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P08637

- FCG3A_HUMAN

UniProt

P08637 - FCG3A_HUMAN

Protein

Low affinity immunoglobulin gamma Fc region receptor III-A

Gene

FCGR3A

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 164 (01 Oct 2014)
      Sequence version 2 (01 Aug 1990)
      Previous versions | rss
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    Functioni

    Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.2 Publications

    GO - Biological processi

    1. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    2. immune response Source: ProtInc
    3. innate immune response Source: Reactome
    4. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Receptor

    Keywords - Ligandi

    IgG-binding protein

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160274. FCGR activation.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor III-A
    Alternative name(s):
    CD16a antigen
    Fc-gamma RIII-alpha
    Short name:
    Fc-gamma RIII
    Short name:
    Fc-gamma RIIIa
    Short name:
    FcRIII
    Short name:
    FcRIIIa
    FcR-10
    IgG Fc receptor III-2
    CD_antigen: CD16a
    Gene namesi
    Name:FCGR3A
    Synonyms:CD16A, FCG3, FCGR3, IGFR3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3619. FCGR3A.

    Subcellular locationi

    Cell membrane Curated; Single-pass type I membrane protein Curated. Secreted
    Note: Exists also as a soluble receptor.

    GO - Cellular componenti

    1. external side of plasma membrane Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28065.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 254238Low affinity immunoglobulin gamma Fc region receptor III-APRO_0000015150Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi47 ↔ 89
    Glycosylationi56 – 561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi63 – 631N-linked (GlcNAc...)2 Publications
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi128 ↔ 172
    Glycosylationi180 – 1801N-linked (GlcNAc...)2 Publications
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated. Contains high mannose- and complex-type oligosaccharides. Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.2 Publications
    The soluble form is produced by a proteolytic cleavage.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP08637.
    PRIDEiP08637.

    PTM databases

    PhosphoSiteiP08637.

    Expressioni

    Tissue specificityi

    Expressed on natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placental trophoblasts.

    Gene expression databases

    ArrayExpressiP08637.
    BgeeiP08637.
    CleanExiHS_FCGR3A.
    GenevestigatoriP08637.

    Organism-specific databases

    HPAiCAB032435.
    HPA055431.

    Interactioni

    Subunit structurei

    Exists as a heterooligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit. Interacts with INPP5D/SHIP1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi108508. 5 interactions.
    IntActiP08637. 3 interactions.
    STRINGi9606.ENSP00000356946.

    Structurei

    Secondary structure

    1
    254
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 336
    Beta strandi35 – 384
    Beta strandi43 – 475
    Beta strandi51 – 544
    Beta strandi60 – 656
    Beta strandi71 – 788
    Helixi81 – 833
    Beta strandi85 – 895
    Beta strandi100 – 1056
    Beta strandi107 – 1126
    Beta strandi116 – 1194
    Beta strandi124 – 1307
    Helixi131 – 1333
    Beta strandi137 – 1437
    Beta strandi146 – 1538
    Beta strandi157 – 1615
    Helixi164 – 1663
    Beta strandi168 – 1769
    Beta strandi179 – 1824
    Beta strandi186 – 1916

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3AY4X-ray2.20C21-193[»]
    3SGJX-ray2.20C19-208[»]
    3SGKX-ray2.40C19-208[»]
    ProteinModelPortaliP08637.
    SMRiP08637. Positions 24-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP08637.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini17 – 208192ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini230 – 25425CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei209 – 22921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 10582Ig-like C2-type 1Add
    BLAST
    Domaini107 – 18983Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG47725.
    HOVERGENiHBG051602.
    InParanoidiP08637.
    KOiK06463.
    PhylomeDBiP08637.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P08637-1 [UniParc]FASTAAdd to Basket

    « Hide

    MWQLLLPTAL LLLVSAGMRT EDLPKAVVFL EPQWYRVLEK DSVTLKCQGA    50
    YSPEDNSTQW FHNESLISSQ ASSYFIDAAT VDDSGEYRCQ TNLSTLSDPV 100
    QLEVHIGWLL LQAPRWVFKE EDPIHLRCHS WKNTALHKVT YLQNGKGRKY 150
    FHHNSDFYIP KATLKDSGSY FCRGLFGSKN VSSETVNITI TQGLAVSTIS 200
    SFFPPGYQVS FCLVMVLLFA VDTGLYFSVK TNIRSSTRDW KDHKFKWRKD 250
    PQDK 254
    Length:254
    Mass (Da):29,089
    Last modified:August 1, 1990 - v2
    Checksum:iD38D178D32C67337
    GO

    Sequence cautioni

    The sequence BAD96988.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD97015.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti106 – 1061I → V in BAD96988. 1 PublicationCurated
    Sequence conflicti106 – 1061I → V in BAD97015. 1 PublicationCurated
    Sequence conflicti195 – 1951A → S in AAH33678. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti66 – 661L → H.1 Publication
    Corresponds to variant rs10127939 [ dbSNP | Ensembl ].
    VAR_008800
    Natural varianti66 – 661L → R.1 Publication
    Corresponds to variant rs10127939 [ dbSNP | Ensembl ].
    VAR_008799
    Natural varianti147 – 1471G → D.
    Corresponds to variant rs443082 [ dbSNP | Ensembl ].
    VAR_058398
    Natural varianti158 – 1581Y → H.
    Corresponds to variant rs396716 [ dbSNP | Ensembl ].
    VAR_058399
    Natural varianti176 – 1761F → V Shows a higher binding capacity of IgG1, IgG3 and IgG4. 5 Publications
    Corresponds to variant rs396991 [ dbSNP | Ensembl ].
    VAR_003960
    Natural varianti203 – 2031F → S.
    Corresponds to variant rs1042206 [ dbSNP | Ensembl ].
    VAR_058400

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52645 mRNA. Translation: CAA36870.1.
    AK223268 mRNA. Translation: BAD96988.1. Different initiation.
    AK223295 mRNA. Translation: BAD97015.1. Different initiation.
    AL590385 Genomic DNA. No translation available.
    BC017865 mRNA. Translation: AAH17865.1.
    BC033678 mRNA. Translation: AAH33678.1.
    Z46222 Genomic DNA. Translation: CAA86295.1.
    S76824 mRNA. Translation: AAB33925.2.
    M24853 mRNA. Translation: AAA53506.1.
    CCDSiCCDS44266.1.
    PIRiJL0107.
    RefSeqiNP_000560.5. NM_000569.6.
    NP_001121064.1. NM_001127592.1.
    NP_001121065.1. NM_001127593.1.
    NP_001121067.1. NM_001127595.1.
    NP_001121068.1. NM_001127596.1.
    UniGeneiHs.372679.

    Genome annotation databases

    EnsembliENST00000367967; ENSP00000356944; ENSG00000203747.
    ENST00000436743; ENSP00000416607; ENSG00000203747.
    GeneIDi2214.
    KEGGihsa:2214.
    UCSCiuc001gar.3. human.

    Polymorphism databases

    DMDMi119876.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    FCGR3Abase

    FCGR3A mutation db

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X52645 mRNA. Translation: CAA36870.1 .
    AK223268 mRNA. Translation: BAD96988.1 . Different initiation.
    AK223295 mRNA. Translation: BAD97015.1 . Different initiation.
    AL590385 Genomic DNA. No translation available.
    BC017865 mRNA. Translation: AAH17865.1 .
    BC033678 mRNA. Translation: AAH33678.1 .
    Z46222 Genomic DNA. Translation: CAA86295.1 .
    S76824 mRNA. Translation: AAB33925.2 .
    M24853 mRNA. Translation: AAA53506.1 .
    CCDSi CCDS44266.1.
    PIRi JL0107.
    RefSeqi NP_000560.5. NM_000569.6.
    NP_001121064.1. NM_001127592.1.
    NP_001121065.1. NM_001127593.1.
    NP_001121067.1. NM_001127595.1.
    NP_001121068.1. NM_001127596.1.
    UniGenei Hs.372679.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3AY4 X-ray 2.20 C 21-193 [» ]
    3SGJ X-ray 2.20 C 19-208 [» ]
    3SGK X-ray 2.40 C 19-208 [» ]
    ProteinModelPortali P08637.
    SMRi P08637. Positions 24-231.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108508. 5 interactions.
    IntActi P08637. 3 interactions.
    STRINGi 9606.ENSP00000356946.

    Chemistry

    DrugBanki DB00054. Abciximab.
    DB00051. Adalimumab.
    DB00092. Alefacept.
    DB00087. Alemtuzumab.
    DB00074. Basiliximab.
    DB00112. Bevacizumab.
    DB00002. Cetuximab.
    DB00111. Daclizumab.
    DB00095. Efalizumab.
    DB00005. Etanercept.
    DB00056. Gemtuzumab ozogamicin.
    DB00078. Ibritumomab.
    DB00028. Immune globulin.
    DB00075. Muromonab.
    DB00108. Natalizumab.
    DB00110. Palivizumab.
    DB00073. Rituximab.
    DB00081. Tositumomab.
    DB00072. Trastuzumab.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P08637.

    Polymorphism databases

    DMDMi 119876.

    Proteomic databases

    PaxDbi P08637.
    PRIDEi P08637.

    Protocols and materials databases

    DNASUi 2214.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367967 ; ENSP00000356944 ; ENSG00000203747 .
    ENST00000436743 ; ENSP00000416607 ; ENSG00000203747 .
    GeneIDi 2214.
    KEGGi hsa:2214.
    UCSCi uc001gar.3. human.

    Organism-specific databases

    CTDi 2214.
    GeneCardsi GC01M161511.
    HGNCi HGNC:3619. FCGR3A.
    HPAi CAB032435.
    HPA055431.
    MIMi 146740. gene.
    neXtProti NX_P08637.
    PharmGKBi PA28065.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG47725.
    HOVERGENi HBG051602.
    InParanoidi P08637.
    KOi K06463.
    PhylomeDBi P08637.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160274. FCGR activation.

    Miscellaneous databases

    ChiTaRSi FCGR3A. human.
    EvolutionaryTracei P08637.
    GeneWikii FCGR3A.
    GenomeRNAii 2214.
    NextBioi 8979.
    PROi P08637.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P08637.
    Bgeei P08637.
    CleanExi HS_FCGR3A.
    Genevestigatori P08637.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions."
      Ravetch J.V., Perussia B.
      J. Exp. Med. 170:481-497(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions."
      Rogers K.A., Scinicariello F., Attanasio R.
      J. Immunol. 177:3848-3856(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Blood.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-176.
      Tissue: Synovium.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-176.
      Tissue: Lung.
    6. "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions."
      Gessner J.E., Grussenmeyer T., Kolanus W., Schmidt R.E.
      J. Biol. Chem. 270:1350-1361(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-39.
      Tissue: Placenta.
    7. "Human glomerular mesangial cells express CD16 and may be stimulated via this receptor."
      Morcos M., Hansch G.M., Schonermark M., Ellwanger S., Harle M., Heckl-Ostreicher B.
      Kidney Int. 46:1627-1634(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-254, VARIANT VAL-176.
    8. "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms."
      Scallon B.J., Scigliano E., Freedman V.H., Miedel M.C., Pan Y.C., Unkeless J.C., Kochan J.P.
      Proc. Natl. Acad. Sci. U.S.A. 86:5079-5083(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-254.
      Tissue: Lung.
    9. "Structural basis for improved efficacy of therapeutic antibodies on defucosylation of their Fc glycans."
      Mizushima T., Yagi H., Takemoto E., Shibata-Koyama M., Isoda Y., Iida S., Masuda K., Satoh M., Kato K.
      Genes Cells 16:1071-1080(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 21-193 IN COMPLEX WITH IGHG1, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-63 AND ASN-180.
    10. "Unique carbohydrate-carbohydrate interactions are required for high affinity binding between FcgammaRIII and antibodies lacking core fucose."
      Ferrara C., Grau S., Jager C., Sondermann P., Brunker P., Waldhauer I., Hennig M., Ruf A., Rufer A.C., Stihle M., Umana P., Benz J.
      Proc. Natl. Acad. Sci. U.S.A. 108:12669-12674(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-208 IN COMPLEX WITH IGHG1, FUNCTION, DISULFIDE BONDS, GLYCOSYLATION AT ASN-63 AND ASN-180.
    11. "A triallelic Fc gamma receptor type IIIA polymorphism influences the binding of human IgG by NK cell Fc gamma RIIIa."
      de Haas M., Koene H.R., Kleijer M., de Vries E., Simsek S., van Tol M.J.D., Roos D., von dem Borne A.E.G.K.
      J. Immunol. 156:2948-2955(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS ARG-66 AND HIS-66.
    12. "Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype."
      Koene H.R., Kleijer M., Algra J., Roos D., von dem Borne A.E.G.K., de Haas M.
      Blood 90:1109-1114(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-176.
    13. "A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease."
      Wu J., Edberg J.C., Redecha P.B., Bansal V., Guyre P.M., Coleman K., Salmon J.E., Kimberly R.P.
      J. Clin. Invest. 100:1059-1070(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT VAL-176.

    Entry informationi

    Entry nameiFCG3A_HUMAN
    AccessioniPrimary (citable) accession number: P08637
    Secondary accession number(s): A2N6W9
    , Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: August 1, 1990
    Last modified: October 1, 2014
    This is version 164 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Encoded by one of two nearly indentical genes: FCGR3A (Shown here) and FCGR3B which are expressed in a tissue-specific manner. The Phe-203 in III-A determines the transmembrane domains whereas the 'Ser-203' in III-B determines the GPI-anchoring.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3