ID   FGF4_HUMAN     STANDARD;      PRT;   206 AA.
AC   P08620;
DT   01-AUG-1988 (Rel. 08, Created)
DT   01-AUG-1988 (Rel. 08, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Fibroblast growth factor-4 precursor (FGF-4) (Heparin secretory
DE   transforming protein) (HST-1) (HST) (Transforming protein KS3) (HBGF-
DE   4).
GN   FGF4 OR HST OR HSTF1 OR KS3.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=88041096; PubMed=2959959;
RA   Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R.,
RA   Terada M., Sugimura T.;
RT   "Genomic sequence of hst, a transforming gene encoding a protein
RT   homologous to fibroblast growth factors and the int-2-encoded
RT   protein.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87204251; PubMed=2953031;
RA   Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M.,
RA   Sugimura T.;
RT   "cDNA sequence of human transforming gene hst and identification of
RT   the coding sequence required for transforming activity.";
RL   Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE=87301716; PubMed=2957062;
RA   Delli Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M.,
RA   Basilico C.;
RT   "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes
RT   a growth factor that is a member of the FGF family.";
RL   Cell 50:729-737(1987).
CC   -!- FUNCTION: CAN TRANSFORM NIH 3T3 CELLS FROM A HUMAN STOMACH TUMOR
CC       (HST) AND FROM KARPOSI'S SARCOMA (KS3). IT HAS A MITOGENIC
CC       ACTIVITY.
CC   -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
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DR   EMBL; J02986; AAB59555.1; -.
DR   EMBL; M17446; AAA59473.1; -.
DR   PIR; A28417; TVHUHS.
DR   PDB; 1IJT; 15-AUG-01.
DR   Genew; HGNC:3682; FGF4.
DR   MIM; 164980; -.
DR   GO; GO:0005576; C:extracellular; TAS.
DR   GO; GO:0008083; F:growth factor activity; TAS.
DR   GO; GO:0007267; P:cell-cell signaling; TAS.
DR   GO; GO:0007048; P:oncogenesis; TAS.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; TAS.
DR   GO; GO:0007165; P:signal transduction; TAS.
DR   InterPro; IPR002348; IL1_HBGF.
DR   Pfam; PF00167; FGF; 1.
DR   PRINTS; PR00262; IL1HBGF.
DR   ProDom; PD000831; IL1_HBGF; 1.
DR   SMART; SM00442; FGF; 1.
DR   PROSITE; PS00247; HBGF_FGF; 1.
KW   Proto-oncogene; Growth factor; Mitogen; Signal; 3D-structure.
FT   SIGNAL        1     27       POTENTIAL.
FT   CHAIN        28    206       FIBROBLAST GROWTH FACTOR-4.
SQ   SEQUENCE   206 AA;  22047 MW;  C7FD54A0272A1569 CRC64;
     MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV
     AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP
     VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA
     LSKNGKTKKG NRVSPTMKVT HFLPRL
//