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P08630

- BTKL_DROME

UniProt

P08630 - BTKL_DROME

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Protein
Tyrosine-protein kinase Btk29A
Gene
Btk29A, Src2, Src29A, Tec29, CG8049
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Cofactori

Binds 1 zinc ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi195 – 1951Zinc By similarity
Metal bindingi206 – 2061Zinc By similarity
Metal bindingi207 – 2071Zinc By similarity
Metal bindingi217 – 2171Zinc By similarity
Binding sitei554 – 5541ATP By similarity
Active sitei647 – 6471Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 22337Btk-type
Add
BLAST
Nucleotide bindingi532 – 5409ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein tyrosine kinase activity Source: FlyBase

GO - Biological processi

  1. DNA endoreduplication Source: FlyBase
  2. JNK cascade Source: FlyBase
  3. actin cytoskeleton organization Source: FlyBase
  4. cellularization Source: FlyBase
  5. courtship behavior Source: FlyBase
  6. determination of adult lifespan Source: UniProtKB
  7. dorsal closure Source: FlyBase
  8. female germline ring canal formation Source: UniProtKB
  9. head involution Source: FlyBase
  10. imaginal disc-derived male genitalia development Source: UniProtKB
  11. imaginal disc-derived wing morphogenesis Source: FlyBase
  12. karyosome formation Source: FlyBase
  13. oogenesis Source: FlyBase
  14. open tracheal system development Source: FlyBase
  15. ovarian fusome organization Source: FlyBase
  16. ovarian nurse cell to oocyte transport Source: FlyBase
  17. peptidyl-tyrosine phosphorylation Source: FlyBase
  18. protein phosphorylation Source: FlyBase
  19. regulation of actin filament polymerization Source: FlyBase
  20. regulation of imaginal disc-derived wing size Source: FlyBase
  21. salivary gland morphogenesis Source: FlyBase
  22. sensitization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinkiP08630.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Btk29A (EC:2.7.10.2)
Alternative name(s):
Dsrc28C
Dsrc29a
Gene namesi
Name:Btk29A
Synonyms:Src2, Src29A, Tec29
ORF Names:CG8049
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003502. Btk29A.

Subcellular locationi


Note: Ring canals.

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. germline ring canal Source: UniProtKB
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Flies exhibit shortened copulatory duration (due to incomplete fusion of the left and right halves of the apodeme that holds the penis during copulation) and reduced adult-stage life span.1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Tyrosine-protein kinase Btk29A
PRO_0000088068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei677 – 6771Phosphotyrosine; by autocatalysis By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08630.

Expressioni

Tissue specificityi

Ring canals in the egg chambers and imaginal disks of third-instar larvae.3 Publications

Developmental stagei

Expressed both maternally and zygotically. Predominantly in early to middle embryogenesis, in larvae and adult females.2 Publications

Gene expression databases

BgeeiP08630.

Interactioni

Protein-protein interaction databases

BioGridi60259. 13 interactions.
DIPiDIP-23748N.
IntActiP08630. 1 interaction.
MINTiMINT-896102.

Structurei

3D structure databases

ProteinModelPortaliP08630.
SMRiP08630. Positions 48-217, 346-777.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 184144PH
Add
BLAST
Domaini342 – 40261SH3
Add
BLAST
Domaini410 – 50394SH2
Add
BLAST
Domaini526 – 779254Protein kinase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 2714Ser-rich
Add
BLAST
Compositional biasi231 – 26434Ser-rich
Add
BLAST
Compositional biasi263 – 28927Gly-rich
Add
BLAST

Sequence similaritiesi

Contains 1 PH domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00640000091251.
InParanoidiP08630.
KOiK07364.
OMAiRRNEEYC.
OrthoDBiEOG7KM5SC.
PhylomeDBiP08630.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P08630-1) [UniParc]FASTAAdd to Basket

Also known as: D, E, Type 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MMGTKHRNSH VNGSIKSSSS LRSSSKSFQA KMDLMSERLY DVVKSGSMVK    50
RAQNKKRFTP VNYKHRWFEL TKRTFSYFDV ENVERRRERG RIHLKGVRLV 100
EEATVSGEGG DPFAPDGYPF QVGYCEISAS ANSHQLENGN GGGSGVGIEG 150
QQSGRAVPQY TLYVIANSEK ERSEWIRAIR QVCEDSNTPK SYRYHPGLWS 200
GKKWSCCKGL SRTTFGCRAA AHWREANNNP SNGSSPAQNS TRSISPNSST 250
TNSQFSLQHN SSGSLGGGVG GGLGGGGSLG LGGGGGGGGS CTPTSLQPQS 300
SLTTFKQSPT LLNGNGTLLD ANMPGGIPTP GTPNSKAKDN SHFVKLVVAL 350
YPFKAIEGGD LSLEKNAEYE VIDDSQEHWW KVKDALGNVG YIPSNYVKPK 400
ALLGLERYEW YVGDMSRQRA ESLLKQGDKE GCFVVRKSST KGLYTLSLHT 450
KVPQSHVKHY HIKQNARCEY YLSEKHCCET IPDLINYHRH NSGGLACRLK 500
SSPCDRPVPP TAGLSHDKWE IHPMELMLME ELGSGQFGVV RRGKWRGSID 550
TAVKMMKEGT MSEDDFIEEA KVMTKLQHPN LVQLYGVCSK HRPIYIVTEY 600
MKHGSLLNYL RRHEKTLIGN MGLLLDMCIQ VSKGMTYLER HNYIHRDLAA 650
RNCLVGSENV VKVADFGLAR YVLDDQYTSS GGTKFPIKWA PPEVLNYTRF 700
SSKSDVWAYG VLMWEIFTCG KMPYGRLKNT EVVERVQRGI ILEKPKSCAK 750
EIYDVMKLCW SHGPEERPAF RVLMDQLALV AQTLTD 786
Length:786
Mass (Da):87,392
Last modified:November 25, 2002 - v2
Checksum:iE2BCE122E6AAA0AA
GO
Isoform A (identifier: P08630-2) [UniParc]FASTAAdd to Basket

Also known as: C, F, Type 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.
     184-231: EDSNTPKSYR...HWREANNNPS → MIPCVSLAET...SLTSSKTKEG

Show »
Length:603
Mass (Da):66,750
Checksum:i6FDEE9B1F2C230AD
GO

Sequence cautioni

The sequence AAA28912.1 differs from that shown. Reason: Frameshift at positions 62, 215, 218, 220 and 401.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 183183Missing in isoform A.
VSP_004964Add
BLAST
Alternative sequencei184 – 23148EDSNT…NNNPS → MIPCVSLAETSVIGNMKERV KEMKVFGCRLNFWNHIGHSL TSSKTKEG in isoform A.
VSP_004965Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431S → A in AAA28912. 1 Publication
Sequence conflicti317 – 3171T → N in AAA28912. 1 Publication
Sequence conflicti317 – 3171T → N in BAA24063. 1 Publication
Sequence conflicti317 – 3171T → N in BAA24064. 1 Publication
Sequence conflicti352 – 3532PF → LG in AAA28912. 1 Publication
Sequence conflicti363 – 3631L → VG in AAA28912. 1 Publication
Sequence conflicti398 – 4003KPK → QAE in AAA28912. 1 Publication
Sequence conflicti414 – 4141D → Y in AAA28912. 1 Publication
Sequence conflicti524 – 5252ME → IQ in AAA28912. 1 Publication
Sequence conflicti589 – 5891S → T in AAA28912. 1 Publication
Sequence conflicti589 – 5891S → T in CAA26170. 1 Publication
Sequence conflicti657 – 6571S → F in CAA26170. 1 Publication
Sequence conflicti681 – 6844GGTK → AEPS in CAA26170. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16599 mRNA. Translation: AAA28912.1. Frameshift.
AB009840 mRNA. Translation: BAA24063.1.
AB009841 mRNA. Translation: BAA24064.1.
AE014134 Genomic DNA. Translation: AAF52631.3.
AE014134 Genomic DNA. Translation: AAF52632.2.
AE014134 Genomic DNA. Translation: AAN11161.1.
AE014134 Genomic DNA. Translation: AAN11162.1.
AE014134 Genomic DNA. Translation: ABV53648.1.
AE014134 Genomic DNA. Translation: ABV53649.1.
AY069457 mRNA. Translation: AAL39602.1.
AY128441 mRNA. Translation: AAM75034.1.
BT011183 mRNA. Translation: AAR88544.1.
AF044337 mRNA. Translation: AAB99858.1.
X02305 Genomic DNA. Translation: CAA26170.1.
PIRiA23051.
A27807. TVFFDS.
RefSeqiNP_001097120.1. NM_001103650.2. [P08630-2]
NP_001097121.1. NM_001103651.2. [P08630-1]
NP_476745.1. NM_057397.5. [P08630-1]
NP_476746.1. NM_057398.4. [P08630-2]
NP_723369.1. NM_164804.2. [P08630-1]
NP_723370.1. NM_164805.2. [P08630-2]
UniGeneiDm.7306.

Genome annotation databases

EnsemblMetazoaiFBtr0079616; FBpp0079236; FBgn0003502. [P08630-1]
FBtr0079617; FBpp0079237; FBgn0003502. [P08630-1]
FBtr0112836; FBpp0111749; FBgn0003502. [P08630-1]
GeneIDi34132.
KEGGidme:Dmel_CG8049.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16599 mRNA. Translation: AAA28912.1 . Frameshift.
AB009840 mRNA. Translation: BAA24063.1 .
AB009841 mRNA. Translation: BAA24064.1 .
AE014134 Genomic DNA. Translation: AAF52631.3 .
AE014134 Genomic DNA. Translation: AAF52632.2 .
AE014134 Genomic DNA. Translation: AAN11161.1 .
AE014134 Genomic DNA. Translation: AAN11162.1 .
AE014134 Genomic DNA. Translation: ABV53648.1 .
AE014134 Genomic DNA. Translation: ABV53649.1 .
AY069457 mRNA. Translation: AAL39602.1 .
AY128441 mRNA. Translation: AAM75034.1 .
BT011183 mRNA. Translation: AAR88544.1 .
AF044337 mRNA. Translation: AAB99858.1 .
X02305 Genomic DNA. Translation: CAA26170.1 .
PIRi A23051.
A27807. TVFFDS.
RefSeqi NP_001097120.1. NM_001103650.2. [P08630-2 ]
NP_001097121.1. NM_001103651.2. [P08630-1 ]
NP_476745.1. NM_057397.5. [P08630-1 ]
NP_476746.1. NM_057398.4. [P08630-2 ]
NP_723369.1. NM_164804.2. [P08630-1 ]
NP_723370.1. NM_164805.2. [P08630-2 ]
UniGenei Dm.7306.

3D structure databases

ProteinModelPortali P08630.
SMRi P08630. Positions 48-217, 346-777.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60259. 13 interactions.
DIPi DIP-23748N.
IntActi P08630. 1 interaction.
MINTi MINT-896102.

Proteomic databases

PaxDbi P08630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0079616 ; FBpp0079236 ; FBgn0003502 . [P08630-1 ]
FBtr0079617 ; FBpp0079237 ; FBgn0003502 . [P08630-1 ]
FBtr0112836 ; FBpp0111749 ; FBgn0003502 . [P08630-1 ]
GeneIDi 34132.
KEGGi dme:Dmel_CG8049.

Organism-specific databases

CTDi 34132.
FlyBasei FBgn0003502. Btk29A.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00640000091251.
InParanoidi P08630.
KOi K07364.
OMAi RRNEEYC.
OrthoDBi EOG7KM5SC.
PhylomeDBi P08630.

Enzyme and pathway databases

Reactomei REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinki P08630.

Miscellaneous databases

ChiTaRSi Btk29A. drosophila.
GenomeRNAii 34132.
NextBioi 787021.
PROi P08630.

Gene expression databases

Bgeei P08630.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary sequence and developmental expression of a novel Drosophila melanogaster src gene."
    Gregory R.J., Kammermeyer K.L., Vincent W.S. III, Wadsworth S.G.
    Mol. Cell. Biol. 7:2119-2127(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation."
    Baba K., Takeshita A., Majima K., Ueda R., Kondo S., Juni N., Yamamoto D.
    Mol. Cell. Biol. 19:4405-4413(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Canton-S and Oregon-R.
    Tissue: Head.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
  7. "SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth."
    Guarnieri D.J., Dodson G.S., Simon M.A.
    Mol. Cell 1:831-840(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-786 (ISOFORM A).
    Tissue: Eye-antennal disk.
  8. "Maternal inheritance of transcripts from three Drosophila src-related genes."
    Wadsworth S.C., Madhavan K., Bilodeau-Wentworth D.
    Nucleic Acids Res. 13:2153-2170(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 552-684.
  9. "Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis."
    Dodson G.S., Guarnieri D.J., Simon M.A.
    Development 125:2883-2892(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. Sjolander K.
    Unpublished observations (JUL-1997)
    Cited for: SIMILARITY TO BTK SUBFAMILY.

Entry informationi

Entry nameiBTKL_DROME
AccessioniPrimary (citable) accession number: P08630
Secondary accession number(s): A4V0F3
, A4V0F4, O45032, O76132, O76133, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 25, 2002
Last modified: September 3, 2014
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi