Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nuclear factor 1 C-type

Gene

NFIC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi1 – 195CTF/NF-IPROSITE-ProRule annotationAdd BLAST195

GO - Molecular functioni

GO - Biological processi

  • DNA replication Source: UniProtKB-KW
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • odontogenesis of dentin-containing tooth Source: Ensembl
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionActivator, DNA-binding
Biological processDNA replication, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
SignaLinkiP08651
SIGNORiP08651

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear factor 1 C-type
Short name:
NF1-C
Short name:
Nuclear factor 1/C
Alternative name(s):
CCAAT-box-binding transcription factor
Short name:
CTF
Nuclear factor I/C
Short name:
NF-I/C
Short name:
NFI-C
TGGCA-binding protein
Gene namesi
Name:NFIC
Synonyms:NFI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000141905.17
HGNCiHGNC:7786 NFIC
MIMi600729 gene
neXtProtiNX_P08651

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi4782
OpenTargetsiENSG00000141905
PharmGKBiPA31592

Polymorphism and mutation databases

BioMutaiNFIC
DMDMi14195672

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001001991 – 508Nuclear factor 1 C-typeAdd BLAST508

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei194PhosphoserineCombined sources1
Modified residuei294PhosphoserineCombined sources1
Modified residuei300PhosphotyrosineBy similarity1
Modified residuei302PhosphoserineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei305PhosphoserineCombined sources1
Modified residuei323PhosphoserineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Modified residuei337PhosphoserineCombined sources1
Modified residuei339PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei365Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei365Omega-N-methylarginine; alternateCombined sources1
Modified residuei395Asymmetric dimethylarginineCombined sources1
Modified residuei451Omega-N-methylarginineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei477PhosphoserineCombined sources1
Modified residuei487PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP08651
MaxQBiP08651
PaxDbiP08651
PeptideAtlasiP08651
PRIDEiP08651
ProteomicsDBi52148
52149 [P08651-2]
52150 [P08651-3]
52151 [P08651-4]
52152 [P08651-5]

PTM databases

iPTMnetiP08651
PhosphoSitePlusiP08651

Expressioni

Gene expression databases

BgeeiENSG00000141905
CleanExiHS_NFIC
GenevisibleiP08651 HS

Organism-specific databases

HPAiCAB004300
CAB004674
HPA052625

Interactioni

Subunit structurei

Binds DNA as a homodimer.

Protein-protein interaction databases

BioGridi110854, 22 interactors
DIPiDIP-44692N
IntActiP08651, 18 interactors
MINTiP08651
STRINGi9606.ENSP00000465655

Structurei

3D structure databases

ProteinModelPortaliP08651
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CTF/NF-I family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3663 Eukaryota
ENOG410Y16G LUCA
GeneTreeiENSGT00390000009905
HOGENOMiHOG000013028
HOVERGENiHBG006561
InParanoidiP08651
KOiK09170
OMAiACDPANQ
OrthoDBiEOG091G0HVY
PhylomeDBiP08651

Family and domain databases

InterProiView protein in InterPro
IPR000647 CTF/NFI
IPR020604 CTF/NFI_DNA-bd-dom
IPR019739 CTF/NFI_DNA-bd_CS
IPR019548 CTF/NFI_DNA-bd_N
IPR003619 MAD_homology1_Dwarfin-type
PANTHERiPTHR11492 PTHR11492, 1 hit
PfamiView protein in Pfam
PF00859 CTF_NFI, 1 hit
PF03165 MH1, 1 hit
PF10524 NfI_DNAbd_pre-N, 1 hit
SMARTiView protein in SMART
SM00523 DWA, 1 hit
PROSITEiView protein in PROSITE
PS00349 CTF_NFI_1, 1 hit
PS51080 CTF_NFI_2, 1 hit

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 4 (identifier: P08651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMS
60 70 80 90 100
KDEERAVKDE LLGEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK
110 120 130 140 150
APGCVLSNPD QKGKMRRIDC LRQADKVWRL DLVMVILFKG IPLESTDGER
160 170 180 190 200
LVKAAQCGHP VLCVQPHHIG VAVKELDLYL AYFVRERDAE QSGSPRTGMG
210 220 230 240 250
SDQEDSKPIT LDTTDFQESF VTSGVFSVTE LIQVSRTPVV TGTGPNFSLG
260 270 280 290 300
ELQGHLAYDL NPASTGLRRT LPSTSSSGSK RHKSGSMEED VDTSPGGDYY
310 320 330 340 350
TSPSSPTSSS RNWTEDMEGG ISSPVKKTEM DKSPFNSPSP QDSPRLSSFT
360 370 380 390 400
QHHRPVIAVH SGIARSPHPS SALHFPTTSI LPQTASTYFP HTAIRYPPHL
410 420 430 440 450
NPQDPLKDLV SLACDPASQQ PGPLNGSGQL KMPSHCLSAQ MLAPPPPGLP
460 470 480 490 500
RLALPPATKP ATTSEGGATS PTSPSYSPPD TSPANRSFVG LGPRDPAGIY

QAQSWYLG
Length:508
Mass (Da):55,675
Last modified:June 1, 2001 - v2
Checksum:i3D0F97DA0F3AF992
GO
Isoform 1 (identifier: P08651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M

Show »
Length:499
Mass (Da):54,682
Checksum:iB6A59BD10B4B6D1B
GO
Isoform 2 (identifier: P08651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:430
Mass (Da):47,901
Checksum:i99820E6484D655B3
GO
Isoform 3 (identifier: P08651-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-10: MYSSPLCLTQ → M
     188-211: Missing.
     424-439: LNGSGQLKMPSHCLSA → PTLRPTRPLQTVPLWD
     440-508: Missing.

Show »
Length:406
Mass (Da):45,413
Checksum:iEA00A93762A9FAC1
GO
Isoform 5 (identifier: P08651-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-503: Missing.

Show »
Length:428
Mass (Da):47,629
Checksum:i239F7A15BBEA2539
GO
Isoform 6 (identifier: P08651-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     424-508: LNGSGQLKMP...IYQAQSWYLG → PTLRPTRPLQTVPLWD

Note: No experimental confirmation available.
Show »
Length:439
Mass (Da):48,894
Checksum:i5A9A6B88FAF84891
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130L → P in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti212D → V in CAA63440 (PubMed:8710515).Curated1
Sequence conflicti329E → K in BAH12681 (PubMed:14702039).Curated1
Sequence conflicti353H → Y in BAH12681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057656417A → S. Corresponds to variant dbSNP:rs10412720Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0035521 – 10MYSSPLCLTQ → M in isoform 1, isoform 2 and isoform 3. 2 Publications10
Alternative sequenceiVSP_003553188 – 211Missing in isoform 3. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_047539424 – 508LNGSG…SWYLG → PTLRPTRPLQTVPLWD in isoform 6. 1 PublicationAdd BLAST85
Alternative sequenceiVSP_003554424 – 503Missing in isoform 5. 2 PublicationsAdd BLAST80
Alternative sequenceiVSP_003555424 – 439LNGSG…HCLSA → PTLRPTRPLQTVPLWD in isoform 2 and isoform 3. 2 PublicationsAdd BLAST16
Alternative sequenceiVSP_003556440 – 508Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST69

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X12492 mRNA Translation: CAA31012.1
X92857 mRNA Translation: CAA63440.1
AK289885 mRNA Translation: BAF82574.1
AK297867 mRNA Translation: BAH12681.1
AK304816 mRNA Translation: BAH14259.1
AC005514 Genomic DNA Translation: AAC32593.1
AC005514 Genomic DNA Translation: AAC32594.1
AC005551 Genomic DNA Translation: AAC33190.1
AC005551 Genomic DNA Translation: AAC33191.1
AC005551 Genomic DNA Translation: AAC33192.1
AC005778 Genomic DNA Translation: AAC62842.1
CH471139 Genomic DNA Translation: EAW69325.1
CH471139 Genomic DNA Translation: EAW69326.1
BC012120 mRNA Translation: AAH12120.1
CCDSiCCDS12107.1 [P08651-5]
CCDS45914.1 [P08651-2]
CCDS58640.1 [P08651-3]
CCDS59330.1 [P08651-1]
CCDS59331.1 [P08651-6]
PIRiB33416
S01038
RefSeqiNP_001231931.1, NM_001245002.1 [P08651-1]
NP_001231933.1, NM_001245004.1 [P08651-6]
NP_001231934.1, NM_001245005.1 [P08651-3]
NP_005588.2, NM_005597.3 [P08651-5]
NP_995315.1, NM_205843.2 [P08651-2]
XP_016882324.1, XM_017026835.1 [P08651-6]
UniGeneiHs.170131

Genome annotation databases

EnsembliENST00000341919; ENSP00000342194; ENSG00000141905 [P08651-5]
ENST00000395111; ENSP00000378543; ENSG00000141905 [P08651-3]
ENST00000443272; ENSP00000396843; ENSG00000141905 [P08651-1]
ENST00000586919; ENSP00000465177; ENSG00000141905 [P08651-4]
ENST00000589123; ENSP00000465655; ENSG00000141905 [P08651-2]
ENST00000590282; ENSP00000466647; ENSG00000141905 [P08651-6]
GeneIDi4782
KEGGihsa:4782
UCSCiuc002lxo.3 human [P08651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNFIC_HUMAN
AccessioniPrimary (citable) accession number: P08651
Secondary accession number(s): A8K1H0
, B7Z4U5, B7Z9C3, K7EMU1, P08652, Q14932, Q9UPJ3, Q9UPJ9, Q9UPK0, Q9UPK1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: June 1, 2001
Last modified: June 20, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health