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P08650

- CO5_RAT

UniProt

P08650 - CO5_RAT

Protein

Complement C5

Gene

C5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C5a also stimulates the locomotion of polymorphonuclear leukocytes (chemokinesis) and direct their migration toward sites of inflammation (chemotaxis).

    GO - Molecular functioni

    1. C5a anaphylatoxin chemotactic receptor binding Source: RGD

    GO - Biological processi

    1. cellular calcium ion homeostasis Source: RGD
    2. chemotaxis Source: RGD
    3. complement activation, alternative pathway Source: UniProtKB-KW
    4. complement activation, classical pathway Source: UniProtKB-KW
    5. glucose homeostasis Source: RGD
    6. inflammatory response Source: RGD
    7. in utero embryonic development Source: Ensembl
    8. leukocyte migration involved in inflammatory response Source: RGD
    9. negative regulation of dopamine secretion Source: RGD
    10. negative regulation of macrophage chemotaxis Source: Ensembl
    11. negative regulation of norepinephrine secretion Source: RGD
    12. positive regulation of angiogenesis Source: Ensembl
    13. positive regulation of chemokine secretion Source: Ensembl
    14. positive regulation of chemotaxis Source: RGD
    15. positive regulation vascular endothelial growth factor production Source: Ensembl

    Keywords - Biological processi

    Complement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

    Enzyme and pathway databases

    ReactomeiREACT_199224. Regulation of Complement cascade.
    REACT_203432. Activation of C3 and C5.

    Protein family/group databases

    MEROPSiI39.952.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement C5
    Cleaved into the following chain:
    Gene namesi
    Name:C5
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2237. C5.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7777C5a anaphylatoxinPRO_0000005996Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi24 ↔ 50PROSITE-ProRule annotation
    Disulfide bondi25 ↔ 57PROSITE-ProRule annotation
    Disulfide bondi37 ↔ 58PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP08650.

    PTM databases

    PhosphoSiteiP08650.

    Expressioni

    Gene expression databases

    GenevestigatoriP08650.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000060337.

    Structurei

    3D structure databases

    ProteinModelPortaliP08650.
    SMRiP08650. Positions 4-65.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 5835Anaphylatoxin-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 anaphylatoxin-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiKOG1366.
    InParanoidiP08650.

    Family and domain databases

    Gene3Di1.20.91.20. 1 hit.
    InterProiIPR000020. Anaphylatoxin/fibulin.
    IPR018081. Anaphylatoxin_comp_syst.
    IPR001840. Anaphylatoxn_comp_syst_dom.
    [Graphical view]
    PfamiPF01821. ANATO. 1 hit.
    [Graphical view]
    PRINTSiPR00004. ANAPHYLATOXN.
    SMARTiSM00104. ANATO. 1 hit.
    [Graphical view]
    SUPFAMiSSF47686. SSF47686. 1 hit.
    PROSITEiPS01177. ANAPHYLATOXIN_1. 1 hit.
    PS01178. ANAPHYLATOXIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08650-1 [UniParc]FASTAAdd to Basket

    « Hide

    DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC   50
    IRAFNECCTI ADKIRKESHH KGMLLGR 77
    Length:77
    Mass (Da):8,981
    Last modified:April 13, 2004 - v2
    Checksum:i14141F41CC38BD28
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti55 – 551N → K AA sequence 1 PublicationCurated
    Sequence conflicti55 – 551N → K AA sequence (PubMed:7987212)Curated
    Sequence conflicti61 – 633ADK → DP AA sequence 1 PublicationCurated
    Sequence conflicti63 – 631K → H AA sequence (PubMed:7987212)Curated
    Sequence conflicti67 – 693ESH → NES AA sequence (PubMed:7987212)Curated
    Sequence conflicti67 – 693ESH → NQS AA sequence 1 PublicationCurated
    Non-terminal residuei77 – 771

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91892 mRNA. Translation: CAA62994.1.
    PIRiA57689.
    UniGeneiRn.21259.

    Genome annotation databases

    UCSCiRGD:2237. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X91892 mRNA. Translation: CAA62994.1 .
    PIRi A57689.
    UniGenei Rn.21259.

    3D structure databases

    ProteinModelPortali P08650.
    SMRi P08650. Positions 4-65.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000060337.

    Protein family/group databases

    MEROPSi I39.952.

    PTM databases

    PhosphoSitei P08650.

    Proteomic databases

    PRIDEi P08650.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi RGD:2237. rat.

    Organism-specific databases

    RGDi 2237. C5.

    Phylogenomic databases

    eggNOGi KOG1366.
    InParanoidi P08650.

    Enzyme and pathway databases

    Reactomei REACT_199224. Regulation of Complement cascade.
    REACT_203432. Activation of C3 and C5.

    Gene expression databases

    Genevestigatori P08650.

    Family and domain databases

    Gene3Di 1.20.91.20. 1 hit.
    InterProi IPR000020. Anaphylatoxin/fibulin.
    IPR018081. Anaphylatoxin_comp_syst.
    IPR001840. Anaphylatoxn_comp_syst_dom.
    [Graphical view ]
    Pfami PF01821. ANATO. 1 hit.
    [Graphical view ]
    PRINTSi PR00004. ANAPHYLATOXN.
    SMARTi SM00104. ANATO. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47686. SSF47686. 1 hit.
    PROSITEi PS01177. ANAPHYLATOXIN_1. 1 hit.
    PS01178. ANAPHYLATOXIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of rat C5a, a uniquely active spasmogen."
      Cui L.-X., Ferreri K., Hugli T.E.
      Complement 2:18-19(1985)
      Cited for: PROTEIN SEQUENCE.
    2. "Primary structure and functional characterization of rat C5a: an anaphylatoxin with unusually high potency."
      Cui L.-X., Carney D.F., Hugli T.E.
      Protein Sci. 3:1169-1177(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE, CHARACTERIZATION.
      Tissue: Serum.
    3. "Nucleotide and corrected amino acid sequence of the functional recombinant rat anaphylatoxin C5a."
      Rothermel E., Rolf O., Goetze O., Zwirner J.
      Biochim. Biophys. Acta 1351:9-12(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Brown Norway, Lewis and Wistar.
      Tissue: Liver.

    Entry informationi

    Entry nameiCO5_RAT
    AccessioniPrimary (citable) accession number: P08650
    Secondary accession number(s): Q63078
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3