Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cadherin-1

Gene

CDH1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha-E/beta-7.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi263 – 2631Calcium 1By similarity
Metal bindingi263 – 2631Calcium 2By similarity
Metal bindingi294 – 2941Calcium 3By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-1
Alternative name(s):
Epithelial cadherin
Short name:
E-cadherin
Liver cell adhesion molecule
Short name:
L-CAM
Gene namesi
Name:CDH1
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini161 – 714554ExtracellularSequence analysisAdd
BLAST
Transmembranei715 – 73521HelicalSequence analysisAdd
BLAST
Topological domaini736 – 887152CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Propeptidei27 – 160134PRO_0000003721Add
BLAST
Chaini161 – 887727Cadherin-1PRO_0000003722Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi291 – 2911N-linked (GlcNAc...)1 Publication
Glycosylationi346 – 3461N-linked (GlcNAc...)1 Publication
Glycosylationi564 – 5641N-linked (GlcNAc...)1 Publication
Glycosylationi643 – 6431N-linked (GlcNAc...)1 Publication

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein

Expressioni

Tissue specificityi

Non-neural epithelial tissues.

Interactioni

Subunit structurei

Homodimer. Interacts with CTNNA2.1 Publication

Protein-protein interaction databases

IntActiP08641. 2 interactions.

Structurei

3D structure databases

ProteinModelPortaliP08641.
SMRiP08641. Positions 161-377, 788-881.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini161 – 268108Cadherin 1PROSITE-ProRule annotationAdd
BLAST
Domaini269 – 381113Cadherin 2PROSITE-ProRule annotationAdd
BLAST
Domaini382 – 493112Cadherin 3PROSITE-ProRule annotationAdd
BLAST
Domaini494 – 599106Cadherin 4PROSITE-ProRule annotationAdd
BLAST
Domaini600 – 704105Cadherin 5PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi844 – 85512Ser-richAdd
BLAST

Domaini

Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.By similarity

Sequence similaritiesi

Contains 5 cadherin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP08641.
KOiK05689.
PhylomeDBiP08641.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P08641-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRWGSPAL QRFPVLVLLL LLQVCGRRCD EAAPCQPGFA AETFSFSVPQ
60 70 80 90 100
DSVAAGRELG RVSFAACSGR PWAVYVPTDT RFKVNGDGVV STKRPLTLYG
110 120 130 140 150
RKISFTIYAQ DAMGKRHSAR VTVGRHRHRR HHHNHHLQDT TPAVLTFPKH
160 170 180 190 200
DPGFLRRQKR DWVIPPISCL ENHRGPYPMR LVQIKSNKDK ESKVYYSITG
210 220 230 240 250
QGADSPPVGI FIIERETGWL EVTEQLDREK IDRYTLLSHA VSASGQPVED
260 270 280 290 300
PMEIIITVMD QNDNKPVFIK EVFVGYIEEN AKPGTSVMTV NATDADDAVN
310 320 330 340 350
TDNGIVSYSI VSQQPPRPHP QMFTIDPAKG IISVLGTGLD RETTPNYTLI
360 370 380 390 400
VQATDQEGKG LSNTATAIIE VTDANDNIPI FNPTMYEGVV EENKPGTEVA
410 420 430 440 450
RLTVTDQDAP GSPAWQAVYH IKSGNLDGAF SIITDPSTNN GILKTAKGLD
460 470 480 490 500
YETKSRYDLV VTVENKVPLS VPITLSTASV LVTVLDVNEP PVFVPPIKRV
510 520 530 540 550
GVPEDLPVGQ QVTSYTAQDP DRDMRQKITY RMGSDPAGWL YIHPENGIVT
560 570 580 590 600
ATQPLDRESV HAINSTYKAI ILAVDNGIPD TTGTGTLLLL LQDVNDNGPT
610 620 630 640 650
PEPRSFEICS RQPEKQILSI VDKDLPPHTY PFKAALEHGS SNNWTVEIRG
660 670 680 690 700
QDELAMGLKK ELEPGEYNIF VKLTDSQGKA QVTQVKAQVC ECEGTAKNCE
710 720 730 740 750
RRSYIVGGLG VPAILGILGG ILALLILLLL LLLFARRRKV EKEPLLPPED
760 770 780 790 800
DMRDNVYNYD EEGGGEEDQD YDLSQLHRGL DARPEVIRND VAPPLMAAPQ
810 820 830 840 850
YRPRPANPDE IGNFIDENLK AADTDPTAPP YDSLLVFDYE GGGSEATSLS
860 870 880
SLNSSASDQD QDYDYLNEWG NRFKKLAELY GGGEDDE
Length:887
Mass (Da):97,783
Last modified:February 1, 1991 - v2
Checksum:iF56A8A9779A94A40
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti140 – 1401T → M in AAA82572 (PubMed:3174655).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22190
, M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA. Translation: AAA82572.1.
M16260 mRNA. Translation: AAA82573.1.
PIRiA30201. IJCHCL.
RefSeqiNP_001034347.2. NM_001039258.2.
UniGeneiGga.2982.

Genome annotation databases

GeneIDi415860.
KEGGigga:415860.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M22190
, M22180, M22181, M22182, M22186, M22183, M22194, M22184, M22185, M22189, M22193, M22187, M22192, M22191, M22195 Genomic DNA. Translation: AAA82572.1.
M16260 mRNA. Translation: AAA82573.1.
PIRiA30201. IJCHCL.
RefSeqiNP_001034347.2. NM_001039258.2.
UniGeneiGga.2982.

3D structure databases

ProteinModelPortaliP08641.
SMRiP08641. Positions 161-377, 788-881.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP08641. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi415860.
KEGGigga:415860.

Organism-specific databases

CTDi999.

Phylogenomic databases

HOGENOMiHOG000231254.
HOVERGENiHBG106438.
InParanoidiP08641.
KOiK05689.
PhylomeDBiP08641.

Miscellaneous databases

PROiP08641.

Family and domain databases

Gene3Di2.60.40.60. 6 hits.
4.10.900.10. 1 hit.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR000233. Cadherin_cytoplasmic-dom.
IPR014868. Cadherin_pro_dom.
IPR027397. Catenin_binding_dom.
[Graphical view]
PfamiPF00028. Cadherin. 5 hits.
PF01049. Cadherin_C. 1 hit.
PF08758. Cadherin_pro. 1 hit.
[Graphical view]
PRINTSiPR00205. CADHERIN.
SMARTiSM00112. CA. 4 hits.
SM01055. Cadherin_pro. 1 hit.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 6 hits.
PROSITEiPS00232. CADHERIN_1. 3 hits.
PS50268. CADHERIN_2. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCADH1_CHICK
AccessioniPrimary (citable) accession number: P08641
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: February 1, 1991
Last modified: June 8, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.