UniProtKB - P08650 (CO5_RAT)
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Protein
Complement C5
Gene
C5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity
GO - Molecular functioni
- C5a anaphylatoxin chemotactic receptor binding Source: RGD
GO - Biological processi
- cellular calcium ion homeostasis Source: RGD
- chemotaxis Source: RGD
- complement activation, alternative pathway Source: UniProtKB-KW
- complement activation, classical pathway Source: UniProtKB-KW
- glucose homeostasis Source: RGD
- inflammatory response Source: RGD
- in utero embryonic development Source: RGD
- leukocyte migration involved in inflammatory response Source: RGD
- negative regulation of dopamine secretion Source: RGD
- negative regulation of macrophage chemotaxis Source: RGD
- negative regulation of norepinephrine secretion Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of chemokine secretion Source: RGD
- positive regulation of chemotaxis Source: RGD
- positive regulation of vascular endothelial growth factor production Source: RGD
Keywordsi
Biological process | Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:C5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2237 C5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000005996 | 1 – 77 | C5a anaphylatoxinAdd BLAST | 77 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 50 | PROSITE-ProRule annotation | ||
Disulfide bondi | 25 ↔ 57 | PROSITE-ProRule annotation | ||
Disulfide bondi | 37 ↔ 58 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P08650 |
PRIDEi | P08650 |
Interactioni
Subunit structurei
The C5a anaphylatoxin interacts with C5AR1.By similarity
GO - Molecular functioni
- C5a anaphylatoxin chemotactic receptor binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000025534 |
Structurei
3D structure databases
ProteinModelPortali | P08650 |
SMRi | P08650 |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 58 | Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST | 35 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 18 – 47 | Involved in C5AR1 bindingBy similarityAdd BLAST | 30 |
Phylogenomic databases
eggNOGi | ENOG410IMYH Eukaryota ENOG410ZFKB LUCA |
InParanoidi | P08650 |
Family and domain databases
InterProi | View protein in InterPro IPR000020 Anaphylatoxin/fibulin IPR018081 Anaphylatoxin_comp_syst IPR001840 Anaphylatoxn_comp_syst_dom IPR037562 Complement_C5 |
PANTHERi | PTHR11412:SF83 PTHR11412:SF83, 1 hit |
Pfami | View protein in Pfam PF01821 ANATO, 1 hit |
PRINTSi | PR00004 ANAPHYLATOXN |
SMARTi | View protein in SMART SM00104 ANATO, 1 hit |
SUPFAMi | SSF47686 SSF47686, 1 hit |
PROSITEi | View protein in PROSITE PS01177 ANAPHYLATOXIN_1, 1 hit PS01178 ANAPHYLATOXIN_2, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
P08650-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC
60 70
IRAFNECCTI ADKIRKESHH KGMLLGR
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Sequence conflicti | 55 | N → K AA sequence (Ref. 1) Curated | 1 | |
Sequence conflicti | 55 | N → K AA sequence (PubMed:7987212).Curated | 1 | |
Sequence conflicti | 61 – 63 | ADK → DP AA sequence (Ref. 1) Curated | 3 | |
Sequence conflicti | 63 | K → H AA sequence (PubMed:7987212).Curated | 1 | |
Sequence conflicti | 67 – 69 | ESH → NES AA sequence (PubMed:7987212).Curated | 3 | |
Sequence conflicti | 67 – 69 | ESH → NQS AA sequence (Ref. 1) Curated | 3 | |
Non-terminal residuei | 77 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X91892 mRNA Translation: CAA62994.1 |
PIRi | A57689 |
UniGenei | Rn.21259 |
Genome annotation databases
UCSCi | RGD:2237 rat |
Similar proteinsi
Entry informationi
Entry namei | CO5_RAT | |
Accessioni | P08650Primary (citable) accession number: P08650 Secondary accession number(s): Q63078 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 1, 1988 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 28, 2018 | |
This is version 122 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |