Fibroblast growth factor 4 precursor

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P08620 (FGF4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 116. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Fibroblast growth factor 4
Short name=FGF-4

Alternative name(s):
Heparin secretory-transforming protein 1
Short name=HST
Short name=HST-1
Short name=HSTF-1
Heparin-binding growth factor 4
Short name=HBGF-4
Transforming protein KS3

Gene names

Name:	FGF4
Synonyms:	HST, HSTF1, KS3

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb and cardiac valve development during embryogenesis. Ref.4
Subunit structure	Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Ref.4
Subcellular location	Secreted Potential.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Secreted
Disease	Proto-oncogene
Domain	Signal
Ligand	Heparin-binding
Molecular function	Developmental protein Growth factor Mitogen
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell-cell signaling Traceable author statement. Source: ProtInc chondroblast differentiation Inferred from direct assay. Source: UniProtKB fibroblast growth factor receptor signaling pathway Inferred from genetic interaction Ref.4. Source: MGI insulin receptor signaling pathway Traceable author statement. Source: Reactome mesenchymal cell proliferation Inferred from direct assay. Source: UniProtKB positive regulation of ERK1 and ERK2 cascade Inferred from direct assay. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Inferred from genetic interaction Ref.4. Source: MGI
Cellular component	extracellular region Traceable author statement. Source: Reactome
Molecular function	growth factor activity Traceable author statement. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Traceable author statement. Source: Reactome
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

Potential

Chain

31 – 206

176

Fibroblast growth factor 4

PRO_0000008953

Secondary structure

206

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

P08620 [UniParc].

Last modified August 1, 1988. Version 1.
Checksum: C7FD54A0272A1569
Show »

FASTA

206

22,048

        10         20         30         40         50         60 
MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 

        70         80         90        100        110        120 
AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 

       130        140        150        160        170        180 
VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 

       190        200 
LSKNGKTKKG NRVSPTMKVT HFLPRL

« Hide

References

[1]	"Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein." Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed: 2959959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity." Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed: 2953031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family." Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., Basilico C. Cell 50:729-737(1987) [PubMed: 2957062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Receptor specificity of the fibroblast growth factor family." Ornitz D.M., Xu J., Colvin J.S., McEwen D.G., MacArthur C.A., Coulier F., Gao G., Goldfarb M. J. Biol. Chem. 271:15292-15297(1996) [PubMed: 8663044] [Abstract] Cited for: INTERACTION WITH FGFR1; FGFR2; FGFR3 AND FGFR4, FUNCTION IN CELL PROLIFERATION.
[5]	"Fibroblast growth factor signalling: from development to cancer." Turner N., Grose R. Nat. Rev. Cancer 10:116-129(2010) [PubMed: 20094046] [Abstract] Cited for: REVIEW.
[6]	"Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis." Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., Basilico C., Mohammadi M. Mol. Cell. Biol. 21:5946-5957(2001) [PubMed: 11486033] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.

IPI

IPI00029760.

PIR

TVHUHS. A28417.

RefSeq

NP_001998.1. NM_002007.2.

UniGene

Hs.1755.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IJT	X-ray	1.80	A	79-206	[»]

ProteinModelPortal

P08620.

SMR

P08620. Positions 79-206.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-4017N.

STRING

P08620.

PTM databases

PhosphoSite

P08620.

Polymorphism databases

DMDM

122750.

Proteomic databases

PRIDE

P08620.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000168712; ENSP00000168712; ENSG00000075388.

GeneID

2249.

KEGG

hsa:2249.

UCSC

uc001opg.1. human.

Organism-specific databases

CTD

2249.

GeneCards

GC11M069588.

H-InvDB

HIX0036033.

HGNC

HGNC:3682. FGF4.

HPA

HPA011209.

MIM

164980. gene.

neXtProt

NX_P08620.

PharmGKB

PA28121.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG09447.

GeneTree

ENSGT00590000082822.

HOGENOM

HBG715603.

HOVERGEN

HBG007580.

InParanoid

P08620.

OMA

PFFTEEC.

OrthoDB

EOG4N8R5V.

PhylomeDB

P08620.

Enzyme and pathway databases

Pathway_Interaction_DB

fgf_pathway. FGF signaling pathway.

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

P08620.

Bgee

P08620.

CleanEx

HS_FGF4.

Genevestigator

P08620.

GermOnline

ENSG00000075388. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin-bd.
IPR002348. IL1_HBGF.
[Graphical view]

K04358.

PANTHER

PTHR11486. IL1_HBGF. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

SMART

SM00442. FGF. 1 hit.
[Graphical view]

SUPFAM

SSF50353. Cytok_IL1_like. 1 hit.

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

DrugBank

DB00686. Pentosan Polysulfate.

NextBio

9103.

SOURCE

Search...

Entry information

Entry name

FGF4_HUMAN

Accession

Primary (citable) accession number: P08620

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	January 25, 2012
This is version 116 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents