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Protein

Ras-related protein Rap1

Gene

Rap1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays a role in photoreceptor cell determination.1 Publication

Enzyme regulationi

Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17GTPBy similarity8
Nucleotide bindingi57 – 61GTPBy similarity5
Nucleotide bindingi116 – 119GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: FlyBase
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • adherens junction assembly Source: FlyBase
  • dorsal closure Source: FlyBase
  • establishment of ommatidial planar polarity Source: FlyBase
  • germ-line stem cell population maintenance Source: FlyBase
  • hemocyte migration Source: FlyBase
  • ovarian follicle cell stalk formation Source: FlyBase
  • positive regulation of cell-cell adhesion Source: FlyBase
  • Rap protein signal transduction Source: FlyBase
  • regulation of embryonic cell shape Source: FlyBase
  • substrate-dependent cell migration, cell extension Source: FlyBase
  • visual perception Source: UniProtKB-KW

Keywordsi

Biological processSensory transduction, Vision
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DME-354192 Integrin alphaIIb beta3 signaling
R-DME-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins
R-DME-372708 p130Cas linkage to MAPK signaling for integrins
R-DME-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-DME-392517 Rap1 signalling
R-DME-5674135 MAP2K and MAPK activation
R-DME-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rap1Imported
Alternative name(s):
Rap1 GTPaseImported
Ras-like protein 31 Publication
Gene namesi
Name:Rap1Imported
Synonyms:RImported, RAP1 Publication, ras31 Publication
ORF Names:CG1956Imported
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi

Organism-specific databases

FlyBaseiFBgn0004636 Rap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Flies exhibit disruption of the early stages of photoreceptor cell determination, adult eyes lack the R7 cell.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000301911 – 181Ras-related protein Rap1Add BLAST181
PropeptideiPRO_0000030192182 – 184Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei181Cysteine methyl esterBy similarity1
Lipidationi181S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiP08645
PRIDEiP08645

Expressioni

Gene expression databases

BgeeiFBgn0004636
ExpressionAtlasiP08645 baseline and differential
GenevisibleiP08645 DM

Interactioni

Protein-protein interaction databases

BioGridi63773, 47 interactors
IntActiP08645, 1 interactor
STRINGi7227.FBpp0072746

Structurei

3D structure databases

ProteinModelPortaliP08645
SMRiP08645
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 40Effector region9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00860000133678
InParanoidiP08645
KOiK04353
OMAiQINRQMP
OrthoDBiEOG091G0OOG
PhylomeDBiP08645

Family and domain databases

CDDicd04175 Rap1, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR038851 Rap1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR020849 Small_GTPase_Ras-type
PANTHERiPTHR24070 PTHR24070, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51421 RAS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08645-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREYKIVVLG SGGVGKSALT VQFVQCIFVE KYDPTIEDSY RKQVEVDGQQ
60 70 80 90 100
CMLEILDTAG TEQFTAMRDL YMKNGQGFVL VYSITAQSTF NDLQDLREQI
110 120 130 140 150
LRVKDTDDVP MVLVGNKCDL EEERVVGKEL GKNLATQFNC AFMETSAKAK
160 170 180
VNVNDIFYDL VRQINKKSPE KKQKKPKKSL CVLL
Length:184
Mass (Da):20,863
Last modified:August 1, 1992 - v2
Checksum:i9A55889B61FEDE13
GO

Sequence cautioni

The sequence CAA26131 differs from that shown. Reason: Frameshift at positions 76, 96, 160 and 180.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45 – 49EVDGQ → KVNER in CAA26131 (PubMed:3926484).Curated5
Sequence conflicti56 – 57LD → VN in CAA26131 (PubMed:3926484).Curated2
Sequence conflicti69D → N in CAA26131 (PubMed:3926484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti157F → L in roughened mutants. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02200 Genomic DNA Translation: CAA26131.1 Frameshift.
M80535 Genomic DNA Translation: AAA28845.1
AF186654 Genomic DNA Translation: AAF15520.1
AE014296 Genomic DNA Translation: AAF47583.1
AY121688 mRNA Translation: AAM52015.1
DQ138746 Genomic DNA Translation: ABA86352.1
PIRiA41217
S07187 TVFFR3
RefSeqiNP_001189023.1, NM_001202094.2
NP_001261295.1, NM_001274366.1
NP_476857.1, NM_057509.5
UniGeneiDm.822

Genome annotation databases

EnsemblMetazoaiFBtr0072867; FBpp0072746; FBgn0004636
FBtr0303154; FBpp0292253; FBgn0004636
FBtr0332671; FBpp0304917; FBgn0004636
GeneIDi38244
KEGGidme:Dmel_CG1956

Similar proteinsi

Entry informationi

Entry nameiRAP1_DROME
AccessioniPrimary (citable) accession number: P08645
Secondary accession number(s): Q2XYB6, Q540V3, Q9V3N0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 13, 1987
Last sequence update: August 1, 1992
Last modified: May 23, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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