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P08650

- CO5_RAT

UniProt

P08650 - CO5_RAT

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Protein
Complement C5
Gene
C5
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

GO - Molecular functioni

  1. C5a anaphylatoxin chemotactic receptor binding Source: RGD

GO - Biological processi

  1. cellular calcium ion homeostasis Source: RGD
  2. chemotaxis Source: RGD
  3. complement activation, alternative pathway Source: UniProtKB-KW
  4. complement activation, classical pathway Source: UniProtKB-KW
  5. glucose homeostasis Source: RGD
  6. in utero embryonic development Source: Ensembl
  7. inflammatory response Source: RGD
  8. leukocyte migration involved in inflammatory response Source: RGD
  9. negative regulation of dopamine secretion Source: RGD
  10. negative regulation of macrophage chemotaxis Source: Ensembl
  11. negative regulation of norepinephrine secretion Source: RGD
  12. positive regulation of angiogenesis Source: Ensembl
  13. positive regulation of chemokine secretion Source: Ensembl
  14. positive regulation of chemotaxis Source: RGD
  15. positive regulation vascular endothelial growth factor production Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiREACT_199224. Regulation of Complement cascade.
REACT_203432. Activation of C3 and C5.

Protein family/group databases

MEROPSiI39.952.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5
Cleaved into the following chain:
Gene namesi
Name:C5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2237. C5.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7777C5a anaphylatoxin
PRO_0000005996Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi24 ↔ 50 By similarity
Disulfide bondi25 ↔ 57 By similarity
Disulfide bondi37 ↔ 58 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP08650.

PTM databases

PhosphoSiteiP08650.

Expressioni

Gene expression databases

GenevestigatoriP08650.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000060337.

Structurei

3D structure databases

ProteinModelPortaliP08650.
SMRiP08650. Positions 4-65.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 5835Anaphylatoxin-like
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1366.
InParanoidiP08650.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiIPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
[Graphical view]
PfamiPF01821. ANATO. 1 hit.
[Graphical view]
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiSM00104. ANATO. 1 hit.
[Graphical view]
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08650-1 [UniParc]FASTAAdd to Basket

« Hide

DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC   50
IRAFNECCTI ADKIRKESHH KGMLLGR 77
Length:77
Mass (Da):8,981
Last modified:April 13, 2004 - v2
Checksum:i14141F41CC38BD28
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti55 – 551N → K AA sequence 1 Publication
Sequence conflicti55 – 551N → K AA sequence 1 Publication
Sequence conflicti61 – 633ADK → DP AA sequence 1 Publication
Sequence conflicti63 – 631K → H AA sequence 1 Publication
Sequence conflicti67 – 693ESH → NES AA sequence 1 Publication
Sequence conflicti67 – 693ESH → NQS AA sequence 1 Publication

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei77 – 771

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91892 mRNA. Translation: CAA62994.1.
PIRiA57689.
UniGeneiRn.21259.

Genome annotation databases

UCSCiRGD:2237. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X91892 mRNA. Translation: CAA62994.1 .
PIRi A57689.
UniGenei Rn.21259.

3D structure databases

ProteinModelPortali P08650.
SMRi P08650. Positions 4-65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000060337.

Protein family/group databases

MEROPSi I39.952.

PTM databases

PhosphoSitei P08650.

Proteomic databases

PRIDEi P08650.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

UCSCi RGD:2237. rat.

Organism-specific databases

RGDi 2237. C5.

Phylogenomic databases

eggNOGi KOG1366.
InParanoidi P08650.

Enzyme and pathway databases

Reactomei REACT_199224. Regulation of Complement cascade.
REACT_203432. Activation of C3 and C5.

Gene expression databases

Genevestigatori P08650.

Family and domain databases

Gene3Di 1.20.91.20. 1 hit.
InterProi IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
[Graphical view ]
Pfami PF01821. ANATO. 1 hit.
[Graphical view ]
PRINTSi PR00004. ANAPHYLATOXN.
SMARTi SM00104. ANATO. 1 hit.
[Graphical view ]
SUPFAMi SSF47686. SSF47686. 1 hit.
PROSITEi PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of rat C5a, a uniquely active spasmogen."
    Cui L.-X., Ferreri K., Hugli T.E.
    Complement 2:18-19(1985)
    Cited for: PROTEIN SEQUENCE.
  2. "Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency."
    Cui L.-X., Carney D.F., Hugli T.E.
    Protein Sci. 3:1169-1177(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
    Tissue: Serum.
  3. "Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a."
    Rothermel E., Rolf O., Goetze O., Zwirner J.
    Biochim. Biophys. Acta 1351:9-12(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Brown Norway, Lewis and Wistar.
    Tissue: Liver.

Entry informationi

Entry nameiCO5_RAT
AccessioniPrimary (citable) accession number: P08650
Secondary accession number(s): Q63078
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 13, 2004
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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