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Protein

Fibroblast growth factor 4

Gene

FGF4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor, Heparin-binding, Mitogen
Biological processDifferentiation

Enzyme and pathway databases

ReactomeiR-HSA-109704 PI3K Cascade
R-HSA-1257604 PIP3 activates AKT signaling
R-HSA-1839122 Signaling by activated point mutants of FGFR1
R-HSA-1839130 Signaling by activated point mutants of FGFR3
R-HSA-190322 FGFR4 ligand binding and activation
R-HSA-190372 FGFR3c ligand binding and activation
R-HSA-190373 FGFR1c ligand binding and activation
R-HSA-190375 FGFR2c ligand binding and activation
R-HSA-2033514 FGFR3 mutant receptor activation
R-HSA-2033519 Activated point mutants of FGFR2
R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer
R-HSA-5654219 Phospholipase C-mediated cascade: FGFR1
R-HSA-5654221 Phospholipase C-mediated cascade, FGFR2
R-HSA-5654227 Phospholipase C-mediated cascade, FGFR3
R-HSA-5654228 Phospholipase C-mediated cascade, FGFR4
R-HSA-5654687 Downstream signaling of activated FGFR1
R-HSA-5654688 SHC-mediated cascade:FGFR1
R-HSA-5654689 PI-3K cascade:FGFR1
R-HSA-5654693 FRS-mediated FGFR1 signaling
R-HSA-5654695 PI-3K cascade:FGFR2
R-HSA-5654699 SHC-mediated cascade:FGFR2
R-HSA-5654700 FRS-mediated FGFR2 signaling
R-HSA-5654704 SHC-mediated cascade:FGFR3
R-HSA-5654706 FRS-mediated FGFR3 signaling
R-HSA-5654710 PI-3K cascade:FGFR3
R-HSA-5654712 FRS-mediated FGFR4 signaling
R-HSA-5654719 SHC-mediated cascade:FGFR4
R-HSA-5654720 PI-3K cascade:FGFR4
R-HSA-5654726 Negative regulation of FGFR1 signaling
R-HSA-5654727 Negative regulation of FGFR2 signaling
R-HSA-5654732 Negative regulation of FGFR3 signaling
R-HSA-5654733 Negative regulation of FGFR4 signaling
R-HSA-5655253 Signaling by FGFR2 in disease
R-HSA-5655302 Signaling by FGFR1 in disease
R-HSA-5658623 FGFRL1 modulation of FGFR1 signaling
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8853338 Signaling by FGFR3 point mutants in cancer
SignaLinkiP08620
SIGNORiP08620

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor 4
Short name:
FGF-4
Alternative name(s):
Heparin secretory-transforming protein 1
Short name:
HST
Short name:
HST-1
Short name:
HSTF-1
Heparin-binding growth factor 4
Short name:
HBGF-4
Transforming protein KS3
Gene namesi
Name:FGF4
Synonyms:HST, HSTF1, KS3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000075388.3
HGNCiHGNC:3682 FGF4
MIMi164980 gene
neXtProtiNX_P08620

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi2249
OpenTargetsiENSG00000075388
PharmGKBiPA28121

Chemistry databases

ChEMBLiCHEMBL3286072
DrugBankiDB00686 Pentosan Polysulfate
DB05309 TP-508

Polymorphism and mutation databases

BioMutaiFGF4
DMDMi122750

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000000895331 – 206Fibroblast growth factor 4Add BLAST176

Proteomic databases

PaxDbiP08620
PRIDEiP08620

PTM databases

iPTMnetiP08620
PhosphoSitePlusiP08620

Expressioni

Gene expression databases

BgeeiENSG00000075388
CleanExiHS_FGF4
GenevisibleiP08620 HS

Organism-specific databases

HPAiHPA011209

Interactioni

Subunit structurei

Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-4017N
STRINGi9606.ENSP00000168712

Chemistry databases

BindingDBiP08620

Structurei

Secondary structure

1206
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi82 – 88Combined sources7
Beta strandi94 – 98Combined sources5
Beta strandi104 – 109Combined sources6
Helixi112 – 114Combined sources3
Beta strandi116 – 122Combined sources7
Beta strandi125 – 130Combined sources6
Turni131 – 134Combined sources4
Beta strandi135 – 139Combined sources5
Beta strandi145 – 150Combined sources6
Beta strandi155 – 161Combined sources7
Helixi163 – 165Combined sources3
Beta strandi167 – 174Combined sources8
Beta strandi185 – 187Combined sources3
Helixi190 – 192Combined sources3
Helixi198 – 200Combined sources3
Beta strandi202 – 205Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IJTX-ray1.80A79-206[»]
ProteinModelPortaliP08620
SMRiP08620
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP08620

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3885 Eukaryota
ENOG4111IPH LUCA
GeneTreeiENSGT00760000118859
HOGENOMiHOG000236341
HOVERGENiHBG007580
InParanoidiP08620
KOiK04358
OMAiYNAYESH
OrthoDBiEOG091G0NAY
PhylomeDBiP08620
TreeFamiTF317805

Family and domain databases

CDDicd00058 FGF, 1 hit
InterProiView protein in InterPro
IPR028239 FGF4
IPR002209 Fibroblast_GF_fam
IPR008996 IL1/FGF
PANTHERiPTHR11486 PTHR11486, 1 hit
PTHR11486:SF31 PTHR11486:SF31, 1 hit
PfamiView protein in Pfam
PF00167 FGF, 1 hit
PRINTSiPR00263 HBGFFGF
SMARTiView protein in SMART
SM00442 FGF, 1 hit
SUPFAMiSSF50353 SSF50353, 1 hit
PROSITEiView protein in PROSITE
PS00247 HBGF_FGF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P08620-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL
60 70 80 90 100
VALSLARLPV AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP
110 120 130 140 150
DGRIGGAHAD TRDSLLELSP VERGVVSIFG VASRFFVAMS SKGKLYGSPF
160 170 180 190 200
FTDECTFKEI LLPNNYNAYE SYKYPGMFIA LSKNGKTKKG NRVSPTMKVT

HFLPRL
Length:206
Mass (Da):22,048
Last modified:August 1, 1988 - v1
Checksum:iC7FD54A0272A1569
GO
Isoform 2 (identifier: P08620-2) [UniParc]FASTAAdd to basket
Also known as: FGF4si

The sequence of this isoform differs from the canonical sequence as follows:
     114-206: SLLELSPVER...MKVTHFLPRL → TLLHR

Note: Antagonist of isoform 1, shutting down FGF4-induced Erk1/2 phosphorylation.
Show »
Length:118
Mass (Da):12,237
Checksum:iAAA97FBB8C667D7F
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_053541114 – 206SLLEL…FLPRL → TLLHR in isoform 2. 1 PublicationAdd BLAST93

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FJ456981 mRNA Translation: ACJ68447.1
J02986 Genomic DNA Translation: AAB59555.1
M17446 mRNA Translation: AAA59473.1
CCDSiCCDS8194.1 [P08620-1]
PIRiA28417 TVHUHS
RefSeqiNP_001998.1, NM_002007.2 [P08620-1]
XP_005273904.1, XM_005273847.1 [P08620-2]
UniGeneiHs.1755
Hs.362432

Genome annotation databases

EnsembliENST00000168712; ENSP00000168712; ENSG00000075388 [P08620-1]
GeneIDi2249
KEGGihsa:2249
UCSCiuc001opg.2 human [P08620-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiFGF4_HUMAN
AccessioniPrimary (citable) accession number: P08620
Secondary accession number(s): B7U994
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 1, 1988
Last sequence update: August 1, 1988
Last modified: March 28, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health