIRi B33416.
S01038.
RefSeqi NP_001231931.1. NM_001245002.1. [P08651-1 ]
NP_001231933.1. NM_001245004.1. [P08651-6 ]
NP_001231934.1. NM_001245005.1. [P08651-3 ]
NP_005588.2. NM_005597.3. [P08651-5 ]
NP_995315.1. NM_205843.2. [P08651-2 ]
UniGenei Hs.170131.

3D structure databases

ProteinModelPortali P08651.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110854. 15 interactions.
IntActi P08651. 6 interactions.
MINTi MINT-1439785.

PTM databases

PhosphoSitei P08651.

Polymorphism databases

DMDMi 14195672.

Proteomic databases

MaxQBi P08651.
PaxDbi P08651.
PRIDEi P08651.

Protocols and materials databases

DNASUi 4782.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341919 ; ENSP00000342194 ; ENSG00000141905 . [P08651-5 ]
ENST00000346156 ; ENSP00000301935 ; ENSG00000141905 . [P08651-4 ]
ENST00000395111 ; ENSP00000378543 ; ENSG00000141905 . [P08651-3 ]
ENST00000443272 ; ENSP00000396843 ; ENSG00000141905 . [P08651-1 ]
ENST00000586919 ; ENSP00000465177 ; ENSG00000141905 . [P08651-4 ]
ENST00000589123 ; ENSP00000465655 ; ENSG00000141905 . [P08651-2 ]
ENST00000590282 ; ENSP00000466647 ; ENSG00000141905 . [P08651-6 ]
GeneIDi 4782.
KEGGi hsa:4782.
UCSCi uc002lxo.3. human. [P08651-2 ]
uc002lxp.3. human. [P08651-5 ]
uc010xhh.2. human. [P08651-3 ]
uc010xhi.2. human. [P08651-1 ]

Organism-specific databases

CTDi 4782.
GeneCardsi GC19P003310.
HGNCi HGNC:7786. NFIC.
HPAi CAB004300.
CAB004674.
HPA052625.
MIMi 600729. gene.
neXtProti NX_P08651.
PharmGKBi PA31592.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG252172.
HOVERGENi HBG006561.
KOi K09170.
OMAi MEGGISP.
OrthoDBi EOG7WDN2K.
PhylomeDBi P08651.

Enzyme and pathway databases

Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
REACT_63. RNA Polymerase III Transcription Termination.
SignaLinki P08651.

Miscellaneous databases

ChiTaRSi NFIC. human.
GeneWikii NFIC_(gene).
GenomeRNAii 4782.
NextBioi 18440.
PROi P08651.
SOURCEi Search...

Gene expression databases

ArrayExpressi P08651.
Bgeei P08651.
CleanExi HS_NFIC.
Genevestigatori P08651.

Family and domain databases

InterProi IPR000647. CTF/NFI.
IPR020604. CTF/NFI_DNA-bd-dom.
IPR019739. CTF/NFI_DNA-bd_CS.
IPR019548. CTF/NFI_DNA-bd_N.
IPR003619. MAD_homology1_Dwarfin-type.
[Graphical view ]
PANTHERi PTHR11492. PTHR11492. 1 hit.
Pfami PF00859. CTF_NFI. 1 hit.
PF03165. MH1. 1 hit.
PF10524. NfI_DNAbd_pre-N. 1 hit.
[Graphical view ]
SMARTi SM00523. DWA. 1 hit.
[Graphical view ]
PROSITEi PS00349. CTF_NFI_1. 1 hit.
PS51080. CTF_NFI_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs."
    Santoro C., Mermod N., Andrews P.C., Tjian R.
    Nature 334:218-224(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), PARTIAL PROTEIN SEQUENCE.
  2. "CTF5 -- a new transcriptional activator of the NFI/CTF family."
    Wenzelides S., Altmann S., Wendler W., Winnacker E.L.
    Nucleic Acids Res. 24:2416-2421(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 6).
    Tissue: Caudate nucleus, Heart and Uterus.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Tissue: Uterus.
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  8. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
    Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
    J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-343, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
    Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
    Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-294; SER-323; SER-333 AND SER-339, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-333, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-194; SER-323; SER-333; SER-337; SER-339; SER-343 AND SER-487, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiNFIC_HUMAN
AccessioniPrimary (citable) accession number: P08651
Secondary accession number(s): A8K1H0
, B7Z4U5, B7Z9C3, K7EMU1, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 155 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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