Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibroblast growth factor 4

Gene

FGF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Growth factor, Mitogen

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075388-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1839122. Signaling by activated point mutants of FGFR1.
R-HSA-1839130. Signaling by activated point mutants of FGFR3.
R-HSA-190322. FGFR4 ligand binding and activation.
R-HSA-190372. FGFR3c ligand binding and activation.
R-HSA-190373. FGFR1c ligand binding and activation.
R-HSA-190375. FGFR2c ligand binding and activation.
R-HSA-2033514. FGFR3 mutant receptor activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654227. Phospholipase C-mediated cascade, FGFR3.
R-HSA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654704. SHC-mediated cascade:FGFR3.
R-HSA-5654706. FRS-mediated FGFR3 signaling.
R-HSA-5654710. PI-3K cascade:FGFR3.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5654720. PI-3K cascade:FGFR4.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5654732. Negative regulation of FGFR3 signaling.
R-HSA-5654733. Negative regulation of FGFR4 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853338. Signaling by FGFR3 point mutants in cancer.
SignaLinkiP08620.
SIGNORiP08620.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin secretory-transforming protein 1
Short name:
HST
Short name:
HST-1
Short name:
HSTF-1
Heparin-binding growth factor 4
Short name:
HBGF-4
Transforming protein KS3
Gene namesi
Name:FGF4
Synonyms:HST, HSTF1, KS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:3682. FGF4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2249.
OpenTargetsiENSG00000075388.
PharmGKBiPA28121.

Chemistry databases

ChEMBLiCHEMBL3286072.
DrugBankiDB00686. Pentosan Polysulfate.

Polymorphism and mutation databases

BioMutaiFGF4.
DMDMi122750.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000895331 – 206Fibroblast growth factor 4Add BLAST176

Proteomic databases

PaxDbiP08620.
PRIDEiP08620.

PTM databases

iPTMnetiP08620.
PhosphoSitePlusiP08620.

Expressioni

Gene expression databases

BgeeiENSG00000075388.
CleanExiHS_FGF4.
GenevisibleiP08620. HS.

Organism-specific databases

HPAiHPA011209.

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

  • growth factor activity Source: ProtInc

Protein-protein interaction databases

DIPiDIP-4017N.
STRINGi9606.ENSP00000168712.

Chemistry databases

BindingDBiP08620.

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi82 – 88Combined sources7
Beta strandi94 – 98Combined sources5
Beta strandi104 – 109Combined sources6
Helixi112 – 114Combined sources3
Beta strandi116 – 122Combined sources7
Beta strandi125 – 130Combined sources6
Turni131 – 134Combined sources4
Beta strandi135 – 139Combined sources5
Beta strandi145 – 150Combined sources6
Beta strandi155 – 161Combined sources7
Helixi163 – 165Combined sources3
Beta strandi167 – 174Combined sources8
Beta strandi185 – 187Combined sources3
Helixi190 – 192Combined sources3
Helixi198 – 200Combined sources3
Beta strandi202 – 205Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IJTX-ray1.80A79-206[»]
ProteinModelPortaliP08620.
SMRiP08620.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08620.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP08620.
KOiK04358.
OMAiYNAYESH.
OrthoDBiEOG091G0NAY.
PhylomeDBiP08620.
TreeFamiTF317805.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF31. PTHR11486:SF31. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08620-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL
60 70 80 90 100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP
110 120 130 140 150
DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF
160 170 180 190 200
FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT

HFLPRL
Length:206
Mass (Da):22,048
Last modified:August 1, 1988 - v1
Checksum:iC7FD54A0272A1569
GO
Isoform 2 (identifier: P08620-2) [UniParc]FASTAAdd to basket
Also known as: FGF4si

The sequence of this isoform differs from the canonical sequence as follows:
     114-206: SLLELSPVER...MKVTHFLPRL → TLLHR

Note: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation.
Show »
Length:118
Mass (Da):12,237
Checksum:iAAA97FBB8C667D7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053541114 – 206SLLEL…FLPRL → TLLHR in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ456981 mRNA. Translation: ACJ68447.1.
J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.
CCDSiCCDS8194.1. [P08620-1]
PIRiA28417. TVHUHS.
RefSeqiNP_001998.1. NM_002007.2. [P08620-1]
XP_005273904.1. XM_005273847.1. [P08620-2]
UniGeneiHs.1755.

Genome annotation databases

EnsembliENST00000168712; ENSP00000168712; ENSG00000075388. [P08620-1]
GeneIDi2249.
KEGGihsa:2249.
UCSCiuc001opg.2. human. [P08620-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ456981 mRNA. Translation: ACJ68447.1.
J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.
CCDSiCCDS8194.1. [P08620-1]
PIRiA28417. TVHUHS.
RefSeqiNP_001998.1. NM_002007.2. [P08620-1]
XP_005273904.1. XM_005273847.1. [P08620-2]
UniGeneiHs.1755.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IJTX-ray1.80A79-206[»]
ProteinModelPortaliP08620.
SMRiP08620.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-4017N.
STRINGi9606.ENSP00000168712.

Chemistry databases

BindingDBiP08620.
ChEMBLiCHEMBL3286072.
DrugBankiDB00686. Pentosan Polysulfate.

PTM databases

iPTMnetiP08620.
PhosphoSitePlusiP08620.

Polymorphism and mutation databases

BioMutaiFGF4.
DMDMi122750.

Proteomic databases

PaxDbiP08620.
PRIDEiP08620.

Protocols and materials databases

DNASUi2249.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000168712; ENSP00000168712; ENSG00000075388. [P08620-1]
GeneIDi2249.
KEGGihsa:2249.
UCSCiuc001opg.2. human. [P08620-1]

Organism-specific databases

CTDi2249.
DisGeNETi2249.
GeneCardsiFGF4.
HGNCiHGNC:3682. FGF4.
HPAiHPA011209.
MIMi164980. gene.
neXtProtiNX_P08620.
OpenTargetsiENSG00000075388.
PharmGKBiPA28121.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3885. Eukaryota.
ENOG4111IPH. LUCA.
GeneTreeiENSGT00760000118859.
HOGENOMiHOG000236341.
HOVERGENiHBG007580.
InParanoidiP08620.
KOiK04358.
OMAiYNAYESH.
OrthoDBiEOG091G0NAY.
PhylomeDBiP08620.
TreeFamiTF317805.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000075388-MONOMER.
ReactomeiR-HSA-109704. PI3K Cascade.
R-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-1839122. Signaling by activated point mutants of FGFR1.
R-HSA-1839130. Signaling by activated point mutants of FGFR3.
R-HSA-190322. FGFR4 ligand binding and activation.
R-HSA-190372. FGFR3c ligand binding and activation.
R-HSA-190373. FGFR1c ligand binding and activation.
R-HSA-190375. FGFR2c ligand binding and activation.
R-HSA-2033514. FGFR3 mutant receptor activation.
R-HSA-2033519. Activated point mutants of FGFR2.
R-HSA-2219530. Constitutive Signaling by Aberrant PI3K in Cancer.
R-HSA-5654219. Phospholipase C-mediated cascade: FGFR1.
R-HSA-5654221. Phospholipase C-mediated cascade, FGFR2.
R-HSA-5654227. Phospholipase C-mediated cascade, FGFR3.
R-HSA-5654228. Phospholipase C-mediated cascade, FGFR4.
R-HSA-5654687. Downstream signaling of activated FGFR1.
R-HSA-5654688. SHC-mediated cascade:FGFR1.
R-HSA-5654689. PI-3K cascade:FGFR1.
R-HSA-5654693. FRS-mediated FGFR1 signaling.
R-HSA-5654695. PI-3K cascade:FGFR2.
R-HSA-5654699. SHC-mediated cascade:FGFR2.
R-HSA-5654700. FRS-mediated FGFR2 signaling.
R-HSA-5654704. SHC-mediated cascade:FGFR3.
R-HSA-5654706. FRS-mediated FGFR3 signaling.
R-HSA-5654710. PI-3K cascade:FGFR3.
R-HSA-5654712. FRS-mediated FGFR4 signaling.
R-HSA-5654719. SHC-mediated cascade:FGFR4.
R-HSA-5654720. PI-3K cascade:FGFR4.
R-HSA-5654726. Negative regulation of FGFR1 signaling.
R-HSA-5654727. Negative regulation of FGFR2 signaling.
R-HSA-5654732. Negative regulation of FGFR3 signaling.
R-HSA-5654733. Negative regulation of FGFR4 signaling.
R-HSA-5655253. Signaling by FGFR2 in disease.
R-HSA-5655302. Signaling by FGFR1 in disease.
R-HSA-5658623. FGFRL1 modulation of FGFR1 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-HSA-8853338. Signaling by FGFR3 point mutants in cancer.
SignaLinkiP08620.
SIGNORiP08620.

Miscellaneous databases

EvolutionaryTraceiP08620.
GeneWikiiFGF4.
GenomeRNAii2249.
PROiP08620.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075388.
CleanExiHS_FGF4.
GenevisibleiP08620. HS.

Family and domain databases

CDDicd00058. FGF. 1 hit.
InterProiIPR008996. Cytokine_IL1-like.
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERiPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF31. PTHR11486:SF31. 1 hit.
PfamiPF00167. FGF. 1 hit.
[Graphical view]
PRINTSiPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTiSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFGF4_HUMAN
AccessioniPrimary (citable) accession number: P08620
Secondary accession number(s): B7U994
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: November 30, 2016
This is version 163 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.