C5 - Complement C5 - Rattus norvegicus (Rat)

Functionⁱ

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Molecular functionⁱ

C5a anaphylatoxin chemotactic receptor binding
Source: RGD
Inferred from direct assayⁱ
- 10410979
- 7987212

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Biological process

Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement C5 Cleaved into the following chain: C5a anaphylatoxin
Gene namesⁱ	Name:C5
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2237 C5

RGDⁱ

2237 C5

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000005996	1 – 77	C5a anaphylatoxinAdd BLAST		77

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	24 ↔ 50	PROSITE-ProRule annotation
Disulfide bondⁱ	25 ↔ 57	PROSITE-ProRule annotation
Disulfide bondⁱ	37 ↔ 58	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P08650
PRIDEⁱ	P08650

Interactionⁱ

Subunit structureⁱ

The C5a anaphylatoxin interacts with C5AR1.By similarity

GO - Molecular functionⁱ

C5a anaphylatoxin chemotactic receptor binding
Source: RGD
Inferred from direct assayⁱ
- 10410979
- 7987212

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000025534

STRINGⁱ

10116.ENSRNOP00000025534

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08650
SMRⁱ	P08650
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 58	Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST		35

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	18 – 47	Involved in C5AR1 bindingBy similarityAdd BLAST		30

Phylogenomic databases

eggNOGⁱ	ENOG410IMYH Eukaryota ENOG410ZFKB LUCA
InParanoidⁱ	P08650

Family and domain databases

InterProⁱ	View protein in InterPro IPR000020 Anaphylatoxin/fibulin IPR018081 Anaphylatoxin_comp_syst IPR001840 Anaphylatoxn_comp_syst_dom IPR037562 Complement_C5
PANTHERⁱ	PTHR11412:SF83 PTHR11412:SF83, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01821 ANATO, 1 hit
PRINTSⁱ	PR00004 ANAPHYLATOXN
SMARTⁱ	View protein in SMART SM00104 ANATO, 1 hit
SUPFAMⁱ	SSF47686 SSF47686, 1 hit
PROSITEⁱ	View protein in PROSITE PS01177 ANAPHYLATOXIN_1, 1 hit PS01178 ANAPHYLATOXIN_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Fragment.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08650-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC 
        60         70 
IRAFNECCTI ADKIRKESHH KGMLLGR

Length:77

Mass (Da):8,981

Last modified:April 13, 2004 - v2

Checksum:ⁱ14141F41CC38BD28

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Non-terminal residueⁱ	1		1
Sequence conflictⁱ	55	N → K AA sequence (Ref. 1) Curated	1
Sequence conflictⁱ	55	N → K AA sequence (PubMed:7987212).Curated	1
Sequence conflictⁱ	61 – 63	ADK → DP AA sequence (Ref. 1) Curated	3
Sequence conflictⁱ	63	K → H AA sequence (PubMed:7987212).Curated	1
Sequence conflictⁱ	67 – 69	ESH → NES AA sequence (PubMed:7987212).Curated	3
Sequence conflictⁱ	67 – 69	ESH → NQS AA sequence (Ref. 1) Curated	3
Non-terminal residueⁱ	77		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X91892 mRNA Translation: CAA62994.1
PIRⁱ	A57689
UniGeneⁱ	Rn.21259

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2237 rat

UCSCⁱ

RGD:2237 rat

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	A0A1B0GWQ4 UPI00026879EA UPI0004E488A7	Rattus norvegicus (Rat)	77	UniRef100_P08650	Cluster: Complement C5 (Fragment)	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	A0A1B0GWQ4 UPI00026879EA UPI0004E488A7 A0A096P6L9	Rattus norvegicus (Rat)	77	UniRef90_P08650	Cluster: Complement C5 (Fragment)	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	P01031 UPI000789C194 UPI0000E22055 UPI000CEFF985 UPI000057A2B7 UPI0007DC751B UPI000789C18B UPI0004F02390 A0A2J8NCJ0 UPI0005D00BD9 +234	Homo sapiens (Human) Pan troglodytes (Chimpanzee) Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii) Pan paniscus (Pygmy chimpanzee) (Bonobo) Callithrix jacchus (White-tufted-ear marmoset) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Mandrillus leucophaeus (Drill) (Papio leucophaeus) Macaca nemestrina (Pig-tailed macaque) Papio anubis (Olive baboon) And more	1,676	UniRef50_P01031	Cluster: Complement C5	245

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X91892 mRNA Translation: CAA62994.1
PIRⁱ	A57689
UniGeneⁱ	Rn.21259

3D structure databases

ProteinModelPortalⁱ	P08650
SMRⁱ	P08650
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000025534

STRINGⁱ

10116.ENSRNOP00000025534

Proteomic databases

PaxDbⁱ	P08650
PRIDEⁱ	P08650

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2237 rat

UCSCⁱ

RGD:2237 rat

Organism-specific databases

Rat genome database More...RGDⁱ	2237 C5

RGDⁱ

2237 C5

Phylogenomic databases

eggNOGⁱ	ENOG410IMYH Eukaryota ENOG410ZFKB LUCA
InParanoidⁱ	P08650

Family and domain databases

InterProⁱ	View protein in InterPro IPR000020 Anaphylatoxin/fibulin IPR018081 Anaphylatoxin_comp_syst IPR001840 Anaphylatoxn_comp_syst_dom IPR037562 Complement_C5
PANTHERⁱ	PTHR11412:SF83 PTHR11412:SF83, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01821 ANATO, 1 hit
PRINTSⁱ	PR00004 ANAPHYLATOXN
SMARTⁱ	View protein in SMART SM00104 ANATO, 1 hit
SUPFAMⁱ	SSF47686 SSF47686, 1 hit
PROSITEⁱ	View protein in PROSITE PS01177 ANAPHYLATOXIN_1, 1 hit PS01178 ANAPHYLATOXIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CO5_RAT
Accessionⁱ	P08650Primary (citable) accession number: P08650 Secondary accession number(s): Q63078
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	April 13, 2004
	Last modified:	February 28, 2018
	This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08650 (CO5_RAT)

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Complement C5

C5

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

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Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

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Family and domain databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ