Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P08620 (FGF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 139. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fibroblast growth factor 4

Short name=FGF-4
Alternative name(s):
Heparin secretory-transforming protein 1
Short name=HST
Short name=HST-1
Short name=HSTF-1
Heparin-binding growth factor 4
Short name=HBGF-4
Transforming protein KS3
Gene names
Name:FGF4
Synonyms:HST, HSTF1, KS3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. Ref.5

Subunit structure

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.5

Subcellular location

Secreted Potential.

Sequence similarities

Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
   Biological processDifferentiation
   Cellular componentSecreted
   Coding sequence diversityAlternative splicing
   DiseaseProto-oncogene
   DomainSignal
   LigandHeparin-binding
   Molecular functionDevelopmental protein
Growth factor
Mitogen
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processFc-epsilon receptor signaling pathway

Traceable author statement. Source: Reactome

apoptotic process involved in morphogenesis

Inferred from electronic annotation. Source: Ensembl

cartilage condensation

Inferred from electronic annotation. Source: Ensembl

cell-cell signaling

Traceable author statement Ref.2. Source: ProtInc

chondroblast differentiation

Inferred from direct assay PubMed 17167778. Source: UniProtKB

cranial suture morphogenesis

Inferred from electronic annotation. Source: Ensembl

embryonic hindlimb morphogenesis

Inferred from electronic annotation. Source: Ensembl

epidermal growth factor receptor signaling pathway

Traceable author statement. Source: Reactome

fibroblast growth factor receptor signaling pathway

Inferred from genetic interaction Ref.5. Source: MGI

innate immune response

Traceable author statement. Source: Reactome

insulin receptor signaling pathway

Traceable author statement. Source: Reactome

mesenchymal cell proliferation

Inferred from direct assay PubMed 11023873. Source: UniProtKB

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

neurotrophin TRK receptor signaling pathway

Traceable author statement. Source: Reactome

odontogenesis of dentin-containing tooth

Inferred from electronic annotation. Source: Ensembl

phosphatidylinositol-mediated signaling

Traceable author statement. Source: Reactome

positive regulation of ERK1 and ERK2 cascade

Inferred from direct assay PubMed 17167778. Source: UniProtKB

positive regulation of cell division

Inferred from electronic annotation. Source: UniProtKB-KW

positive regulation of cell proliferation

Inferred from genetic interaction Ref.5. Source: MGI

positive regulation of protein phosphorylation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

signal transduction

Traceable author statement Ref.2. Source: ProtInc

stem cell maintenance

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytosol

Inferred from electronic annotation. Source: Ensembl

extracellular region

Traceable author statement. Source: Reactome

nucleus

Inferred from electronic annotation. Source: Ensembl

   Molecular_functiongrowth factor activity

Traceable author statement Ref.2. Source: ProtInc

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: P08620-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: P08620-2)

Also known as: FGF4si;

The sequence of this isoform differs from the canonical sequence as follows:
     114-206: SLLELSPVER...MKVTHFLPRL → TLLHR
Note: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 Potential
Chain31 – 206176Fibroblast growth factor 4
PRO_0000008953

Natural variations

Alternative sequence114 – 20693SLLEL…FLPRL → TLLHR in isoform 2.
VSP_053541

Secondary structure

............................... 206
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: C7FD54A0272A1569

FASTA20622,048
        10         20         30         40         50         60 
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 

        70         80         90        100        110        120 
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 

       130        140        150        160        170        180 
VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 

       190        200 
LSKNGKTKKG NRVSPTMKVT HFLPRL 

« Hide

Isoform 2 (FGF4si) [UniParc].

Checksum: AAA97FBB8C667D7F
Show »

FASTA11812,237

References

[1]"Fibroblast growth factor 4 and its novel splice isoform have opposing effects on the maintenance of human embryonic stem cell self-renewal."
Mayshar Y., Rom E., Chumakov I., Kronman A., Yayon A., Benvenisty N.
Stem Cells 26:767-774(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), ALTERNATIVE SPLICING.
[2]"Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein."
Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., Terada M., Sugimura T.
Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity."
Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T.
Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family."
Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., Basilico C.
Cell 50:729-737(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[5]"Receptor specificity of the fibroblast growth factor family."
Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M.
J. Biol. Chem. 271:15292-15297(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[6]"Fibroblast growth factor signalling: from development to cancer."
Turner N., Grose R.
Nat. Rev. Cancer 10:116-129(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.
[7]"Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis."
Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., Basilico C., Mohammadi M.
Mol. Cell. Biol. 21:5946-5957(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FJ456981 mRNA. Translation: ACJ68447.1.
J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.
PIRTVHUHS. A28417.
RefSeqNP_001998.1. NM_002007.2.
XP_005273904.1. XM_005273847.1.
UniGeneHs.1755.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1IJTX-ray1.80A79-206[»]
ProteinModelPortalP08620.
SMRP08620. Positions 79-206.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

DIPDIP-4017N.
STRING9606.ENSP00000168712.

Chemistry

DrugBankDB00686. Pentosan Polysulfate.

PTM databases

PhosphoSiteP08620.

Polymorphism databases

DMDM122750.

Proteomic databases

PaxDbP08620.
PRIDEP08620.

Protocols and materials databases

DNASU2249.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000168712; ENSP00000168712; ENSG00000075388. [P08620-1]
GeneID2249.
KEGGhsa:2249.
UCSCuc001opg.1. human. [P08620-1]

Organism-specific databases

CTD2249.
GeneCardsGC11M069588.
HGNCHGNC:3682. FGF4.
HPAHPA011209.
MIM164980. gene.
neXtProtNX_P08620.
PharmGKBPA28121.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG290420.
HOGENOMHOG000236341.
HOVERGENHBG007580.
InParanoidP08620.
KOK04358.
OMAYNAYESH.
OrthoDBEOG7992S1.
PhylomeDBP08620.
TreeFamTF317805.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.
REACT_116125. Disease.
REACT_6900. Immune System.
SignaLinkP08620.

Gene expression databases

BgeeP08620.
CleanExHS_FGF4.
GenevestigatorP08620.

Family and domain databases

InterProIPR008996. Cytokine_IL1-like.
IPR028239. FGF4.
IPR002209. Fibroblast_GF_fam.
IPR028142. IL-1_fam/FGF_fam.
[Graphical view]
PANTHERPTHR11486. PTHR11486. 1 hit.
PTHR11486:SF31. PTHR11486:SF31. 1 hit.
PfamPF00167. FGF. 1 hit.
[Graphical view]
PRINTSPR00263. HBGFFGF.
PR00262. IL1HBGF.
SMARTSM00442. FGF. 1 hit.
[Graphical view]
SUPFAMSSF50353. SSF50353. 1 hit.
PROSITEPS00247. HBGF_FGF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP08620.
GeneWikiFGF4.
GenomeRNAi2249.
NextBio35478625.
PROP08620.
SOURCESearch...

Entry information

Entry nameFGF4_HUMAN
AccessionPrimary (citable) accession number: P08620
Secondary accession number(s): B7U994
Entry history
Integrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: April 16, 2014
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM