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P08650 (CO5_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Complement C5

Cleaved into the following chain:

  1. C5a anaphylatoxin
Gene names
Name:C5
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length77 AA.
Sequence statusFragment.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

Subcellular location

Secreted.

Sequence similarities

Contains 1 anaphylatoxin-like domain.

Ontologies

Keywords
   Biological processComplement alternate pathway
Complement pathway
Immunity
Inflammatory response
Innate immunity
   Cellular componentSecreted
   PTMDisulfide bond
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological_processcellular calcium ion homeostasis

Inferred from direct assay PubMed 10532591. Source: RGD

chemotaxis

Inferred from direct assay PubMed 10410979. Source: RGD

complement activation, alternative pathway

Inferred from electronic annotation. Source: UniProtKB-KW

complement activation, classical pathway

Inferred from electronic annotation. Source: UniProtKB-KW

glucose homeostasis

Inferred from direct assay PubMed 10421654. Source: RGD

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from direct assay PubMed 8755663. Source: RGD

leukocyte migration involved in inflammatory response

Inferred from mutant phenotype PubMed 10843715. Source: RGD

negative regulation of dopamine secretion

Inferred from direct assay PubMed 18648551. Source: RGD

negative regulation of macrophage chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of norepinephrine secretion

Inferred from direct assay PubMed 18648551. Source: RGD

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemokine secretion

Inferred from electronic annotation. Source: Ensembl

positive regulation of chemotaxis

Inferred from direct assay Ref.2PubMed 8755663. Source: RGD

positive regulation vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from direct assay PubMed 9246574. Source: RGD

   Molecular_functionC5a anaphylatoxin chemotactic receptor binding

Inferred from direct assay PubMed 10410979Ref.2. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7777C5a anaphylatoxin
PRO_0000005996

Regions

Domain24 – 5835Anaphylatoxin-like

Amino acid modifications

Disulfide bond24 ↔ 50 By similarity
Disulfide bond25 ↔ 57 By similarity
Disulfide bond37 ↔ 58 By similarity

Experimental info

Sequence conflict551N → K AA sequence Ref.1
Sequence conflict551N → K AA sequence Ref.2
Sequence conflict61 – 633ADK → DP AA sequence Ref.1
Sequence conflict631K → H AA sequence Ref.2
Sequence conflict67 – 693ESH → NES AA sequence Ref.2
Sequence conflict67 – 693ESH → NQS AA sequence Ref.1
Non-terminal residue11
Non-terminal residue771

Sequences

Sequence LengthMass (Da)Tools
P08650 [UniParc].

Last modified April 13, 2004. Version 2.
Checksum: 14141F41CC38BD28

FASTA778,981
        10         20         30         40         50         60 
DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC IRAFNECCTI 

        70 
ADKIRKESHH KGMLLGR 

« Hide

References

[1]"Characterization of rat C5a, a uniquely active spasmogen."
Cui L.-X., Ferreri K., Hugli T.E.
Complement 2:18-19(1985)
Cited for: PROTEIN SEQUENCE.
[2]"Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency."
Cui L.-X., Carney D.F., Hugli T.E.
Protein Sci. 3:1169-1177(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
Tissue: Serum.
[3]"Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a."
Rothermel E., Rolf O., Goetze O., Zwirner J.
Biochim. Biophys. Acta 1351:9-12(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Brown Norway, Lewis and Wistar.
Tissue: Liver.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X91892 mRNA. Translation: CAA62994.1.
PIRA57689.
UniGeneRn.21259.

3D structure databases

ProteinModelPortalP08650.
SMRP08650. Positions 4-65.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000060337.

Protein family/group databases

MEROPSI39.952.

PTM databases

PhosphoSiteP08650.

Proteomic databases

PRIDEP08650.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCRGD:2237. rat.

Organism-specific databases

RGD2237. C5.

Phylogenomic databases

eggNOGKOG1366.
InParanoidP08650.

Gene expression databases

GenevestigatorP08650.

Family and domain databases

Gene3D1.20.91.20. 1 hit.
InterProIPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
[Graphical view]
PfamPF01821. ANATO. 1 hit.
[Graphical view]
PRINTSPR00004. ANAPHYLATOXN.
SMARTSM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMSSF47686. SSF47686. 1 hit.
PROSITEPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCO5_RAT
AccessionPrimary (citable) accession number: P08650
Secondary accession number(s): Q63078
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 100 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families