ID FGF4_HUMAN Reviewed; 206 AA. AC P08620; DT 01-AUG-1988, integrated into UniProtKB/Swiss-Prot. DT 01-AUG-1988, sequence version 1. DT 30-NOV-2010, entry version 107. DE RecName: Full=Fibroblast growth factor 4; DE Short=FGF-4; DE AltName: Full=Heparin secretory-transforming protein 1; DE Short=HST; DE Short=HST-1; DE Short=HSTF-1; DE AltName: Full=Heparin-binding growth factor 4; DE Short=HBGF-4; DE AltName: Full=Transforming protein KS3; DE Flags: Precursor; GN Name=FGF4; Synonyms=HST, HSTF1, KS3; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=88041096; PubMed=2959959; DOI=10.1073/pnas.84.20.7305; RA Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., RA Terada M., Sugimura T.; RT "Genomic sequence of hst, a transforming gene encoding a protein RT homologous to fibroblast growth factors and the int-2-encoded RT protein."; RL Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RX MEDLINE=87204251; PubMed=2953031; DOI=10.1073/pnas.84.9.2980; RA Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., RA Sugimura T.; RT "cDNA sequence of human transforming gene hst and identification of RT the coding sequence required for transforming activity."; RL Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987). RN [3] RP NUCLEOTIDE SEQUENCE [MRNA]. RX MEDLINE=87301716; PubMed=2957062; DOI=10.1016/0092-8674(87)90331-X; RA Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., RA Basilico C.; RT "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes RT a growth factor that is a member of the FGF family."; RL Cell 50:729-737(1987). RN [4] RP X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206. RX MEDLINE=21378624; PubMed=11486033; RX DOI=10.1128/MCB.21.17.5946-5957.2001; RA Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., RA Basilico C., Mohammadi M.; RT "Identification of receptor and heparin binding sites in fibroblast RT growth factor 4 by structure-based mutagenesis."; RL Mol. Cell. Biol. 21:5946-5957(2001). CC -!- FUNCTION: Can transform NIH 3T3 cells from a human stomach tumor CC (hst) and from karposi's sarcoma (KS3). It has a mitogenic CC activity. CC -!- SUBCELLULAR LOCATION: Secreted (Potential). CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; J02986; AAB59555.1; -; Genomic_DNA. DR EMBL; M17446; AAA59473.1; -; mRNA. DR IPI; IPI00029760; -. DR PIR; A28417; TVHUHS. DR RefSeq; NP_001998.1; NM_002007.2. DR UniGene; Hs.1755; -. DR PDB; 1IJT; X-ray; 1.80 A; A=79-206. DR PDBsum; 1IJT; -. DR ProteinModelPortal; P08620; -. DR SMR; P08620; 79-206. DR DIP; DIP-4017N; -. DR STRING; P08620; -. DR PRIDE; P08620; -. DR Ensembl; ENST00000168712; ENSP00000168712; ENSG00000075388. DR GeneID; 2249; -. DR KEGG; hsa:2249; -. DR UCSC; uc001opg.1; human. DR CTD; 2249; -. DR GeneCards; GC11M069588; -. DR H-InvDB; HIX0036033; -. DR HGNC; HGNC:3682; FGF4. DR HPA; HPA011209; -. DR MIM; 164980; gene. DR PharmGKB; PA28121; -. DR eggNOG; prNOG09447; -. DR HOGENOM; HBG715603; -. DR HOVERGEN; HBG007580; -. DR InParanoid; P08620; -. DR OMA; YNAYESH; -. DR OrthoDB; EOG9PK4TV; -. DR PhylomeDB; P08620; -. DR Pathway_Interaction_DB; fgf_pathway; FGF signaling pathway. DR Reactome; REACT_498; Signaling by Insulin receptor. DR Reactome; REACT_9470; Signaling by FGFR. DR DrugBank; DB00686; Pentosan Polysulfate. DR NextBio; 9103; -. DR ArrayExpress; P08620; -. DR Bgee; P08620; -. DR CleanEx; HS_FGF4; -. DR Genevestigator; P08620; -. DR GermOnline; ENSG00000075388; Homo sapiens. DR GO; GO:0005576; C:extracellular region; EXP:Reactome. DR GO; GO:0008083; F:growth factor activity; TAS:ProtInc. DR GO; GO:0008201; F:heparin binding; IEA:UniProtKB-KW. DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc. DR GO; GO:0060591; P:chondroblast differentiation; IDA:UniProtKB. DR GO; GO:0008543; P:fibroblast growth factor receptor signaling...; IGI:MGI. DR GO; GO:0010463; P:mesenchymal cell proliferation; IDA:UniProtKB. DR GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW. DR GO; GO:0008284; P:positive regulation of cell proliferation; IGI:MGI. DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:UniProtKB. DR GO; GO:0007165; P:signal transduction; TAS:ProtInc. DR InterPro; IPR008996; Cytokine_IL1-like. DR InterPro; IPR002209; GF_heparin-bd. DR InterPro; IPR002348; IL1_HBGF. DR PANTHER; PTHR11486; IL1_HBGF; 1. DR Pfam; PF00167; FGF; 1. DR PRINTS; PR00263; HBGFFGF. DR PRINTS; PR00262; IL1HBGF. DR SMART; SM00442; FGF; 1. DR SUPFAM; SSF50353; Cytok_IL1_like; 1. DR PROSITE; PS00247; HBGF_FGF; 1. PE 1: Evidence at protein level; KW 3D-structure; Complete proteome; Growth factor; Heparin-binding; KW Mitogen; Proto-oncogene; Secreted; Signal. FT SIGNAL 1 30 Potential. FT CHAIN 31 206 Fibroblast growth factor 4. FT /FTId=PRO_0000008953. FT STRAND 82 88 FT STRAND 94 98 FT STRAND 104 109 FT HELIX 112 114 FT STRAND 116 122 FT STRAND 125 130 FT TURN 131 134 FT STRAND 135 139 FT STRAND 145 150 FT STRAND 155 161 FT HELIX 163 165 FT STRAND 167 174 FT STRAND 185 187 FT HELIX 190 192 FT HELIX 198 200 FT STRAND 202 205 SQ SEQUENCE 206 AA; 22048 MW; C7FD54A0272A1569 CRC64; MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT HFLPRL //