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Protein

Complement C5

Gene

C5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.By similarity

GO - Molecular functioni

  • C5a anaphylatoxin chemotactic receptor binding Source: RGD

GO - Biological processi

  • cellular calcium ion homeostasis Source: RGD
  • chemotaxis Source: RGD
  • complement activation, alternative pathway Source: UniProtKB-KW
  • complement activation, classical pathway Source: UniProtKB-KW
  • glucose homeostasis Source: RGD
  • inflammatory response Source: RGD
  • leukocyte migration involved in inflammatory response Source: RGD
  • negative regulation of dopamine secretion Source: RGD
  • negative regulation of norepinephrine secretion Source: RGD
  • positive regulation of chemotaxis Source: RGD

Keywordsi

Biological processComplement alternate pathway, Complement pathway, Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement C5
Cleaved into the following chain:
Gene namesi
Name:C5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2237. C5.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • extracellular space Source: RGD

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000059961 – 77C5a anaphylatoxinAdd BLAST77

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 50PROSITE-ProRule annotation
Disulfide bondi25 ↔ 57PROSITE-ProRule annotation
Disulfide bondi37 ↔ 58PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP08650.
PRIDEiP08650.

Expressioni

Gene expression databases

BgeeiENSRNOG00000018899.

Interactioni

Subunit structurei

The C5a anaphylatoxin interacts with C5AR1.By similarity

GO - Molecular functioni

  • C5a anaphylatoxin chemotactic receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025534.

Structurei

3D structure databases

ProteinModelPortaliP08650.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 58Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST35

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni18 – 47Involved in C5AR1 bindingBy similarityAdd BLAST30

Phylogenomic databases

eggNOGiENOG410IMYH. Eukaryota.
ENOG410ZFKB. LUCA.
InParanoidiP08650.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiView protein in InterPro
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
PfamiView protein in Pfam
PF01821. ANATO. 1 hit.
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiView protein in SMART
SM00104. ANATO. 1 hit.
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiView protein in PROSITE
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08650-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DLQLLHQKVE EQAAKYKHRV PKKCCYDGAR ENKYETCEQR VARVTIGPHC
60 70
IRAFNECCTI ADKIRKESHH KGMLLGR
Length:77
Mass (Da):8,981
Last modified:April 13, 2004 - v2
Checksum:i14141F41CC38BD28
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Sequence conflicti55N → K AA sequence (Ref. 1) Curated1
Sequence conflicti55N → K AA sequence (PubMed:7987212).Curated1
Sequence conflicti61 – 63ADK → DP AA sequence (Ref. 1) Curated3
Sequence conflicti63K → H AA sequence (PubMed:7987212).Curated1
Sequence conflicti67 – 69ESH → NES AA sequence (PubMed:7987212).Curated3
Sequence conflicti67 – 69ESH → NQS AA sequence (Ref. 1) Curated3
Non-terminal residuei771

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91892 mRNA. Translation: CAA62994.1.
PIRiA57689.
UniGeneiRn.21259.

Genome annotation databases

UCSCiRGD:2237. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X91892 mRNA. Translation: CAA62994.1.
PIRiA57689.
UniGeneiRn.21259.

3D structure databases

ProteinModelPortaliP08650.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025534.

Proteomic databases

PaxDbiP08650.
PRIDEiP08650.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:2237. rat.

Organism-specific databases

RGDi2237. C5.

Phylogenomic databases

eggNOGiENOG410IMYH. Eukaryota.
ENOG410ZFKB. LUCA.
InParanoidiP08650.

Gene expression databases

BgeeiENSRNOG00000018899.

Family and domain databases

Gene3Di1.20.91.20. 1 hit.
InterProiView protein in InterPro
IPR000020. Anaphylatoxin/fibulin.
IPR018081. Anaphylatoxin_comp_syst.
IPR001840. Anaphylatoxn_comp_syst_dom.
PfamiView protein in Pfam
PF01821. ANATO. 1 hit.
PRINTSiPR00004. ANAPHYLATOXN.
SMARTiView protein in SMART
SM00104. ANATO. 1 hit.
SUPFAMiSSF47686. SSF47686. 1 hit.
PROSITEiView protein in PROSITE
PS01177. ANAPHYLATOXIN_1. 1 hit.
PS01178. ANAPHYLATOXIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCO5_RAT
AccessioniPrimary (citable) accession number: P08650
Secondary accession number(s): Q63078
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: April 13, 2004
Last modified: February 15, 2017
This is version 117 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.