Reviewed, UniProtKB/Swiss-Prot P08620 (FGF4_HUMAN)

Names and origin

Protein names

Recommended name:
    Fibroblast growth factor 4
      Short name=FGF-4
Alternative name(s):
    Heparin secretory-transforming protein
    HST-1
      Short name=HST
    Transforming protein KS3
    Heparin-binding growth factor 4
      Short name=HBGF-4

Gene names

Name:	FGF4
Synonyms:	HST, HSTF1, KS3

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Can transform NIH 3T3 cells from a human stomach tumor (hst) and from karposi's sarcoma (KS3). It has a mitogenic activity.
Sequence similarities	Belongs to the heparin-binding growth factors family.

Ontologies

Keywords
Disease	Proto-oncogene
Domain	Signal
Ligand	Heparin-binding
Molecular function	Growth factor Mitogen
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	cell-cell signaling Ref.1 Traceable author statement. Source: ProtInc fibroblast growth factor receptor signaling pathway Inferred from genetic interaction. Source: MGI mesenchymal cell proliferation Inferred from direct assay. Source: UniProtKB positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW positive regulation of cell proliferation Ref.1 Inferred from genetic interaction. Source: MGI
Cellular component	extracellular region Ref.1 Inferred from Experiment. Source: Reactome
Molecular function	growth factor activity Ref.1 Traceable author statement. Source: ProtInc heparin binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 30

30

Potential

Chain

31 – 206

176

Fibroblast growth factor 4

PRO_0000008953

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

206

Helix Strand Turn

Details...

Beta strand

82 – 88

7

Beta strand

94 – 98

5

Beta strand

104 – 109

6

Helix

112 – 114

3

Beta strand

116 – 122

7

Beta strand

125 – 130

6

Turn

131 – 134

4

Beta strand

135 – 139

5

Beta strand

145 – 150

6

Beta strand

155 – 161

7

Helix

163 – 165

3

Beta strand

167 – 174

8

Beta strand

185 – 187

3

Helix

190 – 192

3

Helix

198 – 200

3

Beta strand

202 – 205

4

Sequences

	Sequence		Length	Mass (Da)
	P08620-1 [UniParc]. Last modified August 1, 1988. Version 1. Checksum: C7FD54A0272A1569	FASTA	206	22,048
	10 20 30 40 50 60 MSGPGTAAVA LLPAVLLALL APWAGRGGAA APTAPNGTLE AELERRWESL VALSLARLPV 70 80 90 100 110 120 AAQPKEAAVQ SGAGDYLLGI KRLRRLYCNV GIGFHLQALP DGRIGGAHAD TRDSLLELSP 130 140 150 160 170 180 VERGVVSIFG VASRFFVAMS SKGKLYGSPF FTDECTFKEI LLPNNYNAYE SYKYPGMFIA 190 200 LSKNGKTKKG NRVSPTMKVT HFLPRL

References

[1]	"Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein." Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little P.F.R., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:7305-7309(1987) [PubMed: 2959959] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"cDNA sequence of human transforming gene hst and identification of the coding sequence required for transforming activity." Taira M., Yoshida T., Miyagawa K., Sakamoto H., Terada M., Sugimura T. Proc. Natl. Acad. Sci. U.S.A. 84:2980-2984(1987) [PubMed: 2953031] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family." Delli-Bovi P., Curatola A.M., Kern F.G., Greco A., Ittmann M., Basilico C. Cell 50:729-737(1987) [PubMed: 2957062] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]	"Identification of receptor and heparin binding sites in fibroblast growth factor 4 by structure-based mutagenesis." Bellosta P., Iwahori A., Plotnikov A.N., Eliseenkova A.V., Basilico C., Mohammadi M. Mol. Cell. Biol. 21:5946-5957(2001) [PubMed: 11486033] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 79-206.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J02986 Genomic DNA. Translation: AAB59555.1.
M17446 mRNA. Translation: AAA59473.1.

IPI

IPI00029760.

PIR

TVHUHS. A28417.

RefSeq

NP_001998.1.

UniGene

Hs.1755

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1IJT	X-ray	1.80	A	79-206	[»]

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-4017N.

STRING

P08620.

Proteomic databases

PRIDE

P08620.

Genome annotation databases

Ensembl

ENST00000168712; ENSP00000168712; ENSG00000075388; Homo sapiens. [Genome view]

GeneID

2249.

KEGG

hsa:2249.

UCSC

uc001opg.1. human.

Organism-specific databases

CTD

2249.

GeneCards

GC11M069297.

H-InvDB

HIX0036033.

HGNC

HGNC:3682. FGF4.

HPA

HPA011209.

MIM

164980. gene.

PharmGKB

PA28121.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG09447.

HOGENOM

HBG715603.

HOVERGEN

P08620.

InParanoid

P08620.

OMA

YNAYESH.

OrthoDB

EOG9PK4TV.

PhylomeDB

P08620.

Enzyme and pathway databases

Pathway_Interaction_DB

fgf_pathway. FGF signaling pathway.

Reactome

REACT_9470. Signaling by FGFR.

Gene expression databases

ArrayExpress

P08620.

Bgee

P08620.

CleanEx

HS_FGF4.

Genevestigator

P08620.

GermOnline

ENSG00000075388. Homo sapiens.

Family and domain databases

InterPro

IPR008996. Cytokine_IL1-like.
IPR002209. GF_heparin_bd.
IPR002348. IL1_HBGF.
[Graphical view]

PANTHER

PTHR11486. IL1_HBGF. 1 hit.

Pfam

PF00167. FGF. 1 hit.
[Graphical view]

PRINTS

PR00263. HBGFFGF.
PR00262. IL1HBGF.

SMART

SM00442. FGF. 1 hit.
[Graphical view]

PROSITE

PS00247. HBGF_FGF. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00686. Pentosan Polysulfate.

NextBio

9103.

SOURCE

Search...

Entry information

Entry name

FGF4_HUMAN

Accession

Primary (citable) accession number: P08620

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 1, 1988
Last sequence update:	August 1, 1988
Last modified:	February 9, 2010
This is version 100 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.