P08620 (FGF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 4
Short name=FGF-4

Alternative name(s):
Heparin secretory-transforming protein 1
Short name=HST
Short name=HST-1
Short name=HSTF-1
Heparin-binding growth factor 4
Short name=HBGF-4
Transforming protein KS3

Gene names

Name:	FGF4
Synonyms:	HST, HSTF1, KS3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. Ref.4
Subunit structure	Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.4
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Disease	Proto-oncogene
Domain	Signal
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	apoptotic process involved in morphogenesis Inferred from electronic annotation. Source: Compara cartilage condensation Inferred from electronic annotation. Source: Compara cell-cell signaling Traceable author statement Ref.1. Source: ProtInc chondroblast differentiation Inferred from direct assay PubMed 17167778. Source: UniProtKB cranial suture morphogenesis Inferred from electronic annotation. Source: Compara embryonic hindlimb morphogenesis Inferred from electronic annotation. Source: Compara fibroblast growth factor receptor signaling pathway Inferred from genetic interaction Ref.4. Source: MGI insulin receptor signaling pathway Traceable author statement. Source: Reactome mesenchymal cell proliferation Inferred from direct assay PubMed 11023873. Source: UniProtKB negative regulation of apoptotic process Inferred from electronic annotation. Source: Compara odontogenesis of dentin-containing tooth Inferred from electronic annotation. Source: Compara positive regulation of ERK1 and ERK2 cascade Inferred from direct assay PubMed 17167778. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from genetic interaction Ref.4. Source: MGI positive regulation of protein phosphorylation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara stem cell maintenance Inferred from electronic annotation. Source: Compara
Cellular_component	cytosol Inferred from electronic annotation. Source: Compara extracellular region Traceable author statement. Source: Reactome nucleus Inferred from electronic annotation. Source: Compara
Molecular_function	growth factor activity Traceable author statement Ref.1. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Potential

Chain

31 – 206

176

Fibroblast growth factor 4

PRO_0000008953

Secondary structure

1

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206

Helix Strand Turn

Details...

Beta strand

82 – 88

7

Beta strand

94 – 98

5

Beta strand

104 – 109

6

Helix

112 – 114

3

Beta strand

116 – 122

7

Beta strand

125 – 130

6

Turn

131 – 134

4

Beta strand

135 – 139

5

Beta strand

145 – 150

6

Beta strand

155 – 161

7

Helix

163 – 165

3

Beta strand

167 – 174

8

Beta strand

185 – 187

3

Helix

190 – 192

3

Helix

198 – 200

3

Beta strand

202 – 205

4

Sequences

	Sequence		Length	Mass (Da)
	P08620 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: C7FD54A0272A1569	FASTA	206	22,048
	10 20 30 40 50 60 MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 70 80 90 100 110 120 AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 130 140 150 160 170 180 VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 190 200 LSKNGKTKKG NRVSPTMKVT HFLPRL

References

[1]	"Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein." Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity." Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family." Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., Basilico C. Cell 50:729-737(1987) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Receptor specificity of the fibroblast growth factor family." Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[5]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract] Cited for: REVIEW.
[6]	"Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis." Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., Basilico C., Mohammadi M. Mol. Cell. Biol. 21:5946-5957(2001) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.

IPI

IPI00029760.

PIR

TVHUHS. A28417.

RefSeq

NP_001998.1. NM_002007.2.

UniGene

Hs.1755.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IJT	X-ray	1.80	A	79-206	[»]

ProteinModelPortal

P08620.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-4017N.

STRING

9606.ENSP00000168712.

PTM databases

PhosphoSite

P08620.

Polymorphism databases

DMDM

122750.

Proteomic databases

PaxDb

P08620.

PRIDE

P08620.

Protocols and materials databases

DNASU

2249.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000168712; ENSP00000168712; ENSG00000075388.

GeneID

2249.

KEGG

hsa:2249.

UCSC

uc001opg.1. human.

Organism-specific databases

CTD

2249.

GeneCards

GC11M069588.

HGNC

HGNC:3682. FGF4.

HPA

HPA011209.

MIM

164980. gene.

neXtProt

NX_P08620.

PharmGKB

PA28121.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG290420.

HOGENOM

HOG000236341.

HOVERGEN

HBG007580.

InParanoid

P08620.

KO

K04358.

OMA

YNAYESH.

OrthoDB

EOG4N8R5V.

PhylomeDB

P08620.

Enzyme and pathway databases

Pathway_Interaction_DB

fgf_pathway. FGF signaling pathway.

Reactome

REACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.

Gene expression databases

Bgee

P08620.

CleanEx

HS_FGF4.

Genevestigator

P08620.

GermOnline

ENSG00000075388. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin-bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. PTHR11486. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

SMART

SM00442. FGF. 1 hit.
[Graphical view]

SUPFAM

SSF50353. Cytok_IL1_like. 1 hit.

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00686. Pentosan Polysulfate.

EvolutionaryTrace

P08620.

GenomeRNAi

2249.

NextBio

9103.

SOURCE

Search...

Entry information

Entry name

FGF4_HUMAN

Accession

Primary (citable) accession number: P08620

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	May 1, 2013
This is version 129 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.