P08646 (RAS1_DROME) Reviewed, UniProtKB/Swiss-Prot
Last modified
May 29, 2013.
Version 136.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Ras-like protein 1 Short name=Dras1 Alternative name(s): Dmras85D | ||||||
| Gene names |
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| Organism | Drosophila melanogaster (Fruit fly) [Reference proteome] | ||||||
| Taxonomic identifier | 7227 [NCBI] | ||||||
| Taxonomic lineage | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › ![]() |
Protein attributes
| Sequence length | 189 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | May mediate a signal that determines the fate of photoreceptor cells in the developing compound eye. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. |
| Enzyme regulation | Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). |
| Subcellular location | Cell membrane; Lipid-anchor; Cytoplasmic side. Note: Loss of prenylation causes protein location to the cytoplasm. Ref.8 |
| Tissue specificity | Expressed in the posterior termini of the embryo, restricted mainly to the embryonic central nervous system, and in the eye imaginal disk. Ref.7 |
| Sequence similarities | Belongs to the small GTPase superfamily. Ras family. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 186 | 186 | Ras-like protein 1 | PRO_0000082665 | |||||
| Propeptide | 187 – 189 | 3 | Removed in mature form Probable | PRO_0000281313 | |||||
Regions | |||||||||
| Nucleotide binding | 10 – 17 | 8 | GTP By similarity | ||||||
| Nucleotide binding | 57 – 61 | 5 | GTP By similarity | ||||||
| Nucleotide binding | 116 – 119 | 4 | GTP By similarity | ||||||
| Motif | 32 – 40 | 9 | Effector region By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 186 | 1 | Cysteine methyl ester Probable | ||||||
| Lipidation | 186 | 1 | S-geranylgeranyl cysteine Probable | ||||||
Experimental info | |||||||||
| Sequence conflict | 11 | 1 | A → P in AAA28846. Ref.2 | ||||||
| Sequence conflict | 44 – 45 | 2 | VV → RF in AAA28846. Ref.2 | ||||||
| Sequence conflict | 84 | 1 | V → I in AAA28846. Ref.2 | ||||||
| Sequence conflict | 102 | 1 | R → H in AAA28846. Ref.2 | ||||||
| Sequence conflict | 114 | 1 | V → A in AAA28846. Ref.2 | ||||||
| Sequence conflict | 182 | 1 | R → C in AAA28846. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence and genomic structure of ras homologues Dmras85D and Dmras64B of Drosophila melanogaster." Brock H.W. Gene 51:129-137(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "The Drosophila ras oncogenes: structure and nucleotide sequence." Neuman-Silberberg F.S., Schejter E., Hoffmann F.M., Shilo B.-Z. Cell 37:1027-1033(1984) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [3] | "Absence of protein polymorphism in the Ras genes of Drosophila melanogaster." Gasperini R., Gibson G. J. Mol. Evol. 49:583-590(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: W13. |
| [4] | "The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. Venter J.C.Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley. |
| [5] | "Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. Lewis S.E.Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENOME REANNOTATION. Strain: Berkeley. |
| [6] | "A Drosophila full-length cDNA resource." Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A., Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M., Celniker S.E. Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Berkeley. Tissue: Embryo. |
| [7] | "Differential expression during embryogenesis of three genes clustered in the Ras1 region of Drosophila melanogaster." Ezer S.T., Sahar D., Salzberg A., Lev Z. Dev. Dyn. 201:179-190(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46, TISSUE SPECIFICITY. Strain: Canton-S. |
| [8] | "Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein." Day J.P., Cleghon V., Houslay M.D., Davies S.-A. Biochem. J. 414:363-374(2008) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, ISOPRENYLATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | M16429, M16123, M16428 Genomic DNA. Translation: AAA28847.1. K01960 mRNA. Translation: AAA28846.1. AF186648 Genomic DNA. Translation: AAF15514.1. AE014297 Genomic DNA. Translation: AAF54388.1. AY089541 mRNA. Translation: AAL90279.1. AY094888 mRNA. Translation: AAM11241.1. X73219 Genomic DNA. Translation: CAA51689.1. |
| PIR | TVFF85. A29048. S35097. |
| RefSeq | NP_476699.1. NM_057351.5. |
| UniGene | Dm.4812. |
3D structure databases | |
| ProteinModelPortal | P08646. |
| SMR | P08646. Positions 1-165. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-23541N. |
| MINT | MINT-293375. |
| STRING | 7227.FBpp0081600. |
Proteomic databases | |
| PaxDb | P08646. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | FBtr0082122; FBpp0081600; FBgn0003205. |
| GeneID | 41140. |
| KEGG | dme:Dmel_CG9375. |
Organism-specific databases | |
| CTD | 41140. |
| FlyBase | FBgn0003205. Ras85D. |
Phylogenomic databases | |
| eggNOG | COG1100. |
| GeneTree | ENSGT00690000101785. |
| InParanoid | P08646. |
| KO | K07827. |
| OMA | MSKEGKK. |
| OrthoDB | EOG425491. |
| PhylomeDB | P08646. |
Enzyme and pathway databases | |
| SignaLink | P08646. |
Gene expression databases | |
| Bgee | P08646. |
| GermOnline | CG9375. Drosophila melanogaster. |
Family and domain databases | |
| InterPro | IPR027417. P-loop_NTPase. IPR005225. Small_GTP-bd_dom. IPR001806. Small_GTPase. IPR020849. Small_GTPase_Ras. [Graphical view] |
| PANTHER | PTHR24070. PTHR24070. 1 hit. |
| Pfam | PF00071. Ras. 1 hit. [Graphical view] |
| PRINTS | PR00449. RASTRNSFRMNG. |
| SMART | SM00173. RAS. 1 hit. [Graphical view] |
| SUPFAM | SSF52540. SSF52540. 1 hit. |
| TIGRFAMs | TIGR00231. small_GTP. 1 hit. |
| PROSITE | PS51421. RAS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| ChiTaRS | Ras85D. drosophila. |
| GenomeRNAi | 41140. |
| NextBio | 822376. |
Entry information
| Entry name | RAS1_DROME | ||||||||
| Accession | Primary (citable) accession number: P08646 Secondary accession number(s): Q9V448 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Drosophila annotation project | ||||||||
Relevant documents
| Drosophila Drosophila: entries, gene names and cross-references to FlyBase |
| SIMILARITY comments Index of protein domains and families |

Clusters with
