P08639 (LUXC_VIBHA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acyl-CoA reductase
EC=1.2.1.50

Gene names

Name:

luxC

Organism

Vibrio harveyi (Beneckea harveyi)

Taxonomic identifier

669 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	477 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	LuxC is the fatty acid reductase enzyme responsible for synthesis of the aldehyde substrate for the luminescent reaction catalyzed by luciferase.
Catalytic activity	A long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH.
Pathway	Lipid metabolism; fatty acid reduction for biolumincescence.
Sequence similarities	Belongs to the luxC family.
Sequence caution	The sequence CAA30117.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Luminescence
Ligand	NADP
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	bioluminescence Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acyl-CoA dehydrogenase activity Inferred from electronic annotation. Source: InterPro long-chain-fatty-acyl-CoA reductase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 477	477	Acyl-CoA reductase		PRO_0000220202

Sequences

	Sequence		Length	Mass (Da)
	P08639 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: 86D776D3474A6918	FASTA	477	54,840
	10 20 30 40 50 60 MEKHLPLIVN GQIISTEENR FEISFEEKKV KIDSFNNLHL TQMVNHDYLN DLNINNIINF 70 80 90 100 110 120 LYTTGQRWKS EEYSRRRAYI RSLITYLGYS PQMAKLEANW IAMILCSKSA LYDIIDTELG 130 140 150 160 170 180 STHIQDEWLP QGECYVRAFP KGRTMHLLAG NVPLSGVTSI LRGILTRNQC IVRMSASDPF 190 200 210 220 230 240 TAHALAMSFI DVDPNHPISR SISVLYWPHA SDTTLAEELL SHMDAVVAWG GRDAIDWAVK 250 260 270 280 290 300 HSPSHIDVLK FGPKKSFTVL DHPADLEEAA SGVAHDICFY DQNACFSTQN IYFSGDKYEE 310 320 330 340 350 360 FKLKLVEKLN LYQEVLPKSK QSFDDEALFS MTRLECQFSG LKVISEPENN WMIIESEPGV 370 380 390 400 410 420 EYNHPLSRCV YVHKINKVDD VVQYIEKHQT QTISFYPWES SKKYRDAFAA KGVERIVESG 430 440 450 460 470 MNNIFRAGGA HDAMRPLQRL VRFVSHERPY NFTTKDVSVE IEQTRFLEED KFLVFVP

References

[1]	"Nucleotide sequence of the LuxC gene and the upstream DNA from the bioluminescent system of Vibrio harveyi." Miyamoto C.M., Graham A.F., Meighen E.A. Nucleic Acids Res. 16:1551-1562(1988) [PubMed: 3347497] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	X07084 Genomic DNA. Translation: CAA30116.1. X07084 Genomic DNA. Translation: CAA30117.1. Different initiation.
PIR	A28534.
3D structure databases
ProteinModelPortal	P08639.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR008670. Acyl-CoA_reduct_LuxC. IPR016161. Ald_DH/histidinol_DH. IPR016162. Ald_DH_N. [Graphical view]
Gene3D	G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
Pfam	PF05893. LuxC. 1 hit. [Graphical view]
PIRSF	PIRSF009414. LuxC. 1 hit.
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
ProtoNet	Search...

Entry information

Entry name

LUXC_VIBHA

Accession

Primary (citable) accession number: P08639

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	November 16, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program