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P08630

- BTKL_DROME

UniProt

P08630 - BTKL_DROME

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Protein

Tyrosine-protein kinase Btk29A

Gene

Btk29A

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Required for proper ring canal development. Also required for the development of male genitalia and for adult survival.2 Publications

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Cofactori

Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi195 – 1951ZincBy similarity
Metal bindingi206 – 2061ZincBy similarity
Metal bindingi207 – 2071ZincBy similarity
Metal bindingi217 – 2171ZincBy similarity
Binding sitei554 – 5541ATPPROSITE-ProRule annotation
Active sitei647 – 6471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 22337Btk-typePROSITE-ProRule annotationAdd
BLAST
Nucleotide bindingi532 – 5409ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. non-membrane spanning protein tyrosine kinase activity Source: UniProtKB-EC
  4. protein tyrosine kinase activity Source: FlyBase

GO - Biological processi

  1. actin cytoskeleton organization Source: FlyBase
  2. cellularization Source: FlyBase
  3. courtship behavior Source: FlyBase
  4. determination of adult lifespan Source: UniProtKB
  5. DNA endoreduplication Source: FlyBase
  6. dorsal closure Source: FlyBase
  7. female germline ring canal formation Source: UniProtKB
  8. head involution Source: FlyBase
  9. imaginal disc-derived male genitalia development Source: UniProtKB
  10. imaginal disc-derived wing morphogenesis Source: FlyBase
  11. JNK cascade Source: FlyBase
  12. karyosome formation Source: FlyBase
  13. oogenesis Source: FlyBase
  14. open tracheal system development Source: FlyBase
  15. ovarian fusome organization Source: FlyBase
  16. ovarian nurse cell to oocyte transport Source: FlyBase
  17. peptidyl-tyrosine phosphorylation Source: FlyBase
  18. protein phosphorylation Source: FlyBase
  19. regulation of actin filament polymerization Source: FlyBase
  20. regulation of imaginal disc-derived wing size Source: FlyBase
  21. salivary gland morphogenesis Source: FlyBase
  22. sensitization Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase, Tyrosine-protein kinase

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinkiP08630.

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein kinase Btk29A (EC:2.7.10.2)
Alternative name(s):
Dsrc28C
Dsrc29a
Gene namesi
Name:Btk29A
Synonyms:Src2, Src29A, Tec29
ORF Names:CG8049
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
ProteomesiUP000000803: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0003502. Btk29A.

Subcellular locationi


Note: Ring canals.

GO - Cellular componenti

  1. cytoplasm Source: FlyBase
  2. germline ring canal Source: UniProtKB
  3. plasma membrane Source: FlyBase
Complete GO annotation...

Pathology & Biotechi

Disruption phenotypei

Flies exhibit shortened copulatory duration (due to incomplete fusion of the left and right halves of the apodeme that holds the penis during copulation) and reduced adult-stage life span.1 Publication

Keywords - Diseasei

Proto-oncogene

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Tyrosine-protein kinase Btk29APRO_0000088068Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei677 – 6771Phosphotyrosine; by autocatalysisBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP08630.

Expressioni

Tissue specificityi

Ring canals in the egg chambers and imaginal disks of third-instar larvae.3 Publications

Developmental stagei

Expressed both maternally and zygotically. Predominantly in early to middle embryogenesis, in larvae and adult females.2 Publications

Gene expression databases

BgeeiP08630.
ExpressionAtlasiP08630. differential.

Interactioni

Protein-protein interaction databases

BioGridi60259. 13 interactions.
DIPiDIP-23748N.
IntActiP08630. 1 interaction.
MINTiMINT-896102.

Structurei

3D structure databases

ProteinModelPortaliP08630.
SMRiP08630. Positions 48-217, 346-777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini41 – 184144PHPROSITE-ProRule annotationAdd
BLAST
Domaini342 – 40261SH3PROSITE-ProRule annotationAdd
BLAST
Domaini410 – 50394SH2PROSITE-ProRule annotationAdd
BLAST
Domaini526 – 779254Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi14 – 2714Ser-richAdd
BLAST
Compositional biasi231 – 26434Ser-richAdd
BLAST
Compositional biasi263 – 28927Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.PROSITE-ProRule annotation
Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 SH2 domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri187 – 22337Btk-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

SH2 domain, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119011.
InParanoidiP08630.
KOiK07364.
OMAiRRNEEYC.
OrthoDBiEOG7KM5SC.
PhylomeDBiP08630.

Family and domain databases

Gene3Di2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
InterProiIPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
PRINTSiPR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTiSM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P08630-1) [UniParc]FASTAAdd to Basket

Also known as: D, E, Type 2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMGTKHRNSH VNGSIKSSSS LRSSSKSFQA KMDLMSERLY DVVKSGSMVK
60 70 80 90 100
RAQNKKRFTP VNYKHRWFEL TKRTFSYFDV ENVERRRERG RIHLKGVRLV
110 120 130 140 150
EEATVSGEGG DPFAPDGYPF QVGYCEISAS ANSHQLENGN GGGSGVGIEG
160 170 180 190 200
QQSGRAVPQY TLYVIANSEK ERSEWIRAIR QVCEDSNTPK SYRYHPGLWS
210 220 230 240 250
GKKWSCCKGL SRTTFGCRAA AHWREANNNP SNGSSPAQNS TRSISPNSST
260 270 280 290 300
TNSQFSLQHN SSGSLGGGVG GGLGGGGSLG LGGGGGGGGS CTPTSLQPQS
310 320 330 340 350
SLTTFKQSPT LLNGNGTLLD ANMPGGIPTP GTPNSKAKDN SHFVKLVVAL
360 370 380 390 400
YPFKAIEGGD LSLEKNAEYE VIDDSQEHWW KVKDALGNVG YIPSNYVKPK
410 420 430 440 450
ALLGLERYEW YVGDMSRQRA ESLLKQGDKE GCFVVRKSST KGLYTLSLHT
460 470 480 490 500
KVPQSHVKHY HIKQNARCEY YLSEKHCCET IPDLINYHRH NSGGLACRLK
510 520 530 540 550
SSPCDRPVPP TAGLSHDKWE IHPMELMLME ELGSGQFGVV RRGKWRGSID
560 570 580 590 600
TAVKMMKEGT MSEDDFIEEA KVMTKLQHPN LVQLYGVCSK HRPIYIVTEY
610 620 630 640 650
MKHGSLLNYL RRHEKTLIGN MGLLLDMCIQ VSKGMTYLER HNYIHRDLAA
660 670 680 690 700
RNCLVGSENV VKVADFGLAR YVLDDQYTSS GGTKFPIKWA PPEVLNYTRF
710 720 730 740 750
SSKSDVWAYG VLMWEIFTCG KMPYGRLKNT EVVERVQRGI ILEKPKSCAK
760 770 780
EIYDVMKLCW SHGPEERPAF RVLMDQLALV AQTLTD
Length:786
Mass (Da):87,392
Last modified:November 25, 2002 - v2
Checksum:iE2BCE122E6AAA0AA
GO
Isoform A (identifier: P08630-2) [UniParc]FASTAAdd to Basket

Also known as: C, F, Type 1

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.
     184-231: EDSNTPKSYR...HWREANNNPS → MIPCVSLAET...SLTSSKTKEG

Show »
Length:603
Mass (Da):66,750
Checksum:i6FDEE9B1F2C230AD
GO

Sequence cautioni

The sequence AAA28912.1 differs from that shown. Reason: Frameshift at positions 62, 215, 218, 220 and 401.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431S → A in AAA28912. (PubMed:3110602)Curated
Sequence conflicti317 – 3171T → N in AAA28912. (PubMed:3110602)Curated
Sequence conflicti317 – 3171T → N in BAA24063. (PubMed:10330180)Curated
Sequence conflicti317 – 3171T → N in BAA24064. (PubMed:10330180)Curated
Sequence conflicti352 – 3532PF → LG in AAA28912. (PubMed:3110602)Curated
Sequence conflicti363 – 3631L → VG in AAA28912. (PubMed:3110602)Curated
Sequence conflicti398 – 4003KPK → QAE in AAA28912. (PubMed:3110602)Curated
Sequence conflicti414 – 4141D → Y in AAA28912. (PubMed:3110602)Curated
Sequence conflicti524 – 5252ME → IQ in AAA28912. (PubMed:3110602)Curated
Sequence conflicti589 – 5891S → T in AAA28912. (PubMed:3110602)Curated
Sequence conflicti589 – 5891S → T in CAA26170. (PubMed:9660966)Curated
Sequence conflicti657 – 6571S → F in CAA26170. (PubMed:9660966)Curated
Sequence conflicti681 – 6844GGTK → AEPS in CAA26170. (PubMed:9660966)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 183183Missing in isoform A. 5 PublicationsVSP_004964Add
BLAST
Alternative sequencei184 – 23148EDSNT…NNNPS → MIPCVSLAETSVIGNMKERV KEMKVFGCRLNFWNHIGHSL TSSKTKEG in isoform A. 5 PublicationsVSP_004965Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16599 mRNA. Translation: AAA28912.1. Frameshift.
AB009840 mRNA. Translation: BAA24063.1.
AB009841 mRNA. Translation: BAA24064.1.
AE014134 Genomic DNA. Translation: AAF52631.3.
AE014134 Genomic DNA. Translation: AAF52632.2.
AE014134 Genomic DNA. Translation: AAN11161.1.
AE014134 Genomic DNA. Translation: AAN11162.1.
AE014134 Genomic DNA. Translation: ABV53648.1.
AE014134 Genomic DNA. Translation: ABV53649.1.
AY069457 mRNA. Translation: AAL39602.1.
AY128441 mRNA. Translation: AAM75034.1.
BT011183 mRNA. Translation: AAR88544.1.
AF044337 mRNA. Translation: AAB99858.1.
X02305 Genomic DNA. Translation: CAA26170.1.
PIRiA23051.
A27807. TVFFDS.
RefSeqiNP_001097120.1. NM_001103650.2. [P08630-2]
NP_001097121.1. NM_001103651.3. [P08630-1]
NP_476745.1. NM_057397.6. [P08630-1]
NP_476746.1. NM_057398.4. [P08630-2]
NP_723369.1. NM_164804.2. [P08630-1]
NP_723370.1. NM_164805.2. [P08630-2]
UniGeneiDm.7306.

Genome annotation databases

EnsemblMetazoaiFBtr0079616; FBpp0079236; FBgn0003502. [P08630-1]
FBtr0079617; FBpp0079237; FBgn0003502. [P08630-1]
FBtr0112836; FBpp0111749; FBgn0003502. [P08630-1]
GeneIDi34132.
KEGGidme:Dmel_CG8049.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M16599 mRNA. Translation: AAA28912.1 . Frameshift.
AB009840 mRNA. Translation: BAA24063.1 .
AB009841 mRNA. Translation: BAA24064.1 .
AE014134 Genomic DNA. Translation: AAF52631.3 .
AE014134 Genomic DNA. Translation: AAF52632.2 .
AE014134 Genomic DNA. Translation: AAN11161.1 .
AE014134 Genomic DNA. Translation: AAN11162.1 .
AE014134 Genomic DNA. Translation: ABV53648.1 .
AE014134 Genomic DNA. Translation: ABV53649.1 .
AY069457 mRNA. Translation: AAL39602.1 .
AY128441 mRNA. Translation: AAM75034.1 .
BT011183 mRNA. Translation: AAR88544.1 .
AF044337 mRNA. Translation: AAB99858.1 .
X02305 Genomic DNA. Translation: CAA26170.1 .
PIRi A23051.
A27807. TVFFDS.
RefSeqi NP_001097120.1. NM_001103650.2. [P08630-2 ]
NP_001097121.1. NM_001103651.3. [P08630-1 ]
NP_476745.1. NM_057397.6. [P08630-1 ]
NP_476746.1. NM_057398.4. [P08630-2 ]
NP_723369.1. NM_164804.2. [P08630-1 ]
NP_723370.1. NM_164805.2. [P08630-2 ]
UniGenei Dm.7306.

3D structure databases

ProteinModelPortali P08630.
SMRi P08630. Positions 48-217, 346-777.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 60259. 13 interactions.
DIPi DIP-23748N.
IntActi P08630. 1 interaction.
MINTi MINT-896102.

Proteomic databases

PaxDbi P08630.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai FBtr0079616 ; FBpp0079236 ; FBgn0003502 . [P08630-1 ]
FBtr0079617 ; FBpp0079237 ; FBgn0003502 . [P08630-1 ]
FBtr0112836 ; FBpp0111749 ; FBgn0003502 . [P08630-1 ]
GeneIDi 34132.
KEGGi dme:Dmel_CG8049.

Organism-specific databases

CTDi 34132.
FlyBasei FBgn0003502. Btk29A.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119011.
InParanoidi P08630.
KOi K07364.
OMAi RRNEEYC.
OrthoDBi EOG7KM5SC.
PhylomeDBi P08630.

Enzyme and pathway databases

Reactomei REACT_85224. Interleukin-3, 5 and GM-CSF signaling.
SignaLinki P08630.

Miscellaneous databases

ChiTaRSi Btk29A. drosophila.
GenomeRNAii 34132.
NextBioi 787021.
PROi P08630.

Gene expression databases

Bgeei P08630.
ExpressionAtlasi P08630. differential.

Family and domain databases

Gene3Di 2.30.29.30. 2 hits.
3.30.505.10. 1 hit.
InterProi IPR011009. Kinase-like_dom.
IPR001849. PH_domain.
IPR011993. PH_like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR000980. SH2.
IPR001452. SH3_domain.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR001562. Znf_Btk_motif.
[Graphical view ]
Pfami PF00779. BTK. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF00017. SH2. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
PRINTSi PR00401. SH2DOMAIN.
PR00109. TYRKINASE.
SMARTi SM00107. BTK. 1 hit.
SM00233. PH. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view ]
SUPFAMi SSF50044. SSF50044. 1 hit.
SSF55550. SSF55550. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Primary sequence and developmental expression of a novel Drosophila melanogaster src gene."
    Gregory R.J., Kammermeyer K.L., Vincent W.S. III, Wadsworth S.G.
    Mol. Cell. Biol. 7:2119-2127(1987) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
  2. "The Drosophila Bruton's tyrosine kinase (Btk) homolog is required for adult survival and male genital formation."
    Baba K., Takeshita A., Majima K., Ueda R., Kondo S., Juni N., Yamamoto D.
    Mol. Cell. Biol. 19:4405-4413(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.
    Strain: Canton-S and Oregon-R.
    Tissue: Head.
  3. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Berkeley.
  4. Cited for: GENOME REANNOTATION, ALTERNATIVE SPLICING.
    Strain: Berkeley.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS A AND B).
    Strain: Berkeley.
    Tissue: Embryo.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM A).
    Strain: Berkeley.
  7. "SRC64 regulates the localization of a Tec-family kinase required for Drosophila ring canal growth."
    Guarnieri D.J., Dodson G.S., Simon M.A.
    Mol. Cell 1:831-840(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 199-786 (ISOFORM A).
    Tissue: Eye-antennal disk.
  8. "Maternal inheritance of transcripts from three Drosophila src-related genes."
    Wadsworth S.C., Madhavan K., Bilodeau-Wentworth D.
    Nucleic Acids Res. 13:2153-2170(1985) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 552-684.
  9. "Src64 is required for ovarian ring canal morphogenesis during Drosophila oogenesis."
    Dodson G.S., Guarnieri D.J., Simon M.A.
    Development 125:2883-2892(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  10. Sjolander K.
    Unpublished observations (JUL-1997)
    Cited for: SIMILARITY TO BTK SUBFAMILY.

Entry informationi

Entry nameiBTKL_DROME
AccessioniPrimary (citable) accession number: P08630
Secondary accession number(s): A4V0F3
, A4V0F4, O45032, O76132, O76133, P11361, Q6NNV0, Q8T0A0, Q9VLQ2, Q9VLQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: November 25, 2002
Last modified: October 29, 2014
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3