C5 - Complement C5 - Rattus norvegicus (Rat)

Functionⁱ

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Molecular functionⁱ

C5a anaphylatoxin chemotactic receptor binding
Source: RGD
Inferred from direct assayⁱ
- 10410979
- 7987212

Complete GO annotation...

GO - Biological processⁱ

cellular calcium ion homeostasis
Source: RGD
Inferred from direct assayⁱ
- 10532591
chemotaxis
Source: RGD
Inferred from direct assayⁱ
- 10410979
complement activation, alternative pathway Source: UniProtKB-KW
complement activation, classical pathway Source: UniProtKB-KW
glucose homeostasis
Source: RGD
Inferred from direct assayⁱ
- 10421654
inflammatory response
Source: RGD
Inferred from direct assayⁱ
- 8755663
leukocyte migration involved in inflammatory response
Source: RGD
Inferred from mutant phenotypeⁱ
- 10843715
negative regulation of dopamine secretion
Source: RGD
Inferred from direct assayⁱ
- 18648551
negative regulation of norepinephrine secretion
Source: RGD
Inferred from direct assayⁱ
- 18648551
positive regulation of chemotaxis
Source: RGD
Inferred from direct assayⁱ
- 7987212
- 8755663

Complete GO annotation...

Keywordsⁱ

Biological process	Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Biological process

Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Complement C5 Cleaved into the following chain: C5a anaphylatoxin
Gene namesⁱ	Name:C5
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Unplaced

Organism-specific databases

Rat genome database More...RGDⁱ	2237. C5.

RGDⁱ

2237. C5.

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000005996	1 – 77	C5a anaphylatoxinAdd BLAST		77

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	24 ↔ 50	PROSITE-ProRule annotation
Disulfide bondⁱ	25 ↔ 57	PROSITE-ProRule annotation
Disulfide bondⁱ	37 ↔ 58	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	P08650.
PRIDEⁱ	P08650.

Interactionⁱ

Subunit structureⁱ

The C5a anaphylatoxin interacts with C5AR1.By similarity

GO - Molecular functionⁱ

C5a anaphylatoxin chemotactic receptor binding
Source: RGD
Inferred from direct assayⁱ
- 10410979
- 7987212

Complete GO annotation...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000025534.

STRINGⁱ

10116.ENSRNOP00000025534.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P08650.
SMRⁱ	P08650.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	24 – 58	Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST		35

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	18 – 47	Involved in C5AR1 bindingBy similarityAdd BLAST		30

Phylogenomic databases

eggNOGⁱ	ENOG410IMYH. Eukaryota. ENOG410ZFKB. LUCA.
InParanoidⁱ	P08650.

Family and domain databases

Gene3Dⁱ	1.20.91.20. 1 hit.
InterProⁱ	View protein in InterPro IPR000020. Anaphylatoxin/fibulin. IPR018081. Anaphylatoxin_comp_syst. IPR001840. Anaphylatoxn_comp_syst_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01821. ANATO. 1 hit.
PRINTSⁱ	PR00004. ANAPHYLATOXN.
SMARTⁱ	View protein in SMART SM00104. ANATO. 1 hit.
SUPFAMⁱ	SSF47686. SSF47686. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01177. ANAPHYLATOXIN_1. 1 hit. PS01178. ANAPHYLATOXIN_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Fragment.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P08650-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC 
        60         70 
IRAFNECCTI ADKIRKESHH KGMLLGR

Length:77

Mass (Da):8,981

Last modified:April 13, 2004 - v2

Checksum:ⁱ14141F41CC38BD28

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Non-terminal residueⁱ	1		1
Sequence conflictⁱ	55	N → K AA sequence (Ref. 1) Curated	1
Sequence conflictⁱ	55	N → K AA sequence (PubMed:7987212).Curated	1
Sequence conflictⁱ	61 – 63	ADK → DP AA sequence (Ref. 1) Curated	3
Sequence conflictⁱ	63	K → H AA sequence (PubMed:7987212).Curated	1
Sequence conflictⁱ	67 – 69	ESH → NES AA sequence (PubMed:7987212).Curated	3
Sequence conflictⁱ	67 – 69	ESH → NQS AA sequence (Ref. 1) Curated	3
Non-terminal residueⁱ	77		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X91892 mRNA. Translation: CAA62994.1.
PIRⁱ	A57689.
UniGeneⁱ	Rn.21259.

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2237. rat.

UCSCⁱ

RGD:2237. rat.

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	A0A1B0GWQ4 UPI00026879EA UPI0004E488A7	Rattus norvegicus (Rat)	77	UniRef100_P08650	Cluster: Complement C5 (Fragment)	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	A0A1B0GWQ4 UPI00026879EA UPI0004E488A7 A0A096P6L9	Rattus norvegicus (Rat)	77	UniRef90_P08650	Cluster: Complement C5 (Fragment)	5

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P08650	P01031 UPI000789C194 G3SBU0 UPI0000E22055 UPI000057A2B7 UPI000789C18B UPI0007DC751B UPI0004F02390 UPI000511E4B2 UPI0005D00BD9 +226	Homo sapiens (Human) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Pan paniscus (Pygmy chimpanzee) (Bonobo) Callithrix jacchus (White-tufted-ear marmoset) Papio anubis (Olive baboon) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Macaca mulatta (Rhesus macaque) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) And more	1,676	UniRef50_P01031	Cluster: Complement C5	237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X91892 mRNA. Translation: CAA62994.1.
PIRⁱ	A57689.
UniGeneⁱ	Rn.21259.

3D structure databases

ProteinModelPortalⁱ	P08650.
SMRⁱ	P08650.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10116.ENSRNOP00000025534.

STRINGⁱ

10116.ENSRNOP00000025534.

Proteomic databases

PaxDbⁱ	P08650.
PRIDEⁱ	P08650.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

UCSC genome browser More...UCSCⁱ	RGD:2237. rat.

UCSCⁱ

RGD:2237. rat.

Organism-specific databases

Rat genome database More...RGDⁱ	2237. C5.

RGDⁱ

2237. C5.

Phylogenomic databases

eggNOGⁱ	ENOG410IMYH. Eukaryota. ENOG410ZFKB. LUCA.
InParanoidⁱ	P08650.

Family and domain databases

Gene3Dⁱ	1.20.91.20. 1 hit.
InterProⁱ	View protein in InterPro IPR000020. Anaphylatoxin/fibulin. IPR018081. Anaphylatoxin_comp_syst. IPR001840. Anaphylatoxn_comp_syst_dom.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01821. ANATO. 1 hit.
PRINTSⁱ	PR00004. ANAPHYLATOXN.
SMARTⁱ	View protein in SMART SM00104. ANATO. 1 hit.
SUPFAMⁱ	SSF47686. SSF47686. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01177. ANAPHYLATOXIN_1. 1 hit. PS01178. ANAPHYLATOXIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CO5_RAT
Accessionⁱ	P08650Primary (citable) accession number: P08650 Secondary accession number(s): Q63078
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
	Last sequence update:	April 13, 2004
	Last modified:	August 30, 2017
	This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P08650 (CO5_RAT)

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Complement C5

C5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ