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P08630

- BTKL_DROME

UniProt

P08630 - BTKL_DROME

Protein

Tyrosine-protein kinase Btk29A

Gene

Btk29A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 2 (25 Nov 2002)
      Previous versions | rss
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    Functioni

    Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.2 Publications

    Catalytic activityi

    ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi195 – 1951ZincBy similarity
    Metal bindingi206 – 2061ZincBy similarity
    Metal bindingi207 – 2071ZincBy similarity
    Metal bindingi217 – 2171ZincBy similarity
    Binding sitei554 – 5541ATPPROSITE-ProRule annotation
    Active sitei647 – 6471Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri187 – 22337Btk-typePROSITE-ProRule annotationAdd
    BLAST
    Nucleotide bindingi532 – 5409ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
    4. protein tyrosine kinase activity Source: FlyBase

    GO - Biological processi

    1. actin cytoskeleton organization Source: FlyBase
    2. cellularization Source: FlyBase
    3. courtship behavior Source: FlyBase
    4. determination of adult lifespan Source: UniProtKB
    5. DNA endoreduplication Source: FlyBase
    6. dorsal closure Source: FlyBase
    7. female germline ring canal formation Source: UniProtKB
    8. head involution Source: FlyBase
    9. imaginal disc-derived male genitalia development Source: UniProtKB
    10. imaginal disc-derived wing morphogenesis Source: FlyBase
    11. JNK cascade Source: FlyBase
    12. karyosome formation Source: FlyBase
    13. oogenesis Source: FlyBase
    14. open tracheal system development Source: FlyBase
    15. ovarian fusome organization Source: FlyBase
    16. ovarian nurse cell to oocyte transport Source: FlyBase
    17. peptidyl-tyrosine phosphorylation Source: FlyBase
    18. protein phosphorylation Source: FlyBase
    19. regulation of actin filament polymerization Source: FlyBase
    20. regulation of imaginal disc-derived wing size Source: FlyBase
    21. salivary gland morphogenesis Source: FlyBase
    22. sensitization Source: FlyBase

    Keywords - Molecular functioni

    Kinase, Transferase, Tyrosine-protein kinase

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinkiP08630.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tyrosine-protein kinase Btk29A (EC:2.7.10.2)
    Alternative name(s):
    Dsrc28C
    Dsrc29a
    Gene namesi
    Name:Btk29A
    Synonyms:Src2, Src29A, Tec29
    ORF Names:CG8049
    OrganismiDrosophila melanogaster (Fruit fly)
    Taxonomic identifieri7227 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
    ProteomesiUP000000803: Chromosome 2L

    Organism-specific databases

    FlyBaseiFBgn0003502. Btk29A.

    Subcellular locationi


    Note: Ring canals.

    GO - Cellular componenti

    1. cytoplasm Source: FlyBase
    2. germline ring canal Source: UniProtKB
    3. plasma membrane Source: FlyBase

    Pathology & Biotechi

    Disruption phenotypei

    Flies exhibit shortened copulatory duration (due to incomplete fusion of the left and right halves of the apodeme that holds the penis during copulation) and reduced adult-stage life span.1 Publication

    Keywords - Diseasei

    Proto-oncogene

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 786786Tyrosine-protein kinase Btk29APRO_0000088068Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei677 – 6771Phosphotyrosine; by autocatalysisBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiP08630.

    Expressioni

    Tissue specificityi

    Ring canals in the egg chambers and imaginal disks of third-instar larvae.3 Publications

    Developmental stagei

    Expressed both maternally and zygotically. Predominantly in early to middle embryogenesis, in larvae and adult females.2 Publications

    Gene expression databases

    BgeeiP08630.

    Interactioni

    Protein-protein interaction databases

    BioGridi60259. 13 interactions.
    DIPiDIP-23748N.
    IntActiP08630. 1 interaction.
    MINTiMINT-896102.

    Structurei

    3D structure databases

    ProteinModelPortaliP08630.
    SMRiP08630. Positions 48-217, 346-777.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini41 – 184144PHPROSITE-ProRule annotationAdd
    BLAST
    Domaini342 – 40261SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini410 – 50394SH2PROSITE-ProRule annotationAdd
    BLAST
    Domaini526 – 779254Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi14 – 2714Ser-richAdd
    BLAST
    Compositional biasi231 – 26434Ser-richAdd
    BLAST
    Compositional biasi263 – 28927Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
    Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
    Contains 1 PH domain.PROSITE-ProRule annotation
    Contains 1 protein kinase domain.PROSITE-ProRule annotation
    Contains 1 SH2 domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri187 – 22337Btk-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    SH2 domain, SH3 domain, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00640000091251.
    InParanoidiP08630.
    KOiK07364.
    OMAiRRNEEYC.
    OrthoDBiEOG7KM5SC.
    PhylomeDBiP08630.

    Family and domain databases

    Gene3Di2.30.29.30. 2 hits.
    3.30.505.10. 1 hit.
    InterProiIPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view]
    PfamiPF00779. BTK. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    PRINTSiPR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTiSM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEiPS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: P08630-1) [UniParc]FASTAAdd to Basket

    Also known as: D, E, Type 2

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMGTKHRNSH VNGSIKSSSS LRSSSKSFQA KMDLMSERLY DVVKSGSMVK    50
    RAQNKKRFTP VNYKHRWFEL TKRTFSYFDV ENVERRRERG RIHLKGVRLV 100
    EEATVSGEGG DPFAPDGYPF QVGYCEISAS ANSHQLENGN GGGSGVGIEG 150
    QQSGRAVPQY TLYVIANSEK ERSEWIRAIR QVCEDSNTPK SYRYHPGLWS 200
    GKKWSCCKGL SRTTFGCRAA AHWREANNNP SNGSSPAQNS TRSISPNSST 250
    TNSQFSLQHN SSGSLGGGVG GGLGGGGSLG LGGGGGGGGS CTPTSLQPQS 300
    SLTTFKQSPT LLNGNGTLLD ANMPGGIPTP GTPNSKAKDN SHFVKLVVAL 350
    YPFKAIEGGD LSLEKNAEYE VIDDSQEHWW KVKDALGNVG YIPSNYVKPK 400
    ALLGLERYEW YVGDMSRQRA ESLLKQGDKE GCFVVRKSST KGLYTLSLHT 450
    KVPQSHVKHY HIKQNARCEY YLSEKHCCET IPDLINYHRH NSGGLACRLK 500
    SSPCDRPVPP TAGLSHDKWE IHPMELMLME ELGSGQFGVV RRGKWRGSID 550
    TAVKMMKEGT MSEDDFIEEA KVMTKLQHPN LVQLYGVCSK HRPIYIVTEY 600
    MKHGSLLNYL RRHEKTLIGN MGLLLDMCIQ VSKGMTYLER HNYIHRDLAA 650
    RNCLVGSENV VKVADFGLAR YVLDDQYTSS GGTKFPIKWA PPEVLNYTRF 700
    SSKSDVWAYG VLMWEIFTCG KMPYGRLKNT EVVERVQRGI ILEKPKSCAK 750
    EIYDVMKLCW SHGPEERPAF RVLMDQLALV AQTLTD 786
    Length:786
    Mass (Da):87,392
    Last modified:November 25, 2002 - v2
    Checksum:iE2BCE122E6AAA0AA
    GO
    Isoform A (identifier: P08630-2) [UniParc]FASTAAdd to Basket

    Also known as: C, F, Type 1

    The sequence of this isoform differs from the canonical sequence as follows:
         1-183: Missing.
         184-231: EDSNTPKSYR...HWREANNNPS → MIPCVSLAET...SLTSSKTKEG

    Show »
    Length:603
    Mass (Da):66,750
    Checksum:i6FDEE9B1F2C230AD
    GO

    Sequence cautioni

    The sequence AAA28912.1 differs from that shown. Reason: Frameshift at positions 62, 215, 218, 220 and 401.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti243 – 2431S → A in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti317 – 3171T → N in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti317 – 3171T → N in BAA24063. (PubMed:10330180)Curated
    Sequence conflicti317 – 3171T → N in BAA24064. (PubMed:10330180)Curated
    Sequence conflicti352 – 3532PF → LG in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti363 – 3631L → VG in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti398 – 4003KPK → QAE in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti414 – 4141D → Y in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti524 – 5252ME → IQ in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti589 – 5891S → T in AAA28912. (PubMed:3110602)Curated
    Sequence conflicti589 – 5891S → T in CAA26170. (PubMed:9660966)Curated
    Sequence conflicti657 – 6571S → F in CAA26170. (PubMed:9660966)Curated
    Sequence conflicti681 – 6844GGTK → AEPS in CAA26170. (PubMed:9660966)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 183183Missing in isoform A. 5 PublicationsVSP_004964Add
    BLAST
    Alternative sequencei184 – 23148EDSNT…NNNPS → MIPCVSLAETSVIGNMKERV KEMKVFGCRLNFWNHIGHSL TSSKTKEG in isoform A. 5 PublicationsVSP_004965Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16599 mRNA. Translation: AAA28912.1. Frameshift.
    AB009840 mRNA. Translation: BAA24063.1.
    AB009841 mRNA. Translation: BAA24064.1.
    AE014134 Genomic DNA. Translation: AAF52631.3.
    AE014134 Genomic DNA. Translation: AAF52632.2.
    AE014134 Genomic DNA. Translation: AAN11161.1.
    AE014134 Genomic DNA. Translation: AAN11162.1.
    AE014134 Genomic DNA. Translation: ABV53648.1.
    AE014134 Genomic DNA. Translation: ABV53649.1.
    AY069457 mRNA. Translation: AAL39602.1.
    AY128441 mRNA. Translation: AAM75034.1.
    BT011183 mRNA. Translation: AAR88544.1.
    AF044337 mRNA. Translation: AAB99858.1.
    X02305 Genomic DNA. Translation: CAA26170.1.
    PIRiA23051.
    A27807. TVFFDS.
    RefSeqiNP_001097120.1. NM_001103650.2. [P08630-2]
    NP_001097121.1. NM_001103651.2. [P08630-1]
    NP_476745.1. NM_057397.5. [P08630-1]
    NP_476746.1. NM_057398.4. [P08630-2]
    NP_723369.1. NM_164804.2. [P08630-1]
    NP_723370.1. NM_164805.2. [P08630-2]
    UniGeneiDm.7306.

    Genome annotation databases

    EnsemblMetazoaiFBtr0079616; FBpp0079236; FBgn0003502. [P08630-1]
    FBtr0079617; FBpp0079237; FBgn0003502. [P08630-1]
    FBtr0112836; FBpp0111749; FBgn0003502. [P08630-1]
    GeneIDi34132.
    KEGGidme:Dmel_CG8049.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M16599 mRNA. Translation: AAA28912.1 . Frameshift.
    AB009840 mRNA. Translation: BAA24063.1 .
    AB009841 mRNA. Translation: BAA24064.1 .
    AE014134 Genomic DNA. Translation: AAF52631.3 .
    AE014134 Genomic DNA. Translation: AAF52632.2 .
    AE014134 Genomic DNA. Translation: AAN11161.1 .
    AE014134 Genomic DNA. Translation: AAN11162.1 .
    AE014134 Genomic DNA. Translation: ABV53648.1 .
    AE014134 Genomic DNA. Translation: ABV53649.1 .
    AY069457 mRNA. Translation: AAL39602.1 .
    AY128441 mRNA. Translation: AAM75034.1 .
    BT011183 mRNA. Translation: AAR88544.1 .
    AF044337 mRNA. Translation: AAB99858.1 .
    X02305 Genomic DNA. Translation: CAA26170.1 .
    PIRi A23051.
    A27807. TVFFDS.
    RefSeqi NP_001097120.1. NM_001103650.2. [P08630-2 ]
    NP_001097121.1. NM_001103651.2. [P08630-1 ]
    NP_476745.1. NM_057397.5. [P08630-1 ]
    NP_476746.1. NM_057398.4. [P08630-2 ]
    NP_723369.1. NM_164804.2. [P08630-1 ]
    NP_723370.1. NM_164805.2. [P08630-2 ]
    UniGenei Dm.7306.

    3D structure databases

    ProteinModelPortali P08630.
    SMRi P08630. Positions 48-217, 346-777.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 60259. 13 interactions.
    DIPi DIP-23748N.
    IntActi P08630. 1 interaction.
    MINTi MINT-896102.

    Proteomic databases

    PaxDbi P08630.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblMetazoai FBtr0079616 ; FBpp0079236 ; FBgn0003502 . [P08630-1 ]
    FBtr0079617 ; FBpp0079237 ; FBgn0003502 . [P08630-1 ]
    FBtr0112836 ; FBpp0111749 ; FBgn0003502 . [P08630-1 ]
    GeneIDi 34132.
    KEGGi dme:Dmel_CG8049.

    Organism-specific databases

    CTDi 34132.
    FlyBasei FBgn0003502. Btk29A.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00640000091251.
    InParanoidi P08630.
    KOi K07364.
    OMAi RRNEEYC.
    OrthoDBi EOG7KM5SC.
    PhylomeDBi P08630.

    Enzyme and pathway databases

    Reactomei REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
    SignaLinki P08630.

    Miscellaneous databases

    ChiTaRSi Btk29A. drosophila.
    GenomeRNAii 34132.
    NextBioi 787021.
    PROi P08630.

    Gene expression databases

    Bgeei P08630.

    Family and domain databases

    Gene3Di 2.30.29.30. 2 hits.
    3.30.505.10. 1 hit.
    InterProi IPR011009. Kinase-like_dom.
    IPR001849. PH_domain.
    IPR011993. PH_like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
    IPR000980. SH2.
    IPR001452. SH3_domain.
    IPR008266. Tyr_kinase_AS.
    IPR020635. Tyr_kinase_cat_dom.
    IPR001562. Znf_Btk_motif.
    [Graphical view ]
    Pfami PF00779. BTK. 1 hit.
    PF07714. Pkinase_Tyr. 1 hit.
    PF00017. SH2. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00401. SH2DOMAIN.
    PR00109. TYRKINASE.
    SMARTi SM00107. BTK. 1 hit.
    SM00233. PH. 1 hit.
    SM00252. SH2. 1 hit.
    SM00326. SH3. 1 hit.
    SM00219. TyrKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50044. SSF50044. 1 hit.
    SSF55550. SSF55550. 1 hit.
    SSF56112. SSF56112. 1 hit.
    PROSITEi PS50003. PH_DOMAIN. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00109. PROTEIN_KINASE_TYR. 1 hit.
    PS50001. SH2. 1 hit.
    PS50002. SH3. 1 hit.
    PS51113. ZF_BTK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary sequence and developmental expression of a novel Drosophila melanogaster src gene."
      Gregory R.J., Kammermeyer K.L., Vincent W.S. III, Wadsworth S.G.
      Mol. Cell. Biol. 7:2119-2127(1987) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation."
      Baba K., Takeshita A., Majima K., Ueda R., Kondo S., Juni N., Yamamoto D.
      Mol. Cell. Biol. 19:4405-4413(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
      Strain: Canton-S and Oregon-R.
      Tissue: Head.
    3. "The genome sequence of Drosophila melanogaster."
      Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
      , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
      Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Berkeley.
    4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
      Strain: Berkeley.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
      Strain: Berkeley.
      Tissue: Embryo.
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
      Strain: Berkeley.
    7. "SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth."
      Guarnieri D.J., Dodson G.S., Simon M.A.
      Mol. Cell 1:831-840(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-786 (ISOFORM A).
      Tissue: Eye-antennal disk.
    8. "Maternal inheritance of transcripts from three Drosophila src-related genes."
      Wadsworth S.C., Madhavan K., Bilodeau-Wentworth D.
      Nucleic Acids Res. 13:2153-2170(1985) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 552-684.
    9. "Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis."
      Dodson G.S., Guarnieri D.J., Simon M.A.
      Development 125:2883-2892(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.
    10. Sjolander K.
      Unpublished observations (JUL-1997)
      Cited for: SIMILARITY TO BTK SUBFAMILY.

    Entry informationi

    Entry nameiBTKL_DROME
    AccessioniPrimary (citable) accession number: P08630
    Secondary accession number(s): A4V0F3
    , A4V0F4, O45032, O76132, O76133, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 1, 1988
    Last sequence update: November 25, 2002
    Last modified: October 1, 2014
    This is version 167 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programDrosophila annotation project

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Drosophila
      Drosophila: entries, gene names and cross-references to FlyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3