ID FGF4_HUMAN STANDARD; PRT; 206 AA. AC P08620; DT 01-AUG-1988 (Rel. 08, Created) DT 01-AUG-1988 (Rel. 08, Last sequence update) DT 13-SEP-2005 (Rel. 48, Last annotation update) DE Fibroblast growth factor-4 precursor (FGF-4) (Heparin secretory DE transforming protein) (HST-1) (HST) (Transforming protein KS3) (HBGF- DE 4). GN Name=FGF4; Synonyms=HST, HSTF1, KS3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=88041096; PubMed=2959959; RA Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., RA Terada M., Sugimura T.; RT "Genomic sequence of hst, a transforming gene encoding a protein RT homologous to fibroblast growth factors and the int-2-encoded RT protein."; RL Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987). RN [2] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=87204251; PubMed=2953031; RA Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., RA Sugimura T.; RT "cDNA sequence of human transforming gene hst and identification of RT the coding sequence required for transforming activity."; RL Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987). RN [3] RP NUCLEOTIDE SEQUENCE. RX MEDLINE=87301716; PubMed=2957062; DOI=10.1016/0092-8674(87)90331-X; RA Delli Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., RA Basilico C.; RT "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes RT a growth factor that is a member of the FGF family."; RL Cell 50:729-737(1987). RN [4] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206. RX MEDLINE=21378624; PubMed=11486033; RX DOI=10.1128/MCB.21.17.5946-5957.2001; RA Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., RA Basilico C., Mohammadi M.; RT "Identification of receptor and heparin binding sites in fibroblast RT growth factor 4 by structure-based mutagenesis."; RL Mol. Cell. Biol. 21:5946-5957(2001). CC -!- FUNCTION: Can transform NIH 3T3 cells from a human stomach tumor CC (hst) and from karposi's sarcoma (KS3). It has a mitogenic CC activity. CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02986; AAB59555.1; -; Genomic_DNA. DR EMBL; M17446; AAA59473.1; -; mRNA. DR PIR; A28417; TVHUHS. DR PDB; 1IJT; X-ray; A=79-206. DR Ensembl; ENSG00000075388; Homo sapiens. DR HGNC; HGNC:3682; FGF4. DR MIM; 164980; -. DR GO; GO:0005576; C:extracellular region; TAS. DR GO; GO:0008083; F:growth factor activity; TAS. DR GO; GO:0007267; P:cell-cell signaling; TAS. DR GO; GO:0008284; P:positive regulation of cell proliferation; TAS. DR GO; GO:0007165; P:signal transduction; TAS. DR InterPro; IPR008996; Cytok_IL1_like. DR InterPro; IPR002209; HB/F_growthfact. DR InterPro; IPR002348; IL1_HBGF. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR ProDom; PD000831; IL1_HBGF; 1. DR SMART; SM00442; FGF; 1. DR PROSITE; PS00247; HBGF_FGF; 1. KW 3D-structure; Growth factor; Heparin-binding; Mitogen; Proto-oncogene; KW Signal. FT SIGNAL 1 30 Potential. FT CHAIN 31 206 Fibroblast growth factor-4. FT STRAND 82 88 FT TURN 91 92 FT STRAND 94 98 FT TURN 100 101 FT STRAND 104 107 FT HELIX 112 114 FT STRAND 116 122 FT TURN 123 124 FT STRAND 125 130 FT TURN 131 134 FT STRAND 135 139 FT TURN 141 142 FT STRAND 145 148 FT TURN 153 154 FT STRAND 156 161 FT HELIX 163 165 FT STRAND 167 171 FT TURN 175 176 FT STRAND 178 178 FT STRAND 181 181 FT TURN 183 184 FT STRAND 187 187 FT HELIX 190 192 FT TURN 195 196 FT HELIX 198 200 FT STRAND 202 206 SQ SEQUENCE 206 AA; 22048 MW; C7FD54A0272A1569 CRC64; MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT HFLPRL //