Reviewed,
UniProtKB/Swiss-Prot P08620 (FGF4_HUMAN)
Last modified
June 16, 2009.
Version 91.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Fibroblast growth factor 4 Short name=FGF-4 Alternative name(s): Heparin secretory-transforming protein HST-1 Short name=HST Transforming protein KS3 Heparin-binding growth factor 4 Short name=HBGF-4 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 206 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity. |
| Sequence similarities | Belongs to the heparin-binding growth factors family. |
Ontologies
| Keywords | |
|---|---|
| Disease | Proto-oncogene |
| Domain | Signal |
| Ligand | Heparin-binding |
| Molecular function | Growth factor Mitogen |
| Technical term | 3D-structure |
| Gene Ontology (GO) | |
| Biological process | cell proliferation Inferred from electronic annotation. Source: UniProtKB-KW cell-cell signaling Ref.1Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathwayInferred from Experiment. Source: Reactome positive regulation of cell proliferation Ref.1Traceable author statement. Source: ProtInc |
| Cellular component | extracellular region Ref.1 Inferred from Experiment. Source: Reactome |
| Molecular function | growth factor activity Ref.1 Traceable author statement. Source: ProtInc heparin bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 30 | 30 | Potential | ||||||||||||||||||||||||||||||||||||
| Chain | 31 – 206 | 176 | Fibroblast growth factor 4 | PRO_0000008953 | |||||||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||||||||
| Beta strand | 82 – 88 | 7 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 94 – 98 | 5 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 104 – 109 | 6 | |||||||||||||||||||||||||||||||||||||
| Helix | 112 – 114 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 116 – 122 | 7 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 125 – 130 | 6 | |||||||||||||||||||||||||||||||||||||
| Turn | 131 – 134 | 4 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 135 – 139 | 5 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 145 – 150 | 6 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 155 – 161 | 7 | |||||||||||||||||||||||||||||||||||||
| Helix | 163 – 165 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 167 – 174 | 8 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 185 – 187 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 190 – 192 | 3 | |||||||||||||||||||||||||||||||||||||
| Helix | 198 – 200 | 3 | |||||||||||||||||||||||||||||||||||||
| Beta strand | 202 – 205 | 4 | |||||||||||||||||||||||||||||||||||||
Sequences
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References
| [1] | "Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein." Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed: 2959959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [2] | "cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity." Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed: 2953031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family." Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., Basilico C. Cell 50:729-737(1987) [PubMed: 2957062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [4] | "Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis." Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., Basilico C., Mohammadi M. Mol. Cell. Biol. 21:5946-5957(2001) [PubMed: 11486033] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| J02986 Genomic DNA. Translation: AAB59555.1. M17446 mRNA. Translation: AAA59473.1. | |||||||||||||
| IPI | IPI00029760. | ||||||||||||
| PIR | TVHUHS. A28417. | ||||||||||||
| RefSeq | NP_001998.1. | ||||||||||||
| UniGene | Hs.1755 | ||||||||||||
3D structure databases | |||||||||||||
| |||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| DIP | DIP:4017N. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P08620. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000075388. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 2249. | ||||||||||||
| KEGG | hsa:2249. | ||||||||||||
Organism-specific databases | |||||||||||||
| GeneCards | GC11M069297. | ||||||||||||
| H-InvDB | HIX0036033. | ||||||||||||
| HGNC | HGNC:3682. FGF4. | ||||||||||||
| HPA | HPA011209. | ||||||||||||
| MIM | 164980. gene. | ||||||||||||
| PharmGKB | PA28121. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | P08620. | ||||||||||||
| HOVERGEN | P08620. | ||||||||||||
| OMA | P08620. YNAYESH. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | fgf_pathway. FGF signaling pathway. | ||||||||||||
| Reactome | REACT_9470. Signaling by FGFR. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P08620. | ||||||||||||
| Bgee | P08620. | ||||||||||||
| CleanEx | HS_FGF4. | ||||||||||||
| GermOnline | ENSG00000075388. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR002209. GF_heparin_bd. IPR002348. IL1_HBGF. [Graphical view] | ||||||||||||
| PANTHER | PTHR11486. IL1_HBGF. 1 hit. | ||||||||||||
| Pfam | PF00167. FGF. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00263. HBGFFGF. PR00262. IL1HBGF. | ||||||||||||
| ProDom | PD000831. IL1_HBGF. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| SMART | SM00442. FGF. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00247. HBGF_FGF. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| DrugBank | DB00686. Pentosan Polysulfate. | ||||||||||||
| NextBio | 9103. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | FGF4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P08620 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with


