ID   FGF4_HUMAN     STANDARD;      PRT;   206 AA.
AC   P08620;
DT   01-AUG-1988 (REL. 08, CREATED)
DT   01-AUG-1988 (REL. 08, LAST SEQUENCE UPDATE)
DT   01-FEB-1996 (REL. 33, LAST ANNOTATION UPDATE)
DE   FIBROBLAST GROWTH FACTOR-4 PRECURSOR (FGF-4) (HEPARIN SECRETORY
DE   TRANSFORMING PROTEIN) (HST-1) (HST) (TRANSFORMING PROTEIN KS3) (HBGF-
DE   4).
GN   FGF4 OR HST OR HSTF1 OR KS3.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; MAMMALIA; EUTHERIA;
OC   PRIMATES; CATARRHINI; HOMINIDAE; HOMO.
RN   [1]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 88041096.
RA   YOSHIDA T., MIYAGAWA K., ODAGIRI H., SAKAMOTO H., LITTLE P.F.R.,
RA   TERADA M., SUGIMURA T.;
RT   "Genomic sequence of hst, a transforming gene encoding a protein
RT   homologous to fibroblast growth factors and the int-2-encoded
RT   protein.";
RL   PROC. NATL. ACAD. SCI. U.S.A. 84:7305-7309(1987).
RN   [2]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 87204251.
RA   TAIRA M., YOSHIDA T., MIYAGAWA K., SAKAMOTO H., TERADA M.,
RA   SUGIMURA T.;
RT   "cDNA sequence of human transforming gene hst and identification of
RT   the coding sequence required for transforming activity.";
RL   PROC. NATL. ACAD. SCI. U.S.A. 84:2980-2984(1987).
RN   [3]
RP   SEQUENCE FROM N.A.
RX   MEDLINE; 87301716.
RA   DELLI BOVI P., CURATOLA A.M., KERN F.G., GRECO A., ITTMANN M.,
RA   BASILICO C.;
RT   "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes
RT   a growth factor that is a member of the FGF family.";
RL   CELL 50:729-737(1987).
CC   -!- FUNCTION: CAN TRANSFORM NIH 3T3 CELLS FROM A HUMAN STOMACH TUMOR
CC       (HST) AND FROM KARPOSI'S SARCOMA (KS3). IT HAS A MITOGENIC
CC       ACTIVITY.
CC   -!- SIMILARITY: BELONGS TO THE HEPARIN-BINDING GROWTH FACTORS FAMILY.
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DR   EMBL; J02986; G386788; -.
DR   EMBL; M17446; G307092; -.
DR   PIR; A28417; TVHUHS.
DR   MIM; 164980; -.
DR   PROSITE; PS00247; HBGF_FGF; 1.
DR   PFAM; PF00167; FGF; 1.
DR   HSSP; P09038; 1BFF.
KW   TRANSFORMING PROTEIN; ONCOGENE; GROWTH FACTOR; MITOGEN; SIGNAL.
FT   SIGNAL        1      ?       POTENTIAL.
FT   CHAIN         ?    206       FIBROBLAST GROWTH FACTOR-4.
SQ   SEQUENCE   206 AA;  22047 MW;  D1C40A8B CRC32;
     MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV
     AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP
     VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA
     LSKNGKTKKG NRVSPTMKVT HFLPRL
//